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Adult Pilocytic Astrocytoma

MedGen UID:
128889
•Concept ID:
C0280781
•
Neoplastic Process

Definition

A pilocytic astrocytoma occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Pilocytic Astrocytoma

Professional guidelines

PubMed

Advances in the management of glioblastoma.
Ma R, Taphoorn MJB, Plaha P
J Neurol Neurosurg Psychiatry 2021 Oct;92(10):1103-1111. Epub 2021 Jun 23 doi: 10.1136/jnnp-2020-325334. PMID: 34162730
The management of low-grade gliomas in adults.
Morshed RA, Young JS, Hervey-Jumper SL, Berger MS
J Neurosurg Sci 2019 Aug;63(4):450-457. Epub 2019 Mar 27 doi: 10.23736/S0390-5616.19.04701-5. PMID: 30916536
Glioblastoma: Overview of Disease and Treatment.
Davis ME
Clin J Oncol Nurs 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8. PMID: 27668386Free PMC Article

Recent clinical studies

Etiology

Effect of radiation therapy on overall survival following subtotal resection of adult pilocytic astrocytoma.
Khalafallah AM, Jimenez AE, Shah PP, Brem H, Mukherjee D
J Clin Neurosci 2020 Nov;81:340-345. Epub 2020 Oct 21 doi: 10.1016/j.jocn.2020.10.020. PMID: 33222942
Bevacizumab Use in Refractory Adult Pilocytic Astrocytoma: A Single-Center Case Series.
Carabenciov ID, Bhargav AG, Uhm JH, Ruff MW
Neurologist 2019 May;24(3):87-89. doi: 10.1097/NRL.0000000000000227. PMID: 31045718
Extent of resection predicts risk of progression in adult pilocytic astrocytoma.
Nelson AJ, Zakaria R, Jenkinson MD, Brodbelt AR
Br J Neurosurg 2019 Jun;33(3):343-347. Epub 2019 Jan 17 doi: 10.1080/02688697.2018.1549315. PMID: 30653383
Genetic alterations related to BRAF-FGFR genes and dysregulated MAPK/ERK/mTOR signaling in adult pilocytic astrocytoma.
Pathak P, Kumar A, Jha P, Purkait S, Faruq M, Suri A, Suri V, Sharma MC, Sarkar C
Brain Pathol 2017 Sep;27(5):580-589. Epub 2017 Jan 6 doi: 10.1111/bpa.12444. PMID: 27608415Free PMC Article
Upfront observation versus radiation for adult pilocytic astrocytoma.
Ishkanian A, Laperriere NJ, Xu W, Millar BA, Payne D, Mason W, Sahgal A
Cancer 2011 Sep 1;117(17):4070-9. Epub 2011 Mar 9 doi: 10.1002/cncr.25988. PMID: 21391213

Diagnosis

Adult pilocytic astrocytoma in the molecular era: a comprehensive review.
Gregory TA, Chumbley LB, Henson JW, Theeler BJ
CNS Oncol 2021 Mar 1;10(1):CNS68. Epub 2021 Jan 15 doi: 10.2217/cns-2020-0027. PMID: 33448230Free PMC Article
Effect of radiation therapy on overall survival following subtotal resection of adult pilocytic astrocytoma.
Khalafallah AM, Jimenez AE, Shah PP, Brem H, Mukherjee D
J Clin Neurosci 2020 Nov;81:340-345. Epub 2020 Oct 21 doi: 10.1016/j.jocn.2020.10.020. PMID: 33222942
Adult Pilocytic Astrocytoma: An Institutional Series and Systematic Literature Review for Extent of Resection and Recurrence.
Bond KM, Hughes JD, Porter AL, Orina J, Fang S, Parney IF
World Neurosurg 2018 Feb;110:276-283. Epub 2017 Nov 24 doi: 10.1016/j.wneu.2017.11.102. PMID: 29180079
Adult pilocytic astrocytoma of conus medullaris: clinical considerations and review of the literature.
Lavrador JP, Oliveira E, Pimentel J, Livraghi S
CNS Oncol 2017 Apr;6(2):107-110. doi: 10.2217/cns-2016-0030. PMID: 28425761Free PMC Article
Upfront observation versus radiation for adult pilocytic astrocytoma.
Ishkanian A, Laperriere NJ, Xu W, Millar BA, Payne D, Mason W, Sahgal A
Cancer 2011 Sep 1;117(17):4070-9. Epub 2011 Mar 9 doi: 10.1002/cncr.25988. PMID: 21391213

