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Positive CSF nucleic acid pathogen test

MedGen UID:
1054534
Concept ID:
CN377083
Finding
HPO: HP:0430140

Definition

Positive (abnormal) result of a cerebrospinal fluid (CSF) test such as polymerase chain reaction that is targeted against a nucleic acid sequence specific for a pathogen. [from HPO]

Professional guidelines

PubMed

Wilen CB, Monaco CL, Hoppe-Bauer J, Jackups R Jr, Bucelli RC, Burnham CA
J Clin Microbiol 2015 Mar;53(3):887-95. Epub 2015 Jan 7 doi: 10.1128/JCM.03161-14. PMID: 25568435Free PMC Article

Recent clinical studies

Etiology

De Vito F, Musella A, Fresegna D, Rizzo FR, Gentile A, Stampanoni Bassi M, Gilio L, Buttari F, Procaccini C, Colamatteo A, Bullitta S, Guadalupi L, Caioli S, Vanni V, Balletta S, Sanna K, Bruno A, Dolcetti E, Furlan R, Finardi A, Licursi V, Drulovic J, Pekmezovic T, Fusco C, Bruzzaniti S, Hornstein E, Uccelli A, Salvetti M, Matarese G, Centonze D, Mandolesi G
Neuropathol Appl Neurobiol 2022 Feb;48(2):e12765. Epub 2021 Oct 6 doi: 10.1111/nan.12765. PMID: 34490928Free PMC Article
Chaturvedi S, Victor TR, Marathe A, Sidamonidze K, Crucillo KL, Chaturvedi V
PLoS Negl Trop Dis 2021 Sep;15(9):e0009765. Epub 2021 Sep 16 doi: 10.1371/journal.pntd.0009765. PMID: 34529679Free PMC Article
Gisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW
PLoS One 2021;16(5):e0250987. Epub 2021 May 13 doi: 10.1371/journal.pone.0250987. PMID: 33983973Free PMC Article
Li X, Du W, Wang Y, Liu Z, Li K, Chen H, Liu R, Ma L, Zhang L, Dong Y, Che N, Gao M
Am J Clin Pathol 2020 Jan 1;153(1):126-130. doi: 10.1093/ajcp/aqz135. PMID: 31585003
Han TH, Chung JY, You SJ, Youn JL, Shim GH
J Clin Virol 2013 Sep;58(1):194-9. Epub 2013 Jun 22 doi: 10.1016/j.jcv.2013.05.023. PMID: 23800693

Diagnosis

Zhu Y, Xu M, Ding C, Peng Z, Wang W, Sun B, Cheng J, Chen C, Chen W, Wei H, Hu Z
Front Public Health 2021;9:738412. Epub 2022 Jan 21 doi: 10.3389/fpubh.2021.738412. PMID: 35127608Free PMC Article
Chaturvedi S, Victor TR, Marathe A, Sidamonidze K, Crucillo KL, Chaturvedi V
PLoS Negl Trop Dis 2021 Sep;15(9):e0009765. Epub 2021 Sep 16 doi: 10.1371/journal.pntd.0009765. PMID: 34529679Free PMC Article
Li X, Du W, Wang Y, Liu Z, Li K, Chen H, Liu R, Ma L, Zhang L, Dong Y, Che N, Gao M
Am J Clin Pathol 2020 Jan 1;153(1):126-130. doi: 10.1093/ajcp/aqz135. PMID: 31585003
Miller S, Naccache SN, Samayoa E, Messacar K, Arevalo S, Federman S, Stryke D, Pham E, Fung B, Bolosky WJ, Ingebrigtsen D, Lorizio W, Paff SM, Leake JA, Pesano R, DeBiasi R, Dominguez S, Chiu CY
Genome Res 2019 May;29(5):831-842. Epub 2019 Apr 16 doi: 10.1101/gr.238170.118. PMID: 30992304Free PMC Article
Roos KL
Curr Opin Neurol 2004 Jun;17(3):343-6. doi: 10.1097/00019052-200406000-00016. PMID: 15167070

