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Metastatic Carcinoma in the Lung

MedGen UID:
116051
•Concept ID:
C0238254
•
Neoplastic Process
Synonyms: Metastatic Carcinoma to the Lung; Secondary Lung Cancer; Secondary Lung Carcinoma

Definition

The spread of a carcinoma to the lung. This may be from a primary lung carcinoma, or from a carcinoma at a distant anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Carcinoma in the Lung

Professional guidelines

PubMed

Cell death-based treatment of lung adenocarcinoma.
Denisenko TV, Budkevich IN, Zhivotovsky B
Cell Death Dis 2018 Jan 25;9(2):117. doi: 10.1038/s41419-017-0063-y. PMID: 29371589Free PMC Article
Management of toxicities of immune checkpoint inhibitors.
Spain L, Diem S, Larkin J
Cancer Treat Rev 2016 Mar;44:51-60. Epub 2016 Feb 6 doi: 10.1016/j.ctrv.2016.02.001. PMID: 26874776
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Cemiplimab Plus Chemotherapy Versus Chemotherapy Alone in Advanced NSCLC: 2-Year Follow-Up From the Phase 3 EMPOWER-Lung 3 Part 2 Trial.
Makharadze T, Gogishvili M, Melkadze T, Baramidze A, Giorgadze D, Penkov K, Laktionov K, Nemsadze G, Nechaeva M, Rozhkova I, Kalinka E, Li S, Li Y, Kaul M, Quek RGW, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
J Thorac Oncol 2023 Jun;18(6):755-768. Epub 2023 Mar 29 doi: 10.1016/j.jtho.2023.03.008. PMID: 37001859
Explanted malignancies after lung transplantation: the University of Michigan experience.
Mondoñedo JR, Huang T, Lin J, Wakeam E
Interact Cardiovasc Thorac Surg 2022 Jul 9;35(2) doi: 10.1093/icvts/ivac203. PMID: 35877066Free PMC Article
Long-Term Prognosis of Patients With Resected Adenocarcinoma In Situ and Minimally Invasive Adenocarcinoma of the Lung.
Yotsukura M, Asamura H, Motoi N, Kashima J, Yoshida Y, Nakagawa K, Shiraishi K, Kohno T, Yatabe Y, Watanabe SI
J Thorac Oncol 2021 Aug;16(8):1312-1320. Epub 2021 Apr 27 doi: 10.1016/j.jtho.2021.04.007. PMID: 33915249
NUT Midline Carcinoma of the Lung: Computed Tomography Findings in 10 Patients.
Chang AI, Kim TS, Han J, Kim TJ, Choi JY
J Comput Assist Tomogr 2021 Mar-Apr 01;45(2):330-336. doi: 10.1097/RCT.0000000000001133. PMID: 33661151
Recent advances in the molecular landscape of lung neuroendocrine tumors.
Pelosi G, Bianchi F, Hofman P, Pattini L, Ströbel P, Calabrese F, Naheed S, Holden C, Cave J, Bohnenberger H, Dinter H, Harari S, Albini A, Sonzogni A, Papotti M, Volante M, Ottensmeier CH
Expert Rev Mol Diagn 2019 Apr;19(4):281-297. Epub 2019 Mar 27 doi: 10.1080/14737159.2019.1595593. PMID: 30900485

Diagnosis

The potential use of miRNAs in the diagnosis and prediction of metastatic lung carcinoma.
Skaličanová M, Matáková T, Dzian A, Halašová E, Duffek M, Škereňová M, Šarlinová M
Gen Physiol Biophys 2022 Sep;41(5):393-405. doi: 10.4149/gpb_2022034. PMID: 36222338
Challenging Diagnosis in NUT Carcinoma.
Claudia G, Alexandra G
Int J Surg Pathol 2021 Oct;29(7):722-725. Epub 2021 Jun 9 doi: 10.1177/10668969211019532. PMID: 34106022Free PMC Article
Unusual cutaneous metastatic carcinoma.
Ruiz SJ, Al Salihi S, Prieto VG, Nagarajan P, Tetzlaff MT, Curry JL, Ivan D, Torres-Cabala CA, Aung PP
Ann Diagn Pathol 2019 Dec;43:151399. Epub 2019 Aug 12 doi: 10.1016/j.anndiagpath.2019.08.003. PMID: 31675677
Pathologic differential diagnosis of metastatic carcinoma in the liver.
Park JH, Kim JH
Clin Mol Hepatol 2019 Mar;25(1):12-20. Epub 2018 Oct 5 doi: 10.3350/cmh.2018.0067. PMID: 30300991Free PMC Article
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Therapy

