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Recurrent Adult Immunoblastic Lymphoma

MedGen UID:
124711
•Concept ID:
C0280190
•
Neoplastic Process
Synonyms: Recurrent Adult Immunoblastic Large Cell Lymphoma; Relapsed Adult Immunoblastic Large Cell Lymphoma; Relapsed Adult Immunoblastic Lymphoma

Definition

The reemergence of adult immunoblastic lymphoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Adult Immunoblastic Lymphoma

Professional guidelines

PubMed

Bendamustine for the treatment of relapsed or refractory peripheral T cell lymphomas: A French retrospective multicenter study.
Reboursiere E, Le Bras F, Herbaux C, Gyan E, Clavert A, Morschhauser F, Malak S, Sibon D, Broussais F, Braun T, Fornecker LM, Garidi R, Tricot S, Houot R, Joly B, Abarah W, Choufi B, Pham AD, Gac AC, Fruchart C, Marin E, Safar V, Parcelier A, Maisonneuve H, Bachy E, Cartron G, Jaccard A, Tournilhac O, Rossi C, Schirmer L, Martignoles JA, Gaulard P, Tilly H, Damaj G; From the Lymphoma Study Association (LYSA) centers
Oncotarget 2016 Dec 20;7(51):85573-85583. doi: 10.18632/oncotarget.10764. PMID: 27458168Free PMC Article
Risk factors, treatment, and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma.
van Besien K, Ha CS, Murphy S, McLaughlin P, Rodriguez A, Amin K, Forman A, Romaguera J, Hagemeister F, Younes A, Bachier C, Sarris A, Sobocinski KS, Cox JD, Cabanillas F
Blood 1998 Feb 15;91(4):1178-84. PMID: 9454747
Clinicopathologic features and treatment outcome of children with large-cell lymphoma and the t(2;5)(p23;q35).
Sandlund JT, Pui CH, Roberts WM, Santana VM, Morris SW, Berard CW, Hutchison RE, Ribeiro RC, Mahmoud H, Crist WM
Blood 1994 Oct 15;84(8):2467-71. PMID: 7919366

Recent clinical studies

Etiology

Impact of conditioning regimen intensity on the outcomes of peripheral T-cell lymphoma, anaplastic large cell lymphoma and angioimmunoblastic T-cell lymphoma patients undergoing allogeneic transplant.
Savani M, Ahn KW, Chen Y, Ahmed S, Cashen AF, Shadman M, Modi D, Khimani F, Cutler CS, Zain J, Brammer JE, Rezvani AR, Fenske TS, Sauter CS, Kharfan-Dabaja MA, Herrera AF, Hamadani M
Br J Haematol 2022 Apr;197(2):212-222. Epub 2022 Feb 2 doi: 10.1111/bjh.18052. PMID: 35106754Free PMC Article
Diagnosis and Outcome of Extranodal Primary Intestinal Lymphoma in Inflammatory Bowel Disease: An ECCO CONFER Case Series.
Phillips F, Verstockt B, Ribaldone DG, Guerra I, Teich N, Katsanos K, Filip R, Molner T, Karmiris K; ECCO CONFER Investigators
J Crohns Colitis 2022 Mar 14;16(3):500-505. doi: 10.1093/ecco-jcc/jjab164. PMID: 34508639
Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome.
Trimech M, Letourneau A, Missiaglia E, De Prijck B, Nagy-Hulliger M, Somja J, Vivario M, Gaulard P, Lambert F, Bisig B, de Leval L
Am J Surg Pathol 2021 Jun 1;45(6):773-786. doi: 10.1097/PAS.0000000000001646. PMID: 33739791
Cytogenetic abnormalities and clinical correlations in peripheral T-cell lymphoma.
Nelson M, Horsman DE, Weisenburger DD, Gascoyne RD, Dave BJ, Loberiza FR, Ludkovski O, Savage KJ, Armitage JO, Sanger WG
Br J Haematol 2008 May;141(4):461-9. Epub 2008 Mar 12 doi: 10.1111/j.1365-2141.2008.07042.x. PMID: 18341637
Stage IE non-Hodgkin's lymphoma involving the dura: A clinicopathologic study of five cases.
Miranda RN, Glantz LK, Myint MA, Levy N, Jackson CL, Rhodes CH, Glantz MJ, Medeiros LJ
Arch Pathol Lab Med 1996 Mar;120(3):254-60. PMID: 8629900

