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Reduced circulating interleukin 6 concentration

MedGen UID:
1052699
Concept ID:
CN377085
Finding
Synonym: IL-6 low in blood
 
HPO: HP:0430142

Definition

The concentration of interleukin-6 in the blood circulation is below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced circulating interleukin 6 concentration

Professional guidelines

PubMed

Beltrán LM, Muñoz Hernández R, de Pablo Bernal RS, García Morillo JS, Egido J, Noval ML, Ferrando-Martinez S, Blanco-Colio LM, Genebat M, Villar JR, Moreno-Luna R, Moreno JA
PLoS One 2014;9(3):e90541. Epub 2014 Mar 4 doi: 10.1371/journal.pone.0090541. PMID: 24594990Free PMC Article
Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, Caulder E, Wen X, Li Y, Waeltz P, Rupar M, Burn T, Lo Y, Kelley J, Covington M, Shepard S, Rodgers JD, Haley P, Kantarjian H, Fridman JS, Verstovsek S
Blood 2010 Apr 15;115(15):3109-17. Epub 2010 Feb 3 doi: 10.1182/blood-2009-04-214957. PMID: 20130243Free PMC Article
Schieffer B, Drexler H
Am J Cardiol 2003 Jun 19;91(12A):12H-18H. doi: 10.1016/s0002-9149(03)00429-6. PMID: 12818730

Recent clinical studies

Etiology

Hasse IMC, Grosse GM, Schuppner R, Van Gemmeren T, Gabriel MM, Weissenborn K, Lichtinghagen R, Worthmann H
Int J Mol Sci 2022 Nov 9;23(22) doi: 10.3390/ijms232213747. PMID: 36430226Free PMC Article
La Grotta R, de Candia P, Olivieri F, Matacchione G, Giuliani A, Rippo MR, Tagliabue E, Mancino M, Rispoli F, Ferroni S, Berra CC, Ceriello A, Prattichizzo F
Cell Mol Life Sci 2022 May 3;79(5):273. doi: 10.1007/s00018-022-04289-z. PMID: 35503137Free PMC Article
Pérez-López A, Gonzalo-Encabo P, Pérez-Köhler B, García-Honduvilla N, Valadés D
Eur J Sport Sci 2022 Sep;22(9):1426-1435. Epub 2021 Jul 5 doi: 10.1080/17461391.2021.1939430. PMID: 34086518
Derella CC, Tingen MS, Blanks A, Sojourner SJ, Tucker MA, Thomas J, Harris RA
Sci Rep 2021 Dec 16;11(1):24122. doi: 10.1038/s41598-021-03476-5. PMID: 34916543Free PMC Article
Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium, Swerdlow DI, Holmes MV, Kuchenbaecker KB, Engmann JE, Shah T, Sofat R, Guo Y, Chung C, Peasey A, Pfister R, Mooijaart SP, Ireland HA, Leusink M, Langenberg C, Li KW, Palmen J, Howard P, Cooper JA, Drenos F, Hardy J, Nalls MA, Li YR, Lowe G, Stewart M, Bielinski SJ, Peto J, Timpson NJ, Gallacher J, Dunlop M, Houlston R, Tomlinson I, Tzoulaki I, Luan J, Boer JM, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Ferrucci L, Bandenelli S, Tanaka T, Meschia JF, Singleton A, Navis G, Mateo Leach I, Bakker SJ, Gansevoort RT, Ford I, Epstein SE, Burnett MS, Devaney JM, Jukema JW, Westendorp RG, Jan de Borst G, van der Graaf Y, de Jong PA, Mailand-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Stephens JW, Eaton CB, Robinson JG, Manson JE, Fowkes FG, Frayling TM, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Redline S, Lange LA, Kumari M, Wareham NJ, Verschuren WM, Benjamin EJ, Whittaker JC, Hamsten A, Dudbridge F, Delaney JA, Wong A, Kuh D, Hardy R, Castillo BA, Connolly JJ, van der Harst P, Brunner EJ, Marmot MG, Wassel CL, Humphries SE, Talmud PJ, Kivimaki M, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Hakonarson H, Reiner AP, Keating BJ, Sattar N, Hingorani AD, Casas JP
Lancet 2012 Mar 31;379(9822):1214-24. Epub 2012 Mar 14 doi: 10.1016/S0140-6736(12)60110-X. PMID: 22421340Free PMC Article