Cemiplimab Plus Chemotherapy Versus Chemotherapy Alone in Advanced NSCLC: 2-Year Follow-Up From the Phase 3 EMPOWER-Lung 3 Part 2 Trial.
Makharadze T, Gogishvili M, Melkadze T, Baramidze A, Giorgadze D, Penkov K, Laktionov K, Nemsadze G, Nechaeva M, Rozhkova I, Kalinka E, Li S, Li Y, Kaul M, Quek RGW, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
J Thorac Oncol 2023 Jun;18(6):755-768. Epub 2023 Mar 29 doi: 10.1016/j.jtho.2023.03.008. PMID: 37001859
Nivolumab Plus Ipilimumab vs Nivolumab for Previously Treated Patients With Stage IV Squamous Cell Lung Cancer: The Lung-MAP S1400I Phase 3 Randomized Clinical Trial.
Gettinger SN, Redman MW, Bazhenova L, Hirsch FR, Mack PC, Schwartz LH, Bradley JD, Stinchcombe TE, Leighl NB, Ramalingam SS, Tavernier SS, Yu H, Unger JM, Minichiello K, Highleyman L, Papadimitrakopoulou VA, Kelly K, Gandara DR, Herbst RS
JAMA Oncol 2021 Sep 1;7(9):1368-1377. doi: 10.1001/jamaoncol.2021.2209. PMID: 34264316Free PMC Article
Commonwealth Neuroendocrine Tumour Research Collaboration and the North American Neuroendocrine Tumor Society Guidelines for the Diagnosis and Management of Patients With Lung Neuroendocrine Tumors: An International Collaborative Endorsement and Update of the 2015 European Neuroendocrine Tumor Society Expert Consensus Guidelines.
Singh S, Bergsland EK, Card CM, Hope TA, Kunz PL, Laidley DT, Lawrence B, Leyden S, Metz DC, Michael M, Modahl LE, Myrehaug S, Padda SK, Pommier RF, Ramirez RA, Soulen M, Strosberg J, Sung A, Thawer A, Wei B, Xu B, Segelov E
J Thorac Oncol 2020 Oct;15(10):1577-1598. Epub 2020 Jul 11 doi: 10.1016/j.jtho.2020.06.021. PMID: 32663527
Current and Emerging Therapies in Metastatic Pancreatic Cancer.
Manji GA, Olive KP, Saenger YM, Oberstein P
Clin Cancer Res 2017 Apr 1;23(7):1670-1678. doi: 10.1158/1078-0432.CCR-16-2319. PMID: 28373365
Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group.
Ginsberg RJ, Rubinstein LV
Ann Thorac Surg 1995 Sep;60(3):615-22; discussion 622-3. doi: 10.1016/0003-4975(95)00537-u. PMID: 7677489