Diagnosis

Diagnosis and Outcome of Extranodal Primary Intestinal Lymphoma in Inflammatory Bowel Disease: An ECCO CONFER Case Series.
Phillips F, Verstockt B, Ribaldone DG, Guerra I, Teich N, Katsanos K, Filip R, Molner T, Karmiris K; ECCO CONFER Investigators
J Crohns Colitis 2022 Mar 14;16(3):500-505. doi: 10.1093/ecco-jcc/jjab164. PMID: 34508639
Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome.
Trimech M, Letourneau A, Missiaglia E, De Prijck B, Nagy-Hulliger M, Somja J, Vivario M, Gaulard P, Lambert F, Bisig B, de Leval L
Am J Surg Pathol 2021 Jun 1;45(6):773-786. doi: 10.1097/PAS.0000000000001646. PMID: 33739791
Mantle cell lymphomas with concomitant MYC and CCND1 breakpoints are recurrently TdT positive and frequently show high-grade pathological and genetic features.
Aukema SM, Croci GA, Bens S, Oehl-Huber K, Wagener R, Ott G, Rosenwald A, Kluin PM, van den Berg E, Bosga-Bouwer AG, Hoogendoorn M, Hoster E, Bittmann I, Nagel I, Murga Penas EM, Kreuz M, Bausinger J, Belder W, Oschlies I, Dyer MJS, Jayne S, Siebert R, Klapper W
Virchows Arch 2021 Jul;479(1):133-145. Epub 2021 Feb 2 doi: 10.1007/s00428-021-03022-8. PMID: 33528622
Stage IE non-Hodgkin's lymphoma involving the dura: A clinicopathologic study of five cases.
Miranda RN, Glantz LK, Myint MA, Levy N, Jackson CL, Rhodes CH, Glantz MJ, Medeiros LJ
Arch Pathol Lab Med 1996 Mar;120(3):254-60. PMID: 8629900
Hodgkin's disease following non-Hodgkin's lymphoma. A clinicopathologic and immunophenotypic study of nine cases.
Zarate-Osorno A, Medeiros LJ, Kingma DW, Longo DL, Jaffe ES
Am J Surg Pathol 1993 Feb;17(2):123-32. PMID: 8422110

Therapy

Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome.
Trimech M, Letourneau A, Missiaglia E, De Prijck B, Nagy-Hulliger M, Somja J, Vivario M, Gaulard P, Lambert F, Bisig B, de Leval L
Am J Surg Pathol 2021 Jun 1;45(6):773-786. doi: 10.1097/PAS.0000000000001646. PMID: 33739791
The survival outcome of patients with relapsed/refractory peripheral T-cell lymphoma-not otherwise specified and angioimmunoblastic T-cell lymphoma.
Chihara D, Fanale MA, Miranda RN, Noorani M, Westin JR, Nastoupil LJ, Hagemeister FB, Fayad LE, Romaguera JE, Samaniego F, Turturro F, Lee HJ, Neelapu SS, Rodriguez MA, Wang M, Fowler NH, Davis RE, Medeiros LJ, Hosing C, Nieto YL, Oki Y
Br J Haematol 2017 Mar;176(5):750-758. Epub 2016 Dec 16 doi: 10.1111/bjh.14477. PMID: 27983760Free PMC Article
A clinical, molecular and cytogenetic study of 12 cases of human herpesvirus 8 associated primary effusion lymphoma in HIV-infected patients.
Boulanger E, Agbalika F, Maarek O, Daniel MT, Grollet L, Molina JM, Sigaux F, Oksenhendler E
Hematol J 2001;2(3):172-9. doi: 10.1038/sj.thj.6200096. PMID: 11920242
Five-year results of the treatment of 23 patients with immunoproliferative small intestinal disease: a Turkish experience.
Akbulut H, Soykan I, Yakaryilmaz F, Icii F, Aksoy F, Haznedaroglu S, Yildirim S
Cancer 1997 Jul 1;80(1):8-14. doi: 10.1002/(sici)1097-0142(19970701)80:1<8::aid-cncr2>3.0.co;2-t. PMID: 9210703
Clinicopathologic features and treatment outcome of children with large-cell lymphoma and the t(2;5)(p23;q35).
Sandlund JT, Pui CH, Roberts WM, Santana VM, Morris SW, Berard CW, Hutchison RE, Ribeiro RC, Mahmoud H, Crist WM
Blood 1994 Oct 15;84(8):2467-71. PMID: 7919366

