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Reduced erythrocyte glutathione reductase activity

MedGen UID:
1053456
•Concept ID:
CN377356
•
Finding
HPO: HP:6000525

Definition

Activity of glutathione reductase (EC 1.6.4.2) in erythrocytes below the lower limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced erythrocyte glutathione reductase activity

Conditions with this feature

Hemolytic anemia due to glutathione reductase deficiency
MedGen UID:
1684855
•Concept ID:
C5231513
•
Disease or Syndrome
Haemolytic anaemia due to glutathione reductase (GSR) deficiency is characterised by nearly complete absence of GSR activity in erythrocytes.
See: Condition Record
Hemolytic anemia due to glutathione reductase deficiency

Professional guidelines

PubMed

CHANGES IN BIOCHEMICAL BLOOD VALUES DURING COMPLEX TREATMENT OF RHINOSINUSITIS POLYPOSA PATIENTS.
Khobotova NV, Mishchenko VK
Wiad Lek 2021;74(3 cz 1):535-538. PMID: 33813464
Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition.
McAuley E, McNulty H, Hughes C, Strain JJ, Ward M
Proc Nutr Soc 2016 Aug;75(3):405-14. Epub 2016 May 12 doi: 10.1017/S0029665116000197. PMID: 27170501
Lipid peroxidation, erythrocyte antioxidants and plasma antioxidants in osteoarthritis before and after homeopathic treatment.
Pinto S, Rao AV, Rao A
Homeopathy 2008 Oct;97(4):185-9. doi: 10.1016/j.homp.2008.08.004. PMID: 19371566

Recent clinical studies

Etiology

Glutathione Component of Antioxidant Status in Menopausal Women with Insomnia.
Semenova NV, Madaeva IM, Brichagina AS, Kolesnikov SI, Kolesnikova LI
Bull Exp Biol Med 2022 Oct;173(6):775-778. Epub 2022 Nov 2 doi: 10.1007/s10517-022-05628-7. PMID: 36322310
CHANGES IN BIOCHEMICAL BLOOD VALUES DURING COMPLEX TREATMENT OF RHINOSINUSITIS POLYPOSA PATIENTS.
Khobotova NV, Mishchenko VK
Wiad Lek 2021;74(3 cz 1):535-538. PMID: 33813464
Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition.
McAuley E, McNulty H, Hughes C, Strain JJ, Ward M
Proc Nutr Soc 2016 Aug;75(3):405-14. Epub 2016 May 12 doi: 10.1017/S0029665116000197. PMID: 27170501
Plasma glutathione reductase activity and prognosis of septic shock.
Kim JS, Kwon WY, Suh GJ, Kim KS, Jung YS, Kim SH, Lee SE
J Surg Res 2016 Jan;200(1):298-307. Epub 2015 Aug 5 doi: 10.1016/j.jss.2015.07.044. PMID: 26316444
Study of the activity of glutathione-peroxidase, glutathione-transferase, and glutathione-reductase in renal transplants.
De Vega L, Pérez Fernández R, Martin Mateo MC, Bustamante J, Bustamante A, Herrero AM, Bustamante Munguira E
Transplant Proc 2003 Jun;35(4):1346-50. doi: 10.1016/s0041-1345(03)00475-5. PMID: 12826156

Diagnosis

Vanadium: Risks and possible benefits in the light of a comprehensive overview of its pharmacotoxicological mechanisms and multi-applications with a summary of further research trends.
Ścibior A, Pietrzyk Ł, Plewa Z, Skiba A
J Trace Elem Med Biol 2020 Sep;61:126508. Epub 2020 Apr 12 doi: 10.1016/j.jtemb.2020.126508. PMID: 32305626Free PMC Article
Amperometric sensor for glutathione reductase activity determination in erythrocyte hemolysate.
Alves AA, Pereira da Silva L, Macedo DV, Kubota LT
Anal Biochem 2003 Dec 1;323(1):33-8. doi: 10.1016/j.ab.2003.08.025. PMID: 14622956
Superoxide dismutase activity and glutathione system in erythrocytes of men with Behchet's disease.
Dincer Y, Alademir Z, Hamuryudan V, Fresko I, Akcay T
Tohoku J Exp Med 2002 Nov;198(3):191-5. doi: 10.1620/tjem.198.191. PMID: 12597246
Markers of oxidative stress and antioxidant activity in plasma and erythrocytes in neonatal respiratory distress syndrome.
van Zoeren-Grobben D, Lindeman JH, Houdkamp E, Moison RM, Wijnen JT, Berger HM
Acta Paediatr 1997 Dec;86(12):1356-62. doi: 10.1111/j.1651-2227.1997.tb14913.x. PMID: 9475316
Bioaccumulative potential and toxicity of endosulfan insecticide to non-target animals.
Naqvi SM, Vaishnavi C
Comp Biochem Physiol C Comp Pharmacol Toxicol 1993 Jul;105(3):347-61. doi: 10.1016/0742-8413(93)90071-r. PMID: 7900959

