U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Adrenal Cortical Carcinoma

MedGen UID:
124515
•Concept ID:
C0278818
•
Neoplastic Process
Synonyms: Recurrent Adrenal Cortex Cancer; Recurrent Adrenal Cortex Carcinoma; Recurrent Adrenocortical Carcinoma; Recurrent Carcinoma of Adrenal Cortex; Recurrent Carcinoma of the Adrenal Cortex; Relapsed Adrenal Cortex Carcinoma; Relapsed Adrenocortical Carcinoma; Relapsed Carcinoma of Adrenal Cortex; Relapsed Carcinoma of the Adrenal Cortex

Definition

The reemergence of adrenal cortical carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Adrenal Cortical Carcinoma

Professional guidelines

PubMed

American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
New perspectives for mitotane treatment of adrenocortical carcinoma.
Puglisi S, Calabrese A, Basile V, Pia A, Reimondo G, Perotti P, Terzolo M
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101415. Epub 2020 Mar 5 doi: 10.1016/j.beem.2020.101415. PMID: 32179008
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884

Recent clinical studies

Etiology

Adrenocortical carcinoma: current treatment options.
De Filpo G, Mannelli M, Canu L
Curr Opin Oncol 2021 Jan;33(1):16-22. doi: 10.1097/CCO.0000000000000695. PMID: 33186181
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
New perspectives for mitotane treatment of adrenocortical carcinoma.
Puglisi S, Calabrese A, Basile V, Pia A, Reimondo G, Perotti P, Terzolo M
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101415. Epub 2020 Mar 5 doi: 10.1016/j.beem.2020.101415. PMID: 32179008
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884

Diagnosis

American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
Surgery for adrenocortical carcinoma: When and how?
Sinclair TJ, Gillis A, Alobuia WM, Wild H, Kebebew E
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101408. Epub 2020 Mar 3 doi: 10.1016/j.beem.2020.101408. PMID: 32265101
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
Surgical approaches in hereditary endocrine tumors.
Iacobone M, Citton M, Viel G, Schiavone D, Torresan F
Updates Surg 2017 Jun;69(2):181-191. Epub 2017 Apr 28 doi: 10.1007/s13304-017-0451-y. PMID: 28455835
Malignant adrenal tumors.
Rescorla FJ
Semin Pediatr Surg 2006 Feb;15(1):48-56. doi: 10.1053/j.sempedsurg.2005.11.008. PMID: 16458846

Therapy

CDK1 serves as a therapeutic target of adrenocortical carcinoma via regulating epithelial-mesenchymal transition, G2/M phase transition, and PANoptosis.
Ren L, Yang Y, Li W, Zheng X, Liu J, Li S, Yang H, Zhang Y, Ge B, Zhang S, Fu W, Dong D, Du G, Wang J
J Transl Med 2022 Oct 2;20(1):444. doi: 10.1186/s12967-022-03641-y. PMID: 36184616Free PMC Article
American Association of Clinical Endocrinology Disease State Clinical Review on the Evaluation and Management of Adrenocortical Carcinoma in an Adult: a Practical Approach.
Kiseljak-Vassiliades K, Bancos I, Hamrahian A, Habra M, Vaidya A, Levine AC, Else T
Endocr Pract 2020 Nov;26(11):1366-1383. Epub 2020 Dec 14 doi: 10.4158/DSCR-2020-0567. PMID: 33875173Free PMC Article
New perspectives for mitotane treatment of adrenocortical carcinoma.
Puglisi S, Calabrese A, Basile V, Pia A, Reimondo G, Perotti P, Terzolo M
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101415. Epub 2020 Mar 5 doi: 10.1016/j.beem.2020.101415. PMID: 32179008
Adrenocortical Cancer Treatment.
Long SE, Miller BS
Surg Clin North Am 2019 Aug;99(4):759-771. Epub 2019 May 27 doi: 10.1016/j.suc.2019.04.012. PMID: 31255205
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884

Prognosis

Surgery for adrenocortical carcinoma: When and how?
Sinclair TJ, Gillis A, Alobuia WM, Wild H, Kebebew E
Best Pract Res Clin Endocrinol Metab 2020 May;34(3):101408. Epub 2020 Mar 3 doi: 10.1016/j.beem.2020.101408. PMID: 32265101
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Adrenocortical Cancer Treatment.
Long SE, Miller BS
Surg Clin North Am 2019 Aug;99(4):759-771. Epub 2019 May 27 doi: 10.1016/j.suc.2019.04.012. PMID: 31255205
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
Malignant adrenal tumors.
Rescorla FJ
Semin Pediatr Surg 2006 Feb;15(1):48-56. doi: 10.1053/j.sempedsurg.2005.11.008. PMID: 16458846

Clinical prediction guides

Multimodality Imaging of Abdominopelvic Tumors with Venous Invasion.
LeGout JD, Bailey RE, Bolan CW, Bowman AW, Chen F, Cernigliaro JG, Alexander LF
Radiographics 2020 Nov-Dec;40(7):2098-2116. Epub 2020 Oct 16 doi: 10.1148/rg.2020200047. PMID: 33064623
Recurrent hepatocellular carcinoma and non-classic adreno-genital syndrome.
Vergani E, Bruno C, Raimondo S, Macis G, Vecchio FM, Riccardi L, Ponziani FR, Pompili M, Mancini A
Eur Rev Med Pharmacol Sci 2020 Apr;24(8):4172-4179. doi: 10.26355/eurrev_202004_20997. PMID: 32373953
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Fassnacht M, Dekkers OM, Else T, Baudin E, Berruti A, de Krijger R, Haak HR, Mihai R, Assie G, Terzolo M
Eur J Endocrinol 2018 Oct 1;179(4):G1-G46. doi: 10.1530/EJE-18-0608. PMID: 30299884
Adrenocortical Carcinoma: A Clinician's Perspective.
Elfiky A
Surg Pathol Clin 2015 Dec;8(4):751-4. doi: 10.1016/j.path.2015.07.002. PMID: 26612225

Recent systematic reviews

Operative Management of Recurrent and Metastatic Adrenocortical Carcinoma: A Systematic Review.
Lo WM, Kariya CM, Hernandez JM
Am Surg 2019 Jan 1;85(1):23-28. PMID: 30760340Free PMC Article
Influence of hormonal functional status on survival in adrenocortical carcinoma: systematic review and meta-analysis.
Vanbrabant T, Fassnacht M, Assie G, Dekkers OM
Eur J Endocrinol 2018 Dec 1;179(6):429-436. doi: 10.1530/EJE-18-0450. PMID: 30325179
Molecular Imaging in the Management of Adrenocortical Cancer: A Systematic Review.
Wong KK, Miller BS, Viglianti BL, Dwamena BA, Gauger PG, Cook GJ, Colletti PM, Rubello D, Gross MD
Clin Nucl Med 2016 Aug;41(8):e368-82. doi: 10.1097/RLU.0000000000001112. PMID: 26825212
Laparoscopic Adrenalectomy for Large Adrenocortical Carcinoma.
Machado NO, Al Qadhi H, Al Wahaibi K, Rizvi SG
JSLS 2015 Jul-Sep;19(3) doi: 10.4293/JSLS.2015.00036. PMID: 26175553Free PMC Article
Minimally invasive adrenalectomy in children.
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...