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Gottron sign

MedGen UID:
1053906
•Concept ID:
CN376451
•
Finding
HPO: HP:0430033

Definition

Erythematous macules or patches over extensor surfaces of elbows, knuckles, knees, and ankles. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGottron sign

Professional guidelines

PubMed

Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
The diagnosis and classification of amyopathic dermatomyositis: a historical review and assessment of existing criteria.
Concha JSS, Tarazi M, Kushner CJ, Gaffney RG, Werth VP
Br J Dermatol 2019 May;180(5):1001-1008. Epub 2019 Feb 25 doi: 10.1111/bjd.17536. PMID: 30561064Free PMC Article
Applicability of EULAR/ACR classification criteria for dermatomyositis to amyopathic disease.
Patel B, Khan N, Werth VP
J Am Acad Dermatol 2018 Jul;79(1):77-83.e1. Epub 2017 Dec 29 doi: 10.1016/j.jaad.2017.12.055. PMID: 29291954

Recent clinical studies

Etiology

Clinical features of dermatomyositis patients with anti-TIF1 antibodies: A case based comprehensive review.
Kilinc OC, Ugurlu S
Autoimmun Rev 2023 Dec;22(12):103464. Epub 2023 Oct 19 doi: 10.1016/j.autrev.2023.103464. PMID: 37863375
Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash.
Ichimura Y, Konishi R, Shobo M, Inoue S, Okune M, Maeda A, Tanaka R, Kubota N, Matsumoto I, Ishii A, Tamaoka A, Shimbo A, Mori M, Morio T, Kishi T, Miyamae T, Tanboon J, Inoue M, Nishino I, Fujimoto M, Nomura T, Okiyama N
Rheumatology (Oxford) 2022 Mar 2;61(3):1222-1227. doi: 10.1093/rheumatology/keab518. PMID: 34152410
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Gottron Papules and Gottron Sign with Ulceration: A Distinctive Cutaneous Feature in a Subset of Patients with Classic Dermatomyositis and Clinically Amyopathic Dermatomyositis.
Cao H, Xia Q, Pan M, Zhao X, Li X, Shi R, Zhou M, Ding X, Kuwana M, Zheng J
J Rheumatol 2016 Sep;43(9):1735-42. Epub 2016 Jun 15 doi: 10.3899/jrheum.160024. PMID: 27307530
Scleroderma overlap syndromes.
Jablonska S, Blaszczyk M
Adv Exp Med Biol 1999;455:85-92. doi: 10.1007/978-1-4615-4857-7_12. PMID: 10599327

Diagnosis

Characteristics of dermatomyositis patients with and without associated malignancy.
Lauinger J, Ghoreschi K, Volc S
J Dtsch Dermatol Ges 2021 Nov;19(11):1601-1611. Epub 2021 Nov 5 doi: 10.1111/ddg.14566. PMID: 34738719
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
The diagnosis and classification of amyopathic dermatomyositis: a historical review and assessment of existing criteria.
Concha JSS, Tarazi M, Kushner CJ, Gaffney RG, Werth VP
Br J Dermatol 2019 May;180(5):1001-1008. Epub 2019 Feb 25 doi: 10.1111/bjd.17536. PMID: 30561064Free PMC Article
Inverse Gottron papules in juvenile dermatomyositis: an under recognized clinical entity.
Jindal AK, Guleria S, Pilania RK, Bishnoi A, Vinay K, Dogra S, Suri D, Rawat A, Singh S
Rheumatol Int 2018 Jun;38(6):1153-1160. Epub 2018 May 2 doi: 10.1007/s00296-018-4038-9. PMID: 29721695
Palmar Gottron papules and Gottron sign.
Vinay K, Dogra S
J Clin Rheumatol 2015 Apr;21(3):164. doi: 10.1097/RHU.0000000000000239. PMID: 25807098

Therapy

Machine learning for screening and predicting the risk of anti-MDA5 antibody in juvenile dermatomyositis children.
Xue Y, Zhang J, Li C, Liu X, Kuang W, Deng J, Wang J, Tan X, Li S, Li C
Front Immunol 2022;13:940802. Epub 2023 Jan 10 doi: 10.3389/fimmu.2022.940802. PMID: 36703989Free PMC Article
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Cutaneous improvement in refractory adult and juvenile dermatomyositis after treatment with rituximab.
Aggarwal R, Loganathan P, Koontz D, Qi Z, Reed AM, Oddis CV
Rheumatology (Oxford) 2017 Feb;56(2):247-254. Epub 2016 Nov 11 doi: 10.1093/rheumatology/kew396. PMID: 27837048Free PMC Article
Palmar Gottron papules and Gottron sign.
Vinay K, Dogra S
J Clin Rheumatol 2015 Apr;21(3):164. doi: 10.1097/RHU.0000000000000239. PMID: 25807098

