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Interstitial cystitis

MedGen UID:
129176
•Concept ID:
C0282488
•
Disease or Syndrome
Synonyms: Cystitides, Interstitial; Cystitis, Interstitial; Interstitial Cystitides; Interstitial Cystitis
SNOMED CT: Ulcerative cystitis (111409009); IC - Interstitial cystitis (197834003); Interstitial cystitis (197834003)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0018301
Orphanet: ORPHA37202

Definition

A rare non-infectious, chronic and most often progressive disease of the urinary bladder. It is characterized by varying combinations and extent of pain, urinary frequency (pollakisuria), nocturia and urgency. Interstitial cystitis (IC) has a broad intersection with Bladder Pain Syndrome (BPS) and Overactive Bladder (OAB). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInterstitial cystitis
Follow this link to review classifications for Interstitial cystitis in Orphanet.

Professional guidelines

PubMed

Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome.
Clemens JQ, Erickson DR, Varela NP, Lai HH
J Urol 2022 Jul;208(1):34-42. Epub 2022 May 10 doi: 10.1097/JU.0000000000002756. PMID: 35536143
Pelvic Floor Physical Therapy for Pelvic Floor Hypertonicity: A Systematic Review of Treatment Efficacy.
van Reijn-Baggen DA, Han-Geurts IJM, Voorham-van der Zalm PJ, Pelger RCM, Hagenaars-van Miert CHAC, Laan ETM
Sex Med Rev 2022 Apr;10(2):209-230. Epub 2021 Jun 12 doi: 10.1016/j.sxmr.2021.03.002. PMID: 34127429
Dysuria: Evaluation and Differential Diagnosis in Adults.
Michels TC, Sands JE
Am Fam Physician 2015 Nov 1;92(9):778-86. PMID: 26554471

Recent clinical studies

Etiology

Multimodal Single-Cell Analyses Outline the Immune Microenvironment and Therapeutic Effectors of Interstitial Cystitis/Bladder Pain Syndrome.
Su F, Zhang W, Meng L, Zhang W, Liu X, Liu X, Chen M, Zhang Y, Xiao F
Adv Sci (Weinh) 2022 Jun;9(18):e2106063. Epub 2022 Apr 25 doi: 10.1002/advs.202106063. PMID: 35470584Free PMC Article
Association between Chronic Interstitial Cystitis and Herpes Zoster.
Hsu CY, Lin CL, Kao CH
Int J Environ Res Public Health 2020 Mar 26;17(7) doi: 10.3390/ijerph17072228. PMID: 32224999Free PMC Article
Bladder Pain Syndrome.
Huffman MM, Slack A, Hoke M
Prim Care 2019 Jun;46(2):213-221. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.002. PMID: 31030822
Interstitial Cystitis: An Update on the Disease Process and Treatment.
Daniels AM, Schulte AR, Herndon CM
J Pain Palliat Care Pharmacother 2018 Mar;32(1):49-58. Epub 2018 Sep 13 doi: 10.1080/15360288.2018.1476433. PMID: 30212267
Interstitial cystitis: epidemiology, pathophysiology, and clinical presentation.
McLennan MT
Obstet Gynecol Clin North Am 2014 Sep;41(3):385-95. Epub 2014 Jul 9 doi: 10.1016/j.ogc.2014.05.004. PMID: 25155120

Diagnosis

Broaden Horizons: The Advancement of Interstitial Cystitis/Bladder Pain Syndrome.
Li J, Yi X, Ai J
Int J Mol Sci 2022 Nov 23;23(23) doi: 10.3390/ijms232314594. PMID: 36498919Free PMC Article
Understanding bladder pain syndrome/interstitial cystitis.
Tailor V, Torella M, Manriquez V, Digesu GA
Int Urogynecol J 2020 Aug;31(8):1495-1496. doi: 10.1007/s00192-020-04232-5. PMID: 32095957
Bladder Pain Syndrome.
Huffman MM, Slack A, Hoke M
Prim Care 2019 Jun;46(2):213-221. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.002. PMID: 31030822
Interstitial Cystitis/Bladder Pain Syndrome.
Marcu I, Campian EC, Tu FF
Semin Reprod Med 2018 Mar;36(2):123-135. Epub 2018 Dec 19 doi: 10.1055/s-0038-1676089. PMID: 30566978
Interstitial cystitis.
Kelada E, Jones A
Arch Gynecol Obstet 2007 Apr;275(4):223-9. Epub 2006 Sep 22 doi: 10.1007/s00404-006-0247-7. PMID: 17021774

Therapy

Intravesical liposome therapy for interstitial cystitis.
Tyagi P, Kashyap M, Majima T, Kawamorita N, Yoshizawa T, Yoshimura N
Int J Urol 2017 Apr;24(4):262-271. Epub 2017 Mar 4 doi: 10.1111/iju.13317. PMID: 28258657
Interstitial cystitis.
Banerjee S
J Pain Palliat Care Pharmacother 2011;25(1):72-5. doi: 10.3109/15360288.2010.548850. PMID: 21426224
Interstitial cystitis.
Kelada E, Jones A
Arch Gynecol Obstet 2007 Apr;275(4):223-9. Epub 2006 Sep 22 doi: 10.1007/s00404-006-0247-7. PMID: 17021774
Interstitial cystitis.
Hanno PM, Wein AJ
J Urol 1987 Sep;138(3):595-6. doi: 10.1016/s0022-5347(17)43268-x. PMID: 2442420
Interstitial cystitis.
Rosin RD, Griffiths T, Sofras F, James DC, Edwards L
Br J Urol 1979 Dec;51(6):524-7. doi: 10.1111/j.1464-410x.1979.tb03593.x. PMID: 119564

