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Brown tumor

MedGen UID:
1052484
•Concept ID:
CN376601
•
Finding
Synonym: Osteitis fibrosa cystica
 
HPO: HP:6000089

Definition

A brown tumor is a bone lesion that results from bony resorption by excess osteoclastic activity, and replacement by fibrous tissue and giant cells. Brown tumor is an uncommon pathognomonic sign of hyperparathyroidism. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBrown tumor

Professional guidelines

PubMed

Management of Hepatocellular Carcinoma: A Review.
Brown ZJ, Tsilimigras DI, Ruff SM, Mohseni A, Kamel IR, Cloyd JM, Pawlik TM
JAMA Surg 2023 Apr 1;158(4):410-420. doi: 10.1001/jamasurg.2022.7989. PMID: 36790767
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Pretransplant solid organ malignancy and organ transplant candidacy: A consensus expert opinion statement.
Al-Adra DP, Hammel L, Roberts J, Woodle ES, Levine D, Mandelbrot D, Verna E, Locke J, D'Cunha J, Farr M, Sawinski D, Agarwal PK, Plichta J, Pruthi S, Farr D, Carvajal R, Walker J, Zwald F, Habermann T, Gertz M, Bierman P, Dizon DS, Langstraat C, Al-Qaoud T, Eggener S, Richgels JP, Chang GJ, Geltzeiler C, Sapisochin G, Ricciardi R, Krupnick AS, Kennedy C, Mohindra N, Foley DP, Watt KD
Am J Transplant 2021 Feb;21(2):460-474. Epub 2020 Oct 23 doi: 10.1111/ajt.16318. PMID: 32969590Free PMC Article

Recent clinical studies

Etiology

Association Between Parafibromin Expression and Presence of Brown Tumors and Jaw Tumors in Patients with Primary Hyperparathyroidism: Series of Cases with Review of the Literature.
Popow M, Kaszczewska M, Góralska M, Kaszczewski P, Skwarek-Szewczyk A, Chudziński W, Jażdżewski K, Kolanowska M, Bogdańska M, Starzyńska-Kubicka A, Gałązka Z
Am J Case Rep 2022 Oct 22;23:e936135. doi: 10.12659/AJCR.936135. PMID: 36271606Free PMC Article
Soft Tissue Special Issue: Giant Cell-Rich Lesions of the Head and Neck Region.
Lee JC, Huang HY
Head Neck Pathol 2020 Mar;14(1):97-108. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01086-2. PMID: 31950466Free PMC Article
Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy.
Kwee TC, de Klerk JMH, Nix M, Heggelman BGF, Dubois SV, Adams HJA
Semin Nucl Med 2017 Jul;47(4):322-351. Epub 2017 Apr 12 doi: 10.1053/j.semnuclmed.2017.02.004. PMID: 28583274
Brown tumor of secondary hyperparathyroidism: surgical approach and clinical outcome.
Queiroz IV, Queiroz SP, Medeiros R Jr, Ribeiro RB, Crusoé-Rebello IM, Leão JC
Oral Maxillofac Surg 2016 Dec;20(4):435-439. Epub 2016 Sep 17 doi: 10.1007/s10006-016-0575-0. PMID: 27640197
Brown tumor of the facial bones: case report and literature review.
Lessa MM, Sakae FA, Tsuji RK, Filho BC, Voegels RL, Butugan O
Ear Nose Throat J 2005 Jul;84(7):432-4. PMID: 16813033