Therapy

A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status.
Clements M, Heffernan M, Ward M, Hoey L, Doherty LC, Hack Mendes R, Clarke MM, Hughes CF, Love I, Murphy S, McDermott E, Grehan J, McCann A, McAnena LB, Strain JJ, Brennan L, McNulty H
J Bone Miner Res 2022 Dec;37(12):2443-2455. Epub 2022 Oct 14 doi: 10.1002/jbmr.4709. PMID: 36128889Free PMC Article
Riboflavin status, MTHFR genotype and blood pressure: current evidence and implications for personalised nutrition.
McAuley E, McNulty H, Hughes C, Strain JJ, Ward M
Proc Nutr Soc 2016 Aug;75(3):405-14. Epub 2016 May 12 doi: 10.1017/S0029665116000197. PMID: 27170501
Markers of Antioxidant Defense in Patients with Type 2 Diabetes.
Gawlik K, Naskalski JW, Fedak D, Pawlica-Gosiewska D, Grudzień U, Dumnicka P, Małecki MT, Solnica B
Oxid Med Cell Longev 2016;2016:2352361. Epub 2015 Nov 10 doi: 10.1155/2016/2352361. PMID: 26640613Free PMC Article
1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents.
Belorgey D, Lanfranchi DA, Davioud-Charvet E
Curr Pharm Des 2013;19(14):2512-28. doi: 10.2174/1381612811319140003. PMID: 23116403Free PMC Article
Dantrolene inhibits human erythrocyte glutathione reductase.
Sentürk M, Gülçin I, Ciftci M, Küfrevioğlu OI
Biol Pharm Bull 2008 Nov;31(11):2036-9. doi: 10.1248/bpb.31.2036. PMID: 18981569

Prognosis

Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men.
Papanikolaou K, Jamurtas AZ, Poulios A, Tsimeas P, Draganidis D, Margaritelis NV, Baloyiannis I, Papadopoulos C, Sovatzidis A, Deli CK, Rosvoglou A, Georgakouli K, Tzatzakis T, Nikolaidis MG, Fatouros IG
Eur J Nutr 2023 Jun;62(4):1767-1782. Epub 2023 Feb 24 doi: 10.1007/s00394-023-03102-2. PMID: 36828945
Plasma glutathione reductase activity and prognosis of septic shock.
Kim JS, Kwon WY, Suh GJ, Kim KS, Jung YS, Kim SH, Lee SE
J Surg Res 2016 Jan;200(1):298-307. Epub 2015 Aug 5 doi: 10.1016/j.jss.2015.07.044. PMID: 26316444
Study of the activity of glutathione-peroxidase, glutathione-transferase, and glutathione-reductase in renal transplants.
De Vega L, Pérez Fernández R, Martin Mateo MC, Bustamante J, Bustamante A, Herrero AM, Bustamante Munguira E
Transplant Proc 2003 Jun;35(4):1346-50. doi: 10.1016/s0041-1345(03)00475-5. PMID: 12826156
Low activity of superoxide dismutase and high activity of glutathione reductase in erythrocytes from centenarians.
Andersen HR, Jeune B, Nybo H, Nielsen JB, Andersen-Ranberg K, Grandjean P
Age Ageing 1998 Sep;27(5):643-8. doi: 10.1093/ageing/27.5.643. PMID: 12675104
Markers of oxidative stress and antioxidant activity in plasma and erythrocytes in neonatal respiratory distress syndrome.
van Zoeren-Grobben D, Lindeman JH, Houdkamp E, Moison RM, Wijnen JT, Berger HM
Acta Paediatr 1997 Dec;86(12):1356-62. doi: 10.1111/j.1651-2227.1997.tb14913.x. PMID: 9475316

Clinical prediction guides

Skeletal muscle and erythrocyte redox status is associated with dietary cysteine intake and physical fitness in healthy young physically active men.
Papanikolaou K, Jamurtas AZ, Poulios A, Tsimeas P, Draganidis D, Margaritelis NV, Baloyiannis I, Papadopoulos C, Sovatzidis A, Deli CK, Rosvoglou A, Georgakouli K, Tzatzakis T, Nikolaidis MG, Fatouros IG
Eur J Nutr 2023 Jun;62(4):1767-1782. Epub 2023 Feb 24 doi: 10.1007/s00394-023-03102-2. PMID: 36828945
Fullerenol C(60)(OH)(36) Protects the Antioxidant Enzymes in Human Erythrocytes against Oxidative Damage Induced by High-Energy Electrons.
Grebowski J, Kazmierska-Grebowska P, Cichon N, Konarska A, Wolszczak M, Litwinienko G
Int J Mol Sci 2022 Sep 19;23(18) doi: 10.3390/ijms231810939. PMID: 36142851Free PMC Article
A study on the effects of inhibition mechanism of curcumin, quercetin, and resveratrol on human glutathione reductase through in vitro and in silico approaches.
Güller P, Karaman M, Güller U, Aksoy M, Küfrevioğlu Öİ
J Biomol Struct Dyn 2021 Mar;39(5):1744-1753. Epub 2020 Mar 16 doi: 10.1080/07391102.2020.1738962. PMID: 32141392
1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents.
Belorgey D, Lanfranchi DA, Davioud-Charvet E
Curr Pharm Des 2013;19(14):2512-28. doi: 10.2174/1381612811319140003. PMID: 23116403Free PMC Article
Ozone and human blood.
Buckley RD, Hackney JD, Clark K, Posin C
Arch Environ Health 1975 Jan;30(1):40-3. doi: 10.1080/00039896.1975.10666631. PMID: 1109271

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