Reduced circulating protein Z concentration

MedGen UID:: 1053563
•Concept ID:: CN376997
•: Finding

HPO:	HP:6000401

Definition

The concentration of protein Z in the blood circulation is below the lower limit of normal. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVReduced circulating protein Z concentration

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal circulating metabolite concentration
    - Abnormal circulating protein concentration
      - Reduced circulating protein Z concentration

Recent clinical studies

Diagnosis

Thermodynamic and kinetic characterization of the protein Z-dependent protease inhibitor (ZPI)-protein Z interaction reveals an unexpected role for ZPI Lys-239.

Huang X, Zhou J, Zhou A, Olson ST
J Biol Chem 2015 Apr 10;290(15):9906-18. Epub 2015 Feb 20 doi: 10.1074/jbc.M114.633479. PMID: 25713144 Free PMC Article

Increase in the plasma levels of protein Z-dependent protease inhibitor in normal pregnancies but not in non-pregnant patients with unexplained recurrent miscarriage.

Souri M, Sugiura-Ogasawara M, Saito S, Kemkes-Matthes B, Meijers JC, Ichinose A
Thromb Haemost 2012 Mar;107(3):507-12. Epub 2012 Jan 25 doi: 10.1160/TH11-08-0591. PMID: 22274138

Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion.

Souri M, Iwata H, Zhang WG, Ichinose A
Blood 2009 Apr 16;113(16):3857-64. Epub 2009 Feb 2 doi: 10.1182/blood-2008-07-171884. PMID: 19188667

See all (3)