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Demonstration of Leishmania in tissue

MedGen UID:
1052996
•Concept ID:
CN376767
•
Finding
HPO: HP:6000255

Definition

Presence of Leishmania, a parasitic protozoan, in a tissue specimen. Leishmania is responsible for leishmaniasis. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDemonstration of Leishmania in tissue

Professional guidelines

PubMed

Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis.
Araújo IAC, de Paula RC, Alves CL, Faria KF, Oliveira MM, Mendes GG, Dias EMFA, Ribeiro RR, Oliveira AB, Silva SMD
Exp Parasitol 2019 Apr;199:67-73. Epub 2019 Feb 21 doi: 10.1016/j.exppara.2019.02.013. PMID: 30797783
The treatment of visceral leishmaniasis: safety and efficacy.
Jha RK, Sah AK, Shah DK, Sah P
JNMA J Nepal Med Assoc 2013 Oct-Dec;52(192):645-51. PMID: 25327244
Kala-azar--new developments in diagnosis and treatment.
Aggarwal P, Handa R, Singh S, Wali JP
Indian J Pediatr 1999 Jan-Feb;66(1):63-71. doi: 10.1007/BF02752355. PMID: 10798038

Recent clinical studies

Etiology

Molecular Tracking of the Leishmania Parasite.
Moulik S, Sengupta S, Chatterjee M
Front Cell Infect Microbiol 2021;11:623437. Epub 2021 Feb 22 doi: 10.3389/fcimb.2021.623437. PMID: 33692966Free PMC Article
Mucosal and mucocutaneous leishmaniasis in Iran from 1968 to 2018: a narrative review of clinical features, treatments, and outcomes.
Sabzevari S, Mohebali M, Hashemi SA
Int J Dermatol 2020 May;59(5):606-612. Epub 2020 Jan 13 doi: 10.1111/ijd.14762. PMID: 31943166
Gastrointestinal, skin and blood parasites in Didelphis spp. from urban and sylvatic areas in São Paulo state, Brazil.
Teodoro AKM, Cutolo AA, Motoie G, Meira-Strejevitch CDS, Pereira-Chioccola VL, Mendes TMF, Allegretti SM
Vet Parasitol Reg Stud Reports 2019 Apr;16:100286. Epub 2019 Apr 3 doi: 10.1016/j.vprsr.2019.100286. PMID: 31027595
Detection of Leishmania RNA virus in Leishmania parasites.
Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, Hartley MA, Prevel F, Castiglioni P, Pratlong F, Bastien P, Müller N, Parmentier L, Saravia NG, Beverley SM, Fasel N
PLoS Negl Trop Dis 2013;7(1):e2006. Epub 2013 Jan 10 doi: 10.1371/journal.pntd.0002006. PMID: 23326619Free PMC Article
An overview of paediatric leishmaniasis.
Kafetzis DA
J Postgrad Med 2003 Jan-Mar;49(1):31-8. doi: 10.4103/0022-3859.930. PMID: 12865569

Diagnosis

Quantitative monitoring of experimental and human leishmaniasis employing amastigote-specific genes.
Roy M, Sarkar D, Chatterjee M
Parasitology 2022 Jul;149(8):1085-1093. Epub 2022 May 10 doi: 10.1017/S0031182022000610. PMID: 35535469Free PMC Article
Molecular Tracking of the Leishmania Parasite.
Moulik S, Sengupta S, Chatterjee M
Front Cell Infect Microbiol 2021;11:623437. Epub 2021 Feb 22 doi: 10.3389/fcimb.2021.623437. PMID: 33692966Free PMC Article
Status of IL-4 and IL-10 driven markers in experimental models of Visceral Leishmaniasis.
Moulik S, Karmakar J, Joshi S, Dube A, Mandal C, Chatterjee M
Parasite Immunol 2021 Jan;43(1):e12783. Epub 2020 Aug 27 doi: 10.1111/pim.12783. PMID: 32734677
Detection of Leishmania RNA virus in Leishmania parasites.
Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, Hartley MA, Prevel F, Castiglioni P, Pratlong F, Bastien P, Müller N, Parmentier L, Saravia NG, Beverley SM, Fasel N
PLoS Negl Trop Dis 2013;7(1):e2006. Epub 2013 Jan 10 doi: 10.1371/journal.pntd.0002006. PMID: 23326619Free PMC Article
Visceral leishmaniasis in paediatrics.
Kafetzis DA, Maltezou HC
Curr Opin Infect Dis 2002 Jun;15(3):289-94. doi: 10.1097/00001432-200206000-00012. PMID: 12015464

