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Simple schizophrenia

MedGen UID:
113168
•Concept ID:
C0221520
•
Mental or Behavioral Dysfunction
Synonyms: Schizophrenia simplex; Simple Type Schizophrenia
SNOMED CT: Schizophrenia simplex (191527001); Simple schizophrenia (191527001)

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSimple schizophrenia

Professional guidelines

PubMed

Simple schizophrenia: an investigation of Bleuler's criteria based on the major twin studies of schizophrenia.
Dworkin RH
Acta Psychiatr Scand 1992 Jan;85(1):61-4. doi: 10.1111/j.1600-0447.1992.tb01443.x. PMID: 1546551
Reliability of ICD-10 research criteria: an Arab perspective.
Okasha A, Seif el Dawla A
Acta Psychiatr Scand 1992 Dec;86(6):484-8. doi: 10.1111/j.1600-0447.1992.tb03302.x. PMID: 1471543

Recent clinical studies

Etiology

Proteomic profile of serum from patients with schizophrenia spectrum disorders.
Dmitrieva E, Smirnova L, Seregin A, Zgoda V, Semke A, Ivanova S
PeerJ 2022;10:e13907. Epub 2022 Aug 30 doi: 10.7717/peerj.13907. PMID: 36061748Free PMC Article
Late onset simple schizophrenia.
O'Brien D, Macklin J
Scott Med J 2014 Feb;59(1):e1-3. Epub 2014 Jan 20 doi: 10.1177/0036933013519025. PMID: 24444662
Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives.
Fanous A, Gardner C, Walsh D, Kendler KS
Arch Gen Psychiatry 2001 Jul;58(7):669-73. doi: 10.1001/archpsyc.58.7.669. PMID: 11448374
'Simple schizophrenia': a controlled MRI and clinical/neuropsychological study.
Galderisi S, Bucci P, Mucci A, D'Amato AC, Conforti R, Maj M
Psychiatry Res 1999 Oct 11;91(3):175-84. doi: 10.1016/s0925-4927(99)00026-8. PMID: 10641581
An epidemiologic, clinical, and family study of simple schizophrenia in County Roscommon, Ireland.
Kendler KS, McGuire M, Gruenberg AM, Walsh D
Am J Psychiatry 1994 Jan;151(1):27-34. doi: 10.1176/ajp.151.1.27. PMID: 8267130

Diagnosis

Simple Schizophrenia: A Forgotten Diagnosis in Psychiatry.
Lally J, Maloudi S, Krivoy A, Murphy KC
J Nerv Ment Dis 2019 Sep;207(9):721-725. doi: 10.1097/NMD.0000000000000936. PMID: 31082962
Simple Schizophrenia Remains a Complicated Diagnosis: Case Report and Literature Review.
Agarwal V, Maheshwari S, Agarwal V, Kalra ID
J Nerv Ment Dis 2016 Jan;204(1):57-60. doi: 10.1097/NMD.0000000000000413. PMID: 26704464
Late onset simple schizophrenia.
O'Brien D, Macklin J
Scott Med J 2014 Feb;59(1):e1-3. Epub 2014 Jan 20 doi: 10.1177/0036933013519025. PMID: 24444662
Simple schizophrenia: past, present, and future.
Black DW, Boffeli TJ
Am J Psychiatry 1989 Oct;146(10):1267-73. doi: 10.1176/ajp.146.10.1267. PMID: 2675642
Simple schizophrenia.
Rapp MS
Am J Psychiatry 1969 Apr;125(10):1449-50. doi: 10.1176/ajp.125.10.1449. PMID: 5772936

