U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Third cranial nerve thickening

MedGen UID:
1052658
•Concept ID:
CN377102
•
Finding
Synonym: Oculomotor nerve thickening
 
HPO: HP:6000291

Definition

Increase in diameter of the third cranial nerve (oculomotor nerve). This feature can be observed by magnetic resonance imaging and may be accompanied by contrast enhancement. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThird cranial nerve thickening

Professional guidelines

PubMed

Diagnosis and surgical treatment of unilateral restrictive hypotropia and esotropia.
Lin Q, Man F, Wang N, Chen T, Yu G, Wang Z, Chang Q, Jiao Y, Zhao K
J AAPOS 2011 Feb;15(1):5-8. doi: 10.1016/j.jaapos.2010.09.019. PMID: 21397798

Recent clinical studies

Etiology

Cavernous Sinus MRI Findings in Inflammatory and Ischemic Oculomotor Cranial Nerve Palsies.
Yunqing W, Shilei C, Yong L, Qing L, Xiaohong S, Jiawei W
J Neuroophthalmol 2024 Jun 1;44(2):236-241. Epub 2023 Sep 25 doi: 10.1097/WNO.0000000000001958. PMID: 37751328Free PMC Article
Special features of superior oblique hypofunction due to tendon abnormalities.
Aleassa M, Le A, Demer JL
Strabismus 2021 Dec;29(4):243-251. Epub 2021 Nov 17 doi: 10.1080/09273972.2021.1987931. PMID: 34787034Free PMC Article
Diabetic Oculomotor Nerve Palsy Displaying Enhancement of the Oculomotor Nerve in the Orbit and Cavernous Sinus on MRI.
Zhao J, Li Y, Chang Q, Wang J, Sun H
Eur Neurol 2021;84(4):246-253. Epub 2021 May 11 doi: 10.1159/000514100. PMID: 33975309
Idiopathic hypertrophic cranial pachymeningitis.
Rojana-udomsart A, Pulkes T, Viranuwatti K, Laothamatas J, Phudhichareonrat S, Witoonpanich R
J Clin Neurosci 2008 Apr;15(4):465-9. Epub 2008 Jan 30 doi: 10.1016/j.jocn.2006.11.020. PMID: 18249120
MR of oculomotor nerve palsy.
Blake PY, Mark AS, Kattah J, Kolsky M
AJNR Am J Neuroradiol 1995 Sep;16(8):1665-72. PMID: 7502972Free PMC Article

Diagnosis

Cavernous Sinus MRI Findings in Inflammatory and Ischemic Oculomotor Cranial Nerve Palsies.
Yunqing W, Shilei C, Yong L, Qing L, Xiaohong S, Jiawei W
J Neuroophthalmol 2024 Jun 1;44(2):236-241. Epub 2023 Sep 25 doi: 10.1097/WNO.0000000000001958. PMID: 37751328Free PMC Article
Diabetic Oculomotor Nerve Palsy Displaying Enhancement of the Oculomotor Nerve in the Orbit and Cavernous Sinus on MRI.
Zhao J, Li Y, Chang Q, Wang J, Sun H
Eur Neurol 2021;84(4):246-253. Epub 2021 May 11 doi: 10.1159/000514100. PMID: 33975309
A rare case of orbital myositis.
Yawar B, Malik Z, Naz F
J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S706-S708. PMID: 33754537
Granulomatous meningitis.
Loy ST, Tan CW
Singapore Med J 2009 Nov;50(11):e371-3. PMID: 19960146
Ophthalmoplegic migraine.
Bek S, Genc G, Demirkaya S, Eroglu E, Odabasi Z
Neurologist 2009 May;15(3):147-9. doi: 10.1097/NRL.0b013e3181870408. PMID: 19430270

