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Glomerular immune-complex deposition

MedGen UID:
1054588
•Concept ID:
CN377498
•
Finding
HPO: HP:6000668

Definition

Accumulation of immune deposits, containing immunoglobulins, complement, and other proteins, at various intraglomerular locations. This can lead to glomerulonephritis, with the type of injury that results being dependent on four factors [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGlomerular immune-complex deposition

Professional guidelines

PubMed

Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment.
Chung EYM, Wang YM, Keung K, Hu M, McCarthy H, Wong G, Kairaitis L, Bose B, Harris DCH, Alexander SI
Front Immunol 2022;13:1036249. Epub 2022 Nov 2 doi: 10.3389/fimmu.2022.1036249. PMID: 36405681Free PMC Article
Advances in Understanding of Pathogenesis and Treatment of Immune-Mediated Kidney Disease: A Review.
Kant S, Kronbichler A, Sharma P, Geetha D
Am J Kidney Dis 2022 Apr;79(4):582-600. Epub 2021 Sep 8 doi: 10.1053/j.ajkd.2021.07.019. PMID: 34508831
A Proliferation Inducing Ligand (APRIL) targeted antibody is a safe and effective treatment of murine IgA nephropathy.
Myette JR, Kano T, Suzuki H, Sloan SE, Szretter KJ, Ramakrishnan B, Adari H, Deotale KD, Engler F, Shriver Z, Wollacott AM, Suzuki Y, Pereira BJG
Kidney Int 2019 Jul;96(1):104-116. Epub 2019 Mar 16 doi: 10.1016/j.kint.2019.01.031. PMID: 31027890

Recent clinical studies

Etiology

The lupus susceptibility allele DRB1*03:01 encodes a disease-driving epitope.
Miglioranza Scavuzzi B, van Drongelen V, Kaur B, Fox JC, Liu J, Mesquita-Ferrari RA, Kahlenberg JM, Farkash EA, Benavides F, Miller FW, Sawalha AH, Holoshitz J
Commun Biol 2022 Jul 28;5(1):751. doi: 10.1038/s42003-022-03717-x. PMID: 35902632Free PMC Article
De novo immune complex deposition in kidney allografts: a series of 32 patients.
Lloyd IE, Ahmed F, Revelo MP, Khalighi MA
Hum Pathol 2018 Jan;71:109-116. Epub 2017 Oct 24 doi: 10.1016/j.humpath.2017.10.012. PMID: 29079181
Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice.
Edwards MR, Dai R, Heid B, Cecere TE, Khan D, Mu Q, Cowan C, Luo XM, Ahmed SA
Int Immunol 2017 Jun 1;29(6):263-276. doi: 10.1093/intimm/dxx033. PMID: 28637300Free PMC Article
Significance of histological crescent formation in patients with diffuse proliferative lupus nephritis.
Chen S, Tang Z, Zhang Y, Liu Z, Zhang H, Hu W, Liu Z
Am J Nephrol 2013;38(6):445-52. Epub 2013 Nov 13 doi: 10.1159/000356184. PMID: 24247741
Focal glomerular immune complex deposition: possible role of periglomerular fibrosis/atubular glomeruli.
Satoskar AA, Calomeni E, Bott C, Nadasdy GM, Nadasdy T
Arch Pathol Lab Med 2009 Feb;133(2):283-8. doi: 10.5858/133.2.283. PMID: 19195971

Diagnosis

HIV-associated immune complex kidney disease.
Nobakht E, Cohen SD, Rosenberg AZ, Kimmel PL
Nat Rev Nephrol 2016 May;12(5):291-300. Epub 2016 Jan 19 doi: 10.1038/nrneph.2015.216. PMID: 26782145
Membranous-like glomerulopathy with masked IgG kappa deposits.
Larsen CP, Ambuzs JM, Bonsib SM, Boils CL, Cossey LN, Messias NC, Silva FG, Wang YH, Gokden N, Walker PD
Kidney Int 2014 Jul;86(1):154-61. Epub 2014 Jan 15 doi: 10.1038/ki.2013.548. PMID: 24429395
Significance of histological crescent formation in patients with diffuse proliferative lupus nephritis.
Chen S, Tang Z, Zhang Y, Liu Z, Zhang H, Hu W, Liu Z
Am J Nephrol 2013;38(6):445-52. Epub 2013 Nov 13 doi: 10.1159/000356184. PMID: 24247741
Nephrotic syndrome in African children: lack of evidence for 'tropical nephrotic syndrome'?
Doe JY, Funk M, Mengel M, Doehring E, Ehrich JH
Nephrol Dial Transplant 2006 Mar;21(3):672-6. Epub 2005 Dec 2 doi: 10.1093/ndt/gfi297. PMID: 16326742
Acute glomerulonephritis in a patient with Rocky Mountain spotted fever.
Quigg RJ, Gaines R, Wakely PE Jr, Schoolwerth AC
Am J Kidney Dis 1991 Mar;17(3):339-42. doi: 10.1016/s0272-6386(12)80484-7. PMID: 1996579

