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Reduced tissue gamma-glutamyltransferase activity

MedGen UID:
1053651
•Concept ID:
CN377410
•
Finding
HPO: HP:6000578

Definition

Activity of gamma-glutamyltransferase in the tissues below the lower limit of normal. The activity can be measured in multiple tissues including leukocytes and cultured fibroblasts. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced tissue gamma-glutamyltransferase activity

Conditions with this feature

gamma-Glutamyltransferase deficiency
MedGen UID:
82813
•Concept ID:
C0268524
•
Disease or Syndrome
Level of glutathione in the urine above the upper limit of normal.
See: Condition Record
gamma-Glutamyltransferase deficiency

Professional guidelines

PubMed

AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review.
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
Beneficial effects of treatment with transglutaminase inhibitor cystamine on the severity of inflammation in a rat model of inflammatory bowel disease.
Elli L, Ciulla MM, Busca G, Roncoroni L, Maioli C, Ferrero S, Bardella MT, Bonura A, Paliotti R, Terrani C, Braidotti P
Lab Invest 2011 Mar;91(3):452-61. Epub 2010 Nov 1 doi: 10.1038/labinvest.2010.186. PMID: 21042292
Microvillar peptidase activity in amniotic fluid: possible use in the prenatal diagnosis of cystic fibrosis.
Carbarns NJ, Gosden C, Brock DJ
Lancet 1983 Feb 12;1(8320):329-31. doi: 10.1016/s0140-6736(83)91630-6. PMID: 6130334

Recent clinical studies

Etiology

Cystamine reduces vascular stiffness in Western diet-fed female mice.
Ramirez-Perez FI, Cabral-Amador FJ, Whaley-Connell AT, Aroor AR, Morales-Quinones M, Woodford ML, Ghiarone T, Ferreira-Santos L, Jurrissen TJ, Manrique-Acevedo CM, Jia G, DeMarco VG, Padilla J, Martinez-Lemus LA, Lastra G
Am J Physiol Heart Circ Physiol 2022 Feb 1;322(2):H167-H180. Epub 2021 Dec 10 doi: 10.1152/ajpheart.00431.2021. PMID: 34890280Free PMC Article
The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content.
Gepner Y, Shelef I, Komy O, Cohen N, Schwarzfuchs D, Bril N, Rein M, Serfaty D, Kenigsbuch S, Zelicha H, Yaskolka Meir A, Tene L, Bilitzky A, Tsaban G, Chassidim Y, Sarusy B, Ceglarek U, Thiery J, Stumvoll M, Blüher M, Stampfer MJ, Rudich A, Shai I
J Hepatol 2019 Aug;71(2):379-388. Epub 2019 May 8 doi: 10.1016/j.jhep.2019.04.013. PMID: 31075323
Characterization of Transglutaminase 2 activity inhibitors in monocytes in vitro and their effect in a mouse model for multiple sclerosis.
Chrobok NL, Bol JGJM, Jongenelen CA, Brevé JJP, El Alaoui S, Wilhelmus MMM, Drukarch B, van Dam AM
PLoS One 2018;13(4):e0196433. Epub 2018 Apr 24 doi: 10.1371/journal.pone.0196433. PMID: 29689097Free PMC Article
USING OF CELL LINE HepG2 FOR ASSESSMENT OF TOXIC AND METABOLIC EFECTS OF ANTIPSYCHOTIC DRUGS.
Snopov SA, Teryukova NP, Sakhenberg EI, Tepliashina VV, Nasyrova RF
Tsitologiia 2017;59(3):210-9. PMID: 30183185
Comparison of tissue transglutaminase 2 and bone biological markers osteocalcin, osteopontin and sclerostin expression in human osteoporosis and osteoarthritis.
Tarquini C, Mattera R, Mastrangeli F, Agostinelli S, Ferlosio A, Bei R, Orlandi A, Tarantino U
Amino Acids 2017 Mar;49(3):683-693. Epub 2016 Jun 29 doi: 10.1007/s00726-016-2290-4. PMID: 27357308

