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Placidity

MedGen UID:
1052465
•Concept ID:
CN376544
•
Finding
HPO: HP:6000030

Definition

Flat affect and reduced response to emotional stimuli. Fear and anger responses that are normally present are blunted. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlacidity

Professional guidelines

PubMed

Klüver-Bucy Syndrome Following Traumatic Brain Injury: A Systematic Synthesis and Review of Pharmacological Treatment From Cases in Adolescents and Adults.
Clay FJ, Kuriakose A, Lesche D, Hicks AJ, Zaman H, Azizi E, Ponsford JL, Jayaram M, Hopwood M
J Neuropsychiatry Clin Neurosci 2019 Winter;31(1):6-16. Epub 2018 Oct 31 doi: 10.1176/appi.neuropsych.18050112. PMID: 30376788

Recent clinical studies

Etiology

Is it possible to diagnose Rett syndrome before classical symptoms become obvious? Review of 24 Danish cases born between 2003 and 2012.
Bisgaard AM, Schönewolf-Greulich B, Ravn K, Rønde G
Eur J Paediatr Neurol 2015 Nov;19(6):679-87. Epub 2015 Jul 21 doi: 10.1016/j.ejpn.2015.07.004. PMID: 26228846
Klüver Bucy syndrome following hypoglycaemic coma in a patient with glycogen storage disease type Ib.
Boudjemline AM, Isapof A, Witas JB, Petit FM, Gajdos V, Labrune P
J Inherit Metab Dis 2010 Dec;33 Suppl 3:S477-80. Epub 2010 Nov 20 doi: 10.1007/s10545-010-9243-y. PMID: 21103936
Kluver-Bucy syndrome following heat stroke in a 12-year-old girl.
Pitt DC, Kriel RL, Wagner NC, Krach LE
Pediatr Neurol 1995 Jul;13(1):73-6. doi: 10.1016/0887-8994(95)00084-s. PMID: 7575855

Diagnosis

Unusual complication of Herpes simplex encephalitis: complete Klüver-Bucy syndrome.
Hernandez-Vega M, Badial-Ochoa S, Rivas-Ruvalcaba FJ, Rodriguez-Leyva I
BMJ Case Rep 2022 Jul 11;15(7) doi: 10.1136/bcr-2022-250745. PMID: 35817482Free PMC Article
Mesiotemporal Disconnection and Hypoactivity in Klüver-Bucy Syndrome: Case Series and Literature Review.
Caro MA, Jimenez XF
J Clin Psychiatry 2016 Aug;77(8):e982-8. doi: 10.4088/JCP.14r09497. PMID: 27380585
Is it possible to diagnose Rett syndrome before classical symptoms become obvious? Review of 24 Danish cases born between 2003 and 2012.
Bisgaard AM, Schönewolf-Greulich B, Ravn K, Rønde G
Eur J Paediatr Neurol 2015 Nov;19(6):679-87. Epub 2015 Jul 21 doi: 10.1016/j.ejpn.2015.07.004. PMID: 26228846
Kluver-Bucy syndrome after mycoplasmal bronchitis.
Auvichayapat N, Auvichayapat P, Watanatorn J, Thamaroj J, Jitpimolmard S
Epilepsy Behav 2006 Feb;8(1):320-2. Epub 2005 Dec 13 doi: 10.1016/j.yebeh.2005.10.005. PMID: 16356778
The Kluver-Bucy syndrome.
Góscínski I, Kwiatkowski S, Polak J, Orlowiejska M, Partyk A
J Neurosurg Sci 1997 Sep;41(3):269-72. PMID: 9444580

