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Left atrial fibrosis

MedGen UID:
1053630
•Concept ID:
CN377520
•
Finding
HPO: HP:6000691

Definition

Atrial fibrosis is an hallmark of atrial structural remodelling, characterized by the aberrant activation, proliferation and differentiation of fibroblasts, and subsequent excessive synthesis and irregular deposition of extracellular matrix proteins. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeft atrial fibrosis

Professional guidelines

PubMed

Clinical utility of cardiac magnetic resonance imaging to assess the left atrium before catheter ablation for atrial fibrillation - A systematic review and meta-analysis.
Ghafouri K, Franke KB, Foo FS, Stiles MK
Int J Cardiol 2021 Sep 15;339:192-202. Epub 2021 Jul 23 doi: 10.1016/j.ijcard.2021.07.030. PMID: 34303756
Left atrial fibrosis in atrial fibrillation: Mechanisms, clinical evaluation and management.
Ma J, Chen Q, Ma S
J Cell Mol Med 2021 Mar;25(6):2764-2775. Epub 2021 Feb 11 doi: 10.1111/jcmm.16350. PMID: 33576189Free PMC Article

Recent clinical studies

Etiology

Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The DECAAF II Randomized Clinical Trial.
Marrouche NF, Wazni O, McGann C, Greene T, Dean JM, Dagher L, Kholmovski E, Mansour M, Marchlinski F, Wilber D, Hindricks G, Mahnkopf C, Wells D, Jais P, Sanders P, Brachmann J, Bax JJ, Morrison-de Boer L, Deneke T, Calkins H, Sohns C, Akoum N; DECAAF II Investigators
JAMA 2022 Jun 21;327(23):2296-2305. doi: 10.1001/jama.2022.8831. PMID: 35727277Free PMC Article
Left atrial fibrosis progression detected by LGE-MRI after ablation of atrial fibrillation.
Kheirkhahan M, Baher A, Goldooz M, Kholmovski EG, Morris AK, Csecs I, Chelu MG, Wilson BD, Marrouche NF
Pacing Clin Electrophysiol 2020 Apr;43(4):402-411. doi: 10.1111/pace.13866. PMID: 31867751
Therapeutic Approaches to Atrial Fibrillation Ablation Targeting Atrial Fibrosis.
Kottkamp H, Schreiber D, Moser F, Rieger A
JACC Clin Electrophysiol 2017 Jul;3(7):643-653. Epub 2017 Jul 17 doi: 10.1016/j.jacep.2017.05.009. PMID: 29759532
Left atrium and the imaging of atrial fibrosis: catch it if you can!
Tan TC, Koutsogeorgis ID, Grapsa J, Papadopoulos C, Katsivas A, Nihoyannopoulos P
Eur J Clin Invest 2014 Sep;44(9):872-81. doi: 10.1111/eci.12305. PMID: 25066356
Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study.
Marrouche NF, Wilber D, Hindricks G, Jais P, Akoum N, Marchlinski F, Kholmovski E, Burgon N, Hu N, Mont L, Deneke T, Duytschaever M, Neumann T, Mansour M, Mahnkopf C, Herweg B, Daoud E, Wissner E, Bansmann P, Brachmann J
JAMA 2014 Feb 5;311(5):498-506. doi: 10.1001/jama.2014.3. PMID: 24496537

Diagnosis

Predictors of left atrial fibrosis in patients with atrial fibrillation referred for catheter ablation.
Rossi VA, Krizanovic-Grgic I, Steffel J, Hofer D, Wolber T, Brunckhorst CB, Ruschitzka F, Duru F, Breitenstein A, Saguner AM
Cardiol J 2022;29(3):413-422. Epub 2022 Mar 14 doi: 10.5603/CJ.a2022.0012. PMID: 35285513Free PMC Article
Left atrial fibrosis in atrial fibrillation: Mechanisms, clinical evaluation and management.
Ma J, Chen Q, Ma S
J Cell Mol Med 2021 Mar;25(6):2764-2775. Epub 2021 Feb 11 doi: 10.1111/jcmm.16350. PMID: 33576189Free PMC Article
Left Atrial Structure and Function, and Left Ventricular Diastolic Dysfunction: JACC State-of-the-Art Review.
Thomas L, Marwick TH, Popescu BA, Donal E, Badano LP
J Am Coll Cardiol 2019 Apr 23;73(15):1961-1977. doi: 10.1016/j.jacc.2019.01.059. PMID: 31000000
Left atrium and the imaging of atrial fibrosis: catch it if you can!
Tan TC, Koutsogeorgis ID, Grapsa J, Papadopoulos C, Katsivas A, Nihoyannopoulos P
Eur J Clin Invest 2014 Sep;44(9):872-81. doi: 10.1111/eci.12305. PMID: 25066356
Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study.
Marrouche NF, Wilber D, Hindricks G, Jais P, Akoum N, Marchlinski F, Kholmovski E, Burgon N, Hu N, Mont L, Deneke T, Duytschaever M, Neumann T, Mansour M, Mahnkopf C, Herweg B, Daoud E, Wissner E, Bansmann P, Brachmann J
JAMA 2014 Feb 5;311(5):498-506. doi: 10.1001/jama.2014.3. PMID: 24496537