Diagnosis

Brown tumors in nuclear medicine: a systematic review.
Jacquet-Francillon N, Prevot N
Ann Nucl Med 2023 May;37(5):255-270. Epub 2023 Mar 18 doi: 10.1007/s12149-023-01832-1. PMID: 36933117
Brown tumor regression in parathyroid adenoma.
Mintegui G, Mendoza B
Med Clin (Barc) 2020 Dec 11;155(11):519. Epub 2019 Nov 19 doi: 10.1016/j.medcli.2019.09.008. PMID: 31757395
Benign Bone Conditions That May Be FDG-avid and Mimic Malignancy.
Kwee TC, de Klerk JMH, Nix M, Heggelman BGF, Dubois SV, Adams HJA
Semin Nucl Med 2017 Jul;47(4):322-351. Epub 2017 Apr 12 doi: 10.1053/j.semnuclmed.2017.02.004. PMID: 28583274
Bone tumor mimics: avoiding misdiagnosis.
Gould CF, Ly JQ, Lattin GE Jr, Beall DP, Sutcliffe JB 3rd
Curr Probl Diagn Radiol 2007 May-Jun;36(3):124-41. doi: 10.1067/j.cpradiol.2007.01.001. PMID: 17484955
Brown tumor.
Chew FS, Huang-Hellinger F
AJR Am J Roentgenol 1993 Apr;160(4):752. doi: 10.2214/ajr.160.4.8456657. PMID: 8456657

Therapy

Seven cases of parathyroid carcinoma and review of the literature.
Apaydın T, Yavuz DG
Hormones (Athens) 2021 Mar;20(1):189-195. Epub 2020 Jun 23 doi: 10.1007/s42000-020-00220-y. PMID: 32578053
Brown tumor of the thoracic spine presenting with paraplegia in a patient with peritoneal dialysis.
Eroglu E, Kontas ME, Kocyigit I, Kontas O, Donmez H, Kucuk A, Sipahioglu MH, Tokgoz B, Oymak O
CEN Case Rep 2019 Nov;8(4):227-232. Epub 2019 May 14 doi: 10.1007/s13730-019-00398-0. PMID: 31089951Free PMC Article
Brown tumor of the jaws as a manifestation of tertiary hyperparathyroidism: A literature review and case report.
Dos Santos B, Koth VS, Figueiredo MA, Salum FG, Cherubini K
Spec Care Dentist 2018 May;38(3):163-171. Epub 2018 Mar 30 doi: 10.1111/scd.12284. PMID: 29603323
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report.
Baracaldo RM, Bao D, Iampornpipopchai P, Fogel J, Rubinstein S
Hemodial Int 2015 Oct;19(4):583-92. Epub 2015 Mar 31 doi: 10.1111/hdi.12298. PMID: 25828738
Brown tumor of the mandible associated with secondary hyperparathyroidism: a case report and review of the literature.
Prado FO, Rosales AC, Rodrigues CI, Coletta RD, Lopes MA
Gen Dent 2006 Sep-Oct;54(5):341-3. PMID: 17004570

Prognosis

Mandibular Brown Tumor as a Result of Secondary Hyperparathyroidism: A Case Report with 5 Years Follow-Up and Review of the Literature.
Shavlokhova V, Goeppert B, Gaida MM, Saravi B, Weichel F, Vollmer A, Vollmer M, Freudlsperger C, Mertens C, Hoffmann J
Int J Environ Res Public Health 2021 Jul 9;18(14) doi: 10.3390/ijerph18147370. PMID: 34299820Free PMC Article
Severe hypercalcemia and a pelvic brown tumor in an adolescent with primary hyperparathyroidism: a case report.
Legault O, Inman M, Moolman N, Wiebe S, Poulin A, Nour MA
BMC Pediatr 2020 Dec 5;20(1):547. doi: 10.1186/s12887-020-02445-7. PMID: 33278878Free PMC Article
Brown tumor of secondary hyperparathyroidism: surgical approach and clinical outcome.
Queiroz IV, Queiroz SP, Medeiros R Jr, Ribeiro RB, Crusoé-Rebello IM, Leão JC
Oral Maxillofac Surg 2016 Dec;20(4):435-439. Epub 2016 Sep 17 doi: 10.1007/s10006-016-0575-0. PMID: 27640197
Humeral brown tumor as first presentation of primary hyperparathyroidism caused by ectopic parathyroid adenomas: report of two cases and review of literature.
Wang X, Wang M, Zhang J, Zhu Y, Zhu M, Gao H, He Q, Tian W, Liang X, Suo X, Hu M
Int J Clin Exp Pathol 2014;7(10):7094-9. Epub 2014 Sep 15 PMID: 25400803Free PMC Article
Brown tumor of the facial bones: case report and literature review.
Lessa MM, Sakae FA, Tsuji RK, Filho BC, Voegels RL, Butugan O
Ear Nose Throat J 2005 Jul;84(7):432-4. PMID: 16813033

