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Dermal multinucleated giant cells

MedGen UID:
1053361
•Concept ID:
CN376569
•
Finding
Synonym: Multinucleated giant cells in skin
 
HPO: HP:6000057

Definition

Presence of giant cells in the dermis. Giant cells are formed by fusion of various cells such as macrophage, epithelioid cells, monocytes, etc., These are multi-nucleated, large in size, and generally present at the site of chronic inflammation and other granulomatous conditions. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDermal multinucleated giant cells

Professional guidelines

PubMed

Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria.
Roy SF, Dong D, Myung P, McNiff JM
J Cutan Pathol 2019 Aug;46(8):563-569. Epub 2019 Apr 23 doi: 10.1111/cup.13463. PMID: 30927287
Clear Cell Atypical Fibroxanthoma: Clinicopathological Study of 6 Cases and Review of the Literature With Special Emphasis on the Differential Diagnosis.
Tardío JC, Pinedo F, Aramburu JA, Martínez-González MÁ, Arias D, Khedaoui R, Suárez-Massa D, Santonja C
Am J Dermatopathol 2016 Aug;38(8):586-92. doi: 10.1097/DAD.0000000000000465. PMID: 26848640
Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment.
Sirvent N, Maire G, Pedeutour F
Genes Chromosomes Cancer 2003 May;37(1):1-19. doi: 10.1002/gcc.10202. PMID: 12661001

Recent clinical studies

Etiology

Impact of Chemotherapy and Radiation Therapy on Inflammatory Response, Neovascularization, and Capsule Formation of Acellular Dermal Matrix in Breast Reconstruction: Analysis of the BREASTrial Biopsy Specimens.
Mendenhall SD, Graham EM, Anderson LA, Ying J, Liu T, Agarwal JP
Plast Reconstr Surg 2022 Mar 1;149(3):378e-385e. doi: 10.1097/PRS.0000000000008824. PMID: 35196668
Progressive nodular histiocytosis: an unusual disorder.
Roldan MS, Choc C, Mansilla JJ, Riley G
Dermatol Online J 2021 Feb 15;27(2) PMID: 33818980
Multinucleate cell angiohistiocytoma.
Nguyen AH, Glembocki DJ, Patel NB
Cutis 2017 Dec;100(6):429-431. PMID: 29360886
Multinucleated floret-like giant cells in sporadic and NF1-associated neurofibromas: a clinicopathologic study of 94 cases.
Magro G, Amico P, Vecchio GM, Caltabiano R, Castaing M, Kacerovska D, Kazakov DV, Michal M
Virchows Arch 2010 Jan;456(1):71-6. Epub 2009 Nov 25 doi: 10.1007/s00428-009-0859-y. PMID: 19937344
Pilomatrix carcinoma.
Sau P, Lupton GP, Graham JH
Cancer 1993 Apr 15;71(8):2491-8. doi: 10.1002/1097-0142(19930415)71:8<2491::aid-cncr2820710811>3.0.co;2-i. PMID: 8453573

Diagnosis

Relation Between Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: Histopathologic Features and Review of the Literature.
Iglesias-Pena N, Martínez-Campayo N, López-Solache L
Actas Dermosifiliogr (Engl Ed) 2021 May;112(5):392-405. Epub 2020 Dec 7 doi: 10.1016/j.ad.2020.11.018. PMID: 33301761
Atypical Fibroxanthoma Revisited.
Mentzel T, Requena L, Brenn T
Surg Pathol Clin 2017 Jun;10(2):319-335. Epub 2017 Mar 14 doi: 10.1016/j.path.2017.01.007. PMID: 28477883
Diagnostic approach in lymphoplasmacytic plaque.
Mitteldorf C, Palmedo G, Kutzner H, Kauer F, Prestin M, Schuster C, Hübscher E, Kirsch A, Tronnier M, Kempf W
J Eur Acad Dermatol Venereol 2015 Nov;29(11):2206-15. Epub 2015 Sep 14 doi: 10.1111/jdv.13213. PMID: 26370335
Elastophagocytosis: underlying mechanisms and associated cutaneous entities.
El-Khoury J, Kurban M, Abbas O
J Am Acad Dermatol 2014 May;70(5):934-44. Epub 2014 Jan 18 doi: 10.1016/j.jaad.2013.12.012. PMID: 24447829
Myxoid dermatofibroma.
Zelger BG, Calonje E, Zelger B
Histopathology 1999 Apr;34(4):357-64. doi: 10.1046/j.1365-2559.1999.00633.x. PMID: 10231403