Therapy

Partial Kluver-Bucy syndrome secondary to tubercular meningitis.
Jha KK, Singh SK, Kumar P, Arora CD
BMJ Case Rep 2016 Aug 16;2016 doi: 10.1136/bcr-2016-215926. PMID: 27530874Free PMC Article
Klüver-Bucy syndrome after unilateral frontotemporal resection in a child with tuberous sclerosis.
Boronat S, Newberry P, Mehan W, Thiele EA, Duhaime AC
Childs Nerv Syst 2013 Aug;29(8):1391-4. Epub 2013 May 1 doi: 10.1007/s00381-013-2127-3. PMID: 23636147
Kluver-Bucy syndrome in a boy with non-Hodgkin lymphoma.
Unal E, Koksal Y, Baysal T, Energin Ml, Aydin K, Caliskan U
Pediatr Hematol Oncol 2007 Mar;24(2):149-52. doi: 10.1080/08880010601085183. PMID: 17454782
Kluver-Bucy syndrome after mycoplasmal bronchitis.
Auvichayapat N, Auvichayapat P, Watanatorn J, Thamaroj J, Jitpimolmard S
Epilepsy Behav 2006 Feb;8(1):320-2. Epub 2005 Dec 13 doi: 10.1016/j.yebeh.2005.10.005. PMID: 16356778
Psychic akinesia following bilateral pallidal lesions.
Starkstein SE, Berthier ML, Leiguarda R
Int J Psychiatry Med 1989;19(2):155-64. doi: 10.2190/ae1q-qy7b-lu2f-gjhf. PMID: 2681027

Prognosis

Mesiotemporal Disconnection and Hypoactivity in Klüver-Bucy Syndrome: Case Series and Literature Review.
Caro MA, Jimenez XF
J Clin Psychiatry 2016 Aug;77(8):e982-8. doi: 10.4088/JCP.14r09497. PMID: 27380585
Do the opportunities for learning and personal development lead to happiness? It depends on work-family conciliation.
Rego A, Cunha MPE
J Occup Health Psychol 2009 Jul;14(3):334-348. doi: 10.1037/a0014248. PMID: 19586226
Persistent Klüver-Bucy syndrome after bilateral temporal lobe infarction.
Chou CL, Lin YJ, Sheu YL, Lin CJ, Hseuh IH
Acta Neurol Taiwan 2008 Sep;17(3):199-202. PMID: 18975528
Kluver-Bucy syndrome following heat stroke in a 12-year-old girl.
Pitt DC, Kriel RL, Wagner NC, Krach LE
Pediatr Neurol 1995 Jul;13(1):73-6. doi: 10.1016/0887-8994(95)00084-s. PMID: 7575855
Kluver-Bucy syndrome: report of a case with nasopharyngeal cancer after irradiation and chemotherapy.
Chu CC, Huang CC, Chen HJ
Zhonghua Yi Xue Za Zhi (Taipei) 1994 Dec;54(6):432-5. PMID: 7531610

Clinical prediction guides

Mesiotemporal Disconnection and Hypoactivity in Klüver-Bucy Syndrome: Case Series and Literature Review.
Caro MA, Jimenez XF
J Clin Psychiatry 2016 Aug;77(8):e982-8. doi: 10.4088/JCP.14r09497. PMID: 27380585
The neuropsychology of the Klüver-Bucy syndrome in children.
Lippe S, Gonin-Flambois C, Jambaqué I
Handb Clin Neurol 2013;112:1285-8. doi: 10.1016/B978-0-444-52910-7.00051-9. PMID: 23622339
Do the opportunities for learning and personal development lead to happiness? It depends on work-family conciliation.
Rego A, Cunha MPE
J Occup Health Psychol 2009 Jul;14(3):334-348. doi: 10.1037/a0014248. PMID: 19586226
The Kluver-Bucy syndrome.
Gościński I, Kwiatkowski S, Polak J, Orłowiejska M
Acta Neurochir (Wien) 1997;139(4):303-6. doi: 10.1007/BF01808825. PMID: 9202769
Family violence and the Klüver-Bucy syndrome.
Isern RD Jr
South Med J 1987 Mar;80(3):373-7. doi: 10.1097/00007611-198703000-00026. PMID: 3824025

Recent systematic reviews

Klüver-Bucy Syndrome Following Traumatic Brain Injury: A Systematic Synthesis and Review of Pharmacological Treatment From Cases in Adolescents and Adults.
Clay FJ, Kuriakose A, Lesche D, Hicks AJ, Zaman H, Azizi E, Ponsford JL, Jayaram M, Hopwood M
J Neuropsychiatry Clin Neurosci 2019 Winter;31(1):6-16. Epub 2018 Oct 31 doi: 10.1176/appi.neuropsych.18050112. PMID: 30376788

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