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Undifferentiated carcinoma of nasopharynx

MedGen UID:
124650
•Concept ID:
C0279748
•
Neoplastic Process
Synonyms: Lymphoepithelioma of Nasopharynx; lymphoepithelioma of nasopharynx; Lymphoepithelioma of the Nasopharynx; lymphoepithelioma of the nasopharynx; Nasopharyngeal Lymphoepithelial Carcinoma; Nasopharyngeal Lymphoepithelioma; nasopharyngeal lymphoepithelioma; Nasopharyngeal Nonkeratinizing Undifferentiated Carcinoma; nasopharyngeal nonkeratinizing undifferentiated carcinoma; Nasopharyngeal Undifferentiated Carcinoma; nasopharyngeal undifferentiated carcinoma; nasopharynx undifferentiated carcinoma; Undifferentiated Carcinoma of Nasopharynx; undifferentiated carcinoma of nasopharynx; Undifferentiated Carcinoma of the Nasopharynx; undifferentiated carcinoma of the nasopharynx; undifferentiated nasopharyngeal throat cancer
SNOMED CT: Undifferentiated carcinoma of nasopharynx (422541001)
 
Monarch Initiative: MONDO:0021537

Definition

A nonkeratinizing nasopharyngeal carcinoma characterized by the presence of large cells with vesicular nuclei and prominent nucleoli, a syncytial growth pattern, and a lymphoplasmacytic infiltrate. [from NCI]

Professional guidelines

PubMed

The Chinese Society of Clinical Oncology (CSCO) clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma.
Tang LL, Chen YP, Chen CB, Chen MY, Chen NY, Chen XZ, Du XJ, Fang WF, Feng M, Gao J, Han F, He X, Hu CS, Hu DS, Hu GY, Jiang H, Jiang W, Jin F, Lang JY, Li JG, Lin SJ, Liu X, Liu QF, Ma L, Mai HQ, Qin JY, Shen LF, Sun Y, Wang PG, Wang RS, Wang RZ, Wang XS, Wang Y, Wu H, Xia YF, Xiao SW, Yang KY, Yi JL, Zhu XD, Ma J
Cancer Commun (Lond) 2021 Nov;41(11):1195-1227. Epub 2021 Oct 26 doi: 10.1002/cac2.12218. PMID: 34699681Free PMC Article
Selection of lymph node target volumes for definitive head and neck radiation therapy: a 2019 Update.
Biau J, Lapeyre M, Troussier I, Budach W, Giralt J, Grau C, Kazmierska J, Langendijk JA, Ozsahin M, O'Sullivan B, Bourhis J, Grégoire V
Radiother Oncol 2019 May;134:1-9. Epub 2019 Jan 30 doi: 10.1016/j.radonc.2019.01.018. PMID: 31005201
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis.
Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, Hong RL, Chen MY, Chen L, Li WF, Huang PY, Tan T, Ngan RKC, Zhu G, Mai HQ, Hui EP, Fountzilas G, Zhang L, Carmel A, Kwong DLW, Moon J, Bourhis J, Auperin A, Pignon JP, Blanchard P; MAC-NPC Collaborative Group
Lancet Oncol 2023 Jun;24(6):611-623. doi: 10.1016/S1470-2045(23)00163-8. PMID: 37269842
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
Surgical Management of Oral Cancer.
Shanti RM, O'Malley BW Jr
Dent Clin North Am 2018 Jan;62(1):77-86. Epub 2017 Oct 16 doi: 10.1016/j.cden.2017.08.005. PMID: 29126495
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Diagnosis

Primary nasopharyngeal tuberculosis.
Misirovs R, Johnston L, Green R
BMJ Case Rep 2022 Dec 7;15(12) doi: 10.1136/bcr-2022-251927. PMID: 36593611Free PMC Article
Undifferentiated and dedifferentiated head and neck carcinomas.
Franchi A, Skalova A
Semin Diagn Pathol 2021 Nov;38(6):127-136. Epub 2021 Sep 26 doi: 10.1053/j.semdp.2021.09.001. PMID: 34583858
Head and neck cancer: Current challenges and future perspectives.
Bhat GR, Hyole RG, Li J
Adv Cancer Res 2021;152:67-102. Epub 2021 Jun 16 doi: 10.1016/bs.acr.2021.05.002. PMID: 34353444
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Nasopharyngeal carcinoma.
Worley NK, Miller RH
J La State Med Soc 1991 Nov;143(11):11-4. PMID: 1753177