Therapy

Gisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW
PLoS One 2021;16(5):e0250987. Epub 2021 May 13 doi: 10.1371/journal.pone.0250987. PMID: 33983973Free PMC Article
Premeaux TA, D'Antoni ML, Abdel-Mohsen M, Pillai SK, Kallianpur KJ, Nakamoto BK, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Gisslén M, Price RW, Valcour V, Ndhlovu LC
J Neurovirol 2019 Apr;25(2):150-161. Epub 2018 Nov 26 doi: 10.1007/s13365-018-0696-3. PMID: 30478799Free PMC Article
Favaro M, Savini V, Favalli C, Fontana C
Mol Biotechnol 2013 Jan;53(1):74-9. doi: 10.1007/s12033-012-9534-7. PMID: 22450734
Nolte FS, Rogers BB, Tang YW, Oberste MS, Robinson CC, Kehl KS, Rand KA, Rotbart HA, Romero JR, Nyquist AC, Persing DH
J Clin Microbiol 2011 Feb;49(2):528-33. Epub 2010 Dec 15 doi: 10.1128/JCM.01570-10. PMID: 21159942Free PMC Article
Roos KL
Curr Opin Neurol 2004 Jun;17(3):343-6. doi: 10.1097/00019052-200406000-00016. PMID: 15167070

Prognosis

De Vito F, Musella A, Fresegna D, Rizzo FR, Gentile A, Stampanoni Bassi M, Gilio L, Buttari F, Procaccini C, Colamatteo A, Bullitta S, Guadalupi L, Caioli S, Vanni V, Balletta S, Sanna K, Bruno A, Dolcetti E, Furlan R, Finardi A, Licursi V, Drulovic J, Pekmezovic T, Fusco C, Bruzzaniti S, Hornstein E, Uccelli A, Salvetti M, Matarese G, Centonze D, Mandolesi G
Neuropathol Appl Neurobiol 2022 Feb;48(2):e12765. Epub 2021 Oct 6 doi: 10.1111/nan.12765. PMID: 34490928Free PMC Article
Gisslen M, Keating SM, Spudich S, Arechiga V, Stephenson S, Zetterberg H, Di Germanio C, Blennow K, Fuchs D, Hagberg L, Norris PJ, Peterson J, Shacklett BL, Yiannoutsos CT, Price RW
PLoS One 2021;16(5):e0250987. Epub 2021 May 13 doi: 10.1371/journal.pone.0250987. PMID: 33983973Free PMC Article
Leli C, Di Matteo L, Gotta F, Vay D, Calcagno L, Callegari T, Cassinari M, Cattana E, Ciriello MM, Copponi V, Sacchi MC, Zambon D, Guaschino R, Rocchetti A
Infez Med 2019 Jun 1;27(2):141-148. PMID: 31205036
Bhagchandani SP, Kubade S, Nikhare PP, Manke S, Chandak NH, Kabra D, Baheti NN, Agrawal VS, Sarda P, Mahajan P, Ganjre A, Purohit HJ, Singh L, Taori GM, Daginawala HF, Kashyap RS
Mol Diagn Ther 2016 Feb;20(1):45-54. doi: 10.1007/s40291-015-0174-z. PMID: 26645831
Chakrabarti P, Das BK, Kapil A
Indian J Med Res 2009 Feb;129(2):182-8. PMID: 19293446

Clinical prediction guides

De Vito F, Musella A, Fresegna D, Rizzo FR, Gentile A, Stampanoni Bassi M, Gilio L, Buttari F, Procaccini C, Colamatteo A, Bullitta S, Guadalupi L, Caioli S, Vanni V, Balletta S, Sanna K, Bruno A, Dolcetti E, Furlan R, Finardi A, Licursi V, Drulovic J, Pekmezovic T, Fusco C, Bruzzaniti S, Hornstein E, Uccelli A, Salvetti M, Matarese G, Centonze D, Mandolesi G
Neuropathol Appl Neurobiol 2022 Feb;48(2):e12765. Epub 2021 Oct 6 doi: 10.1111/nan.12765. PMID: 34490928Free PMC Article
Premeaux TA, D'Antoni ML, Abdel-Mohsen M, Pillai SK, Kallianpur KJ, Nakamoto BK, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Gisslén M, Price RW, Valcour V, Ndhlovu LC
J Neurovirol 2019 Apr;25(2):150-161. Epub 2018 Nov 26 doi: 10.1007/s13365-018-0696-3. PMID: 30478799Free PMC Article
Han TH, Chung JY, You SJ, Youn JL, Shim GH
J Clin Virol 2013 Sep;58(1):194-9. Epub 2013 Jun 22 doi: 10.1016/j.jcv.2013.05.023. PMID: 23800693
Chakrabarti P, Das BK, Kapil A
Indian J Med Res 2009 Feb;129(2):182-8. PMID: 19293446
Pillai SK, Pond SL, Liu Y, Good BM, Strain MC, Ellis RJ, Letendre S, Smith DM, Günthard HF, Grant I, Marcotte TD, McCutchan JA, Richman DD, Wong JK
Brain 2006 Jul;129(Pt 7):1872-83. Epub 2006 May 30 doi: 10.1093/brain/awl136. PMID: 16735456

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