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Prolonged N2 sleep

MedGen UID:
1052102
•Concept ID:
CN375776
•
Finding
HPO: HP:5200358

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProlonged N2 sleep

Professional guidelines

PubMed

Systematic review: Clinical effectiveness of interventions for the treatment of nocturnal gastroesophageal reflux.
Schuitenmaker JM, Kuipers T, Smout AJPM, Fockens P, Bredenoord AJ
Neurogastroenterol Motil 2022 Dec;34(12):e14385. Epub 2022 Apr 21 doi: 10.1111/nmo.14385. PMID: 35445777Free PMC Article
Cushing Syndrome is Associated with Increased Stage N2 Sleep and Decreased SWS Partially Reversible After Treatment.
Ismailogullari S, Karaca Z, Firat ST, Unluhizarci K, Kelestimur F
Horm Metab Res 2021 Sep;53(9):608-615. Epub 2021 Sep 8 doi: 10.1055/a-1542-8816. PMID: 34496411
Management of imported cutaneous larva migrans: A case series and mini-review.
Kincaid L, Klowak M, Klowak S, Boggild AK
Travel Med Infect Dis 2015 Sep-Oct;13(5):382-7. Epub 2015 Jul 29 doi: 10.1016/j.tmaid.2015.07.007. PMID: 26243366

Recent clinical studies

Etiology

Insomnia attenuates response inhibition: Evidence from Go/NoGo research.
Fang Z, Liu X, Wang C, Cao J, Peng Y, Lv Y
Sleep Med 2022 Dec;100:518-533. Epub 2022 Oct 12 doi: 10.1016/j.sleep.2022.09.007. PMID: 36306630
Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.
Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570
Systematic review: Clinical effectiveness of interventions for the treatment of nocturnal gastroesophageal reflux.
Schuitenmaker JM, Kuipers T, Smout AJPM, Fockens P, Bredenoord AJ
Neurogastroenterol Motil 2022 Dec;34(12):e14385. Epub 2022 Apr 21 doi: 10.1111/nmo.14385. PMID: 35445777Free PMC Article
Sleep Complaints and Sleep Architecture in Children With Idiopathic Central Sleep Apnea.
Gurbani N, Verhulst SL, Tan C, Simakajornboon N
J Clin Sleep Med 2017 Jun 15;13(6):777-783. doi: 10.5664/jcsm.6614. PMID: 28212689Free PMC Article
Sleep disorders in psychiatry.
Costa e Silva JA
Metabolism 2006 Oct;55(10 Suppl 2):S40-4. doi: 10.1016/j.metabol.2006.07.012. PMID: 16979426

Diagnosis

Language-Independent Sleepy Speech Detection.
Moon J, Kong Y, Chon KH
Annu Int Conf IEEE Eng Med Biol Soc 2022 Jul;2022:1981-1984. doi: 10.1109/EMBC48229.2022.9870900. PMID: 36085715
Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.
Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570
A Systematic Review, Meta-Analysis and Meta-Regression on the Effects of Carbohydrates on Sleep.
Vlahoyiannis A, Giannaki CD, Sakkas GK, Aphamis G, Andreou E
Nutrients 2021 Apr 14;13(4) doi: 10.3390/nu13041283. PMID: 33919698Free PMC Article
Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials.
Clark I, Landolt HP
Sleep Med Rev 2017 Feb;31:70-78. Epub 2016 Jan 30 doi: 10.1016/j.smrv.2016.01.006. PMID: 26899133
Sleep and neuromuscular disorders.
Culebras A
Neurol Clin 2005 Nov;23(4):1209-23, ix. doi: 10.1016/j.ncl.2005.08.004. PMID: 16243623

Therapy

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.
Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570
Systematic review: Clinical effectiveness of interventions for the treatment of nocturnal gastroesophageal reflux.
Schuitenmaker JM, Kuipers T, Smout AJPM, Fockens P, Bredenoord AJ
Neurogastroenterol Motil 2022 Dec;34(12):e14385. Epub 2022 Apr 21 doi: 10.1111/nmo.14385. PMID: 35445777Free PMC Article
A Systematic Review, Meta-Analysis and Meta-Regression on the Effects of Carbohydrates on Sleep.
Vlahoyiannis A, Giannaki CD, Sakkas GK, Aphamis G, Andreou E
Nutrients 2021 Apr 14;13(4) doi: 10.3390/nu13041283. PMID: 33919698Free PMC Article
Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials.
Clark I, Landolt HP
Sleep Med Rev 2017 Feb;31:70-78. Epub 2016 Jan 30 doi: 10.1016/j.smrv.2016.01.006. PMID: 26899133
Narcolepsy and depression and the neurobiology of gammahydroxybutyrate.
Mamelak M
Prog Neurobiol 2009 Oct;89(2):193-219. Epub 2009 Aug 3 doi: 10.1016/j.pneurobio.2009.07.004. PMID: 19654034