Diagnosis

Lupia E, Capuano M, Vizio B, Schiavello M, Bosco O, Gelardi M, Favale E, Pivetta E, Morello F, Husain S, Keshavjee S, Del Sorbo L, Montrucchio G
EBioMedicine 2022 Nov;85:104305. Epub 2022 Oct 13 doi: 10.1016/j.ebiom.2022.104305. PMID: 36242922Free PMC Article
Bonnans C, Thomas G, He W, Jung B, Chen W, Liao M, Heyen J, Buetow B, Pillai S, Matsumoto D, Chaparro-Riggers J, Salek-Ardakani S, Qu Y
J Immunother Cancer 2020 May;8(1) doi: 10.1136/jitc-2020-000624. PMID: 32474414Free PMC Article
Tao H, Gong Y, Yu Q, Zhou H, Liu Y
J Interferon Cytokine Res 2020 Mar;40(3):152-158. Epub 2020 Jan 22 doi: 10.1089/jir.2019.0137. PMID: 31971845
Walsh CP, Lim A, Marsland AL, Ferrell RE, Manuck SB
Brain Behav Immun 2019 May;78:21-30. Epub 2019 Jan 11 doi: 10.1016/j.bbi.2019.01.002. PMID: 30639698Free PMC Article
Coppack SW
Proc Nutr Soc 2001 Aug;60(3):349-56. doi: 10.1079/pns2001110. PMID: 11681809

Therapy

Pérez-López A, Gonzalo-Encabo P, Pérez-Köhler B, García-Honduvilla N, Valadés D
Eur J Sport Sci 2022 Sep;22(9):1426-1435. Epub 2021 Jul 5 doi: 10.1080/17461391.2021.1939430. PMID: 34086518
Derella CC, Tingen MS, Blanks A, Sojourner SJ, Tucker MA, Thomas J, Harris RA
Sci Rep 2021 Dec 16;11(1):24122. doi: 10.1038/s41598-021-03476-5. PMID: 34916543Free PMC Article
Bonnans C, Thomas G, He W, Jung B, Chen W, Liao M, Heyen J, Buetow B, Pillai S, Matsumoto D, Chaparro-Riggers J, Salek-Ardakani S, Qu Y
J Immunother Cancer 2020 May;8(1) doi: 10.1136/jitc-2020-000624. PMID: 32474414Free PMC Article
Interleukin-6 Receptor Mendelian Randomisation Analysis (IL6R MR) Consortium, Swerdlow DI, Holmes MV, Kuchenbaecker KB, Engmann JE, Shah T, Sofat R, Guo Y, Chung C, Peasey A, Pfister R, Mooijaart SP, Ireland HA, Leusink M, Langenberg C, Li KW, Palmen J, Howard P, Cooper JA, Drenos F, Hardy J, Nalls MA, Li YR, Lowe G, Stewart M, Bielinski SJ, Peto J, Timpson NJ, Gallacher J, Dunlop M, Houlston R, Tomlinson I, Tzoulaki I, Luan J, Boer JM, Forouhi NG, Onland-Moret NC, van der Schouw YT, Schnabel RB, Hubacek JA, Kubinova R, Baceviciene M, Tamosiunas A, Pajak A, Topor-Madry R, Malyutina S, Baldassarre D, Sennblad B, Tremoli E, de Faire U, Ferrucci L, Bandenelli S, Tanaka T, Meschia JF, Singleton A, Navis G, Mateo Leach I, Bakker SJ, Gansevoort RT, Ford I, Epstein SE, Burnett MS, Devaney JM, Jukema JW, Westendorp RG, Jan de Borst G, van der Graaf Y, de Jong PA, Mailand-van der Zee AH, Klungel OH, de Boer A, Doevendans PA, Stephens JW, Eaton CB, Robinson JG, Manson JE, Fowkes FG, Frayling TM, Price JF, Whincup PH, Morris RW, Lawlor DA, Smith GD, Ben-Shlomo Y, Redline S, Lange LA, Kumari M, Wareham NJ, Verschuren WM, Benjamin EJ, Whittaker JC, Hamsten A, Dudbridge F, Delaney JA, Wong A, Kuh D, Hardy R, Castillo BA, Connolly JJ, van der Harst P, Brunner EJ, Marmot MG, Wassel CL, Humphries SE, Talmud PJ, Kivimaki M, Asselbergs FW, Voevoda M, Bobak M, Pikhart H, Wilson JG, Hakonarson H, Reiner AP, Keating BJ, Sattar N, Hingorani AD, Casas JP
Lancet 2012 Mar 31;379(9822):1214-24. Epub 2012 Mar 14 doi: 10.1016/S0140-6736(12)60110-X. PMID: 22421340Free PMC Article
Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, Caulder E, Wen X, Li Y, Waeltz P, Rupar M, Burn T, Lo Y, Kelley J, Covington M, Shepard S, Rodgers JD, Haley P, Kantarjian H, Fridman JS, Verstovsek S
Blood 2010 Apr 15;115(15):3109-17. Epub 2010 Feb 3 doi: 10.1182/blood-2009-04-214957. PMID: 20130243Free PMC Article