Prognosis

Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome.
Trimech M, Letourneau A, Missiaglia E, De Prijck B, Nagy-Hulliger M, Somja J, Vivario M, Gaulard P, Lambert F, Bisig B, de Leval L
Am J Surg Pathol 2021 Jun 1;45(6):773-786. doi: 10.1097/PAS.0000000000001646. PMID: 33739791
Mantle cell lymphomas with concomitant MYC and CCND1 breakpoints are recurrently TdT positive and frequently show high-grade pathological and genetic features.
Aukema SM, Croci GA, Bens S, Oehl-Huber K, Wagener R, Ott G, Rosenwald A, Kluin PM, van den Berg E, Bosga-Bouwer AG, Hoogendoorn M, Hoster E, Bittmann I, Nagel I, Murga Penas EM, Kreuz M, Bausinger J, Belder W, Oschlies I, Dyer MJS, Jayne S, Siebert R, Klapper W
Virchows Arch 2021 Jul;479(1):133-145. Epub 2021 Feb 2 doi: 10.1007/s00428-021-03022-8. PMID: 33528622
The survival outcome of patients with relapsed/refractory peripheral T-cell lymphoma-not otherwise specified and angioimmunoblastic T-cell lymphoma.
Chihara D, Fanale MA, Miranda RN, Noorani M, Westin JR, Nastoupil LJ, Hagemeister FB, Fayad LE, Romaguera JE, Samaniego F, Turturro F, Lee HJ, Neelapu SS, Rodriguez MA, Wang M, Fowler NH, Davis RE, Medeiros LJ, Hosing C, Nieto YL, Oki Y
Br J Haematol 2017 Mar;176(5):750-758. Epub 2016 Dec 16 doi: 10.1111/bjh.14477. PMID: 27983760Free PMC Article
Stage IE non-Hodgkin's lymphoma involving the dura: A clinicopathologic study of five cases.
Miranda RN, Glantz LK, Myint MA, Levy N, Jackson CL, Rhodes CH, Glantz MJ, Medeiros LJ
Arch Pathol Lab Med 1996 Mar;120(3):254-60. PMID: 8629900
bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma.
Yunis JJ, Mayer MG, Arnesen MA, Aeppli DP, Oken MM, Frizzera G
N Engl J Med 1989 Apr 20;320(16):1047-54. doi: 10.1056/NEJM198904203201605. PMID: 2648153

Clinical prediction guides

Impact of conditioning regimen intensity on the outcomes of peripheral T-cell lymphoma, anaplastic large cell lymphoma and angioimmunoblastic T-cell lymphoma patients undergoing allogeneic transplant.
Savani M, Ahn KW, Chen Y, Ahmed S, Cashen AF, Shadman M, Modi D, Khimani F, Cutler CS, Zain J, Brammer JE, Rezvani AR, Fenske TS, Sauter CS, Kharfan-Dabaja MA, Herrera AF, Hamadani M
Br J Haematol 2022 Apr;197(2):212-222. Epub 2022 Feb 2 doi: 10.1111/bjh.18052. PMID: 35106754Free PMC Article
Angioimmunoblastic T-Cell Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Novel Form of Composite Lymphoma Potentially Mimicking Richter Syndrome.
Trimech M, Letourneau A, Missiaglia E, De Prijck B, Nagy-Hulliger M, Somja J, Vivario M, Gaulard P, Lambert F, Bisig B, de Leval L
Am J Surg Pathol 2021 Jun 1;45(6):773-786. doi: 10.1097/PAS.0000000000001646. PMID: 33739791
Mantle cell lymphomas with concomitant MYC and CCND1 breakpoints are recurrently TdT positive and frequently show high-grade pathological and genetic features.
Aukema SM, Croci GA, Bens S, Oehl-Huber K, Wagener R, Ott G, Rosenwald A, Kluin PM, van den Berg E, Bosga-Bouwer AG, Hoogendoorn M, Hoster E, Bittmann I, Nagel I, Murga Penas EM, Kreuz M, Bausinger J, Belder W, Oschlies I, Dyer MJS, Jayne S, Siebert R, Klapper W
Virchows Arch 2021 Jul;479(1):133-145. Epub 2021 Feb 2 doi: 10.1007/s00428-021-03022-8. PMID: 33528622
Cytogenetic abnormalities and clinical correlations in peripheral T-cell lymphoma.
Nelson M, Horsman DE, Weisenburger DD, Gascoyne RD, Dave BJ, Loberiza FR, Ludkovski O, Savage KJ, Armitage JO, Sanger WG
Br J Haematol 2008 May;141(4):461-9. Epub 2008 Mar 12 doi: 10.1111/j.1365-2141.2008.07042.x. PMID: 18341637
A clinical, molecular and cytogenetic study of 12 cases of human herpesvirus 8 associated primary effusion lymphoma in HIV-infected patients.
Boulanger E, Agbalika F, Maarek O, Daniel MT, Grollet L, Molina JM, Sigaux F, Oksenhendler E
Hematol J 2001;2(3):172-9. doi: 10.1038/sj.thj.6200096. PMID: 11920242

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