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Elevated circulating beta chorionic gonadotropin concentration

MedGen UID:
1054707
•Concept ID:
CN377316
•
Finding
HPO: HP:6000485

Definition

The concentration of beta chorionic gonadotropin in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating beta chorionic gonadotropin concentration

Recent clinical studies

Etiology

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest.
Stewart JA, Koistinen R, Lempiäinen A, Hotakainen K, Salminen US, Vakkuri A, Wennervirta J, Stenman UH, Koistinen H
Scand J Clin Lab Invest 2020 Dec;80(8):640-643. Epub 2020 Sep 23 doi: 10.1080/00365513.2020.1824297. PMID: 32967482
Persistent versus transient stimulation of the macaque corpus luteum during prolonged exposure to human chorionic gonadotropin: a function of age of the corpus luteum.
Ottobre JS, Stouffer RL
Endocrinology 1984 Jun;114(6):2175-82. doi: 10.1210/endo-114-6-2175. PMID: 6723578
Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism.
Stock JL, Weintraub BD, Rosen SW, Aurbach GD, Spiegel AM, Marx SJ
J Clin Endocrinol Metab 1982 Jan;54(1):57-63. doi: 10.1210/jcem-54-1-57. PMID: 6274898

Diagnosis

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest.
Stewart JA, Koistinen R, Lempiäinen A, Hotakainen K, Salminen US, Vakkuri A, Wennervirta J, Stenman UH, Koistinen H
Scand J Clin Lab Invest 2020 Dec;80(8):640-643. Epub 2020 Sep 23 doi: 10.1080/00365513.2020.1824297. PMID: 32967482
Detection of germ-cell tumor cells in the peripheral blood by nested reverse transcription-polymerase chain reaction for alpha-fetoprotein-messenger RNA and beta human chorionic gonadotropin-messenger RNA.
Hautkappe AL, Lu M, Mueller H, Bex A, Harstrick A, Roggendorf M, Ruebben H
Cancer Res 2000 Jun 15;60(12):3170-4. PMID: 10866307
Urine free beta hCG and beta core in pregnancies affected by Down's syndrome.
Spencer K, Aitken DA, Macri JN, Buchanan PD
Prenat Diagn 1996 Jul;16(7):605-13. doi: 10.1002/(SICI)1097-0223(199607)16:7<605::AID-PD918>3.0.CO;2-Q. PMID: 8843469
Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance.
Carter PG, Iles RK, Neven P, Ind TE, Shepherd JH, Chard T
Br J Cancer 1995 Feb;71(2):350-3. doi: 10.1038/bjc.1995.70. PMID: 7530986Free PMC Article
Human chorionic gonadotropin subunit measurement in primary hyperparathyroidism.
Stock JL, Weintraub BD, Rosen SW, Aurbach GD, Spiegel AM, Marx SJ
J Clin Endocrinol Metab 1982 Jan;54(1):57-63. doi: 10.1210/jcem-54-1-57. PMID: 6274898

Therapy

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest.
Stewart JA, Koistinen R, Lempiäinen A, Hotakainen K, Salminen US, Vakkuri A, Wennervirta J, Stenman UH, Koistinen H
Scand J Clin Lab Invest 2020 Dec;80(8):640-643. Epub 2020 Sep 23 doi: 10.1080/00365513.2020.1824297. PMID: 32967482

Prognosis

Urine free beta hCG and beta core in pregnancies affected by Down's syndrome.
Spencer K, Aitken DA, Macri JN, Buchanan PD
Prenat Diagn 1996 Jul;16(7):605-13. doi: 10.1002/(SICI)1097-0223(199607)16:7<605::AID-PD918>3.0.CO;2-Q. PMID: 8843469
Measurement of urinary beta core fragment of human chorionic gonadotrophin in women with vulvovaginal malignancy and its prognostic significance.
Carter PG, Iles RK, Neven P, Ind TE, Shepherd JH, Chard T
Br J Cancer 1995 Feb;71(2):350-3. doi: 10.1038/bjc.1995.70. PMID: 7530986Free PMC Article

Clinical prediction guides

Dramatic increase in serum trypsinogens, SPINK1 and hCGβ in aortic surgery patients after hypothermic circulatory arrest.
Stewart JA, Koistinen R, Lempiäinen A, Hotakainen K, Salminen US, Vakkuri A, Wennervirta J, Stenman UH, Koistinen H
Scand J Clin Lab Invest 2020 Dec;80(8):640-643. Epub 2020 Sep 23 doi: 10.1080/00365513.2020.1824297. PMID: 32967482
Inhibition of gonadotropin-induced testosterone secretion by the intracerebroventricular injection of interleukin-1 beta in the male rat.
Turnbull AV, Rivier C
Endocrinology 1997 Mar;138(3):1008-13. doi: 10.1210/endo.138.3.5019. PMID: 9048602
Urine free beta hCG and beta core in pregnancies affected by Down's syndrome.
Spencer K, Aitken DA, Macri JN, Buchanan PD
Prenat Diagn 1996 Jul;16(7):605-13. doi: 10.1002/(SICI)1097-0223(199607)16:7<605::AID-PD918>3.0.CO;2-Q. PMID: 8843469
Hypergonadotrophic hypogonadism in an XX female subject due to 17,20 steroid desmolase deficiency.
Larrea F, Lisker R, Bañuelos R, Bermúdez JA, Herrera J, Núñez Rasilla V, Pérez-Palacios G
Acta Endocrinol (Copenh) 1983 Jul;103(3):400-5. doi: 10.1530/acta.0.1030400. PMID: 6308936
Molecular heterogeneity of human chorionic gonadotropin and its subunits in testicular cancer.
Mann K, Karl HJ
Cancer 1983 Aug 15;52(4):654-60. doi: 10.1002/1097-0142(19830815)52:4<654::aid-cncr2820520415>3.0.co;2-s. PMID: 6305481

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