Prognosis

Broaden Horizons: The Advancement of Interstitial Cystitis/Bladder Pain Syndrome.
Li J, Yi X, Ai J
Int J Mol Sci 2022 Nov 23;23(23) doi: 10.3390/ijms232314594. PMID: 36498919Free PMC Article
Pathophysiology of interstitial cystitis.
Birder LA
Int J Urol 2019 Jun;26 Suppl 1:12-15. doi: 10.1111/iju.13985. PMID: 31144735
Interstitial Cystitis/Bladder Pain Syndrome.
Marcu I, Campian EC, Tu FF
Semin Reprod Med 2018 Mar;36(2):123-135. Epub 2018 Dec 19 doi: 10.1055/s-0038-1676089. PMID: 30566978
The Urinary Tract Microbiome in Health and Disease.
Aragón IM, Herrera-Imbroda B, Queipo-Ortuño MI, Castillo E, Del Moral JS, Gómez-Millán J, Yucel G, Lara MF
Eur Urol Focus 2018 Jan;4(1):128-138. Epub 2016 Nov 14 doi: 10.1016/j.euf.2016.11.001. PMID: 28753805
Interstitial cystitis.
Banerjee S
J Pain Palliat Care Pharmacother 2011;25(1):72-5. doi: 10.3109/15360288.2010.548850. PMID: 21426224

Clinical prediction guides

Comparing surgical interventions for interstitial cystitis: A systematic review.
Abelleyra Lastoria DA, Raison N, Aydin A, Khan S, Dasgupta P, Ahmed K
Low Urin Tract Symptoms 2022 Jul;14(4):218-241. Epub 2022 Apr 8 doi: 10.1111/luts.12441. PMID: 35393778
Metabolic syndrome in women with and without interstitial cystitis/bladder pain syndrome.
Peng L, Di XP, He SX, Zeng X, Shen H, Zhu HL, Luo DY
Int Urogynecol J 2021 May;32(5):1299-1306. Epub 2020 Nov 19 doi: 10.1007/s00192-020-04605-w. PMID: 33215272
Pathophysiology of interstitial cystitis.
Birder LA
Int J Urol 2019 Jun;26 Suppl 1:12-15. doi: 10.1111/iju.13985. PMID: 31144735
GAG replenishment therapy for bladder pain syndrome/interstitial cystitis.
Wyndaele JJJ, Riedl C, Taneja R, Lovász S, Ueda T, Cervigni M
Neurourol Urodyn 2019 Feb;38(2):535-544. Epub 2018 Dec 28 doi: 10.1002/nau.23900. PMID: 30592544
Interstitial cystitis: an update.
Oberpenning F, van Ophoven A, Hertle L
Curr Opin Urol 2002 Jul;12(4):321-32. doi: 10.1097/00042307-200207000-00011. PMID: 12072654

Recent systematic reviews

mHealth Intervention for Improving Pain, Quality of Life, and Functional Disability in Patients With Chronic Pain: Systematic Review.
Moreno-Ligero M, Moral-Munoz JA, Salazar A, Failde I
JMIR Mhealth Uhealth 2023 Feb 2;11:e40844. doi: 10.2196/40844. PMID: 36729570Free PMC Article
Diagnosis and Treatment of Interstitial Cystitis/Bladder Pain Syndrome.
Clemens JQ, Erickson DR, Varela NP, Lai HH
J Urol 2022 Jul;208(1):34-42. Epub 2022 May 10 doi: 10.1097/JU.0000000000002756. PMID: 35536143
Medical Cannabis for Gynecologic Pain Conditions: A Systematic Review.
Liang AL, Gingher EL, Coleman JS
Obstet Gynecol 2022 Feb 1;139(2):287-296. doi: 10.1097/AOG.0000000000004656. PMID: 35104069
Pelvic Floor Physical Therapy for Pelvic Floor Hypertonicity: A Systematic Review of Treatment Efficacy.
van Reijn-Baggen DA, Han-Geurts IJM, Voorham-van der Zalm PJ, Pelger RCM, Hagenaars-van Miert CHAC, Laan ETM
Sex Med Rev 2022 Apr;10(2):209-230. Epub 2021 Jun 12 doi: 10.1016/j.sxmr.2021.03.002. PMID: 34127429
Treatment of bladder pain syndrome and interstitial cystitis: a systematic review.
Pazin C, de Souza Mitidieri AM, Silva AP, Gurian MB, Poli-Neto OB, Rosa-E-Silva JC
Int Urogynecol J 2016 May;27(5):697-708. Epub 2015 Aug 14 doi: 10.1007/s00192-015-2815-5. PMID: 26272202

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