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Elevated circulating soluble FASL concentration

MedGen UID:
1053582
•Concept ID:
CN376532
•
Finding
HPO: HP:6000017

Definition

The concentration of soluble FASL in the blood circulation is above the upper limit of normal. The first apoptosis signal receptor (FAS) pathway regulates apoptosis and is critical for proper development and functioning of the immune system. FAS ligand (FASL) can bind to FAS receptors. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating soluble FASL concentration

Recent clinical studies

Etiology

Increased apoptosis and elevated Fas expression in circulating natural killer cells in gastric cancer patients.
Saito H, Takaya S, Osaki T, Ikeguchi M
Gastric Cancer 2013 Oct;16(4):473-9. Epub 2012 Nov 22 doi: 10.1007/s10120-012-0210-1. PMID: 23179366
Soluble fas antigen and soluble fas ligand in intrauterine growth restriction.
Briana DD, Baka S, Boutsikou M, Liosi S, Vraila VM, Gourgiotis D, Hassiakos D, Malamitsi-Puchner A
Neonatology 2010;97(1):31-5. Epub 2009 Jul 7 doi: 10.1159/000227290. PMID: 19590243
Soluble Fas and Fas ligand provide new information on metastasis and response to chemotherapy in SCLC patients.
Shimizu M, Kondo M, Ito Y, Kume H, Suzuki R, Yamaki K
Cancer Detect Prev 2005;29(2):175-80. Epub 2004 Nov 14 doi: 10.1016/j.cdp.2004.09.001. PMID: 15829378
Soluble fas levels correlate with multiple organ dysfunction severity, survival and nitrate levels, but not with cellular apoptotic markers in critically ill patients.
Papathanassoglou ED, Moynihan JA, Vermillion DL, McDermott MP, Ackerman MH
Shock 2000 Aug;14(2):107-12. doi: 10.1097/00024382-200014020-00005. PMID: 10947151

Diagnosis

Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemia.
Baldini M, Maugeri N, Ramirez GA, Giacomassi C, Castiglioni A, Prieto-González S, Corbera-Bellalta M, Di Comite G, Papa I, Dell'antonio G, Ammirati E, Cuccovillo I, Vecchio V, Mantovani A, Rovere-Querini P, Sabbadini MG, Cid MC, Manfredi AA
Arthritis Rheum 2012 Mar;64(3):854-65. doi: 10.1002/art.33411. PMID: 21989653
Pulmonary lesions and serum levels of soluble Fas (sCD95) in former hard coal miners.
Hoffmeyer F, Henry J, Borowitzki G, Merget R, Bünger J, Brüning T, Raulf-Heimsoth M
Eur J Med Res 2010 Nov 4;15 Suppl 2(Suppl 2):60-3. doi: 10.1186/2047-783x-15-s2-60. PMID: 21147622Free PMC Article
Soluble fas antigen and soluble fas ligand in intrauterine growth restriction.
Briana DD, Baka S, Boutsikou M, Liosi S, Vraila VM, Gourgiotis D, Hassiakos D, Malamitsi-Puchner A
Neonatology 2010;97(1):31-5. Epub 2009 Jul 7 doi: 10.1159/000227290. PMID: 19590243

Therapy

Soluble Fas and Fas ligand provide new information on metastasis and response to chemotherapy in SCLC patients.
Shimizu M, Kondo M, Ito Y, Kume H, Suzuki R, Yamaki K
Cancer Detect Prev 2005;29(2):175-80. Epub 2004 Nov 14 doi: 10.1016/j.cdp.2004.09.001. PMID: 15829378

Prognosis

Increased apoptosis and elevated Fas expression in circulating natural killer cells in gastric cancer patients.
Saito H, Takaya S, Osaki T, Ikeguchi M
Gastric Cancer 2013 Oct;16(4):473-9. Epub 2012 Nov 22 doi: 10.1007/s10120-012-0210-1. PMID: 23179366
Soluble Fas and Fas ligand provide new information on metastasis and response to chemotherapy in SCLC patients.
Shimizu M, Kondo M, Ito Y, Kume H, Suzuki R, Yamaki K
Cancer Detect Prev 2005;29(2):175-80. Epub 2004 Nov 14 doi: 10.1016/j.cdp.2004.09.001. PMID: 15829378
Soluble fas levels correlate with multiple organ dysfunction severity, survival and nitrate levels, but not with cellular apoptotic markers in critically ill patients.
Papathanassoglou ED, Moynihan JA, Vermillion DL, McDermott MP, Ackerman MH
Shock 2000 Aug;14(2):107-12. doi: 10.1097/00024382-200014020-00005. PMID: 10947151

Clinical prediction guides

Pulmonary lesions and serum levels of soluble Fas (sCD95) in former hard coal miners.
Hoffmeyer F, Henry J, Borowitzki G, Merget R, Bünger J, Brüning T, Raulf-Heimsoth M
Eur J Med Res 2010 Nov 4;15 Suppl 2(Suppl 2):60-3. doi: 10.1186/2047-783x-15-s2-60. PMID: 21147622Free PMC Article
Soluble fas antigen and soluble fas ligand in intrauterine growth restriction.
Briana DD, Baka S, Boutsikou M, Liosi S, Vraila VM, Gourgiotis D, Hassiakos D, Malamitsi-Puchner A
Neonatology 2010;97(1):31-5. Epub 2009 Jul 7 doi: 10.1159/000227290. PMID: 19590243

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