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Esophageal dysplasia

MedGen UID:
108322
•Concept ID:
C0586354
•
Disease or Syndrome
Synonyms: Esophageal Dysplasia; Esophageal Intraepithelial Neoplasia; Intraepithelial Neoplasia of Esophagus; Intraepithelial Neoplasia of the Esophagus
SNOMED CT: Esophageal dysplasia (308857008)

Definition

A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma. Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade. In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications. (WHO, 2000) [from NCI]

Professional guidelines

PubMed

Development and External Validation of a Model to Predict Complex Treatment After Radiofrequency Ablation for Barrett's Esophagus With Early Neoplasia.
van Munster SN, Nieuwenhuis E, Bisschops R, Willekens H, Weusten BLAM, Herrero LA, Bogte A, Alkhalaf A, Schenk EBE, Schoon EJ, Curvers W, Koch AD, de Jonge PJF, Tang TJ, Nagengast WB, Westerhof J, Houben MHMG, Bergman JJGHM, Pouw RE
Clin Gastroenterol Hepatol 2022 Nov;20(11):2495-2504.e5. Epub 2022 Mar 12 doi: 10.1016/j.cgh.2022.02.057. PMID: 35292379
Antireflux surgery is required after endoscopic treatment for Barrett's esophagus.
Tyselskyi V, Poylin V, Tkachuk O, Kebkalo A
Pol Przegl Chir 2021 May 14;93(5):1-5. doi: 10.5604/01.3001.0014.8863. PMID: 34552027
Cryotherapy in the management of esophageal dysplasia and malignancy.
Halsey KD, Greenwald BD
Gastrointest Endosc Clin N Am 2010 Jan;20(1):75-87, vi-vii. doi: 10.1016/j.giec.2009.07.009. PMID: 19951795

Recent clinical studies

Etiology

Artificial Intelligence and Its Role in Identifying Esophageal Neoplasia.
Syed T, Doshi A, Guleria S, Syed S, Shah T
Dig Dis Sci 2020 Dec;65(12):3448-3455. Epub 2020 Oct 15 doi: 10.1007/s10620-020-06643-2. PMID: 33057945Free PMC Article
Esophageal dysplasia and adenocarcinoma: a study with double immunostaining for intestinal and gastric markers.
Chlumská A, Mukenšnabl P, Waloschek T, Zámečník M
Cesk Patol 2018 Summer;54(2):81-85. PMID: 30441967
Emerging endoscopic techniques for the identification of esophageal disease.
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Endoscopic imaging for the detection of esophageal dysplasia and carcinoma.
Shahid MW, Wallace MB
Gastrointest Endosc Clin N Am 2010 Jan;20(1):11-24, v. doi: 10.1016/j.giec.2009.08.006. PMID: 19951791
Barrett's esophagus.
Bonino JA, Sharma P
Curr Opin Gastroenterol 2005 Jul;21(4):461-5. PMID: 15930989

Diagnosis

Artificial Intelligence and Its Role in Identifying Esophageal Neoplasia.
Syed T, Doshi A, Guleria S, Syed S, Shah T
Dig Dis Sci 2020 Dec;65(12):3448-3455. Epub 2020 Oct 15 doi: 10.1007/s10620-020-06643-2. PMID: 33057945Free PMC Article
Esophageal dysplasia and adenocarcinoma: a study with double immunostaining for intestinal and gastric markers.
Chlumská A, Mukenšnabl P, Waloschek T, Zámečník M
Cesk Patol 2018 Summer;54(2):81-85. PMID: 30441967
Emerging endoscopic techniques for the identification of esophageal disease.
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Endoscopic mucosal resection and endoscopic submucosal dissection for esophageal dysplasia and carcinoma.
Inoue H, Minami H, Kaga M, Sato Y, Kudo SE
Gastrointest Endosc Clin N Am 2010 Jan;20(1):25-34, v-vi. doi: 10.1016/j.giec.2009.08.005. PMID: 19951792
Endoscopic imaging for the detection of esophageal dysplasia and carcinoma.
Shahid MW, Wallace MB
Gastrointest Endosc Clin N Am 2010 Jan;20(1):11-24, v. doi: 10.1016/j.giec.2009.08.006. PMID: 19951791