Therapy

Efficacy of malachite green mediated photodynamic therapy on treatment of Cutaneous Leishmaniasis: In vitro study.
Ozlem-Caliskan S, Ilikci-Sagkan R, Karakas H, Sever S, Yildirim C, Balikci M, Ertabaklar H
Photodiagnosis Photodyn Ther 2022 Dec;40:103111. Epub 2022 Sep 6 doi: 10.1016/j.pdpdt.2022.103111. PMID: 36075521
Quantitative monitoring of experimental and human leishmaniasis employing amastigote-specific genes.
Roy M, Sarkar D, Chatterjee M
Parasitology 2022 Jul;149(8):1085-1093. Epub 2022 May 10 doi: 10.1017/S0031182022000610. PMID: 35535469Free PMC Article
Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis.
Araújo IAC, de Paula RC, Alves CL, Faria KF, Oliveira MM, Mendes GG, Dias EMFA, Ribeiro RR, Oliveira AB, Silva SMD
Exp Parasitol 2019 Apr;199:67-73. Epub 2019 Feb 21 doi: 10.1016/j.exppara.2019.02.013. PMID: 30797783
Visceral leishmaniasis in children: a review.
Palumbo E
Minerva Pediatr 2010 Aug;62(4):389-95. PMID: 20940672
Visceral leishmaniasis in paediatrics.
Kafetzis DA, Maltezou HC
Curr Opin Infect Dis 2002 Jun;15(3):289-94. doi: 10.1097/00001432-200206000-00012. PMID: 12015464

Prognosis

In vivo reflectance confocal microscopic imaging of Leishmania amastigotes (Leishman bodies): A case report.
Yaman B, Karaarslan I, Akalın T, Özdemir F
J Cutan Pathol 2021 Jun;48(6):807-810. Epub 2021 Mar 21 doi: 10.1111/cup.14006. PMID: 33719119
Immunoproteomic Identification and Characterization of Leishmania Membrane Proteins as Non-Invasive Diagnostic Candidates for Clinical Visceral Leishmaniasis.
Ejazi SA, Bhattacharyya A, Choudhury ST, Ghosh S, Sabur A, Pandey K, Das VNR, Das P, Rahaman M, Goswami RP, Ali N
Sci Rep 2018 Aug 14;8(1):12110. doi: 10.1038/s41598-018-30546-y. PMID: 30108316Free PMC Article
Arginase activity in pathogenic and non-pathogenic species of Leishmania parasites.
Badirzadeh A, Taheri T, Taslimi Y, Abdossamadi Z, Heidari-Kharaji M, Gholami E, Sedaghat B, Niyyati M, Rafati S
PLoS Negl Trop Dis 2017 Jul;11(7):e0005774. Epub 2017 Jul 14 doi: 10.1371/journal.pntd.0005774. PMID: 28708893Free PMC Article
Visceral leishmaniasis in paediatrics.
Kafetzis DA, Maltezou HC
Curr Opin Infect Dis 2002 Jun;15(3):289-94. doi: 10.1097/00001432-200206000-00012. PMID: 12015464
Biological behavior of Leishmania amazonensis isolated from humans with cutaneous, mucosal, or visceral leishmaniasis in BALB/C mice.
Almeida RP, Barral-Netto M, De Jesus AM, De Freitas LA, Carvalho EM, Barral A
Am J Trop Med Hyg 1996 Feb;54(2):178-84. doi: 10.4269/ajtmh.1996.54.178. PMID: 8619444

Clinical prediction guides

IL-18 is required for the T(H)1-adaptation of T(REG) cells and the selective suppression of T(H)17 responses in acute and chronic infections.
Alvarez F, Istomine R, Da Silva Lira Filho A, Al-Aubodah TA, Huang D, Okde R, Olivier M, Fritz JH, Piccirillo CA
Mucosal Immunol 2023 Aug;16(4):462-475. Epub 2023 May 13 doi: 10.1016/j.mucimm.2023.05.004. PMID: 37182738
Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis.
Araújo IAC, de Paula RC, Alves CL, Faria KF, Oliveira MM, Mendes GG, Dias EMFA, Ribeiro RR, Oliveira AB, Silva SMD
Exp Parasitol 2019 Apr;199:67-73. Epub 2019 Feb 21 doi: 10.1016/j.exppara.2019.02.013. PMID: 30797783
Arginase activity in pathogenic and non-pathogenic species of Leishmania parasites.
Badirzadeh A, Taheri T, Taslimi Y, Abdossamadi Z, Heidari-Kharaji M, Gholami E, Sedaghat B, Niyyati M, Rafati S
PLoS Negl Trop Dis 2017 Jul;11(7):e0005774. Epub 2017 Jul 14 doi: 10.1371/journal.pntd.0005774. PMID: 28708893Free PMC Article
The role of monocytes in models of infection by protozoan parasites.
Hu S, Wei W, Korner H
Mol Immunol 2017 Aug;88:174-184. Epub 2017 Jul 10 doi: 10.1016/j.molimm.2017.06.020. PMID: 28704704
Enhanced survival of Leishmania major in neutrophil granulocytes in the presence of apoptotic cells.
Salei N, Hellberg L, Köhl J, Laskay T
PLoS One 2017;12(2):e0171850. Epub 2017 Feb 10 doi: 10.1371/journal.pone.0171850. PMID: 28187163Free PMC Article

Recent systematic reviews

Accuracy of the direct agglutination test for diagnosis of visceral leishmaniasis: a systematic review and meta-analysis.
Roberts T, Keddie SH, Rattanavong S, Gomez SR, Bradley J, Keogh RH, Bärenbold O, Falconer J, Mens PF, Hopkins H, Ashley EA
BMC Infect Dis 2023 Nov 9;23(1):782. doi: 10.1186/s12879-023-08772-1. PMID: 37946107Free PMC Article

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