Therapy

Late onset simple schizophrenia.
O'Brien D, Macklin J
Scott Med J 2014 Feb;59(1):e1-3. Epub 2014 Jan 20 doi: 10.1177/0036933013519025. PMID: 24444662
'Simple schizophrenia': a controlled MRI and clinical/neuropsychological study.
Galderisi S, Bucci P, Mucci A, D'Amato AC, Conforti R, Maj M
Psychiatry Res 1999 Oct 11;91(3):175-84. doi: 10.1016/s0925-4927(99)00026-8. PMID: 10641581
A comparative study of opinion and knowledge about mental illness in different societies.
Erinosho OA, Ayonrinde A
Psychiatry 1978 Nov;41(4):403-10. doi: 10.1080/00332747.1978.11023998. PMID: 715098
The effect of L-dopa on young patients with simple schizophrenia, treated with neuroleptic drugs: a double-blind cross-over trial with Madopar and placebo.
Gerlach J, Lühdorf K
Psychopharmacologia 1975 Oct 14;44(1):105-10. doi: 10.1007/BF00421193. PMID: 706

Prognosis

Late onset simple schizophrenia.
O'Brien D, Macklin J
Scott Med J 2014 Feb;59(1):e1-3. Epub 2014 Jan 20 doi: 10.1177/0036933013519025. PMID: 24444662
Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives.
Fanous A, Gardner C, Walsh D, Kendler KS
Arch Gen Psychiatry 2001 Jul;58(7):669-73. doi: 10.1001/archpsyc.58.7.669. PMID: 11448374
Family characteristics of deficit and nondeficit schizophrenia in the Roscommon Family Study.
Kirkpatrick B, Ross DE, Walsh D, Karkowski L, Kendler KS
Schizophr Res 2000 Sep 29;45(1-2):57-64. doi: 10.1016/s0920-9964(99)00164-4. PMID: 10978873
An epidemiologic, clinical, and family study of simple schizophrenia in County Roscommon, Ireland.
Kendler KS, McGuire M, Gruenberg AM, Walsh D
Am J Psychiatry 1994 Jan;151(1):27-34. doi: 10.1176/ajp.151.1.27. PMID: 8267130
Simple schizophrenia.
Rapp MS
Am J Psychiatry 1969 Apr;125(10):1449-50. doi: 10.1176/ajp.125.10.1449. PMID: 5772936

Clinical prediction guides

Toxoplasma gondii infection and schizophrenia: a case control study in a low Toxoplasma seroprevalence Mexican population.
Alvarado-Esquivel C, Urbina-Álvarez JD, Estrada-Martínez S, Torres-Castorena A, Molotla-de-León G, Liesenfeld O, Dubey JP
Parasitol Int 2011 Jun;60(2):151-5. Epub 2011 Feb 1 doi: 10.1016/j.parint.2010.12.003. PMID: 21292026
Self-mutilation of tongue and lip in a patient with simple schizophrenia.
Munerato MC, Moure SP, Machado V, Gomes FG
Clin Med Res 2011 Mar;9(1):42-5. Epub 2010 Sep 17 doi: 10.3121/cmr.2010.930. PMID: 20852088Free PMC Article
Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives.
Fanous A, Gardner C, Walsh D, Kendler KS
Arch Gen Psychiatry 2001 Jul;58(7):669-73. doi: 10.1001/archpsyc.58.7.669. PMID: 11448374
'Simple schizophrenia': a controlled MRI and clinical/neuropsychological study.
Galderisi S, Bucci P, Mucci A, D'Amato AC, Conforti R, Maj M
Psychiatry Res 1999 Oct 11;91(3):175-84. doi: 10.1016/s0925-4927(99)00026-8. PMID: 10641581
Identifying subtypes of schizophrenia by cluster analyses.
Dollfus S, Everitt B, Ribeyre JM, Assouly-Besse F, Sharp C, Petit M
Schizophr Bull 1996;22(3):545-55. doi: 10.1093/schbul/22.3.545. PMID: 8873304

Recent systematic reviews

Simple Schizophrenia: A Forgotten Diagnosis in Psychiatry.
Lally J, Maloudi S, Krivoy A, Murphy KC
J Nerv Ment Dis 2019 Sep;207(9):721-725. doi: 10.1097/NMD.0000000000000936. PMID: 31082962

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