Therapy

PARP1-targeted fluorescence molecular endoscopy as novel tool for early detection of esophageal dysplasia and adenocarcinoma.
Marcazzan S, Braz Carvalho MJ, Nguyen NT, Strangmann J, Slotta-Huspenina J, Tenditnaya A, Tschurtschenthaler M, Rieder J, Proaño-Vasco A, Ntziachristos V, Steiger K, Gorpas D, Quante M, Kossatz S
J Exp Clin Cancer Res 2024 Feb 21;43(1):53. doi: 10.1186/s13046-024-02963-7. PMID: 38383387Free PMC Article
Short-term and long-term effect of nutrition intervention in the Linxian Dysplasia Nutrition Intervention Trial and the reason for disappearance of the intervention effect: A cohort study.
Fan JH, Sun WY, Yang H, Wang XK, Abnet CC, Qiao YL
Cancer 2023 Aug 1;129(15):2360-2372. Epub 2023 May 27 doi: 10.1002/cncr.34761. PMID: 37243894
Characteristics of the esophageal microbiome in patients with achalasia and its changes before and after peroral endoscopic myotomy: A pilot study.
Yeh CC, Chen CC, Chen CC, Han ML, Wu JF, Wang HP, Wu MS, Tseng PH
J Gastroenterol Hepatol 2023 Aug;38(8):1307-1315. Epub 2023 Apr 20 doi: 10.1111/jgh.16192. PMID: 37078564
Artificial Intelligence and Its Role in Identifying Esophageal Neoplasia.
Syed T, Doshi A, Guleria S, Syed S, Shah T
Dig Dis Sci 2020 Dec;65(12):3448-3455. Epub 2020 Oct 15 doi: 10.1007/s10620-020-06643-2. PMID: 33057945Free PMC Article
High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.
Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M
Gastroenterology 2019 Aug;157(2):492-506.e2. Epub 2019 Apr 15 doi: 10.1053/j.gastro.2019.04.013. PMID: 30998992Free PMC Article

Prognosis

Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection.
Li M, Kong J, Wang L, Yan H, Liang W, Wang N, Zhao J
World J Surg Oncol 2022 May 12;20(1):155. doi: 10.1186/s12957-022-02612-3. PMID: 35549728Free PMC Article
Machine learning for grading and prognosis of esophageal dysplasia using mass spectrometry and histological imaging.
Beuque M, Martin-Lorenzo M, Balluff B, Woodruff HC, Lucas M, de Bruin DM, van Timmeren JE, Boer OJ, Heeren RM, Meijer SL, Lambin P
Comput Biol Med 2021 Nov;138:104918. Epub 2021 Oct 4 doi: 10.1016/j.compbiomed.2021.104918. PMID: 34638018
Esophageal dysplasia and adenocarcinoma: a study with double immunostaining for intestinal and gastric markers.
Chlumská A, Mukenšnabl P, Waloschek T, Zámečník M
Cesk Patol 2018 Summer;54(2):81-85. PMID: 30441967
Emerging endoscopic techniques for the identification of esophageal disease.
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis.
Findlay JM, Middleton MR, Tomlinson I
Dig Dis Sci 2016 Jan;61(1):25-38. Epub 2015 Oct 7 doi: 10.1007/s10620-015-3884-5. PMID: 26445852Free PMC Article

Clinical prediction guides

Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection.
Li M, Kong J, Wang L, Yan H, Liang W, Wang N, Zhao J
World J Surg Oncol 2022 May 12;20(1):155. doi: 10.1186/s12957-022-02612-3. PMID: 35549728Free PMC Article
Antireflux surgery is required after endoscopic treatment for Barrett's esophagus.
Tyselskyi V, Poylin V, Tkachuk O, Kebkalo A
Pol Przegl Chir 2021 May 14;93(5):1-5. doi: 10.5604/01.3001.0014.8863. PMID: 34552027
High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett's Esophagus via Interleukin 8 and Alterations to the Gut Microbiome.
Münch NS, Fang HY, Ingermann J, Maurer HC, Anand A, Kellner V, Sahm V, Wiethaler M, Baumeister T, Wein F, Einwächter H, Bolze F, Klingenspor M, Haller D, Kavanagh M, Lysaght J, Friedman R, Dannenberg AJ, Pollak M, Holt PR, Muthupalani S, Fox JG, Whary MT, Lee Y, Ren TY, Elliot R, Fitzgerald R, Steiger K, Schmid RM, Wang TC, Quante M
Gastroenterology 2019 Aug;157(2):492-506.e2. Epub 2019 Apr 15 doi: 10.1053/j.gastro.2019.04.013. PMID: 30998992Free PMC Article
Emerging endoscopic techniques for the identification of esophageal disease.
Triadafilopoulos G, Akiyama J
Expert Rev Gastroenterol Hepatol 2016;10(5):605-13. Epub 2016 Feb 6 doi: 10.1586/17474124.2016.1140037. PMID: 26753504
Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis.
Findlay JM, Middleton MR, Tomlinson I
Dig Dis Sci 2016 Jan;61(1):25-38. Epub 2015 Oct 7 doi: 10.1007/s10620-015-3884-5. PMID: 26445852Free PMC Article

Recent systematic reviews

Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis.
Findlay JM, Middleton MR, Tomlinson I
Dig Dis Sci 2016 Jan;61(1):25-38. Epub 2015 Oct 7 doi: 10.1007/s10620-015-3884-5. PMID: 26445852Free PMC Article

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