Prognosis

Cemiplimab Plus Chemotherapy Versus Chemotherapy Alone in Advanced NSCLC: 2-Year Follow-Up From the Phase 3 EMPOWER-Lung 3 Part 2 Trial.
Makharadze T, Gogishvili M, Melkadze T, Baramidze A, Giorgadze D, Penkov K, Laktionov K, Nemsadze G, Nechaeva M, Rozhkova I, Kalinka E, Li S, Li Y, Kaul M, Quek RGW, Pouliot JF, Seebach F, Lowy I, Gullo G, Rietschel P
J Thorac Oncol 2023 Jun;18(6):755-768. Epub 2023 Mar 29 doi: 10.1016/j.jtho.2023.03.008. PMID: 37001859
Recent updates in salivary gland tumors of the lung.
Roden AC
Semin Diagn Pathol 2021 Sep;38(5):98-108. Epub 2021 Mar 11 doi: 10.1053/j.semdp.2021.03.001. PMID: 33744018
NUT Midline Carcinoma of the Lung: Computed Tomography Findings in 10 Patients.
Chang AI, Kim TS, Han J, Kim TJ, Choi JY
J Comput Assist Tomogr 2021 Mar-Apr 01;45(2):330-336. doi: 10.1097/RCT.0000000000001133. PMID: 33661151
Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group.
Ginsberg RJ, Rubinstein LV
Ann Thorac Surg 1995 Sep;60(3):615-22; discussion 622-3. doi: 10.1016/0003-4975(95)00537-u. PMID: 7677489
Bronchioloalveolar carcinoma.
Epstein DM
Semin Roentgenol 1990 Jan;25(1):105-11. doi: 10.1016/0037-198x(90)90040-b. PMID: 2157287

Clinical prediction guides

Genomic and epigenomic profiles distinguish pulmonary enteric adenocarcinoma from lung metastatic colorectal cancer.
Zuo Y, Zhong J, Bai H, Xu B, Wang Z, Li W, Chen Y, Jin S, Wang S, Wang X, Wan R, Xu J, Fei K, Han J, Yang Z, Bao H, Shao Y, Ying J, Song Q, Duan J, Wang J
EBioMedicine 2022 Aug;82:104165. Epub 2022 Jul 26 doi: 10.1016/j.ebiom.2022.104165. PMID: 35901658Free PMC Article
Metastatic lung carcinoma in thyroid aspirates: A case series and literature review illustrating diagnostic challenges.
Ng JKM, Li JJX
Cytopathology 2022 Nov;33(6):696-706. Epub 2022 Jul 26 doi: 10.1111/cyt.13164. PMID: 35808980
Recent updates in salivary gland tumors of the lung.
Roden AC
Semin Diagn Pathol 2021 Sep;38(5):98-108. Epub 2021 Mar 11 doi: 10.1053/j.semdp.2021.03.001. PMID: 33744018
Incidence and treatment of brain metastasis in patients with esophageal carcinoma.
Feng W, Zhang P, Zheng X, Chen M, Mao WM
World J Gastroenterol 2015 May 21;21(19):5805-12. doi: 10.3748/wjg.v21.i19.5805. PMID: 26019444Free PMC Article
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Genomic Alterations and the Incidence of Brain Metastases in Advanced and Metastatic NSCLC: A Systematic Review and Meta-Analysis.
Gillespie CS, Mustafa MA, Richardson GE, Alam AM, Lee KS, Hughes DM, Escriu C, Zakaria R
J Thorac Oncol 2023 Dec;18(12):1703-1713. Epub 2023 Jun 29 doi: 10.1016/j.jtho.2023.06.017. PMID: 37392903
Cannabis-based medicines and medical cannabis for adults with cancer pain.
Häuser W, Welsch P, Radbruch L, Fisher E, Bell RF, Moore RA
Cochrane Database Syst Rev 2023 Jun 5;6(6):CD014915. doi: 10.1002/14651858.CD014915.pub2. PMID: 37283486Free PMC Article
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Uncommon EGFR mutations in non-small-cell lung cancer: A systematic literature review of prevalence and clinical outcomes.
John T, Taylor A, Wang H, Eichinger C, Freeman C, Ahn MJ
Cancer Epidemiol 2022 Feb;76:102080. Epub 2021 Dec 15 doi: 10.1016/j.canep.2021.102080. PMID: 34922050
Preoperative chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual participant data.
NSCLC Meta-analysis Collaborative Group
Lancet 2014 May 3;383(9928):1561-71. Epub 2014 Feb 25 doi: 10.1016/S0140-6736(13)62159-5. PMID: 24576776Free PMC Article

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