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Anti-factor VIII antibody positivity

MedGen UID:
1054676
•Concept ID:
CN377325
•
Finding
Synonym: Anti-FVIII antibody positivity
 
HPO: HP:6000494

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against factor VIII. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAnti-factor VIII antibody positivity

Professional guidelines

PubMed

Silica clotting time (SCT) as a screening and confirmatory test for detection of the lupus anticoagulants.
Chantarangkul V, Tripodi A, Arbini A, Mannucci PM
Thromb Res 1992 Aug 15;67(4):355-65. doi: 10.1016/0049-3848(92)90266-d. PMID: 1329261

Recent clinical studies

Etiology

Two-center validation of assays for the detection of binding and neutralizing anti-factor VIII antibodies.
Müller J, Neimanis S, Kahle J, Albert T, Schultze Strasser S, Rup B, Pötzsch B, Königs C, Oldenburg J; ABIRISK Consortium
Haemophilia 2024 Jan;30(1):224-231. Epub 2023 Oct 12 doi: 10.1111/hae.14885. PMID: 37824540
Anti-factor VIII IgA as a potential marker of poor prognosis in acquired hemophilia A: results from the GTH-AH 01/2010 study.
Tiede A, Hofbauer CJ, Werwitzke S, Knöbl P, Gottstein S, Scharf RE, Heinz J, Groß J, Holstein K, Dobbelstein C, Scheiflinger F, Koch A, Reipert BM
Blood 2016 May 12;127(19):2289-97. Epub 2016 Feb 24 doi: 10.1182/blood-2015-09-672774. PMID: 26912467
Factor VIII gene variants and inhibitor risk in African American hemophilia A patients.
Gunasekera D, Ettinger RA, Nakaya Fletcher S, James EA, Liu M, Barrett JC, Withycombe J, Matthews DC, Epstein MS, Hughes RJ, Pratt KP; Personalized Approaches to Therapies for Hemophilia (PATH) Study Investigators
Blood 2015 Aug 13;126(7):895-904. Epub 2015 Jan 23 doi: 10.1182/blood-2014-09-599365. PMID: 25617427Free PMC Article
Factor VIII-hydrolyzing IgG in acquired and congenital hemophilia.
Wootla B, Mahendra A, Dimitrov JD, Friboulet A, Borel-Derlon A, Rao DN, Uda T, Borg JY, Bayry J, Kaveri SV, Lacroix-Desmazes S
FEBS Lett 2009 Aug 6;583(15):2565-72. Epub 2009 Jul 15 doi: 10.1016/j.febslet.2009.07.009. PMID: 19595998
Glomus tumors: report on eleven cases and a review of the literature.
Abou Jaoude JF, Roula Farah A, Sargi Z, Khairallah S, Fakih C
Chir Main 2000 Sep;19(4):243-52. doi: 10.1016/s1297-3203(00)73487-1. PMID: 11079182

Diagnosis

The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A.
Oomen I, Verhagen M, Miranda M, Allacher P, Beckers EAM, Blijlevens NMA, van der Bom JG, Coppens M, Driessens M, Eikenboom JCJ, Fijnvandraat K, Hassan S, van Heerde WL, Hooimeijer HL, Jansen JH, Kaijen P, Leebeek FWG, Meijer D, Paul H, Rijpma SR, Rosendaal FR, Smit C, van Vulpen LFD, Voorberg J, Schols SEM, Gouw SC
Front Immunol 2024;15:1355813. Epub 2024 Feb 22 doi: 10.3389/fimmu.2024.1355813. PMID: 38455035Free PMC Article
Comprehensive domain-specific analysis and immunoglobulin G profiling of anti-factor VIII antibodies using a bead-based multiplex immunoassay.
Pezeshkpoor B, Berkemeier AC, Herbst K, Albert T, Müller J, Oldenburg J
J Thromb Haemost 2024 Jun;22(6):1591-1604. Epub 2024 Mar 5 doi: 10.1016/j.jtha.2024.02.016. PMID: 38453023
Methods for anti-factor VIII antibody levels in haemophilia A patients - validation of a multiplex immunoassay and comparability with assays measuring non-neutralising and neutralising antibodies (inhibitors).
Martin M, Augustsson C, Lind V, Al-Sabti R, Lam MC, Andersson NG, Strandberg K
Haemophilia 2023 Jan;29(1):336-347. Epub 2022 Oct 3 doi: 10.1111/hae.14669. PMID: 36193002
Characterization of the anti-factor VIII immunoglobulin profile in patients with hemophilia A by use of a fluorescence-based immunoassay.
Boylan B, Rice AS, Dunn AL, Tarantino MD, Brettler DB, Barrett JC, Miller CH; Hemophilia Inhibitor Research Study Investigators; Hemophilia Inhibitor Research Study Investigators
J Thromb Haemost 2015 Jan;13(1):47-53. Epub 2014 Dec 11 doi: 10.1111/jth.12768. PMID: 25354263Free PMC Article
Glomus tumors: report on eleven cases and a review of the literature.
Abou Jaoude JF, Roula Farah A, Sargi Z, Khairallah S, Fakih C
Chir Main 2000 Sep;19(4):243-52. doi: 10.1016/s1297-3203(00)73487-1. PMID: 11079182

