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Increased urinary bile acid level

MedGen UID:
1053386
•Concept ID:
CN377354
•
Finding
HPO: HP:6000523

Definition

The amount of bile acids in the urine, normalized for urine concentration, is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased urinary bile acid level

Professional guidelines

PubMed

Serum bile acids associate with liver volume in polycystic liver disease and decrease upon treatment with lanreotide.
Dekker SEI, Bierau J, Giera M, Blomberg N, Drenth JPH, Mayboroda OA, de Fijter JW, Soonawala D; DIPAK Consortium
Eur J Clin Invest 2024 Apr;54(4):e14147. Epub 2023 Dec 9 doi: 10.1111/eci.14147. PMID: 38071418
Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis.
Martinez-Gili L, Pechlivanis A, McDonald JAK, Begum S, Badrock J, Dyson JK, Jones R, Hirschfield G, Ryder SD, Sandford R, Rushbrook S, Thorburn D, Taylor-Robinson SD, Crossey MME, Marchesi JR, Mells G, Holmes E, Jones D
Gut Microbes 2023 Jan-Dec;15(1):2208501. doi: 10.1080/19490976.2023.2208501. PMID: 37191344Free PMC Article
Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment.
Batta AK, Arora R, Salen G, Tint GS, Eskreis D, Katz S
J Lipid Res 1989 Dec;30(12):1953-62. PMID: 2621422

Recent clinical studies

Etiology

Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis.
Martinez-Gili L, Pechlivanis A, McDonald JAK, Begum S, Badrock J, Dyson JK, Jones R, Hirschfield G, Ryder SD, Sandford R, Rushbrook S, Thorburn D, Taylor-Robinson SD, Crossey MME, Marchesi JR, Mells G, Holmes E, Jones D
Gut Microbes 2023 Jan-Dec;15(1):2208501. doi: 10.1080/19490976.2023.2208501. PMID: 37191344Free PMC Article
Increased admission serum total bile acids can be associated with decreased 3-month mortality in patients with acute ischemic stroke.
Huang L, Xu G, Zhang R, Wang Y, Ji J, Long F, Sun Y
Lipids Health Dis 2022 Jan 22;21(1):15. doi: 10.1186/s12944-021-01620-8. PMID: 35065639Free PMC Article
Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake.
Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, Giacco R, Mennella I, Ferracane R, Pons N, Pasolli E, Rivellese A, Dragsted LO, Vitaglione P, Ehrlich SD, Ercolini D
Gut 2020 Jul;69(7):1258-1268. Epub 2020 Feb 19 doi: 10.1136/gutjnl-2019-320438. PMID: 32075887Free PMC Article
Δ4-3-oxosteroid-5β-reductase deficiency: Responses to oral bile acid therapy and long-term outcomes.
Zhang MH, Setchell KD, Zhao J, Gong JY, Lu Y, Wang JS
World J Gastroenterol 2019 Feb 21;25(7):859-869. doi: 10.3748/wjg.v25.i7.859. PMID: 30809085Free PMC Article
The urinary bile acid excretion in healthy premature and full-term infants during the neonatal period.
Strandvik B, Wahlén E, Wikström SA
Scand J Clin Lab Invest 1994 Feb;54(1):1-10. doi: 10.3109/00365519409086503. PMID: 8171265

Diagnosis

Urinary Bile Acid Profile of Newborns Born by Cesarean Section Is Characterized by Oxidative Metabolism of Primary Bile Acids: Limited Roles of Fetal-Specific CYP3A7 in Cholate Oxidations.
Wang WX, Chen L, Wang GY, Zhang JL, Tan XW, Lin QH, Chen YJ, Zhang J, Zhu PP, Miao J, Su MM, Liu CX, Jia W, Lan K
Drug Metab Dispos 2020 Aug;48(8):662-672. Epub 2020 Jun 4 doi: 10.1124/dmd.120.000011. PMID: 32499339
Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake.
Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, Giacco R, Mennella I, Ferracane R, Pons N, Pasolli E, Rivellese A, Dragsted LO, Vitaglione P, Ehrlich SD, Ercolini D
Gut 2020 Jul;69(7):1258-1268. Epub 2020 Feb 19 doi: 10.1136/gutjnl-2019-320438. PMID: 32075887Free PMC Article
Bile acid diarrhoea and FGF19: new views on diagnosis, pathogenesis and therapy.
Walters JR
Nat Rev Gastroenterol Hepatol 2014 Jul;11(7):426-34. Epub 2014 Mar 25 doi: 10.1038/nrgastro.2014.32. PMID: 24662279
Early diagnosis of intestinal ischemia using urinary and plasma fatty acid binding proteins.
Thuijls G, van Wijck K, Grootjans J, Derikx JP, van Bijnen AA, Heineman E, Dejong CH, Buurman WA, Poeze M
Ann Surg 2011 Feb;253(2):303-8. doi: 10.1097/SLA.0b013e318207a767. PMID: 21245670
Bile salt metabolism. II. Bile salts and disease.
Campbell CB, Cowen AE
Aust N Z J Med 1977 Dec;7(6):587-95. doi: 10.1111/j.1445-5994.1977.tb02313.x. PMID: 274937

