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Reduced tissue acetyl-CoA carboxylase activity

MedGen UID:: 1054895
•Concept ID:: CN377026
•: Finding

Synonym:	Reduced hepatic acetyl-CoA carboxylase activity

HPO:	HP:6000430

Definition

Activity of acetyl-CoA carboxylase in the tissues below the lower limit of normal. The activity can be measured in multiple tissues including liver. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVReduced tissue acetyl-CoA carboxylase activity

Phenotypic abnormality
- Abnormality of metabolism/homeostasis
  - Abnormal enzyme concentration or activity
    - Abnormal tissue enzyme concentration or activity
      - Reduced tissue acetyl-CoA carboxylase activity

Conditions with this feature

Acetyl-CoA: carboxylase deficiency

MedGen UID:: 124338
•Concept ID:: C0268603
•: Disease or Syndrome

Acetyl-CoA carboxylase-alpha deficiency (ACACAD) is an autosomal recessive disorder characterized by hypotonia and global developmental delay (summary by Shafieipour et al., 2023).

See: Condition Record

Acetyl-CoA: carboxylase deficiency

Professional guidelines

PubMed

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH.

Tacke F, Puengel T, Loomba R, Friedman SL
J Hepatol 2023 Aug;79(2):552-566. Epub 2023 Apr 14 doi: 10.1016/j.jhep.2023.03.038. PMID: 37061196

n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.

Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553

Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome.

Kusunoki J, Kanatani A, Moller DE
Endocrine 2006 Feb;29(1):91-100. doi: 10.1385/ENDO:29:1:91. PMID: 16622296

See all (4)

Recent clinical studies

Etiology

Yam Gruel alone and in combination with metformin regulates hepatic lipid metabolism disorders in a diabetic rat model by activating the AMPK/ACC/CPT-1 pathway.

Dai Y, Qiu C, Zhang D, Li M, Liu W
Lipids Health Dis 2024 Jan 25;23(1):28. doi: 10.1186/s12944-024-02014-2. PMID: 38273354 Free PMC Article

Antenatal corticosteroid therapy modulates hepatic AMPK phosphorylation and maternal lipid metabolism in early lactating rats.

Hecht FB, Teixeira CJ, de Souza DN, Mesquita FPN, Roso REDV, Sodré FS, Veronesi VB, da Rocha DF, Menezes YGD, Pioli MR, Bordin S, Cecatti JG, Luz AG, Anhê GF
Biomed Pharmacother 2021 Dec;144:112355. Epub 2021 Oct 28 doi: 10.1016/j.biopha.2021.112355. PMID: 34794232

Rosmarinic Acid Protects Mice from Concanavalin A-Induced Hepatic Injury through AMPK Signaling.

Wang Y, Meng J, Men L, An B, Jin X, He W, Lu S, Li N
Biol Pharm Bull 2020 Nov 1;43(11):1749-1759. Epub 2020 Sep 4 doi: 10.1248/bpb.b20-00477. PMID: 32893253

Propionate alleviates high-fat diet-induced lipid dysmetabolism by modulating gut microbiota in mice.

Song B, Zhong YZ, Zheng CB, Li FN, Duan YH, Deng JP
J Appl Microbiol 2019 Nov;127(5):1546-1555. Epub 2019 Aug 15 doi: 10.1111/jam.14389. PMID: 31325215

AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes.

Højlund K, Mustard KJ, Staehr P, Hardie DG, Beck-Nielsen H, Richter EA, Wojtaszewski JF
Am J Physiol Endocrinol Metab 2004 Feb;286(2):E239-44. Epub 2003 Oct 7 doi: 10.1152/ajpendo.00326.2003. PMID: 14532170

See all (32)

Diagnosis

The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies.

Szkudelski T, Szkudelska K
Int J Mol Sci 2023 Dec 28;25(1) doi: 10.3390/ijms25010431. PMID: 38203600 Free PMC Article

Hypertrophy and ER Stress Induced by Palmitate Are Counteracted by Mango Peel and Seed Extracts in 3T3-L1 Adipocytes.

Pratelli G, Di Liberto D, Carlisi D, Emanuele S, Giuliano M, Notaro A, De Blasio A, Calvaruso G, D'Anneo A, Lauricella M
Int J Mol Sci 2023 Mar 12;24(6) doi: 10.3390/ijms24065419. PMID: 36982490 Free PMC Article

n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.

Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553

Effects of Coffee Components on Muscle Glycogen Recovery: A Systematic Review.

Loureiro LMR, Reis CEG, da Costa THM
Int J Sport Nutr Exerc Metab 2018 May 1;28(3):284-293. Epub 2018 Jun 12 doi: 10.1123/ijsnem.2017-0342. PMID: 29345166

Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates.

Jobgen WS, Fried SK, Fu WJ, Meininger CJ, Wu G
J Nutr Biochem 2006 Sep;17(9):571-88. Epub 2006 Jan 9 doi: 10.1016/j.jnutbio.2005.12.001. PMID: 16524713

See all (31)

Therapy

The Anti-Diabetic Potential of Baicalin: Evidence from Rodent Studies.

Szkudelski T, Szkudelska K
Int J Mol Sci 2023 Dec 28;25(1) doi: 10.3390/ijms25010431. PMID: 38203600 Free PMC Article

Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney.