Therapy

Two-center validation of assays for the detection of binding and neutralizing anti-factor VIII antibodies.
Müller J, Neimanis S, Kahle J, Albert T, Schultze Strasser S, Rup B, Pötzsch B, Königs C, Oldenburg J; ABIRISK Consortium
Haemophilia 2024 Jan;30(1):224-231. Epub 2023 Oct 12 doi: 10.1111/hae.14885. PMID: 37824540
Methods for anti-factor VIII antibody levels in haemophilia A patients - validation of a multiplex immunoassay and comparability with assays measuring non-neutralising and neutralising antibodies (inhibitors).
Martin M, Augustsson C, Lind V, Al-Sabti R, Lam MC, Andersson NG, Strandberg K
Haemophilia 2023 Jan;29(1):336-347. Epub 2022 Oct 3 doi: 10.1111/hae.14669. PMID: 36193002
Pathogenic immune response to therapeutic factor VIII: exacerbated response or failed induction of tolerance?
Varthaman A, Lacroix-Desmazes S
Haematologica 2019 Feb;104(2):236-244. Epub 2018 Dec 4 doi: 10.3324/haematol.2018.206383. PMID: 30514798Free PMC Article
Long-term anti-FVIII antibody response in Bethesda-negative haemophilia A patients receiving continuous replacement therapy.
Klintman J, Hillarp A, Berntorp E, Astermark J
Br J Haematol 2013 Nov;163(3):385-92. Epub 2013 Aug 30 doi: 10.1111/bjh.12540. PMID: 24032553
Quantitation of anti-factor VIII antibodies in human plasma.
Krudysz-Amblo J, Parhami-Seren B, Butenas S, Brummel-Ziedins KE, Gomperts ED, Rivard GE, Mann KG
Blood 2009 Mar 12;113(11):2587-94. Epub 2009 Jan 14 doi: 10.1182/blood-2008-08-174987. PMID: 19144987Free PMC Article

Prognosis

Comprehensive domain-specific analysis and immunoglobulin G profiling of anti-factor VIII antibodies using a bead-based multiplex immunoassay.
Pezeshkpoor B, Berkemeier AC, Herbst K, Albert T, Müller J, Oldenburg J
J Thromb Haemost 2024 Jun;22(6):1591-1604. Epub 2024 Mar 5 doi: 10.1016/j.jtha.2024.02.016. PMID: 38453023
Anti-factor VIII IgA as a potential marker of poor prognosis in acquired hemophilia A: results from the GTH-AH 01/2010 study.
Tiede A, Hofbauer CJ, Werwitzke S, Knöbl P, Gottstein S, Scharf RE, Heinz J, Groß J, Holstein K, Dobbelstein C, Scheiflinger F, Koch A, Reipert BM
Blood 2016 May 12;127(19):2289-97. Epub 2016 Feb 24 doi: 10.1182/blood-2015-09-672774. PMID: 26912467
Characterization of the anti-factor VIII immunoglobulin profile in patients with hemophilia A by use of a fluorescence-based immunoassay.
Boylan B, Rice AS, Dunn AL, Tarantino MD, Brettler DB, Barrett JC, Miller CH; Hemophilia Inhibitor Research Study Investigators; Hemophilia Inhibitor Research Study Investigators
J Thromb Haemost 2015 Jan;13(1):47-53. Epub 2014 Dec 11 doi: 10.1111/jth.12768. PMID: 25354263Free PMC Article
Long-term anti-FVIII antibody response in Bethesda-negative haemophilia A patients receiving continuous replacement therapy.
Klintman J, Hillarp A, Berntorp E, Astermark J
Br J Haematol 2013 Nov;163(3):385-92. Epub 2013 Aug 30 doi: 10.1111/bjh.12540. PMID: 24032553
Glomus tumors: report on eleven cases and a review of the literature.
Abou Jaoude JF, Roula Farah A, Sargi Z, Khairallah S, Fakih C
Chir Main 2000 Sep;19(4):243-52. doi: 10.1016/s1297-3203(00)73487-1. PMID: 11079182

Clinical prediction guides

The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A.
Oomen I, Verhagen M, Miranda M, Allacher P, Beckers EAM, Blijlevens NMA, van der Bom JG, Coppens M, Driessens M, Eikenboom JCJ, Fijnvandraat K, Hassan S, van Heerde WL, Hooimeijer HL, Jansen JH, Kaijen P, Leebeek FWG, Meijer D, Paul H, Rijpma SR, Rosendaal FR, Smit C, van Vulpen LFD, Voorberg J, Schols SEM, Gouw SC
Front Immunol 2024;15:1355813. Epub 2024 Feb 22 doi: 10.3389/fimmu.2024.1355813. PMID: 38455035Free PMC Article
Comprehensive domain-specific analysis and immunoglobulin G profiling of anti-factor VIII antibodies using a bead-based multiplex immunoassay.
Pezeshkpoor B, Berkemeier AC, Herbst K, Albert T, Müller J, Oldenburg J
J Thromb Haemost 2024 Jun;22(6):1591-1604. Epub 2024 Mar 5 doi: 10.1016/j.jtha.2024.02.016. PMID: 38453023
Pathogenic immune response to therapeutic factor VIII: exacerbated response or failed induction of tolerance?
Varthaman A, Lacroix-Desmazes S
Haematologica 2019 Feb;104(2):236-244. Epub 2018 Dec 4 doi: 10.3324/haematol.2018.206383. PMID: 30514798Free PMC Article
Characterization of the anti-factor VIII immunoglobulin profile in patients with hemophilia A by use of a fluorescence-based immunoassay.
Boylan B, Rice AS, Dunn AL, Tarantino MD, Brettler DB, Barrett JC, Miller CH; Hemophilia Inhibitor Research Study Investigators; Hemophilia Inhibitor Research Study Investigators
J Thromb Haemost 2015 Jan;13(1):47-53. Epub 2014 Dec 11 doi: 10.1111/jth.12768. PMID: 25354263Free PMC Article
Glomus tumors: report on eleven cases and a review of the literature.
Abou Jaoude JF, Roula Farah A, Sargi Z, Khairallah S, Fakih C
Chir Main 2000 Sep;19(4):243-52. doi: 10.1016/s1297-3203(00)73487-1. PMID: 11079182

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