Diagnosis

Saroglitazar, a PPAR-α/γ Agonist, for Treatment of NAFLD: A Randomized Controlled Double-Blind Phase 2 Trial.
Gawrieh S, Noureddin M, Loo N, Mohseni R, Awasty V, Cusi K, Kowdley KV, Lai M, Schiff E, Parmar D, Patel P, Chalasani N
Hepatology 2021 Oct;74(4):1809-1824. Epub 2021 Jul 19 doi: 10.1002/hep.31843. PMID: 33811367
AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review.
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells.
Huang KC, Yang J, Ng MC, Ng SK, Welch WR, Muto MG, Berkowitz RS, Ng SW
Eur J Cancer 2016 Nov;67:152-163. Epub 2016 Sep 24 doi: 10.1016/j.ejca.2016.08.007. PMID: 27669502Free PMC Article
Relationship between resazurin reduction test, reactive oxygen species generation, and gamma-glutamyltransferase.
Zalata A, Hafez T, Mahmoud A, Comhaire F
Hum Reprod 1995 May;10(5):1136-40. doi: 10.1093/oxfordjournals.humrep.a136106. PMID: 7657753
Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies.
Bowen DM, Smith CB, White P, Davison AN
Brain 1976 Sep;99(3):459-96. doi: 10.1093/brain/99.3.459. PMID: 11871

Therapy

Cystamine reduces vascular stiffness in Western diet-fed female mice.
Ramirez-Perez FI, Cabral-Amador FJ, Whaley-Connell AT, Aroor AR, Morales-Quinones M, Woodford ML, Ghiarone T, Ferreira-Santos L, Jurrissen TJ, Manrique-Acevedo CM, Jia G, DeMarco VG, Padilla J, Martinez-Lemus LA, Lastra G
Am J Physiol Heart Circ Physiol 2022 Feb 1;322(2):H167-H180. Epub 2021 Dec 10 doi: 10.1152/ajpheart.00431.2021. PMID: 34890280Free PMC Article
Saroglitazar, a PPAR-α/γ Agonist, for Treatment of NAFLD: A Randomized Controlled Double-Blind Phase 2 Trial.
Gawrieh S, Noureddin M, Loo N, Mohseni R, Awasty V, Cusi K, Kowdley KV, Lai M, Schiff E, Parmar D, Patel P, Chalasani N
Hepatology 2021 Oct;74(4):1809-1824. Epub 2021 Jul 19 doi: 10.1002/hep.31843. PMID: 33811367
The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content.
Gepner Y, Shelef I, Komy O, Cohen N, Schwarzfuchs D, Bril N, Rein M, Serfaty D, Kenigsbuch S, Zelicha H, Yaskolka Meir A, Tene L, Bilitzky A, Tsaban G, Chassidim Y, Sarusy B, Ceglarek U, Thiery J, Stumvoll M, Blüher M, Stampfer MJ, Rudich A, Shai I
J Hepatol 2019 Aug;71(2):379-388. Epub 2019 May 8 doi: 10.1016/j.jhep.2019.04.013. PMID: 31075323
Chinese children with chronic intrahepatic cholestasis and high γ-glutamyl transpeptidase: clinical features and association with ABCB4 mutations.
Fang LJ, Wang XH, Knisely AS, Yu H, Lu Y, Liu LY, Wang JS
J Pediatr Gastroenterol Nutr 2012 Aug;55(2):150-6. doi: 10.1097/MPG.0b013e31824ef36f. PMID: 22343912
Effects of thyroxine excess on peripheral organs.
Bartalena L, Pinchera A
Acta Med Austriaca 1994;21(2):60-5. PMID: 7998484

