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Elevated urinary deoxyuridine level

MedGen UID:
1053619
•Concept ID:
CN376626
•
Finding
Synonym: Deoxyuridine high in urine
 
HPO: HP:6000116

Definition

The amount of deoxyuridine in the urine, normalized for urine concentration, is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urinary deoxyuridine level

Recent clinical studies

Etiology

Effect of miR-133 on apoptosis of trophoblasts in human placenta tissues via Rho/ROCK signaling pathway.
Zhang WM, Cao P, Xin L, Zhang Y, Liu Z, Yao N, Ma YY
Eur Rev Med Pharmacol Sci 2019 Dec;23(24):10600-10608. doi: 10.26355/eurrev_201912_19755. PMID: 31858525
Simulated physiological stretch-induced proliferation of human bladder smooth muscle cells is regulated by MMPs.
Bu S, Zhu Y, Peng C, Cai X, Cao C, Tan H, Cheng J, Zhang J, Liu J, Li H, Wang K
Arch Biochem Biophys 2014 Dec 15;564:197-202. Epub 2014 Sep 28 doi: 10.1016/j.abb.2014.09.012. PMID: 25263962

Therapy

Chicken ovalbumin upstream promoter-transcription factor II protects against cisplatin-induced acute kidney injury.
Ishii S, Yamada M, Koibuchi N
Endocr J 2020 Mar 28;67(3):283-293. Epub 2019 Dec 3 doi: 10.1507/endocrj.EJ19-0459. PMID: 31801919
Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3, 4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion.
Rafi I, Taylor GA, Calvete JA, Boddy AV, Balmanno K, Bailey N, Lind M, Calvert AH, Webber S, Jackson RC
Clin Cancer Res 1995 Nov;1(11):1275-84. PMID: 9815922

Prognosis

Prognostic significance of thymidylate synthase activity in bladder carcinoma.
Mizutani Y, Wada H, Ogawa O, Yoshida O, Fukushima M, Nonomura N, Miki T
Cancer 2001 Aug 1;92(3):510-8. doi: 10.1002/1097-0142(20010801)92:3<510::aid-cncr1349>3.0.co;2-0. PMID: 11505394
Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3, 4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion.
Rafi I, Taylor GA, Calvete JA, Boddy AV, Balmanno K, Bailey N, Lind M, Calvert AH, Webber S, Jackson RC
Clin Cancer Res 1995 Nov;1(11):1275-84. PMID: 9815922

Clinical prediction guides

Chicken ovalbumin upstream promoter-transcription factor II protects against cisplatin-induced acute kidney injury.
Ishii S, Yamada M, Koibuchi N
Endocr J 2020 Mar 28;67(3):283-293. Epub 2019 Dec 3 doi: 10.1507/endocrj.EJ19-0459. PMID: 31801919
Effect of miR-133 on apoptosis of trophoblasts in human placenta tissues via Rho/ROCK signaling pathway.
Zhang WM, Cao P, Xin L, Zhang Y, Liu Z, Yao N, Ma YY
Eur Rev Med Pharmacol Sci 2019 Dec;23(24):10600-10608. doi: 10.26355/eurrev_201912_19755. PMID: 31858525
Multifaceted Mechanisms of Cisplatin Resistance in Long-Term Treated Urothelial Carcinoma Cell Lines.
Skowron MA, Melnikova M, van Roermund JGH, Romano A, Albers P, Thomale J, Schulz WA, Niegisch G, Hoffmann MJ
Int J Mol Sci 2018 Feb 16;19(2) doi: 10.3390/ijms19020590. PMID: 29462944Free PMC Article
Prognostic significance of thymidylate synthase activity in bladder carcinoma.
Mizutani Y, Wada H, Ogawa O, Yoshida O, Fukushima M, Nonomura N, Miki T
Cancer 2001 Aug 1;92(3):510-8. doi: 10.1002/1097-0142(20010801)92:3<510::aid-cncr1349>3.0.co;2-0. PMID: 11505394
Clinical pharmacokinetic and pharmacodynamic studies with the nonclassical antifolate thymidylate synthase inhibitor 3, 4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by 24-hour continuous intravenous infusion.
Rafi I, Taylor GA, Calvete JA, Boddy AV, Balmanno K, Bailey N, Lind M, Calvert AH, Webber S, Jackson RC
Clin Cancer Res 1995 Nov;1(11):1275-84. PMID: 9815922

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