Therapy

Impact of Chemotherapy and Radiation Therapy on Inflammatory Response, Neovascularization, and Capsule Formation of Acellular Dermal Matrix in Breast Reconstruction: Analysis of the BREASTrial Biopsy Specimens.
Mendenhall SD, Graham EM, Anderson LA, Ying J, Liu T, Agarwal JP
Plast Reconstr Surg 2022 Mar 1;149(3):378e-385e. doi: 10.1097/PRS.0000000000008824. PMID: 35196668
The Aetiopathogenesis of Late Inflammatory Reactions (LIRs) After Soft Tissue Filler Use: A Systematic Review of the Literature.
Bachour Y, Kadouch JA, Niessen FB
Aesthetic Plast Surg 2021 Aug;45(4):1748-1759. Epub 2021 Apr 28 doi: 10.1007/s00266-021-02306-3. PMID: 33913021Free PMC Article
Giant cells lepromatous leprosy. Diffuse dermatitis with exuberant foreign body giant cells in treated lepromatous leprosy.
Rodríguez G, Arias V
Biomedica 2019 Aug 1;39(Supl. 2):26-31. doi: 10.7705/biomedica.v39i4.4493. PMID: 31529831
Polyalkylimide: A Nonstable Filler Over Time.
Schelke LW, Velthuis PJ, van Dijk MR
Dermatol Surg 2018 Apr;44(4):563-567. doi: 10.1097/DSS.0000000000001388. PMID: 29059143
Lupus miliaris disseminatus faciei.
Toda-Brito H, Aranha JMP, Tavares ES
An Bras Dermatol 2017 Nov-Dec;92(6):851-853. doi: 10.1590/abd1806-4841.20174534. PMID: 29364447Free PMC Article

Prognosis

Impact of Chemotherapy and Radiation Therapy on Inflammatory Response, Neovascularization, and Capsule Formation of Acellular Dermal Matrix in Breast Reconstruction: Analysis of the BREASTrial Biopsy Specimens.
Mendenhall SD, Graham EM, Anderson LA, Ying J, Liu T, Agarwal JP
Plast Reconstr Surg 2022 Mar 1;149(3):378e-385e. doi: 10.1097/PRS.0000000000008824. PMID: 35196668
Case of Bullous Grover Disease.
Li YM, Milikowski C, Galimberti F
Am J Dermatopathol 2021 Feb 1;43(2):141-143. doi: 10.1097/DAD.0000000000001756. PMID: 32732687
Lupus miliaris disseminatus faciei.
Toda-Brito H, Aranha JMP, Tavares ES
An Bras Dermatol 2017 Nov-Dec;92(6):851-853. doi: 10.1590/abd1806-4841.20174534. PMID: 29364447Free PMC Article
Cutaneous Osteoblastic Osteosarcoma: Report of 2 New Cases Integrated With SATB2 Immunohistochemistry and Review of the Literature.
Falconieri G, Cataldi P, Kavalar R, Štitič V, Luzar B
Am J Dermatopathol 2016 Nov;38(11):824-831. doi: 10.1097/DAD.0000000000000555. PMID: 27043339
Pilomatrix carcinoma.
Sau P, Lupton GP, Graham JH
Cancer 1993 Apr 15;71(8):2491-8. doi: 10.1002/1097-0142(19930415)71:8<2491::aid-cncr2820710811>3.0.co;2-i. PMID: 8453573

Clinical prediction guides

Case of Bullous Grover Disease.
Li YM, Milikowski C, Galimberti F
Am J Dermatopathol 2021 Feb 1;43(2):141-143. doi: 10.1097/DAD.0000000000001756. PMID: 32732687
Giant cells lepromatous leprosy. Diffuse dermatitis with exuberant foreign body giant cells in treated lepromatous leprosy.
Rodríguez G, Arias V
Biomedica 2019 Aug 1;39(Supl. 2):26-31. doi: 10.7705/biomedica.v39i4.4493. PMID: 31529831
Multinucleated floret-like giant cells in sporadic and NF1-associated neurofibromas: a clinicopathologic study of 94 cases.
Magro G, Amico P, Vecchio GM, Caltabiano R, Castaing M, Kacerovska D, Kazakov DV, Michal M
Virchows Arch 2010 Jan;456(1):71-6. Epub 2009 Nov 25 doi: 10.1007/s00428-009-0859-y. PMID: 19937344
Mid-dermal elastolysis revisited.
Gambichler T
Arch Dermatol Res 2010 Mar;302(2):85-93. doi: 10.1007/s00403-009-1004-0. PMID: 19936772
Malignancy-associated multicentric reticulohistiocytosis: a clinical, histological and immunophenotypic study.
Snow JL, Muller SA
Br J Dermatol 1995 Jul;133(1):71-6. doi: 10.1111/j.1365-2133.1995.tb02495.x. PMID: 7669644

Recent systematic reviews

The Aetiopathogenesis of Late Inflammatory Reactions (LIRs) After Soft Tissue Filler Use: A Systematic Review of the Literature.
Bachour Y, Kadouch JA, Niessen FB
Aesthetic Plast Surg 2021 Aug;45(4):1748-1759. Epub 2021 Apr 28 doi: 10.1007/s00266-021-02306-3. PMID: 33913021Free PMC Article
Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence.
Zhao H, Wu C, Wu M, Zhou Y, Zhu H, Li Y, You Y, Luo H, Wang L, Zuo X
Mol Med Rep 2016 Jul;14(1):209-17. Epub 2016 May 12 doi: 10.3892/mmr.2016.5253. PMID: 27175854Free PMC Article

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