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Cancer of unknown primary site

MedGen UID:
113094
Concept ID:
C0220647
Neoplastic Process
Synonyms: cancer of unknown primary site; Carcinoma of Unknown Primary; Carcinoma of Unknown Primary Origin
 
Monarch Initiative: MONDO:0858997

Definition

A carcinoma which has metastasized from an unknown primary anatomic site. [from NCI]

Professional guidelines

PubMed

Losa F, Fernández I, Etxaniz O, Giménez A, Gomila P, Iglesias L, Longo F, Nogales E, Sánchez A, Soler G
Clin Transl Oncol 2022 Apr;24(4):681-692. Epub 2022 Mar 23 doi: 10.1007/s12094-022-02806-x. PMID: 35320504Free PMC Article
Tomuleasa C, Zaharie F, Muresan MS, Pop L, Fekete Z, Dima D, Frinc I, Trifa A, Berce C, Jurj A, Berindan-Neagoe I, Zdrenghea M
J Gastrointestin Liver Dis 2017 Mar;26(1):69-79. doi: 10.15403/jgld.2014.1121.261.haz. PMID: 28338116
Vajdic CM, Goldstein D
Aust Fam Physician 2015 Sep;44(9):640-3. PMID: 26488041

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Occult Primary (Cancer of Unknown Primary [CUP]), 2024

Recent clinical studies

Etiology

Losa F, Fernández I, Etxaniz O, Giménez A, Gomila P, Iglesias L, Longo F, Nogales E, Sánchez A, Soler G
Clin Transl Oncol 2022 Apr;24(4):681-692. Epub 2022 Mar 23 doi: 10.1007/s12094-022-02806-x. PMID: 35320504Free PMC Article
Ding Y, Jiang J, Xu J, Chen Y, Zheng Y, Jiang W, Mao C, Jiang H, Bao X, Shen Y, Li X, Teng L, Xu N
ESMO Open 2022 Apr;7(2):100407. Epub 2022 Mar 3 doi: 10.1016/j.esmoop.2022.100407. PMID: 35248824Free PMC Article
Vajdic CM, Goldstein D
Aust Fam Physician 2015 Sep;44(9):640-3. PMID: 26488041
Pavlidis N, Pentheroudakis G
Lancet 2012 Apr 14;379(9824):1428-35. Epub 2012 Mar 12 doi: 10.1016/S0140-6736(11)61178-1. PMID: 22414598
Aziz M, Afroz N, Awasthi A, Hasan SA, Ahmad I
J Indian Med Assoc 2011 Nov;109(11):812-4. PMID: 22666938

Diagnosis

Tomuleasa C, Zaharie F, Muresan MS, Pop L, Fekete Z, Dima D, Frinc I, Trifa A, Berce C, Jurj A, Berindan-Neagoe I, Zdrenghea M
J Gastrointestin Liver Dis 2017 Mar;26(1):69-79. doi: 10.15403/jgld.2014.1121.261.haz. PMID: 28338116
Vajdic CM, Goldstein D
Aust Fam Physician 2015 Sep;44(9):640-3. PMID: 26488041
Varadhachary GR, Raber MN
N Engl J Med 2014 Aug 21;371(8):757-65. doi: 10.1056/NEJMra1303917. PMID: 25140961
Greco FA
Am Soc Clin Oncol Educ Book 2013:175-81. doi: 10.14694/EdBook_AM.2013.33.175. PMID: 23714493
Pavlidis N, Pentheroudakis G
Lancet 2012 Apr 14;379(9824):1428-35. Epub 2012 Mar 12 doi: 10.1016/S0140-6736(11)61178-1. PMID: 22414598

