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Abnormal circulating CC chemokine concentration

MedGen UID:
1052639
•Concept ID:
CN377048
•
Finding
HPO: HP:6000446

Definition

The concentration in the blood circulation of a member of the CC chemokine family is outside of normal limits. [from HPO]

Recent clinical studies

Etiology

Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.
Chaiworapongsa T, Romero R, Gomez-Lopez N, Suksai M, Gallo DM, Jung E, Berry SM, Awonuga A, Tarca AL, Bryant DR
Am J Obstet Gynecol 2024 Apr;230(4):450.e1-450.e18. Epub 2023 Oct 6 doi: 10.1016/j.ajog.2023.10.002. PMID: 37806612Free PMC Article
Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis.
Kinjo T, Inoue H, Kusuda T, Fujiyoshi J, Ochiai M, Takahata Y, Honjo S, Koga Y, Hara T, Ohga S
Pediatr Neonatol 2019 Aug;60(4):382-388. Epub 2018 Sep 24 doi: 10.1016/j.pedneo.2018.09.005. PMID: 30314728
Correlation between IL-7 and MCP-1 in diabetic chronic non healing ulcer patients at higher risk of coronary artery disease.
Arya AK, Pokharia D, Bhan S, Tripathi R, Tripathi K
Cytokine 2012 Dec;60(3):767-71. Epub 2012 Aug 24 doi: 10.1016/j.cyto.2012.07.034. PMID: 22921903
Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.
Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L, Dennis JW, Lai EK, Fish EN
Antivir Ther 2005;10(2):263-75. PMID: 15865221

Diagnosis

Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis.
Kinjo T, Inoue H, Kusuda T, Fujiyoshi J, Ochiai M, Takahata Y, Honjo S, Koga Y, Hara T, Ohga S
Pediatr Neonatol 2019 Aug;60(4):382-388. Epub 2018 Sep 24 doi: 10.1016/j.pedneo.2018.09.005. PMID: 30314728
Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.
Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L, Dennis JW, Lai EK, Fish EN
Antivir Ther 2005;10(2):263-75. PMID: 15865221

Therapy

Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.
Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L, Dennis JW, Lai EK, Fish EN
Antivir Ther 2005;10(2):263-75. PMID: 15865221

Prognosis

Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis.
Kinjo T, Inoue H, Kusuda T, Fujiyoshi J, Ochiai M, Takahata Y, Honjo S, Koga Y, Hara T, Ohga S
Pediatr Neonatol 2019 Aug;60(4):382-388. Epub 2018 Sep 24 doi: 10.1016/j.pedneo.2018.09.005. PMID: 30314728
Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.
Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L, Dennis JW, Lai EK, Fish EN
Antivir Ther 2005;10(2):263-75. PMID: 15865221
Circulating granulocyte colony-stimulating factor, C-X-C, and C-C chemokines in children with Escherichia coli O157:H7 associated hemolytic uremic syndrome.
Proulx F, Toledano B, Phan V, Clermont MJ, Mariscalco MM, Seidman EG
Pediatr Res 2002 Dec;52(6):928-34. doi: 10.1203/00006450-200212000-00019. PMID: 12438672

Clinical prediction guides

Preeclampsia at term: evidence of disease heterogeneity based on the profile of circulating cytokines and angiogenic factors.
Chaiworapongsa T, Romero R, Gomez-Lopez N, Suksai M, Gallo DM, Jung E, Berry SM, Awonuga A, Tarca AL, Bryant DR
Am J Obstet Gynecol 2024 Apr;230(4):450.e1-450.e18. Epub 2023 Oct 6 doi: 10.1016/j.ajog.2023.10.002. PMID: 37806612Free PMC Article
Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis.
Kinjo T, Inoue H, Kusuda T, Fujiyoshi J, Ochiai M, Takahata Y, Honjo S, Koga Y, Hara T, Ohga S
Pediatr Neonatol 2019 Aug;60(4):382-388. Epub 2018 Sep 24 doi: 10.1016/j.pedneo.2018.09.005. PMID: 30314728
Levels of transforming growth factor-beta are low in systemic lupus erythematosus patients with active disease.
Becker-Merok A, Eilertsen GØ, Nossent JC
J Rheumatol 2010 Oct;37(10):2039-45. Epub 2010 Aug 3 doi: 10.3899/jrheum.100180. PMID: 20682675
Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells.
Toulza F, Nosaka K, Tanaka Y, Schioppa T, Balkwill F, Taylor GP, Bangham CR
J Immunol 2010 Jul 1;185(1):183-9. Epub 2010 Jun 4 doi: 10.4049/jimmunol.0903846. PMID: 20525891Free PMC Article
Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids.
Ward SE, Loutfy MR, Blatt LM, Siminovitch KA, Chen J, Hinek A, Wolff B, Pham DH, Deif H, LaMere EA, Kain KC, Farcas GA, Ferguson P, Latchford M, Levy G, Fung L, Dennis JW, Lai EK, Fish EN
Antivir Ther 2005;10(2):263-75. PMID: 15865221

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