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Anti-NR2A antibody positivity

MedGen UID:
1053034
•Concept ID:
CN377155
•
Finding
HPO: HP:6000347

Definition

The presence of autoantibodies (immunoglobulins) in the blood circulation that react against the N-Methyl-D-aspartate (NMDA) receptor NR2A subunit. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-NR2A antibody positivity

Recent clinical studies

Etiology

Clinical utility of circulating anti-N-methyl-(d)-aspartate receptor subunits NR2A/B antibody for the diagnosis of neuropsychiatric syndromes in systemic lupus erythematosus and Sjögren's syndrome: An updated meta-analysis.
Tay SH, Fairhurst AM, Mak A
Autoimmun Rev 2017 Feb;16(2):114-122. Epub 2016 Dec 15 doi: 10.1016/j.autrev.2016.12.002. PMID: 27988431
Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus.
Gono T, Kawaguchi Y, Kaneko H, Nishimura K, Hanaoka M, Kataoka S, Okamoto Y, Katsumata Y, Yamanaka H
Rheumatology (Oxford) 2011 Sep;50(9):1578-85. Epub 2011 Jan 5 doi: 10.1093/rheumatology/keq408. PMID: 21208977

Diagnosis

Clinical utility of circulating anti-N-methyl-(d)-aspartate receptor subunits NR2A/B antibody for the diagnosis of neuropsychiatric syndromes in systemic lupus erythematosus and Sjögren's syndrome: An updated meta-analysis.
Tay SH, Fairhurst AM, Mak A
Autoimmun Rev 2017 Feb;16(2):114-122. Epub 2016 Dec 15 doi: 10.1016/j.autrev.2016.12.002. PMID: 27988431

Therapy

Clinical utility of circulating anti-N-methyl-(d)-aspartate receptor subunits NR2A/B antibody for the diagnosis of neuropsychiatric syndromes in systemic lupus erythematosus and Sjögren's syndrome: An updated meta-analysis.
Tay SH, Fairhurst AM, Mak A
Autoimmun Rev 2017 Feb;16(2):114-122. Epub 2016 Dec 15 doi: 10.1016/j.autrev.2016.12.002. PMID: 27988431

Prognosis

Clinical utility of circulating anti-N-methyl-(d)-aspartate receptor subunits NR2A/B antibody for the diagnosis of neuropsychiatric syndromes in systemic lupus erythematosus and Sjögren's syndrome: An updated meta-analysis.
Tay SH, Fairhurst AM, Mak A
Autoimmun Rev 2017 Feb;16(2):114-122. Epub 2016 Dec 15 doi: 10.1016/j.autrev.2016.12.002. PMID: 27988431
Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus.
Gono T, Kawaguchi Y, Kaneko H, Nishimura K, Hanaoka M, Kataoka S, Okamoto Y, Katsumata Y, Yamanaka H
Rheumatology (Oxford) 2011 Sep;50(9):1578-85. Epub 2011 Jan 5 doi: 10.1093/rheumatology/keq408. PMID: 21208977

Clinical prediction guides

Anti-NR2A antibody as a predictor for neuropsychiatric systemic lupus erythematosus.
Gono T, Kawaguchi Y, Kaneko H, Nishimura K, Hanaoka M, Kataoka S, Okamoto Y, Katsumata Y, Yamanaka H
Rheumatology (Oxford) 2011 Sep;50(9):1578-85. Epub 2011 Jan 5 doi: 10.1093/rheumatology/keq408. PMID: 21208977

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