Prognosis

Slow-wave sleep and REM sleep without atonia predict motor progression in Parkinson's disease.
Tao MX, Meng L, Xie WY, Li HX, Zhang JR, Yan JH, Cheng XY, Wang F, Mao CJ, Shen Y, Liu CF
Sleep Med 2024 Mar;115:155-161. Epub 2024 Feb 8 doi: 10.1016/j.sleep.2024.02.003. PMID: 38367357
Inter-sleep stage variations in corrected QT interval differ between obstructive sleep apnea patients with and without stroke history.
Ebrahimian S, Sillanmäki S, Hietakoste S, Duce B, Kulkas A, Töyräs J, Leppänen T, Lipponen JA, Kainulainen S
PLoS One 2022;17(12):e0278520. Epub 2022 Dec 1 doi: 10.1371/journal.pone.0278520. PMID: 36454997Free PMC Article
Sleep quality of patients with papillary thyroid carcinoma: a prospective longitudinal study with 5-year follow-up.
Koo DL, Park Y, Nam H, Chai YJ
Sci Rep 2022 Nov 5;12(1):18823. doi: 10.1038/s41598-022-23549-3. PMID: 36335214Free PMC Article
Cushing Syndrome is Associated with Increased Stage N2 Sleep and Decreased SWS Partially Reversible After Treatment.
Ismailogullari S, Karaca Z, Firat ST, Unluhizarci K, Kelestimur F
Horm Metab Res 2021 Sep;53(9):608-615. Epub 2021 Sep 8 doi: 10.1055/a-1542-8816. PMID: 34496411
Sleep in disorders of consciousness: behavioral and polysomnographic recording.
Mertel I, Pavlov YG, Barner C, Müller F, Diekelmann S, Kotchoubey B
BMC Med 2020 Nov 20;18(1):350. doi: 10.1186/s12916-020-01812-6. PMID: 33213463Free PMC Article

Clinical prediction guides

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.
Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570
Sleep fragmentation and decreased REM sleep in a primate model of diurnal cortical seizures.
Vuong JS, York A, Garrett J, Connolly MJ, Devergnas A
Epilepsy Res 2021 Dec;178:106805. Epub 2021 Nov 2 doi: 10.1016/j.eplepsyres.2021.106805. PMID: 34768048
Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep.
Feng H, Wen SY, Qiao QC, Pang YJ, Wang SY, Li HY, Cai J, Zhang KX, Chen J, Hu ZA, Luo FL, Wang GZ, Yang N, Zhang J
Nat Commun 2020 Jul 21;11(1):3661. doi: 10.1038/s41467-020-17401-3. PMID: 32694504Free PMC Article
Insomnia, alcoholism and relapse.
Brower KJ
Sleep Med Rev 2003 Dec;7(6):523-39. doi: 10.1016/s1087-0792(03)90005-0. PMID: 15018094
The function of dreaming.
Staunton H
Rev Neurosci 2001;12(4):365-71. doi: 10.1515/revneuro.2001.12.4.365. PMID: 11783720

Recent systematic reviews

Sleep quality and architecture in Idiopathic generalized epilepsy: A systematic review and meta-analysis.
Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570
Systematic review: Clinical effectiveness of interventions for the treatment of nocturnal gastroesophageal reflux.
Schuitenmaker JM, Kuipers T, Smout AJPM, Fockens P, Bredenoord AJ
Neurogastroenterol Motil 2022 Dec;34(12):e14385. Epub 2022 Apr 21 doi: 10.1111/nmo.14385. PMID: 35445777Free PMC Article
A Systematic Review, Meta-Analysis and Meta-Regression on the Effects of Carbohydrates on Sleep.
Vlahoyiannis A, Giannaki CD, Sakkas GK, Aphamis G, Andreou E
Nutrients 2021 Apr 14;13(4) doi: 10.3390/nu13041283. PMID: 33919698Free PMC Article
Sleep disorders in Wilson disease: a systematic review and meta-analysis.
Xu J, Deng Q, Qin Q, Vgontzas AN, Basta M, Xie C, Li Y
J Clin Sleep Med 2020 Feb 15;16(2):219-230. Epub 2020 Jan 13 doi: 10.5664/jcsm.8170. PMID: 31992405Free PMC Article
Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials.
Clark I, Landolt HP
Sleep Med Rev 2017 Feb;31:70-78. Epub 2016 Jan 30 doi: 10.1016/j.smrv.2016.01.006. PMID: 26899133

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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