Prognosis

Clinical features of dermatomyositis patients with anti-TIF1 antibodies: A case based comprehensive review.
Kilinc OC, Ugurlu S
Autoimmun Rev 2023 Dec;22(12):103464. Epub 2023 Oct 19 doi: 10.1016/j.autrev.2023.103464. PMID: 37863375
Anti-Ro52 antibodies are associated with the prognosis of adult idiopathic inflammatory myopathy-associated interstitial lung disease.
Gui X, Shenyun S, Ding H, Wang R, Tong J, Yu M, Zhao T, Ma M, Ding J, Xin X, Qiu Y, Qiu X, Zhang Y, Cao M, Huang M, Cao M, Dai J, Cai H, Xiao Y
Rheumatology (Oxford) 2022 Nov 2;61(11):4570-4578. doi: 10.1093/rheumatology/keac090. PMID: 35148366
Inverse Gottron papules in juvenile dermatomyositis: an under recognized clinical entity.
Jindal AK, Guleria S, Pilania RK, Bishnoi A, Vinay K, Dogra S, Suri D, Rawat A, Singh S
Rheumatol Int 2018 Jun;38(6):1153-1160. Epub 2018 May 2 doi: 10.1007/s00296-018-4038-9. PMID: 29721695
Gottron Papules and Gottron Sign with Ulceration: A Distinctive Cutaneous Feature in a Subset of Patients with Classic Dermatomyositis and Clinically Amyopathic Dermatomyositis.
Cao H, Xia Q, Pan M, Zhao X, Li X, Shi R, Zhou M, Ding X, Kuwana M, Zheng J
J Rheumatol 2016 Sep;43(9):1735-42. Epub 2016 Jun 15 doi: 10.3899/jrheum.160024. PMID: 27307530
Scleroderma overlap syndromes.
Jablonska S, Blaszczyk M
Adv Exp Med Biol 1999;455:85-92. doi: 10.1007/978-1-4615-4857-7_12. PMID: 10599327

Clinical prediction guides

Machine learning for screening and predicting the risk of anti-MDA5 antibody in juvenile dermatomyositis children.
Xue Y, Zhang J, Li C, Liu X, Kuang W, Deng J, Wang J, Tan X, Li S, Li C
Front Immunol 2022;13:940802. Epub 2023 Jan 10 doi: 10.3389/fimmu.2022.940802. PMID: 36703989Free PMC Article
Anti-Ro52 antibodies are associated with the prognosis of adult idiopathic inflammatory myopathy-associated interstitial lung disease.
Gui X, Shenyun S, Ding H, Wang R, Tong J, Yu M, Zhao T, Ma M, Ding J, Xin X, Qiu Y, Qiu X, Zhang Y, Cao M, Huang M, Cao M, Dai J, Cai H, Xiao Y
Rheumatology (Oxford) 2022 Nov 2;61(11):4570-4578. doi: 10.1093/rheumatology/keac090. PMID: 35148366
Anti-nuclear matrix protein 2 antibody-positive inflammatory myopathies represent extensive myositis without dermatomyositis-specific rash.
Ichimura Y, Konishi R, Shobo M, Inoue S, Okune M, Maeda A, Tanaka R, Kubota N, Matsumoto I, Ishii A, Tamaoka A, Shimbo A, Mori M, Morio T, Kishi T, Miyamae T, Tanboon J, Inoue M, Nishino I, Fujimoto M, Nomura T, Okiyama N
Rheumatology (Oxford) 2022 Mar 2;61(3):1222-1227. doi: 10.1093/rheumatology/keab518. PMID: 34152410
Juvenile Dermatomyositis: Advances in Pathogenesis, Assessment, and Management.
Leung AKC, Lam JM, Alobaida S, Leong KF, Wong AHC
Curr Pediatr Rev 2021;17(4):273-287. doi: 10.2174/1573396317666210426105045. PMID: 33902423
Gottron Papules and Gottron Sign with Ulceration: A Distinctive Cutaneous Feature in a Subset of Patients with Classic Dermatomyositis and Clinically Amyopathic Dermatomyositis.
Cao H, Xia Q, Pan M, Zhao X, Li X, Shi R, Zhou M, Ding X, Kuwana M, Zheng J
J Rheumatol 2016 Sep;43(9):1735-42. Epub 2016 Jun 15 doi: 10.3899/jrheum.160024. PMID: 27307530

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