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Elevated myocardial iron load

MedGen UID:
1054576
•Concept ID:
CN377493
•
Finding
Synonyms: Cardiac iron overload; MRI: heart iron content increased
 
HPO: HP:6000663

Definition

Increased amount of iron in myocardial tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated myocardial iron load

Recent clinical studies

Etiology

Spatial repolarization heterogeneity detected by magnetocardiography correlates with cardiac iron overload and adverse cardiac events in beta-thalassemia major.
Chen CA, Lu MY, Peng SF, Lin KH, Chang HH, Yang YL, Jou ST, Lin DT, Liu YB, Horng HE, Yang HC, Wang JK, Wu MH, Wu CC
PLoS One 2014;9(1):e86524. Epub 2014 Jan 27 doi: 10.1371/journal.pone.0086524. PMID: 24475137Free PMC Article
Practical implications of liver and heart iron load assessment by T2*-MRI in children and adults with transfusion-dependent anemias.
Deborah Chirnomas S, Geukes-Foppen M, Barry K, Braunstein J, Kalish LA, Neufeld EJ, Powell AJ
Am J Hematol 2008 Oct;83(10):781-3. doi: 10.1002/ajh.21221. PMID: 18661491Free PMC Article

Diagnosis

Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity.
Chung YJ, Luo A, Park KC, Loonat AA, Lakhal-Littleton S, Robbins PA, Swietach P
JCI Insight 2019 Apr 4;4(7) doi: 10.1172/jci.insight.125618. PMID: 30779710Free PMC Article
Hepatic and Cardiac Iron-load in Children on Long-term Chelation with Deferiprone for Thalassemia Major.
Totadri S, Bansal D, Trehan A, Khadwal A, Bhatia A, Sodhi KS, Bhatia P, Jain R, Das R, Khandelwal N
Indian Pediatr 2018 Jul 15;55(7):573-575. PMID: 30129538

Therapy

Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity.
Chung YJ, Luo A, Park KC, Loonat AA, Lakhal-Littleton S, Robbins PA, Swietach P
JCI Insight 2019 Apr 4;4(7) doi: 10.1172/jci.insight.125618. PMID: 30779710Free PMC Article
Hepatic and Cardiac Iron-load in Children on Long-term Chelation with Deferiprone for Thalassemia Major.
Totadri S, Bansal D, Trehan A, Khadwal A, Bhatia A, Sodhi KS, Bhatia P, Jain R, Das R, Khandelwal N
Indian Pediatr 2018 Jul 15;55(7):573-575. PMID: 30129538
Deferasirox reduces iron overload in a murine model of juvenile hemochromatosis.
Nick H, Allegrini PR, Fozard L, Junker U, Rojkjaer L, Salie R, Niederkofler V, O'Reilly T
Exp Biol Med (Maywood) 2009 May;234(5):492-503. Epub 2009 Feb 20 doi: 10.3181/0811-RM-337. PMID: 19234060

Prognosis

Deferasirox reduces iron overload in a murine model of juvenile hemochromatosis.
Nick H, Allegrini PR, Fozard L, Junker U, Rojkjaer L, Salie R, Niederkofler V, O'Reilly T
Exp Biol Med (Maywood) 2009 May;234(5):492-503. Epub 2009 Feb 20 doi: 10.3181/0811-RM-337. PMID: 19234060

Clinical prediction guides

Deferasirox reduces iron overload in a murine model of juvenile hemochromatosis.
Nick H, Allegrini PR, Fozard L, Junker U, Rojkjaer L, Salie R, Niederkofler V, O'Reilly T
Exp Biol Med (Maywood) 2009 May;234(5):492-503. Epub 2009 Feb 20 doi: 10.3181/0811-RM-337. PMID: 19234060

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