U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Morpheaform basal cell carcinoma

MedGen UID:
107825
•Concept ID:
C0555191
•
Neoplastic Process
Synonyms: Basal cell carcinoma - morpheic; Basal cell carcinoma - sclerosing type; Basal Cell Carcinoma Sclerosing Type; basal cell carcinoma sclerosing type; basal cell carcinoma, morphea; Basal cell carcinoma, morpheic; Basal cell carcinoma, sclerosing type; cicatricial basal-cell carcinoma; Cicatrising basal cell carcinoma; Morphea-Type (Sclerosing) Basal Cell Carcinoma; morphea-type (sclerosing) basal cell carcinoma; Morphea-Type Basal Cell Carcinoma; morphea-type basal cell carcinoma; Morpheaform Basal Cell Carcinoma; morpheaform basal cell carcinoma; Morpheic basal cell carcinoma; Sclerosing Type Basal Cell Carcinoma; sclerosing type basal cell carcinoma; Skin Morphea-Type (Sclerosing) Basal Cell Carcinoma; skin morphea-type (sclerosing) basal cell carcinoma; Skin Sclerosing/Morphoeic Basal Cell Carcinoma
SNOMED CT: Basal cell carcinoma - morpheic (134152008); Morpheic basal cell carcinoma (403913006); Morpheaform basal cell carcinoma (134152008); Basal cell carcinoma, sclerosing type (302821007); Cicatrising basal cell carcinoma (403913006); Basal cell carcinoma, morpheic (56665009); Basal cell carcinoma - sclerosing type (302821007)
 
Monarch Initiative: MONDO:0002949

Definition

A histologic variant of basal cell carcinoma of the skin characterized by the presence of strands and nests of malignant cells that are embedded in a dense fibrotic stroma. [from NCI]

Professional guidelines

PubMed

A Non-Surgical and Cost-Effective Treatment Approach Employing Topical Imiquimod, 5-Fluorouracil, and Tretinoin for Primary Non-Melanoma Skin Cancers.
Nahm WJ, Shen J, Zito PM, Gonzalez AM, Nagrani N, Moore K, Badiavas EV, Kirsner RS, Nichols AJ
J Drugs Dermatol 2021 Mar 1;20(3):260-267. doi: 10.36849/JDD.5427. PMID: 33683072
The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers.
Sellheyer K, Nelson P, Kutzner H, Patel RM
J Cutan Pathol 2013 Apr;40(4):363-70. Epub 2013 Feb 11 doi: 10.1111/cup.12085. PMID: 23398472

Recent clinical studies

Etiology

Clinical and Molecular Features of Morpheaform Basal Cell Carcinoma: A Systematic Review.
Conte S, Ghezelbash S, Nallanathan B, Lefrançois P
Curr Oncol 2023 Nov 13;30(11):9906-9928. doi: 10.3390/curroncol30110720. PMID: 37999140Free PMC Article
Does Immunohistochemistry Add to Morphology in Differentiating Trichoepithelioma, Desmoplastic Trichoepithelioma, Morpheaform Basal Cell Carcinoma, and Microcystic Adnexal Carcinoma?
Mohanty SK, Sardana R, McFall M, Pradhan D, Usmani A, Jha S, Mishra SK, Sampat NY, Lobo A, Wu JM, Balzer BL, Frishberg DP
Appl Immunohistochem Mol Morphol 2022 Apr 1;30(4):273-277. doi: 10.1097/PAI.0000000000001002. PMID: 35384877
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Histological and immunohistochemical study of the eyelid basal cell carcinomas.
Bălăşoiu AT, Mănescu MR, Bălăşoiu M, Avrămoiu I, Pirici I, Burcea M, Mogoantă L, Mocanu CL
Rom J Morphol Embryol 2015;56(2 Suppl):803-10. PMID: 26429176
Analysis of morpheaform basal cell carcinoma.
Richman T, Penneys NS
J Cutan Pathol 1988 Dec;15(6):359-62. doi: 10.1111/j.1600-0560.1988.tb00565.x. PMID: 3220994

Diagnosis

Clinical and Molecular Features of Morpheaform Basal Cell Carcinoma: A Systematic Review.
Conte S, Ghezelbash S, Nallanathan B, Lefrançois P
Curr Oncol 2023 Nov 13;30(11):9906-9928. doi: 10.3390/curroncol30110720. PMID: 37999140Free PMC Article
Does Immunohistochemistry Add to Morphology in Differentiating Trichoepithelioma, Desmoplastic Trichoepithelioma, Morpheaform Basal Cell Carcinoma, and Microcystic Adnexal Carcinoma?
Mohanty SK, Sardana R, McFall M, Pradhan D, Usmani A, Jha S, Mishra SK, Sampat NY, Lobo A, Wu JM, Balzer BL, Frishberg DP
Appl Immunohistochem Mol Morphol 2022 Apr 1;30(4):273-277. doi: 10.1097/PAI.0000000000001002. PMID: 35384877
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Morpheaform Basal Cell Carcinomas With Areas of Predominantly Single-Cell Pattern of Infiltration: Diagnostic Utility of p63 and Cytokeratin.
East E, Fullen DR, Arps D, Patel RM, Palanisamy N, Carskadon S, Harms PW
Am J Dermatopathol 2016 Oct;38(10):744-50. doi: 10.1097/DAD.0000000000000541. PMID: 27043336
Analysis of morpheaform basal cell carcinoma.
Richman T, Penneys NS
J Cutan Pathol 1988 Dec;15(6):359-62. doi: 10.1111/j.1600-0560.1988.tb00565.x. PMID: 3220994

