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Abnormal QRS complex

MedGen UID:
1370423
•Concept ID:
C4476580
•
Finding
HPO: HP:0025074

Definition

An anomaly of the complex formed by the Q, R, and S waves, which occur in rapid succession on the electrocardiogram. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal QRS complex

Conditions with this feature

Sinoatrial node dysfunction and deafness
MedGen UID:
766932
•Concept ID:
C3554018
•
Disease or Syndrome
Patients with sinoatrial node dysfunction and deafness have congenital severe to profound deafness without vestibular dysfunction, associated with episodic syncope due to intermittent pronounced bradycardia (Baig et al., 2011). See Jervell and Lange-Nielsen syndrome (220400) for discussion of another deafness syndrome with impaired cardiac conduction.
See: Condition Record
Sick sinus syndrome 4
MedGen UID:
1794159
•Concept ID:
C5561949
•
Disease or Syndrome
Sick sinus syndrome-4 (SSS4) is characterized by early and progressive sinus node and atrioventricular conduction dysfunction. Patients show bradycardia and chronotropic incompetence, and may experience syncope. Atrioventricular conduction block ranges from mild to severe, and some patients also have intermittent atrial fibrillation. Many require implantation of a pacemaker, but sudden cardiac death has not been reported (Stallmeyer et al., 2017). For a general phenotypic description and discussion of genetic heterogeneity of sick sinus syndrome, see SSS1 (608567).
See: Condition Record
Sick sinus syndrome 4
Sinoatrial node dysfunction and deafness

Professional guidelines

PubMed

Loperamide Cardiac Toxicity: Pathophysiology, Presentation, and Management.
Wu PE, Juurlink DN
Can J Cardiol 2022 Sep;38(9):1378-1383. Epub 2022 Apr 14 doi: 10.1016/j.cjca.2022.04.005. PMID: 35430193
Initial evaluation and management of wide-complex tachycardia: A simplified and practical approach.
Littmann L, Olson EG, Gibbs MA
Am J Emerg Med 2019 Jul;37(7):1340-1345. Epub 2019 Apr 12 doi: 10.1016/j.ajem.2019.04.027. PMID: 31027937
ST-segment elevation: Differential diagnosis, caveats.
Hanna EB, Glancy DL
Cleve Clin J Med 2015 Jun;82(6):373-84. doi: 10.3949/ccjm.82a.14026. PMID: 26086496

Recent clinical studies

Etiology

Visual saliency detection approach for long-term ECG analysis.
Mukhopadhyay SK, Krishnan S
Comput Methods Programs Biomed 2022 Jan;213:106518. Epub 2021 Nov 11 doi: 10.1016/j.cmpb.2021.106518. PMID: 34808531
QRS abnormalities of the fetal electrocardiogram, and their implications for ST-interval analysis during labor.
Sletten J, Kessler J
Acta Obstet Gynecol Scand 2015 Oct;94(10):1128-35. Epub 2015 Aug 4 doi: 10.1111/aogs.12709. PMID: 26178868
Electrocardiographic abnormalities among arsenic-exposed persons through groundwater in Bangladesh.
Ahmad SA, Khatun F, Sayed MH, Khan MH, Aziz R, Hossain MZ, Faruquee MH
J Health Popul Nutr 2006 Jun;24(2):221-7. PMID: 17195563
Ambulatory (Holter) electrocardiography signal-averaging: a current perspective.
Kennedy HL, Bavishi NS, Buckingham TA
Am Heart J 1992 Nov;124(5):1339-46. doi: 10.1016/0002-8703(92)90421-q. PMID: 1442505

Diagnosis

Electrocardiographic abnormalities among arsenic-exposed persons through groundwater in Bangladesh.
Ahmad SA, Khatun F, Sayed MH, Khan MH, Aziz R, Hossain MZ, Faruquee MH
J Health Popul Nutr 2006 Jun;24(2):221-7. PMID: 17195563
Ambulatory (Holter) electrocardiography signal-averaging: a current perspective.
Kennedy HL, Bavishi NS, Buckingham TA
Am Heart J 1992 Nov;124(5):1339-46. doi: 10.1016/0002-8703(92)90421-q. PMID: 1442505
Supraventricular arrhythmia with abnormal QRS complex.
Zipes DP, Fisch C
Arch Intern Med 1972 Jul;130(1):129-34. PMID: 5035977
Supraventricular arrhythmias with abnormal QRS complex.
Zipes DP, Fisch C
Arch Intern Med 1972 Nov;130(5):781-4. PMID: 4117270
Cancellation of the abnormal QRS complex of heart disease.
SEIDEN GE, KEISMAN RA
Am Heart J 1956 Jul;52(1):62-9. doi: 10.1016/0002-8703(56)90118-1. PMID: 13326835

Therapy

Electrocardiographic abnormalities among arsenic-exposed persons through groundwater in Bangladesh.
Ahmad SA, Khatun F, Sayed MH, Khan MH, Aziz R, Hossain MZ, Faruquee MH
J Health Popul Nutr 2006 Jun;24(2):221-7. PMID: 17195563

Prognosis

Troubleshooting Cardiac Resynchronization Therapy in Nonresponders.
Dhesi S, Lockwood E, Sandhu RK
Can J Cardiol 2017 Aug;33(8):1060-1065. Epub 2017 Apr 23 doi: 10.1016/j.cjca.2017.04.007. PMID: 28666618
Ambulatory (Holter) electrocardiography signal-averaging: a current perspective.
Kennedy HL, Bavishi NS, Buckingham TA
Am Heart J 1992 Nov;124(5):1339-46. doi: 10.1016/0002-8703(92)90421-q. PMID: 1442505

Clinical prediction guides

Electrocardiographic abnormalities among arsenic-exposed persons through groundwater in Bangladesh.
Ahmad SA, Khatun F, Sayed MH, Khan MH, Aziz R, Hossain MZ, Faruquee MH
J Health Popul Nutr 2006 Jun;24(2):221-7. PMID: 17195563
The heart remembers: observations of cardiac memory in the Dorper sheep heart.
Ker J, Webb EC, Ker JA, Bekker PA
Onderstepoort J Vet Res 2003 Dec;70(4):299-305. doi: 10.4102/ojvr.v70i4.294. PMID: 14971732

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