Miguel V, Rey-Serra C, Tituaña J, Sirera B, Alcalde-Estévez E, Herrero JI, Ranz I, Fernández L, Castillo C, Sevilla L, Nagai J, Reimer KC, Jansen J, Kramann R, Costa IG, Castro A, Sancho D, Rodríguez González-Moro JM, Lamas S
Redox Biol 2023 Dec;68:102957. Epub 2023 Nov 3 doi: 10.1016/j.redox.2023.102957. PMID: 37977043 Free PMC Article

Antenatal corticosteroid therapy modulates hepatic AMPK phosphorylation and maternal lipid metabolism in early lactating rats.

n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review.

Wang M, Ma LJ, Yang Y, Xiao Z, Wan JB
Crit Rev Food Sci Nutr 2019;59(sup1):S116-S129. Epub 2018 Dec 22 doi: 10.1080/10408398.2018.1544542. PMID: 30580553

Impact of the renin-angiotensin system on cardiac energy metabolism in heart failure.

Mori J, Zhang L, Oudit GY, Lopaschuk GD
J Mol Cell Cardiol 2013 Oct;63:98-106. Epub 2013 Jul 22 doi: 10.1016/j.yjmcc.2013.07.010. PMID: 23886814

See all (55)

Prognosis

Naringin improves lipid metabolism in a tissue-engineered liver model of NAFLD and the underlying mechanisms.

Zhang X, Zhang Y, Gao W, Guo Z, Wang K, Liu S, Duan Z, Chen Y
Life Sci 2021 Jul 15;277:119487. Epub 2021 Apr 20 doi: 10.1016/j.lfs.2021.119487. PMID: 33862107

Overexpressing TNF-alpha in pancreatic ductal adenocarcinoma cells and fibroblasts modifies cell survival and reduces fatty acid synthesis via downregulation of sterol regulatory element binding protein-1 and activation of acetyl CoA carboxylase.

Al-Zoubi M, Chipitsyna G, Saxena S, Sarosiek K, Gandhi A, Kang CY, Relles D, Andrelsendecki J, Hyslop T, Yeo CJ, Arafat HA
J Gastrointest Surg 2014 Feb;18(2):257-68; discussion 268. Epub 2013 Oct 4 doi: 10.1007/s11605-013-2370-7. PMID: 24091913

Analysis of time-dependent adaptations in whole-body energy balance in obesity induced by high-fat diet in rats.

So M, Gaidhu MP, Maghdoori B, Ceddia RB
Lipids Health Dis 2011 Jun 16;10:99. doi: 10.1186/1476-511X-10-99. PMID: 21679418 Free PMC Article

Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

Calvisi DF, Wang C, Ho C, Ladu S, Lee SA, Mattu S, Destefanis G, Delogu S, Zimmermann A, Ericsson J, Brozzetti S, Staniscia T, Chen X, Dombrowski F, Evert M
Gastroenterology 2011 Mar;140(3):1071-83. Epub 2010 Dec 11 doi: 10.1053/j.gastro.2010.12.006. PMID: 21147110 Free PMC Article

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.

Hurley RL, Anderson KA, Franzone JM, Kemp BE, Means AR, Witters LA
J Biol Chem 2005 Aug 12;280(32):29060-6. Epub 2005 Jun 24 doi: 10.1074/jbc.M503824200. PMID: 15980064

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Clinical prediction guides

Enhanced fatty acid oxidation through metformin and baicalin as therapy for COVID-19 and associated inflammatory states in lung and kidney.

Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via AMPK-NF-κB-snail axis.

Saisomboon S, Kariya R, Boonnate P, Sawanyawisuth K, Cha'on U, Luvira V, Chamgramol Y, Pairojkul C, Seubwai W, Silsirivanit A, Wongkham S, Okada S, Jitrapakdee S, Vaeteewoottacharn K
Biochim Biophys Acta Mol Basis Dis 2023 Jun;1869(5):166694. Epub 2023 Mar 25 doi: 10.1016/j.bbadis.2023.166694. PMID: 36972768

Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation.

Zois CE, Hendriks AM, Haider S, Pires E, Bridges E, Kalamida D, Voukantsis D, Lagerholm BC, Fehrmann RSN, den Dunnen WFA, Tarasov AI, Baba O, Morris J, Buffa FM, McCullagh JSO, Jalving M, Harris AL
Cell Death Dis 2022 Jun 28;13(6):573. doi: 10.1038/s41419-022-05005-2. PMID: 35764612 Free PMC Article

Effects of Coffee Components on Muscle Glycogen Recovery: A Systematic Review.

Loureiro LMR, Reis CEG, da Costa THM
Int J Sport Nutr Exerc Metab 2018 May 1;28(3):284-293. Epub 2018 Jun 12 doi: 10.1123/ijsnem.2017-0342. PMID: 29345166

Regulation of fat metabolism in skeletal muscle.

Jeukendrup AE
Ann N Y Acad Sci 2002 Jun;967:217-35. doi: 10.1111/j.1749-6632.2002.tb04278.x. PMID: 12079850

See all (44)

Recent systematic reviews

Effects of Coffee Components on Muscle Glycogen Recovery: A Systematic Review.

Loureiro LMR, Reis CEG, da Costa THM
Int J Sport Nutr Exerc Metab 2018 May 1;28(3):284-293. Epub 2018 Jun 12 doi: 10.1123/ijsnem.2017-0342. PMID: 29345166

See all (1)

MedGen

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Reduced tissue acetyl-CoA carboxylase activity

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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