Therapy

Orbito-scleral-sinus invasion of basal cell carcinoma in an immunocompromised patient on vismodegib.
Tran AQ, Patete CL, Blessing NW, Rong AJ, Garcia AL, Dubovy S, Tse DT
Orbit 2021 Apr;40(2):155-158. Epub 2020 Apr 14 doi: 10.1080/01676830.2020.1753783. PMID: 32283962
Dermoscopic features of basal cell carcinoma and its subtypes: A systematic review.
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article
Diagnostic utility of cytokeratin 17 immunostaining in morpheaform basal cell carcinoma and for facilitating the detection of tumor cells at the surgical margins.
Anderson-Dockter H, Clark T, Iwamoto S, Lu M, Fiore D, Falanga JK, Falanga V
Dermatol Surg 2012 Aug;38(8):1357-66. Epub 2012 Jun 12 doi: 10.1111/j.1524-4725.2012.02417.x. PMID: 22691048Free PMC Article
Photodynamic therapy as adjunctive therapy for morpheaform basal cell carcinoma.
Torres T, Fernandes I, Costa V, Selores M
Acta Dermatovenerol Alp Pannonica Adriat 2011;20(1):23-5. PMID: 21879201
Can smoking and/or occupational UV exposure have any role in the development of the morpheaform basal cell carcinoma? A critical role for peritumoral mast cells.
Erbagci Z, Erkiliç S
Int J Dermatol 2002 May;41(5):275-8. doi: 10.1046/j.1365-4362.2002.01487.x. PMID: 12100702

Prognosis

Clinical and Molecular Features of Morpheaform Basal Cell Carcinoma: A Systematic Review.
Conte S, Ghezelbash S, Nallanathan B, Lefrançois P
Curr Oncol 2023 Nov 13;30(11):9906-9928. doi: 10.3390/curroncol30110720. PMID: 37999140Free PMC Article
A pearly nodule on an indurated plaque.
Miller A, Siller A Jr, Rodriguez R, Gill P, Curry JL, Tyring SK
Dermatol Online J 2021 Dec 15;27(12) doi: 10.5070/D3271256715. PMID: 35499445
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours.
Aslam A
Curr Treat Options Oncol 2017 Aug;18(8):49. doi: 10.1007/s11864-017-0491-z. PMID: 28681209
Morpheaform Basal Cell Carcinomas With Areas of Predominantly Single-Cell Pattern of Infiltration: Diagnostic Utility of p63 and Cytokeratin.
East E, Fullen DR, Arps D, Patel RM, Palanisamy N, Carskadon S, Harms PW
Am J Dermatopathol 2016 Oct;38(10):744-50. doi: 10.1097/DAD.0000000000000541. PMID: 27043336
Diagnostic utility of cytokeratin 17 immunostaining in morpheaform basal cell carcinoma and for facilitating the detection of tumor cells at the surgical margins.
Anderson-Dockter H, Clark T, Iwamoto S, Lu M, Fiore D, Falanga JK, Falanga V
Dermatol Surg 2012 Aug;38(8):1357-66. Epub 2012 Jun 12 doi: 10.1111/j.1524-4725.2012.02417.x. PMID: 22691048Free PMC Article

Clinical prediction guides

Does Immunohistochemistry Add to Morphology in Differentiating Trichoepithelioma, Desmoplastic Trichoepithelioma, Morpheaform Basal Cell Carcinoma, and Microcystic Adnexal Carcinoma?
Mohanty SK, Sardana R, McFall M, Pradhan D, Usmani A, Jha S, Mishra SK, Sampat NY, Lobo A, Wu JM, Balzer BL, Frishberg DP
Appl Immunohistochem Mol Morphol 2022 Apr 1;30(4):273-277. doi: 10.1097/PAI.0000000000001002. PMID: 35384877
Morpheaform Basal Cell Carcinomas With Areas of Predominantly Single-Cell Pattern of Infiltration: Diagnostic Utility of p63 and Cytokeratin.
East E, Fullen DR, Arps D, Patel RM, Palanisamy N, Carskadon S, Harms PW
Am J Dermatopathol 2016 Oct;38(10):744-50. doi: 10.1097/DAD.0000000000000541. PMID: 27043336
Photodynamic therapy as adjunctive therapy for morpheaform basal cell carcinoma.
Torres T, Fernandes I, Costa V, Selores M
Acta Dermatovenerol Alp Pannonica Adriat 2011;20(1):23-5. PMID: 21879201
Can smoking and/or occupational UV exposure have any role in the development of the morpheaform basal cell carcinoma? A critical role for peritumoral mast cells.
Erbagci Z, Erkiliç S
Int J Dermatol 2002 May;41(5):275-8. doi: 10.1046/j.1365-4362.2002.01487.x. PMID: 12100702
Clinical factors influencing periocular surgical defects after Mohs micrographic surgery.
Carter KD, Nerad JA, Whitaker DC
Ophthalmic Plast Reconstr Surg 1999 Mar;15(2):83-91. doi: 10.1097/00002341-199903000-00004. PMID: 10189634

Recent systematic reviews

Clinical and Molecular Features of Morpheaform Basal Cell Carcinoma: A Systematic Review.
Conte S, Ghezelbash S, Nallanathan B, Lefrançois P
Curr Oncol 2023 Nov 13;30(11):9906-9928. doi: 10.3390/curroncol30110720. PMID: 37999140Free PMC Article
Dermoscopic features of basal cell carcinoma and its subtypes: A systematic review.
Reiter O, Mimouni I, Dusza S, Halpern AC, Leshem YA, Marghoob AA
J Am Acad Dermatol 2021 Sep;85(3):653-664. Epub 2019 Nov 7 doi: 10.1016/j.jaad.2019.11.008. PMID: 31706938Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...