Therapy

Iguratimod ameliorates nephritis by modulating the Th17/Treg paradigm in pristane-induced lupus.
Xia Y, Fang X, Dai X, Li M, Jin L, Tao J, Li X, Wang Y, Li X
Int Immunopharmacol 2021 Jul;96:107563. Epub 2021 Mar 31 doi: 10.1016/j.intimp.2021.107563. PMID: 33812258
Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice.
Edwards MR, Dai R, Heid B, Cecere TE, Khan D, Mu Q, Cowan C, Luo XM, Ahmed SA
Int Immunol 2017 Jun 1;29(6):263-276. doi: 10.1093/intimm/dxx033. PMID: 28637300Free PMC Article
Membranous-like glomerulopathy with masked IgG kappa deposits.
Larsen CP, Ambuzs JM, Bonsib SM, Boils CL, Cossey LN, Messias NC, Silva FG, Wang YH, Gokden N, Walker PD
Kidney Int 2014 Jul;86(1):154-61. Epub 2014 Jan 15 doi: 10.1038/ki.2013.548. PMID: 24429395
Nephrotic syndrome in African children: lack of evidence for 'tropical nephrotic syndrome'?
Doe JY, Funk M, Mengel M, Doehring E, Ehrich JH
Nephrol Dial Transplant 2006 Mar;21(3):672-6. Epub 2005 Dec 2 doi: 10.1093/ndt/gfi297. PMID: 16326742
"Pauci-Immune" proliferative and necrotizing glomerulonephritis with thrombotic microangiopathy in patients with systemic lupus erythematosus and lupus-like syndrome.
Charney DA, Nassar G, Truong L, Nadasdy T
Am J Kidney Dis 2000 Jun;35(6):1193-206. doi: 10.1016/s0272-6386(00)70058-8. PMID: 10845835

Prognosis

Commercial rodent diets differentially regulate autoimmune glomerulonephritis, epigenetics and microbiota in MRL/lpr mice.
Edwards MR, Dai R, Heid B, Cecere TE, Khan D, Mu Q, Cowan C, Luo XM, Ahmed SA
Int Immunol 2017 Jun 1;29(6):263-276. doi: 10.1093/intimm/dxx033. PMID: 28637300Free PMC Article
Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis.
Cui Z, Zhao MH, Wang SX, Liu G, Zou WZ, Wang HY
Ren Fail 2006;28(1):7-14. doi: 10.1080/08860220500461195. PMID: 16526313
Nephrotic syndrome in African children: lack of evidence for 'tropical nephrotic syndrome'?
Doe JY, Funk M, Mengel M, Doehring E, Ehrich JH
Nephrol Dial Transplant 2006 Mar;21(3):672-6. Epub 2005 Dec 2 doi: 10.1093/ndt/gfi297. PMID: 16326742
"Pauci-Immune" proliferative and necrotizing glomerulonephritis with thrombotic microangiopathy in patients with systemic lupus erythematosus and lupus-like syndrome.
Charney DA, Nassar G, Truong L, Nadasdy T
Am J Kidney Dis 2000 Jun;35(6):1193-206. doi: 10.1016/s0272-6386(00)70058-8. PMID: 10845835
Binding of synthetic double-stranded DNA by serum from patients with systemic lupus erythematosus: correlation with renal histology.
Steinman CR, Grishman E, Spiera H, Deesomochok U
Am J Med 1977 Mar;62(3):319-23. doi: 10.1016/0002-9343(77)90827-0. PMID: 139106

Clinical prediction guides

De novo immune complex deposition in kidney allografts: a series of 32 patients.
Lloyd IE, Ahmed F, Revelo MP, Khalighi MA
Hum Pathol 2018 Jan;71:109-116. Epub 2017 Oct 24 doi: 10.1016/j.humpath.2017.10.012. PMID: 29079181
Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.
Chung SA, Brown EE, Williams AH, Ramos PS, Berthier CC, Bhangale T, Alarcon-Riquelme ME, Behrens TW, Criswell LA, Graham DC, Demirci FY, Edberg JC, Gaffney PM, Harley JB, Jacob CO, Kamboh MI, Kelly JA, Manzi S, Moser-Sivils KL, Russell LP, Petri M, Tsao BP, Vyse TJ, Zidovetzki R, Kretzler M, Kimberly RP, Freedman BI, Graham RR, Langefeld CD; International Consortium for Systemic Lupus Erythematosus Genetics
J Am Soc Nephrol 2014 Dec;25(12):2859-70. Epub 2014 Jun 12 doi: 10.1681/ASN.2013050446. PMID: 24925725Free PMC Article
Interaction of fibronectin with DNA/anti-DNA complexes from systemic lupus erythematosus: role of activated complement Cl in modulation of the interactions.
Gupta RC, Simpson WA, Raghow R
Clin Immunol Immunopathol 1988 Mar;46(3):368-81. doi: 10.1016/0090-1229(88)90056-6. PMID: 3257431
Interaction of rheumatoid factor with immune complexes in experimental glomerulonephritis--possible role of antiglobulins in chronicity.
Ford PM
J Rheumatol Suppl 1983 Dec;11:81-4. PMID: 6230448
Binding of synthetic double-stranded DNA by serum from patients with systemic lupus erythematosus: correlation with renal histology.
Steinman CR, Grishman E, Spiera H, Deesomochok U
Am J Med 1977 Mar;62(3):319-23. doi: 10.1016/0002-9343(77)90827-0. PMID: 139106

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