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Ependymal tumor of brain

MedGen UID:
116038
•Concept ID:
C0238029
•
Neoplastic Process
Synonyms: Brain Ependymal Tumor; brain ependymal tumor; brain ependymal tumour; brain ependymoma; Ependymal Tumor of Brain; ependymal tumor of brain; Ependymoma of brain; ependymoma of brain
SNOMED CT: Ependymoma of brain (254939008); Ependymal tumor of brain (254939008)
 
Monarch Initiative: MONDO:0004245

Definition

A finding indicating the presence of an ependymal tumor in the brain. [from NCI]

Professional guidelines

PubMed

Primary intraventricular tumors - Imaging characteristics, post-treatment changes and relapses.
Chong AW, McAdory LE, Low DCY, Lim EJ, Leong NWL, Ho CL
Clin Imaging 2022 Feb;82:38-52. Epub 2021 Oct 29 doi: 10.1016/j.clinimag.2021.10.008. PMID: 34773811
Differential Diagnosis of Central Neurocytoma: Two Cases.
Steinsiepe VK, Frick H, Jochum W, Fournier JY
J Neurol Surg A Cent Eur Neurosurg 2021 Nov;82(6):599-603. Epub 2020 Dec 22 doi: 10.1055/s-0040-1718693. PMID: 33352608
EANO guidelines for the diagnosis and treatment of ependymal tumors.
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article

Recent clinical studies

Etiology

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Ependymal Tumors.
Santi M, Viaene AN, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):59-67. doi: 10.1177/10935266211018928. PMID: 35168420
Histologic classification of gliomas.
Perry A, Wesseling P
Handb Clin Neurol 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. PMID: 26948349
Glioma.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790

Diagnosis

Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours.
Horbinski C, Berger T, Packer RJ, Wen PY
Nat Rev Neurol 2022 Sep;18(9):515-529. Epub 2022 Jun 21 doi: 10.1038/s41582-022-00679-w. PMID: 35729337
Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Ependymal Tumors.
Santi M, Viaene AN, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):59-67. doi: 10.1177/10935266211018928. PMID: 35168420
EANO guidelines for the diagnosis and treatment of ependymal tumors.
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article
Histologic classification of gliomas.
Perry A, Wesseling P
Handb Clin Neurol 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. PMID: 26948349

Therapy

Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours.
Horbinski C, Berger T, Packer RJ, Wen PY
Nat Rev Neurol 2022 Sep;18(9):515-529. Epub 2022 Jun 21 doi: 10.1038/s41582-022-00679-w. PMID: 35729337
Involvement of Phytochemical-Encapsulated Nanoparticles' Interaction with Cellular Signalling in the Amelioration of Benign and Malignant Brain Tumours.
Mehan S, Arora N, Bhalla S, Khan A, U Rehman M, Alghamdi BS, Zughaibi TA, Ashraf GM
Molecules 2022 Jun 1;27(11) doi: 10.3390/molecules27113561. PMID: 35684498Free PMC Article
Recent Advances in the Classification and Treatment of Ependymomas.
Leeper H, Felicella MM, Walbert T
Curr Treat Options Oncol 2017 Aug 10;18(9):55. doi: 10.1007/s11864-017-0496-7. PMID: 28795287
Epidemiology and etiology of gliomas.
Ohgaki H, Kleihues P
Acta Neuropathol 2005 Jan;109(1):93-108. Epub 2005 Feb 1 doi: 10.1007/s00401-005-0991-y. PMID: 15685439
Oncolytic viral therapy and immunotherapy of malignant brain tumors: two potential new approaches of translational research.
Lou E
Ann Med 2004;36(1):2-8. doi: 10.1080/07853890310016315. PMID: 15000342

Prognosis

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Ependymal Tumors.
Santi M, Viaene AN, Hawkins C
Pediatr Dev Pathol 2022 Jan-Feb;25(1):59-67. doi: 10.1177/10935266211018928. PMID: 35168420
EANO guidelines for the diagnosis and treatment of ependymal tumors.
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article
Histologic classification of gliomas.
Perry A, Wesseling P
Handb Clin Neurol 2016;134:71-95. doi: 10.1016/B978-0-12-802997-8.00005-0. PMID: 26948349
Glioma.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790

Clinical prediction guides

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Genomic Molecular Classification of CNS Malignancies.
Spino M, Snuderl M
Adv Anat Pathol 2020 Jan;27(1):44-50. doi: 10.1097/PAP.0000000000000254. PMID: 31714292
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz HJ, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM
Cancer Cell 2015 May 11;27(5):728-43. doi: 10.1016/j.ccell.2015.04.002. PMID: 25965575Free PMC Article
Glioma diagnosis: immunohistochemistry and beyond.
Dunbar E, Yachnis AT
Adv Anat Pathol 2010 May;17(3):187-201. doi: 10.1097/PAP.0b013e3181d98cd9. PMID: 20418673
Classification and controversies in pathology of ependymomas.
Godfraind C
Childs Nerv Syst 2009 Oct;25(10):1185-93. Epub 2009 Feb 11 doi: 10.1007/s00381-008-0804-4. PMID: 19212775

Recent systematic reviews

Adjuvant radiotherapy versus observation after gross total resection of WHO grade II ependymoma: a systematic review and individual-participant data meta-analysis.
Zheng Y, Ong SH, Nga VDW, Vellayappan B
Chin Clin Oncol 2024 Apr;13(2):22. Epub 2024 Apr 17 doi: 10.21037/cco-23-136. PMID: 38644544
The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis.
Salari N, Ghasemi H, Fatahian R, Mansouri K, Dokaneheifard S, Shiri MH, Hemmati M, Mohammadi M
Eur J Med Res 2023 Jan 20;28(1):39. doi: 10.1186/s40001-023-01011-y. PMID: 36670466Free PMC Article
Neuroimaging features of diffuse hemispheric glioma, H3 G34-mutant: A case series and systematic review.
Kurokawa R, Baba A, Kurokawa M, Pinarbasi ES, Makise N, Ota Y, Kim J, Srinivasan A, Moritani T
J Neuroimaging 2022 Jan;32(1):17-27. Epub 2021 Oct 11 doi: 10.1111/jon.12939. PMID: 34632671
Ependymal fluorescence in fluorescence-guided resection of malignant glioma: a systematic review.
Müther M, Stummer W
Acta Neurochir (Wien) 2020 Feb;162(2):365-372. Epub 2019 Nov 21 doi: 10.1007/s00701-019-04144-4. PMID: 31754847
Rapamycin and rapalogs for tuberous sclerosis complex.
Sasongko TH, Ismail NF, Zabidi-Hussin Z
Cochrane Database Syst Rev 2016 Jul 13;7(7):CD011272. doi: 10.1002/14651858.CD011272.pub2. PMID: 27409709Free PMC Article

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