Therapy

Effect of radiation therapy on overall survival following subtotal resection of adult pilocytic astrocytoma.
Khalafallah AM, Jimenez AE, Shah PP, Brem H, Mukherjee D
J Clin Neurosci 2020 Nov;81:340-345. Epub 2020 Oct 21 doi: 10.1016/j.jocn.2020.10.020. PMID: 33222942
Bevacizumab Use in Refractory Adult Pilocytic Astrocytoma: A Single-Center Case Series.
Carabenciov ID, Bhargav AG, Uhm JH, Ruff MW
Neurologist 2019 May;24(3):87-89. doi: 10.1097/NRL.0000000000000227. PMID: 31045718

Prognosis

The age of adult pilocytic astrocytoma cells.
Voronina N, Aichmüller C, Kolb T, Korshunov A, Ryzhova M, Barnholtz-Sloan J, Cioffi G, Sill M, von Deimling A, Pfister SM, Gronych J, Jones DTW, Frisén J, Zapatka M, Ernst A
Oncogene 2021 Apr;40(16):2830-2841. Epub 2021 Mar 17 doi: 10.1038/s41388-021-01738-0. PMID: 33731860Free PMC Article
Adult pilocytic astrocytoma in the molecular era: a comprehensive review.
Gregory TA, Chumbley LB, Henson JW, Theeler BJ
CNS Oncol 2021 Mar 1;10(1):CNS68. Epub 2021 Jan 15 doi: 10.2217/cns-2020-0027. PMID: 33448230Free PMC Article
Effect of radiation therapy on overall survival following subtotal resection of adult pilocytic astrocytoma.
Khalafallah AM, Jimenez AE, Shah PP, Brem H, Mukherjee D
J Clin Neurosci 2020 Nov;81:340-345. Epub 2020 Oct 21 doi: 10.1016/j.jocn.2020.10.020. PMID: 33222942
Extent of resection predicts risk of progression in adult pilocytic astrocytoma.
Nelson AJ, Zakaria R, Jenkinson MD, Brodbelt AR
Br J Neurosurg 2019 Jun;33(3):343-347. Epub 2019 Jan 17 doi: 10.1080/02688697.2018.1549315. PMID: 30653383
Adult Pilocytic Astrocytoma: An Institutional Series and Systematic Literature Review for Extent of Resection and Recurrence.
Bond KM, Hughes JD, Porter AL, Orina J, Fang S, Parney IF
World Neurosurg 2018 Feb;110:276-283. Epub 2017 Nov 24 doi: 10.1016/j.wneu.2017.11.102. PMID: 29180079

Clinical prediction guides

Adult pilocytic astrocytoma in the molecular era: a comprehensive review.
Gregory TA, Chumbley LB, Henson JW, Theeler BJ
CNS Oncol 2021 Mar 1;10(1):CNS68. Epub 2021 Jan 15 doi: 10.2217/cns-2020-0027. PMID: 33448230Free PMC Article
Effect of radiation therapy on overall survival following subtotal resection of adult pilocytic astrocytoma.
Khalafallah AM, Jimenez AE, Shah PP, Brem H, Mukherjee D
J Clin Neurosci 2020 Nov;81:340-345. Epub 2020 Oct 21 doi: 10.1016/j.jocn.2020.10.020. PMID: 33222942
Extent of resection predicts risk of progression in adult pilocytic astrocytoma.
Nelson AJ, Zakaria R, Jenkinson MD, Brodbelt AR
Br J Neurosurg 2019 Jun;33(3):343-347. Epub 2019 Jan 17 doi: 10.1080/02688697.2018.1549315. PMID: 30653383
Adult Pilocytic Astrocytoma: An Institutional Series and Systematic Literature Review for Extent of Resection and Recurrence.
Bond KM, Hughes JD, Porter AL, Orina J, Fang S, Parney IF
World Neurosurg 2018 Feb;110:276-283. Epub 2017 Nov 24 doi: 10.1016/j.wneu.2017.11.102. PMID: 29180079
Genetic alterations related to BRAF-FGFR genes and dysregulated MAPK/ERK/mTOR signaling in adult pilocytic astrocytoma.
Pathak P, Kumar A, Jha P, Purkait S, Faruq M, Suri A, Suri V, Sharma MC, Sarkar C
Brain Pathol 2017 Sep;27(5):580-589. Epub 2017 Jan 6 doi: 10.1111/bpa.12444. PMID: 27608415Free PMC Article

Recent systematic reviews

Adult Pilocytic Astrocytoma: An Institutional Series and Systematic Literature Review for Extent of Resection and Recurrence.
Bond KM, Hughes JD, Porter AL, Orina J, Fang S, Parney IF
World Neurosurg 2018 Feb;110:276-283. Epub 2017 Nov 24 doi: 10.1016/j.wneu.2017.11.102. PMID: 29180079

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