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Anti-prothrombin antibody positivity

MedGen UID:
1054228
•Concept ID:
CN377322
•
Finding
Synonym: Anti-FII antibody positivity
 
HPO: HP:6000491

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against prothrombin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-prothrombin antibody positivity

Professional guidelines

PubMed

Laboratory Testing for Non-criteria Antiphospholipid Antibodies: Anti-phosphatidylserine/Prothrombin Antibodies (aPS/PT).
Devreese KMJ
Methods Mol Biol 2023;2663:315-327. doi: 10.1007/978-1-0716-3175-1_20. PMID: 37204720
Extra-criteria antiphospholipid antibodies in patients with small vessel brain lesions and clinical manifestations associated with antiphospholipid syndrome.
Estévez MÁ, Lanio N, Molina Á, Jiménez-León MR, Picado MJ, Esteban E, Sánchez S, Pallarés L, Julià MR
J Stroke Cerebrovasc Dis 2023 May;32(5):107034. Epub 2023 Feb 25 doi: 10.1016/j.jstrokecerebrovasdis.2023.107034. PMID: 36842350
Thrombotic Risk of Non-Criteria Anti-Phospholipid Antibodies Measured by Line Immunoassay: Superiority of Anti-Phosphatidylserine and Anti-Phosphatidic Acid Antibodies.
Park HS, Gu JY, Jung HS, Kim HK
Clin Lab 2019 Mar 1;65(3) doi: 10.7754/Clin.Lab.2018.171207. PMID: 30868842

Recent clinical studies

Etiology

How to diagnose and manage antiphospholipid syndrome.
Hubben A, McCrae KR
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):606-613. doi: 10.1182/hematology.2023000493. PMID: 38066904Free PMC Article
Anti-phospholipids antibodies and immune complexes in COVID-19 patients: a putative role in disease course for anti-annexin-V antibodies.
Cristiano A, Fortunati V, Cherubini F, Bernardini S, Nuccetelli M
Clin Rheumatol 2021 Jul;40(7):2939-2945. Epub 2021 Jan 19 doi: 10.1007/s10067-021-05580-3. PMID: 33464429Free PMC Article
The challenges of lupus anticoagulants.
Chighizola CB, Raschi E, Banzato A, Borghi MO, Pengo V, Meroni PL
Expert Rev Hematol 2016;9(4):389-400. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1140034. PMID: 26789237
The diagnosis of the antiphospholipid syndrome.
Pengo V, Ruffatti A, Iliceto S
Pathophysiol Haemost Thromb 2006;35(1-2):175-80. doi: 10.1159/000093564. PMID: 16855367
Should we include anti-prothrombin antibodies in the screening for the antiphospholipid syndrome?
Galli M
J Autoimmun 2000 Sep;15(2):101-5. doi: 10.1006/jaut.2000.0413. PMID: 10968893

Diagnosis

How to diagnose and manage antiphospholipid syndrome.
Hubben A, McCrae KR
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):606-613. doi: 10.1182/hematology.2023000493. PMID: 38066904Free PMC Article
Differences in Antiphospholipid Antibody Profile between Patients with Obstetric and Thrombotic Antiphospholipid Syndrome.
Anunciación-Llunell A, Muñoz C, Roggenbuck D, Frasca S, Pardos-Gea J, Esteve-Valverde E, Alijotas-Reig J, Miró-Mur F
Int J Mol Sci 2022 Oct 24;23(21) doi: 10.3390/ijms232112819. PMID: 36361608Free PMC Article
Anti-phospholipids antibodies and immune complexes in COVID-19 patients: a putative role in disease course for anti-annexin-V antibodies.
Cristiano A, Fortunati V, Cherubini F, Bernardini S, Nuccetelli M
Clin Rheumatol 2021 Jul;40(7):2939-2945. Epub 2021 Jan 19 doi: 10.1007/s10067-021-05580-3. PMID: 33464429Free PMC Article
The diagnosis of the antiphospholipid syndrome.
Pengo V, Ruffatti A, Iliceto S
Pathophysiol Haemost Thromb 2006;35(1-2):175-80. doi: 10.1159/000093564. PMID: 16855367
Should we include anti-prothrombin antibodies in the screening for the antiphospholipid syndrome?
Galli M
J Autoimmun 2000 Sep;15(2):101-5. doi: 10.1006/jaut.2000.0413. PMID: 10968893

