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Elevated circulating granulocyte-macrophage colony-stimulating factor concentration

MedGen UID:
1053502
•Concept ID:
CN376758
•
Finding
Synonyms: Elevated circulating GM-CSF concentration; GMCSF high in blood
 
HPO: HP:6000245

Definition

The concentration of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating granulocyte-macrophage colony-stimulating factor concentration

Recent clinical studies

Etiology

Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After Streptococcus pneumoniae Infection.
Hulsebus HJ, Najarro KM, McMahan RH, Boe DM, Orlicky DJ, Kovacs EJ
Front Immunol 2022;13:884719. Epub 2022 May 4 doi: 10.3389/fimmu.2022.884719. PMID: 35603143Free PMC Article
The effect of polyphenols on cytokine and granulocyte response to resistance exercise.
Jajtner AR, Hoffman JR, Townsend JR, Beyer KS, Varanoske AN, Church DD, Oliveira LP, Herrlinger KA, Radom-Aizik S, Fukuda DH, Stout JR
Physiol Rep 2016 Dec;4(24) doi: 10.14814/phy2.13058. PMID: 28039406Free PMC Article
Circulating cytokine concentrations are not associated with major depressive disorder in a community-based cohort.
Einvik G, Vistnes M, Hrubos-Strøm H, Randby A, Namtvedt SK, Nordhus IH, Somers VK, Dammen T, Omland T
Gen Hosp Psychiatry 2012 May-Jun;34(3):262-7. Epub 2012 Mar 7 doi: 10.1016/j.genhosppsych.2012.01.017. PMID: 22401706
Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome.
Torre D, Tambini R, Manfredi M, Mangani V, Livi P, Maldifassi V, Chiaranda M, Campi P, Speranza F
J Infect 2003 Nov;47(4):296-9. doi: 10.1016/s0163-4453(03)00065-3. PMID: 14556753
Recombinant human granulocyte-macrophage colony-stimulating factor plus erythropoietin for the treatment of cytopenias in patients with myelodysplastic syndromes.
Stasi R, Pagano A, Terzoli E, Amadori S
Br J Haematol 1999 Apr;105(1):141-8. PMID: 10233377

Diagnosis

Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemia.
Baldini M, Maugeri N, Ramirez GA, Giacomassi C, Castiglioni A, Prieto-González S, Corbera-Bellalta M, Di Comite G, Papa I, Dell'antonio G, Ammirati E, Cuccovillo I, Vecchio V, Mantovani A, Rovere-Querini P, Sabbadini MG, Cid MC, Manfredi AA
Arthritis Rheum 2012 Mar;64(3):854-65. doi: 10.1002/art.33411. PMID: 21989653
Plasma profiles of circulating granulocyte-macrophage colony-stimulating factor and soluble cellular adhesion molecules in acute myocardial infarction. Contribution to post-infarction left ventricular dysfunction.
Parissis JT, Adamopoulos S, Venetsanou K, Kostakis G, Rigas A, Karas SM, Kremastinos D
Eur Cytokine Netw 2004 Apr-Jun;15(2):139-44. PMID: 15319174
Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome.
Torre D, Tambini R, Manfredi M, Mangani V, Livi P, Maldifassi V, Chiaranda M, Campi P, Speranza F
J Infect 2003 Nov;47(4):296-9. doi: 10.1016/s0163-4453(03)00065-3. PMID: 14556753