Clinical prediction guides

The evolution of primary hyperparathyroidism publications and global productivity from past to present: A bibliometric analysis during 1980 to 2022.
Göbüt H, Bostanci H
Medicine (Baltimore) 2023 Sep 1;102(35):e34622. doi: 10.1097/MD.0000000000034622. PMID: 37657020Free PMC Article
GRM1 Immunohistochemistry Distinguishes Chondromyxoid Fibroma From its Histologic Mimics.
Toland AMS, Lam SW, Varma S, Wang A, Howitt BE, Kunder CA, Kerr DA, Szuhai K, Bovée JVMG, Charville GW
Am J Surg Pathol 2022 Oct 1;46(10):1407-1414. Epub 2022 Jun 1 doi: 10.1097/PAS.0000000000001921. PMID: 35650682Free PMC Article
Seven cases of parathyroid carcinoma and review of the literature.
Apaydın T, Yavuz DG
Hormones (Athens) 2021 Mar;20(1):189-195. Epub 2020 Jun 23 doi: 10.1007/s42000-020-00220-y. PMID: 32578053
Clinical implications of brown tumor uptake in whole-body 99mTc-sestamibi scans for primary hyperparathyroidism.
Meng Z, Zhu M, He Q, Tian W, Zhang Y, Jia Q, Tan J
Nucl Med Commun 2011 Aug;32(8):708-15. doi: 10.1097/MNM.0b013e328347b582. PMID: 21613966
Renal osteodystrophy.
Wong LY, Wu CJ, Lin JC
Zhonghua Yi Xue Za Zhi (Taipei) 1991 May;47(5):342-9. PMID: 1649677

Recent systematic reviews

Brown tumors in nuclear medicine: a systematic review.
Jacquet-Francillon N, Prevot N
Ann Nucl Med 2023 May;37(5):255-270. Epub 2023 Mar 18 doi: 10.1007/s12149-023-01832-1. PMID: 36933117
A Systematic Review of Sellar and Parasellar Brown Tumors: An Analysis of Clinical, Diagnostic, and Management Profiles.
Alwani MM, Monaco GN, Harmon SM, Nwosu OI, Vortmeyer AO, Payner TD, Ting J
World Neurosurg 2019 Dec;132:e423-e429. Epub 2019 Aug 27 doi: 10.1016/j.wneu.2019.08.126. PMID: 31470158
Systematic review of oral manifestations related to hyperparathyroidism.
Palla B, Burian E, Fliefel R, Otto S
Clin Oral Investig 2018 Jan;22(1):1-27. Epub 2017 Jun 14 doi: 10.1007/s00784-017-2124-0. PMID: 28616750
Hyperparathyroidism Diagnosed Due to Brown Tumors of the Jaw: A Case Report and Literature Review.
Brabyn P, Capote A, Belloti M, Zylberberg I
J Oral Maxillofac Surg 2017 Oct;75(10):2162-2169. Epub 2017 Mar 20 doi: 10.1016/j.joms.2017.03.013. PMID: 28412266
Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report.
Baracaldo RM, Bao D, Iampornpipopchai P, Fogel J, Rubinstein S
Hemodial Int 2015 Oct;19(4):583-92. Epub 2015 Mar 31 doi: 10.1111/hdi.12298. PMID: 25828738

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