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Anti-factor IX antibody positivity

MedGen UID:
1052939
•Concept ID:
CN377326
•
Finding
Synonym: Anti-FIX antibody positivity
 
HPO: HP:6000495

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against factor IX. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-factor IX antibody positivity

Recent clinical studies

Etiology

Survey of the anti-factor IX immunoglobulin profiles in patients with hemophilia B using a fluorescence-based immunoassay.
Boylan B, Rice AS, Neff AT, Manco-Johnson MJ, Kempton CL, Miller CH; Hemophilia Inhibitor Research Study Investigators
J Thromb Haemost 2016 Oct;14(10):1931-1940. Epub 2016 Sep 17 doi: 10.1111/jth.13438. PMID: 27501440Free PMC Article

Therapy

Measurement of anti-factor IX IgG subclasses in haemophilia B patients who developed inhibitors with episodes of allergic reactions to factor IX concentrates.
Sawamoto Y, Shima M, Yamamoto M, Kamisue S, Nakai H, Tanaka I, Hayashi K, Giddings JC, Yoshioka A
Thromb Res 1996 Aug 15;83(4):279-86. doi: 10.1016/0049-3848(96)00136-3. PMID: 8870172

Prognosis

Survey of the anti-factor IX immunoglobulin profiles in patients with hemophilia B using a fluorescence-based immunoassay.
Boylan B, Rice AS, Neff AT, Manco-Johnson MJ, Kempton CL, Miller CH; Hemophilia Inhibitor Research Study Investigators
J Thromb Haemost 2016 Oct;14(10):1931-1940. Epub 2016 Sep 17 doi: 10.1111/jth.13438. PMID: 27501440Free PMC Article

Clinical prediction guides

Survey of the anti-factor IX immunoglobulin profiles in patients with hemophilia B using a fluorescence-based immunoassay.
Boylan B, Rice AS, Neff AT, Manco-Johnson MJ, Kempton CL, Miller CH; Hemophilia Inhibitor Research Study Investigators
J Thromb Haemost 2016 Oct;14(10):1931-1940. Epub 2016 Sep 17 doi: 10.1111/jth.13438. PMID: 27501440Free PMC Article

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