Therapy

Effect of MRI-Guided Fibrosis Ablation vs Conventional Catheter Ablation on Atrial Arrhythmia Recurrence in Patients With Persistent Atrial Fibrillation: The DECAAF II Randomized Clinical Trial.
Marrouche NF, Wazni O, McGann C, Greene T, Dean JM, Dagher L, Kholmovski E, Mansour M, Marchlinski F, Wilber D, Hindricks G, Mahnkopf C, Wells D, Jais P, Sanders P, Brachmann J, Bax JJ, Morrison-de Boer L, Deneke T, Calkins H, Sohns C, Akoum N; DECAAF II Investigators
JAMA 2022 Jun 21;327(23):2296-2305. doi: 10.1001/jama.2022.8831. PMID: 35727277Free PMC Article
Predictors of left atrial fibrosis in patients with atrial fibrillation referred for catheter ablation.
Rossi VA, Krizanovic-Grgic I, Steffel J, Hofer D, Wolber T, Brunckhorst CB, Ruschitzka F, Duru F, Breitenstein A, Saguner AM
Cardiol J 2022;29(3):413-422. Epub 2022 Mar 14 doi: 10.5603/CJ.a2022.0012. PMID: 35285513Free PMC Article
Assessment of Left Atrial Fibrosis by Late Gadolinium Enhancement Magnetic Resonance Imaging: Methodology and Clinical Implications.
Siebermair J, Kholmovski EG, Marrouche N
JACC Clin Electrophysiol 2017 Aug;3(8):791-802. Epub 2017 Aug 21 doi: 10.1016/j.jacep.2017.07.004. PMID: 29759774
Non-invasive imaging in atrial fibrillation: focus on prognosis and catheter ablation.
Bax JJ, Marsan NA, Delgado V
Heart 2015 Jan;101(2):94-100. Epub 2014 Nov 20 doi: 10.1136/heartjnl-2013-305150. PMID: 25412729
Hypertension and atrial fibrillation: epidemiology, pathophysiology and therapeutic implications.
Lau YF, Yiu KH, Siu CW, Tse HF
J Hum Hypertens 2012 Oct;26(10):563-9. Epub 2011 Dec 1 doi: 10.1038/jhh.2011.105. PMID: 22129612

Prognosis

How to do left atrial late gadolinium enhancement: a review.
Craft J, Li Y, Bhatti S, Cao JJ
Radiol Med 2021 Sep;126(9):1159-1169. Epub 2021 Jun 16 doi: 10.1007/s11547-021-01383-3. PMID: 34132927
Left atrial fibrosis in atrial fibrillation: Mechanisms, clinical evaluation and management.
Ma J, Chen Q, Ma S
J Cell Mol Med 2021 Mar;25(6):2764-2775. Epub 2021 Feb 11 doi: 10.1111/jcmm.16350. PMID: 33576189Free PMC Article
Cardiac MRI and Fibrosis Quantification.
Kholmovski EG, Morris AK, Chelu MG
Card Electrophysiol Clin 2019 Sep;11(3):537-549. doi: 10.1016/j.ccep.2019.04.005. PMID: 31400877
Left Atrial Structure and Function, and Left Ventricular Diastolic Dysfunction: JACC State-of-the-Art Review.
Thomas L, Marwick TH, Popescu BA, Donal E, Badano LP
J Am Coll Cardiol 2019 Apr 23;73(15):1961-1977. doi: 10.1016/j.jacc.2019.01.059. PMID: 31000000
Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study.
Marrouche NF, Wilber D, Hindricks G, Jais P, Akoum N, Marchlinski F, Kholmovski E, Burgon N, Hu N, Mont L, Deneke T, Duytschaever M, Neumann T, Mansour M, Mahnkopf C, Herweg B, Daoud E, Wissner E, Bansmann P, Brachmann J
JAMA 2014 Feb 5;311(5):498-506. doi: 10.1001/jama.2014.3. PMID: 24496537

Clinical prediction guides

How to do left atrial late gadolinium enhancement: a review.
Craft J, Li Y, Bhatti S, Cao JJ
Radiol Med 2021 Sep;126(9):1159-1169. Epub 2021 Jun 16 doi: 10.1007/s11547-021-01383-3. PMID: 34132927
Left atrial fibrosis in atrial fibrillation: Mechanisms, clinical evaluation and management.
Ma J, Chen Q, Ma S
J Cell Mol Med 2021 Mar;25(6):2764-2775. Epub 2021 Feb 11 doi: 10.1111/jcmm.16350. PMID: 33576189Free PMC Article
Cardiac MRI and Fibrosis Quantification.
Kholmovski EG, Morris AK, Chelu MG
Card Electrophysiol Clin 2019 Sep;11(3):537-549. doi: 10.1016/j.ccep.2019.04.005. PMID: 31400877
Therapeutic Approaches to Atrial Fibrillation Ablation Targeting Atrial Fibrosis.
Kottkamp H, Schreiber D, Moser F, Rieger A
JACC Clin Electrophysiol 2017 Jul;3(7):643-653. Epub 2017 Jul 17 doi: 10.1016/j.jacep.2017.05.009. PMID: 29759532
Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: the DECAAF study.
Marrouche NF, Wilber D, Hindricks G, Jais P, Akoum N, Marchlinski F, Kholmovski E, Burgon N, Hu N, Mont L, Deneke T, Duytschaever M, Neumann T, Mansour M, Mahnkopf C, Herweg B, Daoud E, Wissner E, Bansmann P, Brachmann J
JAMA 2014 Feb 5;311(5):498-506. doi: 10.1001/jama.2014.3. PMID: 24496537

Recent systematic reviews

Clinical utility of cardiac magnetic resonance imaging to assess the left atrium before catheter ablation for atrial fibrillation - A systematic review and meta-analysis.
Ghafouri K, Franke KB, Foo FS, Stiles MK
Int J Cardiol 2021 Sep 15;339:192-202. Epub 2021 Jul 23 doi: 10.1016/j.ijcard.2021.07.030. PMID: 34303756

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