Therapy

Bacterial and metabolic phenotypes associated with inadequate response to ursodeoxycholic acid treatment in primary biliary cholangitis.
Martinez-Gili L, Pechlivanis A, McDonald JAK, Begum S, Badrock J, Dyson JK, Jones R, Hirschfield G, Ryder SD, Sandford R, Rushbrook S, Thorburn D, Taylor-Robinson SD, Crossey MME, Marchesi JR, Mells G, Holmes E, Jones D
Gut Microbes 2023 Jan-Dec;15(1):2208501. doi: 10.1080/19490976.2023.2208501. PMID: 37191344Free PMC Article
A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans.
Caballero-Camino FJ, Rodrigues PM, Wångsell F, Agirre-Lizaso A, Olaizola P, Izquierdo-Sanchez L, Perugorria MJ, Bujanda L, Angelin B, Straniero S, Wallebäck A, Starke I, Gillberg PG, Strängberg E, Bonn B, Mattsson JP, Madsen MR, Hansen HH, Lindström E, Åkerblad P, Banales JM
Hepatology 2023 Sep 1;78(3):709-726. Epub 2023 Apr 1 doi: 10.1097/HEP.0000000000000376. PMID: 36999529Free PMC Article
Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake.
Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, Giacco R, Mennella I, Ferracane R, Pons N, Pasolli E, Rivellese A, Dragsted LO, Vitaglione P, Ehrlich SD, Ercolini D
Gut 2020 Jul;69(7):1258-1268. Epub 2020 Feb 19 doi: 10.1136/gutjnl-2019-320438. PMID: 32075887Free PMC Article
Δ4-3-oxosteroid-5β-reductase deficiency: Responses to oral bile acid therapy and long-term outcomes.
Zhang MH, Setchell KD, Zhao J, Gong JY, Lu Y, Wang JS
World J Gastroenterol 2019 Feb 21;25(7):859-869. doi: 10.3748/wjg.v25.i7.859. PMID: 30809085Free PMC Article
Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

Prognosis

Urinary metabolomic profiling of a cohort of Colombian patients with systemic lupus erythematosus.
Rojo-Sánchez A, Carmona-Martes A, Díaz-Olmos Y, Santamaría-Torres M, Cala MP, Orozco-Acosta E, Aroca-Martínez G, Pacheco-Londoño L, Navarro-Quiroz E, Pacheco-Lugo LA
Sci Rep 2024 Apr 25;14(1):9555. doi: 10.1038/s41598-024-60217-0. PMID: 38664528Free PMC Article
Increased admission serum total bile acids can be associated with decreased 3-month mortality in patients with acute ischemic stroke.
Huang L, Xu G, Zhang R, Wang Y, Ji J, Long F, Sun Y
Lipids Health Dis 2022 Jan 22;21(1):15. doi: 10.1186/s12944-021-01620-8. PMID: 35065639Free PMC Article
Urinary Metabolites Diagnostic and Prognostic of Intrahepatic Cholangiocarcinoma.
Haznadar M, Diehl CM, Parker AL, Krausz KW, Bowman ED, Rabibhadana S, Forgues M, Bhudhisawasdi V, Gonzalez FJ, Mahidol C, Budhu A, Wang XW, Ruchirawat M, Harris CC
Cancer Epidemiol Biomarkers Prev 2019 Oct;28(10):1704-1711. Epub 2019 Jul 29 doi: 10.1158/1055-9965.EPI-19-0453. PMID: 31358519Free PMC Article
Alterations in gut microbial function following liver transplant.
Bajaj JS, Kakiyama G, Cox IJ, Nittono H, Takei H, White M, Fagan A, Gavis EA, Heuman DM, Gilles HC, Hylemon P, Taylor-Robinson SD, Legido-Quigley C, Kim M, Xu J, Williams R, Sikaroodi M, Pandak WM, Gillevet PM
Liver Transpl 2018 Jun;24(6):752-761. Epub 2018 May 13 doi: 10.1002/lt.25046. PMID: 29500907Free PMC Article
Increased levels of typically fetal bile acid species in patients with hepatocellular carcinoma.
El-Mir MY, Badia MD, Luengo N, Monte MJ, Marin JJ
Clin Sci (Lond) 2001 May;100(5):499-508. PMID: 11294690

Clinical prediction guides

G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes.
Wang XX, Edelstein MH, Gafter U, Qiu L, Luo Y, Dobrinskikh E, Lucia S, Adorini L, D'Agati VD, Levi J, Rosenberg A, Kopp JB, Gius DR, Saleem MA, Levi M
J Am Soc Nephrol 2016 May;27(5):1362-78. Epub 2015 Sep 30 doi: 10.1681/ASN.2014121271. PMID: 26424786Free PMC Article
Mechanism underlying an elevated serum bile acid level in chronic renal failure patients.
Chu L, Zhang K, Zhang Y, Jin X, Jiang H
Int Urol Nephrol 2015 Feb;47(2):345-51. Epub 2014 Dec 25 doi: 10.1007/s11255-014-0901-0. PMID: 25539619
Profiling circulating and urinary bile acids in patients with biliary obstruction before and after biliary stenting.
Trottier J, Białek A, Caron P, Straka RJ, Milkiewicz P, Barbier O
PLoS One 2011;6(7):e22094. Epub 2011 Jul 8 doi: 10.1371/journal.pone.0022094. PMID: 21760958Free PMC Article
The clinical pharmacology of losartan in Japanese subjects and patients.
Nakashima M, Umemura K
Blood Press Suppl 1996;2:62-6. PMID: 8913542
Clinical pharmacology of antibiotics and other drugs in cystic fibrosis.
Prandota J
Drugs 1988 May;35(5):542-78. doi: 10.2165/00003495-198835050-00004. PMID: 3293970

Recent systematic reviews

Amphotericin B deoxycholate versus liposomal amphotericin B: effects on kidney function.
Botero Aguirre JP, Restrepo Hamid AM
Cochrane Database Syst Rev 2015 Nov 23;2015(11):CD010481. doi: 10.1002/14651858.CD010481.pub2. PMID: 26595825Free PMC Article

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