Therapy

Immunotherapy for nasopharyngeal carcinoma: Current status and prospects (Review).
Huang H, Yao Y, Deng X, Huang Z, Chen Y, Wang Z, Hong H, Huang H, Lin T
Int J Oncol 2023 Aug;63(2) Epub 2023 Jul 7 doi: 10.3892/ijo.2023.5545. PMID: 37417358Free PMC Article
Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis.
Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, Hong RL, Chen MY, Chen L, Li WF, Huang PY, Tan T, Ngan RKC, Zhu G, Mai HQ, Hui EP, Fountzilas G, Zhang L, Carmel A, Kwong DLW, Moon J, Bourhis J, Auperin A, Pignon JP, Blanchard P; MAC-NPC Collaborative Group
Lancet Oncol 2023 Jun;24(6):611-623. doi: 10.1016/S1470-2045(23)00163-8. PMID: 37269842
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
Sasco AJ, Secretan MB, Straif K
Lung Cancer 2004 Aug;45 Suppl 2:S3-9. doi: 10.1016/j.lungcan.2004.07.998. PMID: 15552776

Prognosis

Perineural Invasion and Perineural Tumor Spread in Head and Neck Cancer.
Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS, Yom SS
Int J Radiat Oncol Biol Phys 2019 Apr 1;103(5):1109-1124. Epub 2018 Dec 15 doi: 10.1016/j.ijrobp.2018.12.009. PMID: 30562546
ACR Appropriateness criteria® for nasopharyngeal carcinoma.
Saba NF, Salama JK, Beitler JJ, Busse PM, Cooper JS, Jones CU, Koyfman S, Quon H, Ridge JA, Siddiqui F, Worden F, Yao M, Yom SS; Expert Panel on Radiation Oncology-Head and Neck Cancer
Head Neck 2016 Jul;38(7):979-86. Epub 2016 Apr 30 doi: 10.1002/hed.24423. PMID: 27131050
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article
Nasopharyngeal carcinoma.
Worley NK, Miller RH
J La State Med Soc 1991 Nov;143(11):11-4. PMID: 1753177

Clinical prediction guides

Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis.
Petit C, Lee A, Ma J, Lacas B, Ng WT, Chan ATC, Hong RL, Chen MY, Chen L, Li WF, Huang PY, Tan T, Ngan RKC, Zhu G, Mai HQ, Hui EP, Fountzilas G, Zhang L, Carmel A, Kwong DLW, Moon J, Bourhis J, Auperin A, Pignon JP, Blanchard P; MAC-NPC Collaborative Group
Lancet Oncol 2023 Jun;24(6):611-623. doi: 10.1016/S1470-2045(23)00163-8. PMID: 37269842
DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway.
Ding S, Gao Y, Lv D, Tao Y, Liu S, Chen C, Huang Z, Zheng S, Hu Y, Chow LK, Wei Y, Feng P, Dai W, Wang X, Xia Y
EBioMedicine 2022 Jul;81:104100. Epub 2022 Jun 8 doi: 10.1016/j.ebiom.2022.104100. PMID: 35689852Free PMC Article
Head and neck cancer: Current challenges and future perspectives.
Bhat GR, Hyole RG, Li J
Adv Cancer Res 2021;152:67-102. Epub 2021 Jun 16 doi: 10.1016/bs.acr.2021.05.002. PMID: 34353444
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Nasopharyngeal carcinoma: a review.
Petersson F
Semin Diagn Pathol 2015 Jan;32(1):54-73. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.021. PMID: 25769204

Recent systematic reviews

Imaging features, therapies, and outcomes of fibrosing inflammatory pseudotumor of the nasopharynx: A systematic review.
Mishra S, Suh CH, Bergmark RW, Jo VY, Miyawaki EK, Schoenfeld JD, Uppaluri R, Guenette JP
J Neuroimaging 2022 Mar;32(2):223-229. Epub 2021 Dec 8 doi: 10.1111/jon.12953. PMID: 34879175
Nasopharyngeal neuroendocrine neoplasms: Systematic review of the literature and case presentation.
Prantesh J, Dorth J, Asa SL, Mohamed A
J Neuroendocrinol 2021 Aug;33(8):e13005. Epub 2021 Aug 3 doi: 10.1111/jne.13005. PMID: 34342078
A systematic review and recommendations on the use of plasma EBV DNA for nasopharyngeal carcinoma.
Lee AWM, Lee VHF, Ng WT, Strojan P, Saba NF, Rinaldo A, Willems SM, Rodrigo JP, Forastiere AA, Ferlito A
Eur J Cancer 2021 Aug;153:109-122. Epub 2021 Jun 18 doi: 10.1016/j.ejca.2021.05.022. PMID: 34153713
Toxicities of chemoradiotherapy and radiotherapy in nasopharyngeal carcinoma: an updated meta-analysis.
Wang C, Wang F, Min X, Zhang Q, Shen LJ, Jiang Y, Yan J
J Int Med Res 2019 Jul;47(7):2832-2847. Epub 2019 Jul 5 doi: 10.1177/0300060519858031. PMID: 31272262Free PMC Article
Systematic review and meta-analysis of prognostic microRNA biomarkers for survival outcome in nasopharyngeal carcinoma.
Sabarimurugan S, Kumarasamy C, Baxi S, Devi A, Jayaraj R
PLoS One 2019;14(2):e0209760. Epub 2019 Feb 8 doi: 10.1371/journal.pone.0209760. PMID: 30735523Free PMC Article

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

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    Reviews

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