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Lymphocytic infiltration of the parotid gland

MedGen UID:
1052388
•Concept ID:
CN376666
•
Finding
HPO: HP:6000153

Definition

Accumulation of lymphocytes in the parotid gland. This feature is generally defined as a count of lymphocytes per area that is above normal limits on histopathological examination. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphocytic infiltration of the parotid gland

Professional guidelines

PubMed

Possible role for IL-40 and IL-40-producing cells in the lymphocytic infiltrated salivary glands of patients with primary Sjögren's syndrome.
Guggino G, Rizzo C, Mohammadnezhad L, Lo Pizzo M, Lentini VL, Di Liberto D, La Barbera L, Raimondo S, Shekarkar Azgomi M, Urzì O, Berardicurti O, Campisi G, Alessandro R, Giacomelli R, Dieli F, Ciccia F
RMD Open 2023 May;9(2) doi: 10.1136/rmdopen-2022-002738. PMID: 37137540Free PMC Article
IgG4-Related Disease and the Salivary Glands: A Review of Pathophysiology, Diagnosis, and Management.
Skillington SA, Ogden MA
Otolaryngol Clin North Am 2021 Jun;54(3):497-508. doi: 10.1016/j.otc.2021.02.002. PMID: 34024478
Abatacept treatment of patients with primary Sjögren's syndrome results in a decrease of germinal centres in salivary gland tissue.
Haacke EA, van der Vegt B, Meiners PM, Vissink A, Spijkervet FK, Bootsma H, Kroese FG
Clin Exp Rheumatol 2017 Mar-Apr;35(2):317-320. Epub 2016 Nov 12 PMID: 27908305

Recent clinical studies

Etiology

A rare case of sebaceous lymphadenoma: Cytohistological correlation of preoperative cytomorphologic findings.
Ronen N, Massey B, Javakhishvili N, Giorgadze T
Ann Diagn Pathol 2022 Dec;61:152058. Epub 2022 Oct 29 doi: 10.1016/j.anndiagpath.2022.152058. PMID: 36334412
Sebaceous Lymphadenoma: Radiology-Pathology Correlation.
Dababneh MN, Griffith CC, Patel MR, Magliocca KR
Head Neck Pathol 2021 Jun;15(2):593-598. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01266-5. PMID: 33398686Free PMC Article
Histopathological and immunohistochemical profile in primary Sjögren's syndrome.
Dinescu ŞC, ForŢofoiu MC, Bumbea AM, Ciurea PL, Busuioc CJ, Muşetescu AE
Rom J Morphol Embryol 2017;58(2):409-417. PMID: 28730224
Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren's syndrome.
Pijpe J, Kalk WW, van der Wal JE, Vissink A, Kluin PM, Roodenburg JL, Bootsma H, Kallenberg CG, Spijkervet FK
Rheumatology (Oxford) 2007 Feb;46(2):335-41. Epub 2006 Aug 5 doi: 10.1093/rheumatology/kel266. PMID: 16891656
Tumefactive fibro-inflammatory lesions of the head and neck.
Wold LE, Weiland LH
Am J Surg Pathol 1983 Jul;7(5):477-82. doi: 10.1097/00000478-198307000-00010. PMID: 6614311

Diagnosis

IgG4-Related Disease and the Salivary Glands: A Review of Pathophysiology, Diagnosis, and Management.
Skillington SA, Ogden MA
Otolaryngol Clin North Am 2021 Jun;54(3):497-508. doi: 10.1016/j.otc.2021.02.002. PMID: 34024478
Sebaceous Lymphadenoma: Radiology-Pathology Correlation.
Dababneh MN, Griffith CC, Patel MR, Magliocca KR
Head Neck Pathol 2021 Jun;15(2):593-598. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01266-5. PMID: 33398686Free PMC Article
Parotid Gland Biopsy, the Alternative Way to Diagnose Sjögren Syndrome.
Spijkervet FK, Haacke E, Kroese FG, Bootsma H, Vissink A
Rheum Dis Clin North Am 2016 Aug;42(3):485-99. Epub 2016 Jun 21 doi: 10.1016/j.rdc.2016.03.007. PMID: 27431350
Salivary gland biopsy for Sjögren's syndrome.
Delli K, Vissink A, Spijkervet FK
Oral Maxillofac Surg Clin North Am 2014 Feb;26(1):23-33. doi: 10.1016/j.coms.2013.09.005. PMID: 24287191
Lymphoepithelial carcinoma of the parotid glands and its relationship with benign lymphoepithelial lesions.
Schneider M, Rizzardi C
Arch Pathol Lab Med 2008 Feb;132(2):278-82. doi: 10.5858/2008-132-278-LCOTPG. PMID: 18251590

