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Silicotuberculosis

MedGen UID:
11426
•Concept ID:
C0037118
•
Disease or Syndrome
Synonym: Silicotuberculoses
SNOMED CT: Silicotuberculosis (233763009)
 
Monarch Initiative: MONDO:0021804

Definition

Tuberculosis caused by the infection of Mycobacterium tuberculosis in patients with silicosis (that is caused by inhalation of silica dust particles). The risk of a patient with silicosis developing pulmonary tuberculosis and extra-pulmonary tuberculosis is higher than in healthy population. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSilicotuberculosis

Professional guidelines

PubMed

A mixed-methods study on impact of silicosis on tuberculosis treatment outcomes and need for TB-silicosis collaborative activities in India.
Rupani MP
Sci Rep 2023 Feb 16;13(1):2785. doi: 10.1038/s41598-023-30012-4. PMID: 36797362Free PMC Article
A rapid point of care CC16 kit for screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis.
Nandi SS, Lambe UP, Sarkar K, Sawant S, Deshpande J
Sci Rep 2021 Dec 6;11(1):23485. doi: 10.1038/s41598-021-02392-y. PMID: 34873200Free PMC Article
DIAGNOSIS, TREATMENT AND PROPHYLAXIS IN SILICOTICS.
APPELMAN AC
Bull Int Union Tuberc 1964 Sep;35:39-41. PMID: 14269403

Recent clinical studies

Etiology

Silicosis: New Challenges from an Old Inflammatory and Fibrotic Disease.
Handra CM, Gurzu IL, Chirila M, Ghita I
Front Biosci (Landmark Ed) 2023 May 22;28(5):96. doi: 10.31083/j.fbl2805096. PMID: 37258484
Silica-associated lung disease in developing countries.
Dhooria S, Sehgal IS, Agarwal R
Curr Opin Pulm Med 2023 Mar 1;29(2):65-75. Epub 2022 Dec 29 doi: 10.1097/MCP.0000000000000940. PMID: 36695765
Farewell, king coal!
Seaton A
Thorax 2016 Apr;71(4):364-6. Epub 2016 Feb 8 doi: 10.1136/thoraxjnl-2016-208339. PMID: 26856364
Tuberculosis and silicosis: epidemiology, diagnosis and chemoprophylaxis.
Barboza CE, Winter DH, Seiscento M, Santos Ude P, Terra Filho M
J Bras Pneumol 2008 Nov;34(11):959-66. doi: 10.1590/s1806-37132008001100012. PMID: 19099104
Short-course chemotherapy for silicotuberculosis.
Escreet BC, Langton ME, Cowie RL
S Afr Med J 1984 Sep 1;66(9):327-30. PMID: 6382640

Diagnosis

Tuberculosis and silicosis: epidemiology, diagnosis and chemoprophylaxis.
Barboza CE, Winter DH, Seiscento M, Santos Ude P, Terra Filho M
J Bras Pneumol 2008 Nov;34(11):959-66. doi: 10.1590/s1806-37132008001100012. PMID: 19099104
Dust-induced interstitial lung disease in the tropics.
Jindal SK, Aggarwal AN, Gupta D
Curr Opin Pulm Med 2001 Sep;7(5):272-7. doi: 10.1097/00063198-200109000-00004. PMID: 11584175
Silicosis and tuberculosis.
Morgan EJ
Chest 1979 Feb;75(2):202-3. doi: 10.1378/chest.75.2.202. PMID: 421560
OPEN LUNG BIOPSY.
DELARUE NC, STRANGWAY DW
Can Med Assoc J 1964 Aug 8;91(6):271-81. PMID: 14180532Free PMC Article
SILICOSIS AND TUBERCULOSIS.
SCHEPERS GW
Ind Med Surg 1964 Jun;33:381-99. PMID: 14173954

Therapy

Silicosis: New Challenges from an Old Inflammatory and Fibrotic Disease.
Handra CM, Gurzu IL, Chirila M, Ghita I
Front Biosci (Landmark Ed) 2023 May 22;28(5):96. doi: 10.31083/j.fbl2805096. PMID: 37258484
Silica-associated lung disease in developing countries.
Dhooria S, Sehgal IS, Agarwal R
Curr Opin Pulm Med 2023 Mar 1;29(2):65-75. Epub 2022 Dec 29 doi: 10.1097/MCP.0000000000000940. PMID: 36695765
Farewell, king coal!
Seaton A
Thorax 2016 Apr;71(4):364-6. Epub 2016 Feb 8 doi: 10.1136/thoraxjnl-2016-208339. PMID: 26856364
Short-course chemotherapy for silicotuberculosis.
Escreet BC, Langton ME, Cowie RL
S Afr Med J 1984 Sep 1;66(9):327-30. PMID: 6382640
Silicosis and tuberculosis.
Morgan EJ
Chest 1979 Feb;75(2):202-3. doi: 10.1378/chest.75.2.202. PMID: 421560

Prognosis

Silicosis: New Challenges from an Old Inflammatory and Fibrotic Disease.
Handra CM, Gurzu IL, Chirila M, Ghita I
Front Biosci (Landmark Ed) 2023 May 22;28(5):96. doi: 10.31083/j.fbl2805096. PMID: 37258484
Silica-associated lung disease in developing countries.
Dhooria S, Sehgal IS, Agarwal R
Curr Opin Pulm Med 2023 Mar 1;29(2):65-75. Epub 2022 Dec 29 doi: 10.1097/MCP.0000000000000940. PMID: 36695765
Farewell, king coal!
Seaton A
Thorax 2016 Apr;71(4):364-6. Epub 2016 Feb 8 doi: 10.1136/thoraxjnl-2016-208339. PMID: 26856364
Short-course chemotherapy for silicotuberculosis.
Escreet BC, Langton ME, Cowie RL
S Afr Med J 1984 Sep 1;66(9):327-30. PMID: 6382640
OPEN LUNG BIOPSY.
DELARUE NC, STRANGWAY DW
Can Med Assoc J 1964 Aug 8;91(6):271-81. PMID: 14180532Free PMC Article

Clinical prediction guides

Computer-aided detection for tuberculosis and silicosis in chest radiographs of gold miners of South Africa.
Young C, Barker S, Ehrlich R, Kistnasamy B, Yassi A
Int J Tuberc Lung Dis 2020 Apr 1;24(4):444-451. doi: 10.5588/ijtld.19.0624. PMID: 32317070
Silicotuberculosis with Esophagobronchial Fistula and Broncholithiasis.
Zhang H, Li L, Sun XW, Zhang CL
Int J Occup Environ Med 2017 Jan;8(1):50-55. doi: 10.15171/ijoem.2017.822. PMID: 28051197Free PMC Article
Farewell, king coal!
Seaton A
Thorax 2016 Apr;71(4):364-6. Epub 2016 Feb 8 doi: 10.1136/thoraxjnl-2016-208339. PMID: 26856364
The pathologist's view of silicosis in 1930 and in 2015. The Johannesburg Conference legacy.
Kambouchner M, Bernaudin JF
Am J Ind Med 2015 Nov;58 Suppl 1:S48-58. doi: 10.1002/ajim.22506. PMID: 26509753
Mortality experience of haematite mine workers in China.
Chen SY, Hayes RB, Liang SR, Li QG, Stewart PA, Blair A
Br J Ind Med 1990 Mar;47(3):175-81. doi: 10.1136/oem.47.3.175. PMID: 2328225Free PMC Article

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