Therapy

Hayashi H, Takiguchi Y, Minami H, Akiyoshi K, Segawa Y, Ueda H, Iwamoto Y, Kondoh C, Matsumoto K, Takahashi S, Yasui H, Sawa T, Onozawa Y, Chiba Y, Togashi Y, Fujita Y, Sakai K, Tomida S, Nishio K, Nakagawa K
JAMA Oncol 2020 Dec 1;6(12):1931-1938. doi: 10.1001/jamaoncol.2020.4643. PMID: 33057591Free PMC Article
Haratani K, Hayashi H, Takahama T, Nakamura Y, Tomida S, Yoshida T, Chiba Y, Sawada T, Sakai K, Fujita Y, Togashi Y, Tanizaki J, Kawakami H, Ito A, Nishio K, Nakagawa K
J Immunother Cancer 2019 Sep 13;7(1):251. doi: 10.1186/s40425-019-0720-z. PMID: 31519206Free PMC Article
Vajdic CM, Perez-Concha O, Rhee JJ, Dobbins T, Ward RL, Schaffer AL, van Leeuwen MT, Laaksonen MA, Craigen G, Pearson SA
Cancer Epidemiol 2019 Aug;61:1-7. Epub 2019 May 10 doi: 10.1016/j.canep.2019.05.001. PMID: 31082704
Tomuleasa C, Zaharie F, Muresan MS, Pop L, Fekete Z, Dima D, Frinc I, Trifa A, Berce C, Jurj A, Berindan-Neagoe I, Zdrenghea M
J Gastrointestin Liver Dis 2017 Mar;26(1):69-79. doi: 10.15403/jgld.2014.1121.261.haz. PMID: 28338116
Pentheroudakis G, Pavlidis N
Cancer Treat Rev 2006 Dec;32(8):637-44. doi: 10.1016/j.ctrv.2006.08.004. PMID: 17046164

Prognosis

Ding Y, Jiang J, Xu J, Chen Y, Zheng Y, Jiang W, Mao C, Jiang H, Bao X, Shen Y, Li X, Teng L, Xu N
ESMO Open 2022 Apr;7(2):100407. Epub 2022 Mar 3 doi: 10.1016/j.esmoop.2022.100407. PMID: 35248824Free PMC Article
Haratani K, Hayashi H, Takahama T, Nakamura Y, Tomida S, Yoshida T, Chiba Y, Sawada T, Sakai K, Fujita Y, Togashi Y, Tanizaki J, Kawakami H, Ito A, Nishio K, Nakagawa K
J Immunother Cancer 2019 Sep 13;7(1):251. doi: 10.1186/s40425-019-0720-z. PMID: 31519206Free PMC Article
Tomuleasa C, Zaharie F, Muresan MS, Pop L, Fekete Z, Dima D, Frinc I, Trifa A, Berce C, Jurj A, Berindan-Neagoe I, Zdrenghea M
J Gastrointestin Liver Dis 2017 Mar;26(1):69-79. doi: 10.15403/jgld.2014.1121.261.haz. PMID: 28338116
Vajdic CM, Goldstein D
Aust Fam Physician 2015 Sep;44(9):640-3. PMID: 26488041
Pavlidis N, Pentheroudakis G
Lancet 2012 Apr 14;379(9824):1428-35. Epub 2012 Mar 12 doi: 10.1016/S0140-6736(11)61178-1. PMID: 22414598

Clinical prediction guides

Ding Y, Jiang J, Xu J, Chen Y, Zheng Y, Jiang W, Mao C, Jiang H, Bao X, Shen Y, Li X, Teng L, Xu N
ESMO Open 2022 Apr;7(2):100407. Epub 2022 Mar 3 doi: 10.1016/j.esmoop.2022.100407. PMID: 35248824Free PMC Article
Vajdic CM, Perez-Concha O, Rhee JJ, Dobbins T, Ward RL, Schaffer AL, van Leeuwen MT, Laaksonen MA, Craigen G, Pearson SA
Cancer Epidemiol 2019 Aug;61:1-7. Epub 2019 May 10 doi: 10.1016/j.canep.2019.05.001. PMID: 31082704
Greco FA, Erlander MG
Mol Diagn Ther 2009 Dec 1;13(6):367-73. doi: 10.1007/BF03256342. PMID: 19925034
Pentheroudakis G, Briasoulis E, Pavlidis N
Oncologist 2007 Apr;12(4):418-25. doi: 10.1634/theoncologist.12-4-418. PMID: 17470684
Muir C
Cancer 1995 Jan 1;75(1 Suppl):353-6. doi: 10.1002/1097-0142(19950101)75:1+<353::aid-cncr2820751317>3.0.co;2-p. PMID: 8001006

Recent systematic reviews

Ding Y, Jiang J, Xu J, Chen Y, Zheng Y, Jiang W, Mao C, Jiang H, Bao X, Shen Y, Li X, Teng L, Xu N
ESMO Open 2022 Apr;7(2):100407. Epub 2022 Mar 3 doi: 10.1016/j.esmoop.2022.100407. PMID: 35248824Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Occult Primary (Cancer of Unknown Primary [CUP]), 2024

    Consumer resources

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