Therapy

Carcinoma showing thymus-like differentiation (CASTLE) of the salivary gland: Report of 2 cases of a hitherto under-recognized extrathyroid counterpart.
Yamamoto H, Kusafuka K, Nozaki Y, Iwasaki T, Nogami M, Hongo T, Yasumatsu R, Oda Y
Pathol Res Pract 2021 Nov;227:153646. Epub 2021 Oct 8 doi: 10.1016/j.prp.2021.153646. PMID: 34649052
Abatacept treatment of patients with primary Sjögren's syndrome results in a decrease of germinal centres in salivary gland tissue.
Haacke EA, van der Vegt B, Meiners PM, Vissink A, Spijkervet FK, Bootsma H, Kroese FG
Clin Exp Rheumatol 2017 Mar-Apr;35(2):317-320. Epub 2016 Nov 12 PMID: 27908305
Clinical and histologic evidence of salivary gland restoration supports the efficacy of rituximab treatment in Sjögren's syndrome.
Pijpe J, Meijer JM, Bootsma H, van der Wal JE, Spijkervet FK, Kallenberg CG, Vissink A, Ihrler S
Arthritis Rheum 2009 Nov;60(11):3251-6. doi: 10.1002/art.24903. PMID: 19877054
Parotid gland biopsy compared with labial biopsy in the diagnosis of patients with primary Sjogren's syndrome.
Pijpe J, Kalk WW, van der Wal JE, Vissink A, Kluin PM, Roodenburg JL, Bootsma H, Kallenberg CG, Spijkervet FK
Rheumatology (Oxford) 2007 Feb;46(2):335-41. Epub 2006 Aug 5 doi: 10.1093/rheumatology/kel266. PMID: 16891656
Primary Sjögren syndrome in childhood: report of a case and review of the literature.
Nikitakis NG, Rivera H, Lariccia C, Papadimitriou JC, Sauk JJ
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003 Jul;96(1):42-7. doi: 10.1016/s1079-2104(03)00159-8. PMID: 12847443

Prognosis

Carcinoma showing thymus-like differentiation (CASTLE) of the salivary gland: Report of 2 cases of a hitherto under-recognized extrathyroid counterpart.
Yamamoto H, Kusafuka K, Nozaki Y, Iwasaki T, Nogami M, Hongo T, Yasumatsu R, Oda Y
Pathol Res Pract 2021 Nov;227:153646. Epub 2021 Oct 8 doi: 10.1016/j.prp.2021.153646. PMID: 34649052
Semi-quantitative evaluation of salivary gland function in Sjögren's syndrome using salivary gland scintigraphy.
Zou Q, Jiao J, Zou MH, Xu JH, Pan YF, Chen JN, Cheng MH, Zhang F, Zhang Y
Clin Rheumatol 2012 Dec;31(12):1699-705. Epub 2012 Sep 2 doi: 10.1007/s10067-012-2076-3. PMID: 22941258
Histiocytic sarcoma of the parotid gland region.
Akiba J, Harada H, Kawahara A, Arakawa F, Mihashi H, Mihashi R, Ohshima K, Yano H
Pathol Int 2011 Jun;61(6):373-6. Epub 2011 May 2 doi: 10.1111/j.1440-1827.2011.02671.x. PMID: 21615614
Diffuse infiltrative CD8+ lymphocytosis syndrome: review of the literature and report of a case.
Feller L, White JP, Bouckaert M, Muthuphei MN
SADJ 2007 Aug;62(7):314-7. PMID: 18019812
Follicular lymphoma of the salivary gland: a clinicopathological and molecular study of six cases.
Kojima M, Nakamura S, Ichimura K, Shimizu K, Itoh H, Masawa N
Int J Surg Pathol 2001 Oct;9(4):287-93. doi: 10.1177/106689690100900405. PMID: 12574844

Clinical prediction guides

Possible role for IL-40 and IL-40-producing cells in the lymphocytic infiltrated salivary glands of patients with primary Sjögren's syndrome.
Guggino G, Rizzo C, Mohammadnezhad L, Lo Pizzo M, Lentini VL, Di Liberto D, La Barbera L, Raimondo S, Shekarkar Azgomi M, Urzì O, Berardicurti O, Campisi G, Alessandro R, Giacomelli R, Dieli F, Ciccia F
RMD Open 2023 May;9(2) doi: 10.1136/rmdopen-2022-002738. PMID: 37137540Free PMC Article
Primary Hyper-IgE-Related Salivary Gland Disease: A New Disease Entity.
Zhu WX, Zhang YY, Gao Y, Chen Y, Zhang ZY, Hua H, Yu GY
Laryngoscope 2022 Nov;132(11):2132-2138. Epub 2022 Feb 23 doi: 10.1002/lary.30064. PMID: 35199865
HCV Infection Alters Salivary Gland Histology and Saliva Composition.
Maldonado JO, Beach ME, Wang Y, Perez P, Yin H, Pelayo E, Fowler S, Alevizos I, Grisius M, Baer AN, Walitt B, De Giorgi V, Alter HJ, Warner BM, Chiorini JA
J Dent Res 2022 May;101(5):534-541. Epub 2022 Jan 20 doi: 10.1177/00220345211049395. PMID: 35045743Free PMC Article
Repertoire Analysis of B-Cells Located in Striated Ducts of Salivary Glands of Patients With Sjögren's Syndrome.
Visser A, Verstappen GM, van der Vegt B, Vissink A, Bende RJ, Bootsma H, Bos NA, Kroese FGM
Front Immunol 2020;11:1486. Epub 2020 Jul 14 doi: 10.3389/fimmu.2020.01486. PMID: 32760405Free PMC Article
Nodular fasciitis in the parotid gland: a case report and review of the literature.
Peng WX, Kudo M, Yamamoto T, Inai S, Fujii T, Teduka K, Kawahara K, Naito Z
Diagn Cytopathol 2013 Sep;41(9):829-33. Epub 2013 Jun 8 doi: 10.1002/dc.22983. PMID: 23749727

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