Therapy

The effect of polyphenols on cytokine and granulocyte response to resistance exercise.
Jajtner AR, Hoffman JR, Townsend JR, Beyer KS, Varanoske AN, Church DD, Oliveira LP, Herrlinger KA, Radom-Aizik S, Fukuda DH, Stout JR
Physiol Rep 2016 Dec;4(24) doi: 10.14814/phy2.13058. PMID: 28039406Free PMC Article
Recombinant human granulocyte-macrophage colony-stimulating factor plus erythropoietin for the treatment of cytopenias in patients with myelodysplastic syndromes.
Stasi R, Pagano A, Terzoli E, Amadori S
Br J Haematol 1999 Apr;105(1):141-8. PMID: 10233377
Phase I trial of intravenous and intraperitoneal administration of granulocyte-macrophage colony-stimulating factor.
Toner GC, Gabrilove JL, Gordon M, Crown J, Jakubowski AA, Meisenberg B, Sheridan C, Boone T, Vincent ME, Markman M
J Immunother Emphasis Tumor Immunol 1994 Jan;15(1):59-66. doi: 10.1097/00002371-199401000-00008. PMID: 8110732
Optimal timing for collections of blood progenitor cells following induction chemotherapy and granulocyte-macrophage colony-stimulating factor for autologous transplantation in advanced breast cancer.
Ho AD, Glück S, Germond C, Sinoff C, Dietz G, Maruyama M, Corringham RE
Leukemia 1993 Nov;7(11):1738-46. PMID: 7901454
Adoptive immunotherapy with high-dose interleukin-2: kinetics of circulating progenitors correlate with interleukin-6, granulocyte colony-stimulating factor level.
Tritarelli E, Rocca E, Testa U, Boccoli G, Camagna A, Calabresi F, Peschle C
Blood 1991 Feb 15;77(4):741-9. PMID: 1704262

Prognosis

Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After Streptococcus pneumoniae Infection.
Hulsebus HJ, Najarro KM, McMahan RH, Boe DM, Orlicky DJ, Kovacs EJ
Front Immunol 2022;13:884719. Epub 2022 May 4 doi: 10.3389/fimmu.2022.884719. PMID: 35603143Free PMC Article
Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome.
Torre D, Tambini R, Manfredi M, Mangani V, Livi P, Maldifassi V, Chiaranda M, Campi P, Speranza F
J Infect 2003 Nov;47(4):296-9. doi: 10.1016/s0163-4453(03)00065-3. PMID: 14556753
Systemic inflammatory response to exhaustive exercise. Cytokine kinetics.
Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K
Exerc Immunol Rev 2002;8:6-48. PMID: 12690937
Recombinant human granulocyte-macrophage colony-stimulating factor plus erythropoietin for the treatment of cytopenias in patients with myelodysplastic syndromes.
Stasi R, Pagano A, Terzoli E, Amadori S
Br J Haematol 1999 Apr;105(1):141-8. PMID: 10233377
Phase I trial of intravenous and intraperitoneal administration of granulocyte-macrophage colony-stimulating factor.
Toner GC, Gabrilove JL, Gordon M, Crown J, Jakubowski AA, Meisenberg B, Sheridan C, Boone T, Vincent ME, Markman M
J Immunother Emphasis Tumor Immunol 1994 Jan;15(1):59-66. doi: 10.1097/00002371-199401000-00008. PMID: 8110732

Clinical prediction guides

Circulating CD34(+) cells are elevated in neonates with respiratory distress syndrome.
Qi Y, Qian L, Sun B, Chen C, Cao Y
Inflamm Res 2010 Oct;59(10):889-95. Epub 2010 Apr 30 doi: 10.1007/s00011-010-0201-9. PMID: 20431906
Circulating levels of granulocyte macrophage colony-stimulating factor in patients with the systemic inflammatory response syndrome.
Torre D, Tambini R, Manfredi M, Mangani V, Livi P, Maldifassi V, Chiaranda M, Campi P, Speranza F
J Infect 2003 Nov;47(4):296-9. doi: 10.1016/s0163-4453(03)00065-3. PMID: 14556753
Systemic inflammatory response to exhaustive exercise. Cytokine kinetics.
Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, Sugawara K
Exerc Immunol Rev 2002;8:6-48. PMID: 12690937
Recombinant human granulocyte-macrophage colony-stimulating factor plus erythropoietin for the treatment of cytopenias in patients with myelodysplastic syndromes.
Stasi R, Pagano A, Terzoli E, Amadori S
Br J Haematol 1999 Apr;105(1):141-8. PMID: 10233377
Phase I trial of intravenous and intraperitoneal administration of granulocyte-macrophage colony-stimulating factor.
Toner GC, Gabrilove JL, Gordon M, Crown J, Jakubowski AA, Meisenberg B, Sheridan C, Boone T, Vincent ME, Markman M
J Immunother Emphasis Tumor Immunol 1994 Jan;15(1):59-66. doi: 10.1097/00002371-199401000-00008. PMID: 8110732

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