Therapy

How to diagnose and manage antiphospholipid syndrome.
Hubben A, McCrae KR
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):606-613. doi: 10.1182/hematology.2023000493. PMID: 38066904Free PMC Article
The effect of anti-tuberculosis treatment on levels of anti-phospholipid and anti-neutrophil cytoplasmatic antibodies in patients with active tuberculosis.
Elkayam O, Bendayan D, Segal R, Shapira Y, Gilburd B, Reuter S, Agmon-Levin N, Shoenfeld Y
Rheumatol Int 2013 Apr;33(4):949-53. Epub 2012 Aug 4 doi: 10.1007/s00296-012-2487-0. PMID: 23011089
Bleeding and thrombosis in a patient with secondary antiphospholipid syndrome.
Kaaroud H, Beji S, Guermazi S, Moussa FB, Hamida FB, Ezzine S, Abdallah TB, El Younsi F, Kheder A
Saudi J Kidney Dis Transpl 2008 Mar;19(2):227-31. PMID: 18310872
Prevalence of anti-cardiolipin, anti-beta2 glycoprotein I, and anti-prothrombin antibodies in young patients with epilepsy.
Cimaz R, Romeo A, Scarano A, Avcin T, Viri M, Veggiotti P, Gatti A, Lodi M, Catelli L, Panzeri P, Cecchini G, Meroni PL
Epilepsia 2002 Jan;43(1):52-9. doi: 10.1046/j.1528-1157.2002.00701.x. PMID: 11879387
Prevalence and significance of anticardiolipin, anti-beta2 glycoprotein I and anti-prothrombin antibodies in chronic hepatitis C.
Leroy V, Arvieux J, Jacob MC, Maynard-Muet M, Baud M, Zarski JP
Br J Haematol 1998 Jun;101(3):468-74. doi: 10.1046/j.1365-2141.1998.00722.x. PMID: 9633888

Prognosis

Anti-phospholipids antibodies and immune complexes in COVID-19 patients: a putative role in disease course for anti-annexin-V antibodies.
Cristiano A, Fortunati V, Cherubini F, Bernardini S, Nuccetelli M
Clin Rheumatol 2021 Jul;40(7):2939-2945. Epub 2021 Jan 19 doi: 10.1007/s10067-021-05580-3. PMID: 33464429Free PMC Article
Thrombotic Risk of Non-Criteria Anti-Phospholipid Antibodies Measured by Line Immunoassay: Superiority of Anti-Phosphatidylserine and Anti-Phosphatidic Acid Antibodies.
Park HS, Gu JY, Jung HS, Kim HK
Clin Lab 2019 Mar 1;65(3) doi: 10.7754/Clin.Lab.2018.171207. PMID: 30868842
The challenges of lupus anticoagulants.
Chighizola CB, Raschi E, Banzato A, Borghi MO, Pengo V, Meroni PL
Expert Rev Hematol 2016;9(4):389-400. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1140034. PMID: 26789237
Study of phosphatidylserine-dependent anti-prothrombin antibody in cerebral infarction.
Okuma H, Kitagawa Y, Ishikawa T, Takagi S
Intern Med 2009;48(16):1351-5. Epub 2009 Aug 17 doi: 10.2169/internalmedicine.48.2232. PMID: 19687578
Prevalence and significance of anticardiolipin, anti-beta2 glycoprotein I and anti-prothrombin antibodies in chronic hepatitis C.
Leroy V, Arvieux J, Jacob MC, Maynard-Muet M, Baud M, Zarski JP
Br J Haematol 1998 Jun;101(3):468-74. doi: 10.1046/j.1365-2141.1998.00722.x. PMID: 9633888

Clinical prediction guides

Longitudinal Analysis of Antiphospholipid Antibody Dynamics after Infection with SARS-CoV-2 or Vaccination with BNT162b2.
Ogrič M, Žigon P, Sodin-Semrl S, Zlatković-Švenda M, Zdravković M, Ovuka M, Švec T, Lakota K, Radšel P, Rotar Ž, Čučnik S
Int J Mol Sci 2022 Dec 22;24(1) doi: 10.3390/ijms24010211. PMID: 36613655Free PMC Article
Differences in Antiphospholipid Antibody Profile between Patients with Obstetric and Thrombotic Antiphospholipid Syndrome.
Anunciación-Llunell A, Muñoz C, Roggenbuck D, Frasca S, Pardos-Gea J, Esteve-Valverde E, Alijotas-Reig J, Miró-Mur F
Int J Mol Sci 2022 Oct 24;23(21) doi: 10.3390/ijms232112819. PMID: 36361608Free PMC Article
The challenges of lupus anticoagulants.
Chighizola CB, Raschi E, Banzato A, Borghi MO, Pengo V, Meroni PL
Expert Rev Hematol 2016;9(4):389-400. Epub 2016 Feb 3 doi: 10.1586/17474086.2016.1140034. PMID: 26789237
Bleeding in the antiphospholipid syndrome.
Forastiero R
Hematology 2012 Apr;17 Suppl 1:S153-5. doi: 10.1179/102453312X13336169156654. PMID: 22507807
Study of phosphatidylserine-dependent anti-prothrombin antibody in cerebral infarction.
Okuma H, Kitagawa Y, Ishikawa T, Takagi S
Intern Med 2009;48(16):1351-5. Epub 2009 Aug 17 doi: 10.2169/internalmedicine.48.2232. PMID: 19687578

Recent systematic reviews

Lupus anticoagulant-hypoprothrombinemia syndrome in children: Three case reports and systematic review of the literature.
Sun YH, Nie WJ, Tian DD, Ye Q
Lupus 2023 Sep;32(10):1211-1221. Epub 2023 Jul 22 doi: 10.1177/09612033231191153. PMID: 37480550
Risk of venous and arterial thrombosis according to type of antiphospholipid antibodies in adults without systemic lupus erythematosus: a systematic review and meta-analysis.
Reynaud Q, Lega JC, Mismetti P, Chapelle C, Wahl D, Cathébras P, Laporte S
Autoimmun Rev 2014 Jun;13(6):595-608. Epub 2014 Jan 11 doi: 10.1016/j.autrev.2013.11.004. PMID: 24418303

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