Prognosis

Hasse IMC, Grosse GM, Schuppner R, Van Gemmeren T, Gabriel MM, Weissenborn K, Lichtinghagen R, Worthmann H
Int J Mol Sci 2022 Nov 9;23(22) doi: 10.3390/ijms232213747. PMID: 36430226Free PMC Article
Lupia E, Capuano M, Vizio B, Schiavello M, Bosco O, Gelardi M, Favale E, Pivetta E, Morello F, Husain S, Keshavjee S, Del Sorbo L, Montrucchio G
EBioMedicine 2022 Nov;85:104305. Epub 2022 Oct 13 doi: 10.1016/j.ebiom.2022.104305. PMID: 36242922Free PMC Article
Ibrahim NE, Januzzi JL
Clin Chem 2021 Jan 8;67(1):79-86. doi: 10.1093/clinchem/hvaa277. PMID: 33316036
Scally C, Abbas H, Ahearn T, Srinivasan J, Mezincescu A, Rudd A, Spath N, Yucel-Finn A, Yuecel R, Oldroyd K, Dospinescu C, Horgan G, Broadhurst P, Henning A, Newby DE, Semple S, Wilson HM, Dawson DK
Circulation 2019 Mar 26;139(13):1581-1592. doi: 10.1161/CIRCULATIONAHA.118.037975. PMID: 30586731Free PMC Article
Moreno Velásquez I, Golabkesh Z, Källberg H, Leander K, de Faire U, Gigante B
Atherosclerosis 2015 Jun;240(2):477-81. Epub 2015 Apr 14 doi: 10.1016/j.atherosclerosis.2015.04.014. PMID: 25910182

Clinical prediction guides

Hasse IMC, Grosse GM, Schuppner R, Van Gemmeren T, Gabriel MM, Weissenborn K, Lichtinghagen R, Worthmann H
Int J Mol Sci 2022 Nov 9;23(22) doi: 10.3390/ijms232213747. PMID: 36430226Free PMC Article
La Grotta R, de Candia P, Olivieri F, Matacchione G, Giuliani A, Rippo MR, Tagliabue E, Mancino M, Rispoli F, Ferroni S, Berra CC, Ceriello A, Prattichizzo F
Cell Mol Life Sci 2022 May 3;79(5):273. doi: 10.1007/s00018-022-04289-z. PMID: 35503137Free PMC Article
Derella CC, Tingen MS, Blanks A, Sojourner SJ, Tucker MA, Thomas J, Harris RA
Sci Rep 2021 Dec 16;11(1):24122. doi: 10.1038/s41598-021-03476-5. PMID: 34916543Free PMC Article
Moradi H, Park C, Streja E, Argueta DA, DiPatrizio NV, You AS, Rhee CM, Vaziri ND, Kalantar-Zadeh K, Piomelli D
Am J Nephrol 2020;51(2):86-95. Epub 2020 Jan 14 doi: 10.1159/000505444. PMID: 31935741Free PMC Article
Quintás-Cardama A, Vaddi K, Liu P, Manshouri T, Li J, Scherle PA, Caulder E, Wen X, Li Y, Waeltz P, Rupar M, Burn T, Lo Y, Kelley J, Covington M, Shepard S, Rodgers JD, Haley P, Kantarjian H, Fridman JS, Verstovsek S
Blood 2010 Apr 15;115(15):3109-17. Epub 2010 Feb 3 doi: 10.1182/blood-2009-04-214957. PMID: 20130243Free PMC Article

Recent systematic reviews

Hou S, Tian Z, Zhao D, Liang Y, Dai S, Ji Q, Fan Z, Liu Z, Liu M, Yang Y
Mol Nutr Food Res 2023 Jul;67(13):e2200800. Epub 2023 May 16 doi: 10.1002/mnfr.202200800. PMID: 37118903
Naseri K, Saadati S, Ghaemi F, Ashtary-Larky D, Asbaghi O, Sadeghi A, Afrisham R, de Courten B
Eur J Nutr 2023 Mar;62(2):543-561. Epub 2022 Oct 14 doi: 10.1007/s00394-022-03012-9. PMID: 36239789Free PMC Article
Gholami A, Mollanoroozy E, Reza Baradaran H, Hariri M
Clin Exp Pharmacol Physiol 2022 Jan;49(1):10-24. Epub 2021 Oct 4 doi: 10.1111/1440-1681.13586. PMID: 34455600
Gholami A, Baradaran HR, Hariri M
Phytother Res 2021 Mar;35(3):1147-1162. Epub 2020 Oct 12 doi: 10.1002/ptr.6881. PMID: 33047387
Brie D, Sahebkar A, Penson PE, Dinca M, Ursoniu S, Serban MC, Zanchetti A, Howard G, Ahmed A, Aronow WS, Muntner P, Lip GY, Wong ND, Rysz J, Banach M; Lipid, Blood Pressure Meta-analysis Collaboration (LBPMC) Group
J Hypertens 2016 Dec;34(12):2318-2329. doi: 10.1097/HJH.0000000000001086. PMID: 27512972

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