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Seminoma

MedGen UID:
11371
Concept ID:
C0036631
Neoplastic Process
Synonym: Seminomas
SNOMED CT: Seminoma (443675005); Malignant seminoma (1162765005)
 
Monarch Initiative: MONDO:0003001
OMIM®: 273300

Definition

A radiosensitive malignant germ cell tumor found in the testis (especially undescended), and extragonadal sites (anterior mediastinum and pineal gland). It is characterized by the presence of uniform cells with clear or dense cytoplasm which contains glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic germ cells form aggregates separated by fibrous septa. The fibrous septa contain chronic inflammatory cells, mainly lymphocytes. [from NCI]

Professional guidelines

PubMed

Alsyouf M, Daneshmand S
World J Urol 2022 Feb;40(2):343-348. Epub 2021 Oct 16 doi: 10.1007/s00345-021-03854-8. PMID: 34655305
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Smith ZL, Werntz RP, Eggener SE
Med Clin North Am 2018 Mar;102(2):251-264. Epub 2017 Dec 21 doi: 10.1016/j.mcna.2017.10.003. PMID: 29406056

Recent clinical studies

Etiology

Maroto P, Anguera G, Martin C
Crit Rev Oncol Hematol 2018 Jan;121:62-67. Epub 2017 Nov 26 doi: 10.1016/j.critrevonc.2017.11.015. PMID: 29279100
Nappi L, Nichols CR, Kollmannsberger CK
Clin Adv Hematol Oncol 2017 Aug;15(8):626-631. PMID: 28949950
Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA
Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2 doi: 10.1148/rg.2017160164. PMID: 28574809Free PMC Article
Pearce SM, Liauw SL, Eggener SE
Urol Clin North Am 2015 Aug;42(3):287-98. Epub 2015 Jun 6 doi: 10.1016/j.ucl.2015.04.003. PMID: 26216816
MacVicar GR, Pienta KJ
Curr Opin Oncol 2004 May;16(3):253-6. doi: 10.1097/00001622-200405000-00011. PMID: 15069322

Diagnosis

Pierorazio PM, Biles MJ
Urol Clin North Am 2019 Aug;46(3):399-407. Epub 2019 May 21 doi: 10.1016/j.ucl.2019.04.005. PMID: 31277734
Nappi L, Nichols CR, Kollmannsberger CK
Clin Adv Hematol Oncol 2017 Aug;15(8):626-631. PMID: 28949950
Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA
Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2 doi: 10.1148/rg.2017160164. PMID: 28574809Free PMC Article
Aggarwal N, Parwani AV
Arch Pathol Lab Med 2009 Dec;133(12):1985-8. doi: 10.5858/133.12.1985. PMID: 19961257
Brock D, Fox S, Gosling G, Haney L, Kneebone P, Nagy C, Qualitza B
Semin Oncol Nurs 1993 Nov;9(4):224-36. doi: 10.1016/s0749-2081(05)80051-8. PMID: 8290818

Therapy

Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Wood GE, Chamberlain F, Tran B, Conduit C, Liow E, Nicol DL, Shamash J, Alifrangis C, Rajan P
Nat Rev Urol 2023 Aug;20(8):502-512. Epub 2023 Mar 7 doi: 10.1038/s41585-023-00727-0. PMID: 36882564
Alsyouf M, Daneshmand S
World J Urol 2022 Feb;40(2):343-348. Epub 2021 Oct 16 doi: 10.1007/s00345-021-03854-8. PMID: 34655305
Pearce SM, Liauw SL, Eggener SE
Urol Clin North Am 2015 Aug;42(3):287-98. Epub 2015 Jun 6 doi: 10.1016/j.ucl.2015.04.003. PMID: 26216816
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Prognosis

Oldenburg J, Berney DM, Bokemeyer C, Climent MA, Daugaard G, Gietema JA, De Giorgi U, Haugnes HS, Huddart RA, Leão R, Sohaib A, Gillessen S, Powles T; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; EURACAN
Ann Oncol 2022 Apr;33(4):362-375. Epub 2022 Jan 19 doi: 10.1016/j.annonc.2022.01.002. PMID: 35065204
Stevenson SM, Lowrance WT
Urol Clin North Am 2015 Aug;42(3):269-75. Epub 2015 Jun 11 doi: 10.1016/j.ucl.2015.04.001. PMID: 26216814
Sokoloff MH, Joyce GF, Wise M; Urologic Diseases in America Project
J Urol 2007 Jun;177(6):2030-41. doi: 10.1016/j.juro.2007.01.127. PMID: 17509283
Forman D, Møller H
Cancer Surv 1994;19-20:323-41. PMID: 7534631
Reddy EK, Burke M, Giri S, Krishnan L, Gemer L, Evans R, Mebust WK, Wiegel J
J Natl Med Assoc 1990 Sep;82(9):651-5. PMID: 2120460Free PMC Article

Clinical prediction guides

von Amsberg G, Hamilton R, Papachristofilou A
Oncol Res Treat 2018;41(6):360-363. Epub 2018 May 16 doi: 10.1159/000489408. PMID: 29763926
Nappi L, Nichols CR, Kollmannsberger CK
Clin Adv Hematol Oncol 2017 Aug;15(8):626-631. PMID: 28949950
Neal RD, Stuart N, Wilkinson C
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454048Free PMC Article
MacVicar GR, Pienta KJ
Curr Opin Oncol 2004 May;16(3):253-6. doi: 10.1097/00001622-200405000-00011. PMID: 15069322
Forman D, Møller H
Cancer Surv 1994;19-20:323-41. PMID: 7534631

Recent systematic reviews

Heinzelbecker J, Schmidt S, Lackner J, Busch J, Bokemeyer C, Classen J, Dieing A, Hakenberg O, Krege S, Papachristofilou A, Pfister D, Ruf C, Schmelz H, Schmidberger H, Souchon R, Winter C, Zengerling F, Kliesch S, Albers P, Oing C
World J Urol 2022 Dec;40(12):2829-2841. Epub 2021 Nov 15 doi: 10.1007/s00345-021-03873-5. PMID: 34779882Free PMC Article
Bräuner EV, Lim YH, Koch T, Uldbjerg CS, Gregersen LS, Pedersen MK, Frederiksen H, Petersen JH, Coull BA, Andersson AM, Hickey M, Skakkebæk NE, Hauser R, Juul A
J Clin Endocrinol Metab 2021 Nov 19;106(12):e4834-e4860. doi: 10.1210/clinem/dgab523. PMID: 34270734Free PMC Article
Gurney J, Shaw C, Stanley J, Signal V, Sarfati D
BMC Cancer 2015 Nov 11;15:897. doi: 10.1186/s12885-015-1905-6. PMID: 26560314Free PMC Article
Chung P, Warde P
BMJ Clin Evid 2011 Jan 25;2011 PMID: 21477387Free PMC Article
Neal RD, Stuart N, Wilkinson C
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454048Free PMC Article

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