Prognosis

The beneficial effects of Mediterranean diet over low-fat diet may be mediated by decreasing hepatic fat content.
Gepner Y, Shelef I, Komy O, Cohen N, Schwarzfuchs D, Bril N, Rein M, Serfaty D, Kenigsbuch S, Zelicha H, Yaskolka Meir A, Tene L, Bilitzky A, Tsaban G, Chassidim Y, Sarusy B, Ceglarek U, Thiery J, Stumvoll M, Blüher M, Stampfer MJ, Rudich A, Shai I
J Hepatol 2019 Aug;71(2):379-388. Epub 2019 May 8 doi: 10.1016/j.jhep.2019.04.013. PMID: 31075323
AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review.
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
Novel peptide GX1 inhibits angiogenesis by specifically binding to transglutaminase-2 in the tumorous endothelial cells of gastric cancer.
Lei Z, Chai N, Tian M, Zhang Y, Wang G, Liu J, Tian Z, Yi X, Chen D, Li X, Yu P, Hu H, Xu B, Jian C, Bian Z, Guo H, Wang J, Peng S, Nie Y, Huang N, Hu S, Wu K
Cell Death Dis 2018 May 21;9(6):579. doi: 10.1038/s41419-018-0594-x. PMID: 29785022Free PMC Article
Monocyte-derived tissue transglutaminase in multiple sclerosis patients: reflecting an anti-inflammatory status and function of the cells?
Sestito C, Brevé JJP, van Eggermond MCJA, Killestein J, Teunissen CE, van Rossum J, Wilhelmus MMM, Drukarch B, van den Elsen PJ, van Dam AM
J Neuroinflammation 2017 Dec 21;14(1):257. doi: 10.1186/s12974-017-1035-y. PMID: 29268771Free PMC Article
Relationship between resazurin reduction test, reactive oxygen species generation, and gamma-glutamyltransferase.
Zalata A, Hafez T, Mahmoud A, Comhaire F
Hum Reprod 1995 May;10(5):1136-40. doi: 10.1093/oxfordjournals.humrep.a136106. PMID: 7657753

Clinical prediction guides

Saroglitazar, a PPAR-α/γ Agonist, for Treatment of NAFLD: A Randomized Controlled Double-Blind Phase 2 Trial.
Gawrieh S, Noureddin M, Loo N, Mohseni R, Awasty V, Cusi K, Kowdley KV, Lai M, Schiff E, Parmar D, Patel P, Chalasani N
Hepatology 2021 Oct;74(4):1809-1824. Epub 2021 Jul 19 doi: 10.1002/hep.31843. PMID: 33811367
AGA Clinical Practice Update on Diagnosis and Monitoring of Celiac Disease-Changing Utility of Serology and Histologic Measures: Expert Review.
Husby S, Murray JA, Katzka DA
Gastroenterology 2019 Mar;156(4):885-889. Epub 2018 Dec 19 doi: 10.1053/j.gastro.2018.12.010. PMID: 30578783Free PMC Article
Tissue Transglutaminase contributes to experimental multiple sclerosis pathogenesis and clinical outcome by promoting macrophage migration.
van Strien ME, de Vries HE, Chrobok NL, Bol JGJM, Breve JJP, van der Pol SMP, Kooij G, van Buul JD, Karpuj M, Steinman L, Wilhelmus MM, Sestito C, Drukarch B, Van Dam AM
Brain Behav Immun 2015 Nov;50:141-154. Epub 2015 Jun 29 doi: 10.1016/j.bbi.2015.06.023. PMID: 26133787
Activation of extracellular transglutaminase 2 by mechanical force in the arterial wall.
Huelsz-Prince G, Belkin AM, VanBavel E, Bakker EN
J Vasc Res 2013;50(5):383-95. Epub 2013 Aug 24 doi: 10.1159/000354222. PMID: 23988702
Influence of platelet γ-glutamyltransferase on oxidative stress and apoptosis in the presence of holo-transferrin.
Sener A, Cevik O, Yanikkaya-Demirel G, Apikoglu-Rabus S, Ozsavci D
Folia Biol (Praha) 2012;58(5):193-202. PMID: 23249638

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