Therapy

Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Ophthalmoplegic "migraine" or recurrent ophthalmoplegic cranial neuropathy: new cases and a systematic review.
Gelfand AA, Gelfand JM, Prabakhar P, Goadsby PJ
J Child Neurol 2012 Jun;27(6):759-66. Epub 2012 Jan 12 doi: 10.1177/0883073811426502. PMID: 22241707Free PMC Article
Tolosa-Hunt syndrome preceded by facial palsy in a child.
Cerisola A, González G, Scavone C
Pediatr Neurol 2011 Jan;44(1):61-4. doi: 10.1016/j.pediatrneurol.2010.08.018. PMID: 21147390
Sarcoidosis presenting as "corset-like" myelopathy: a description of six cases and literature review.
Lidar M, Dori A, Levy Y, Lidar Z, Chapman J, Langevitz P
Clin Rev Allergy Immunol 2010 Apr;38(2-3):270-5. doi: 10.1007/s12016-009-8156-8. PMID: 19603148
Granulomatous meningitis.
Loy ST, Tan CW
Singapore Med J 2009 Nov;50(11):e371-3. PMID: 19960146

Prognosis

A rare case of orbital myositis.
Yawar B, Malik Z, Naz F
J Ayub Med Coll Abbottabad 2020 Oct-Dec;32(Suppl 1)(4):S706-S708. PMID: 33754537
Nasopharyngeal B-cell lymphoma with pan-hypopituitarism and oculomotor nerve palsy: a case report and review of the literature.
Zahedi M, Hizomi Arani R, Tohidi M, Haghighi S, Mehrpour M, Hadaegh F
BMC Endocr Disord 2020 Nov 3;20(1):163. doi: 10.1186/s12902-020-00644-y. PMID: 33143716Free PMC Article
Endoscopic third ventriculostomy in patients with myelomeningocele after shunt failure.
Furtado LMF, da Costa Val Filho JA, Holliday JB, da Silva Costa J, de Matos MA, Nascimento VAM, Ramos Cavalcanti T
Childs Nerv Syst 2020 Dec;36(12):3047-3052. Epub 2020 Apr 4 doi: 10.1007/s00381-020-04596-5. PMID: 32248278
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Sarcoidosis presenting as "corset-like" myelopathy: a description of six cases and literature review.
Lidar M, Dori A, Levy Y, Lidar Z, Chapman J, Langevitz P
Clin Rev Allergy Immunol 2010 Apr;38(2-3):270-5. doi: 10.1007/s12016-009-8156-8. PMID: 19603148

Clinical prediction guides

Diabetic Oculomotor Nerve Palsy Displaying Enhancement of the Oculomotor Nerve in the Orbit and Cavernous Sinus on MRI.
Zhao J, Li Y, Chang Q, Wang J, Sun H
Eur Neurol 2021;84(4):246-253. Epub 2021 May 11 doi: 10.1159/000514100. PMID: 33975309
Clinical features of IgG4-related dacryoadenitis.
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Iwasaki S, Chiba K, Setoguchi K, Horiguchi S, Ozaki N
Graefes Arch Clin Exp Ophthalmol 2014 Mar;252(3):491-7. Epub 2013 Dec 7 doi: 10.1007/s00417-013-2541-y. PMID: 24318531
Ophthalmoplegic migraine.
Bek S, Genc G, Demirkaya S, Eroglu E, Odabasi Z
Neurologist 2009 May;15(3):147-9. doi: 10.1097/NRL.0b013e3181870408. PMID: 19430270
Congenital monocular elevation deficiency.
Kim JH, Hwang JM
Ophthalmology 2009 Mar;116(3):580-4. Epub 2009 Jan 22 doi: 10.1016/j.ophtha.2008.10.023. PMID: 19167083
MR of oculomotor nerve palsy.
Blake PY, Mark AS, Kattah J, Kolsky M
AJNR Am J Neuroradiol 1995 Sep;16(8):1665-72. PMID: 7502972Free PMC Article

Recent systematic reviews

Diagnostic controversies in recurrent painful ophthalmoplegic neuropathy: single case report with a systematic review.
Falsaperla R, Presti S, Lo Bianco M, Catanzaro S, Marino S, Ruggieri M
Ital J Pediatr 2022 Jun 3;48(1):82. doi: 10.1186/s13052-022-01274-x. PMID: 35659705Free PMC Article
Ophthalmoplegic "migraine" or recurrent ophthalmoplegic cranial neuropathy: new cases and a systematic review.
Gelfand AA, Gelfand JM, Prabakhar P, Goadsby PJ
J Child Neurol 2012 Jun;27(6):759-66. Epub 2012 Jan 12 doi: 10.1177/0883073811426502. PMID: 22241707Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...