U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Reduced brain lactate level by MRS

MedGen UID:
1370976
•Concept ID:
C4476565
•
Finding
Synonym: Reduced brain lactate level by magnetic resonance spectroscopy
 
HPO: HP:0025046

Definition

A decrease in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReduced brain lactate level by MRS

Recent clinical studies

Etiology

Acquired Factor XIII Deficiency in Patients with Multiple Trauma.
Hetz M, Juratli T, Tiebel O, Giesecke MT, Tsitsilonis S, Held HC, Beyer F, Kleber C
Injury 2023 May;54(5):1257-1264. Epub 2022 Dec 22 doi: 10.1016/j.injury.2022.12.021. PMID: 36577625
Association between Subcortical Morphology and Cerebral White Matter Energy Metabolism in Neonates with Congenital Heart Disease.
Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Bluml S, Paquette L, Panigrahy A
Sci Rep 2018 Sep 19;8(1):14057. doi: 10.1038/s41598-018-32288-3. PMID: 30232359Free PMC Article
An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment.
Miller CB, Rae CD, Green MA, Yee BJ, Gordon CJ, D'Rozario AL, Kyle SD, Espie CA, Grunstein RR, Bartlett DJ
Sleep 2017 Nov 1;40(11) doi: 10.1093/sleep/zsx148. PMID: 28958033
Prognostic factors for acute encephalopathy with bright tree appearance.
Azuma J, Nabatame S, Nakano S, Iwatani Y, Kitai Y, Tominaga K, Kagitani-Shimono K, Okinaga T, Yamamoto T, Nagai T, Ozono K
Brain Dev 2015 Feb;37(2):191-9. Epub 2014 Apr 28 doi: 10.1016/j.braindev.2014.04.001. PMID: 24787271
Evidence of altered energy metabolism in autistic children.
Chugani DC, Sundram BS, Behen M, Lee ML, Moore GJ
Prog Neuropsychopharmacol Biol Psychiatry 1999 May;23(4):635-41. doi: 10.1016/s0278-5846(99)00022-6. PMID: 10390722

Diagnosis

An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment.
Miller CB, Rae CD, Green MA, Yee BJ, Gordon CJ, D'Rozario AL, Kyle SD, Espie CA, Grunstein RR, Bartlett DJ
Sleep 2017 Nov 1;40(11) doi: 10.1093/sleep/zsx148. PMID: 28958033
MRS of brain metabolite levels demonstrates the ability of scavenging of excess brain glutamate to protect against nerve agent induced seizures.
Ruban A, Biton IE, Markovich A, Mirelman D
Int J Mol Sci 2015 Feb 2;16(2):3226-36. doi: 10.3390/ijms16023226. PMID: 25648322Free PMC Article
Prognostic factors for acute encephalopathy with bright tree appearance.
Azuma J, Nabatame S, Nakano S, Iwatani Y, Kitai Y, Tominaga K, Kagitani-Shimono K, Okinaga T, Yamamoto T, Nagai T, Ozono K
Brain Dev 2015 Feb;37(2):191-9. Epub 2014 Apr 28 doi: 10.1016/j.braindev.2014.04.001. PMID: 24787271
MRI, (1)H-MRS, and functional MRI during and after prolonged nonconvulsive seizure activity.
Lazeyras F, Blanke O, Zimine I, Delavelle J, Perrig SH, Seeck M
Neurology 2000 Dec 12;55(11):1677-82. doi: 10.1212/wnl.55.11.1677. PMID: 11113222
1H MRS in acute traumatic brain injury.
Ross BD, Ernst T, Kreis R, Haseler LJ, Bayer S, Danielsen E, Blüml S, Shonk T, Mandigo JC, Caton W, Clark C, Jensen SW, Lehman NL, Arcinue E, Pudenz R, Shelden CH
J Magn Reson Imaging 1998 Jul-Aug;8(4):829-40. doi: 10.1002/jmri.1880080412. PMID: 9702884

Therapy

Acquired Factor XIII Deficiency in Patients with Multiple Trauma.
Hetz M, Juratli T, Tiebel O, Giesecke MT, Tsitsilonis S, Held HC, Beyer F, Kleber C
Injury 2023 May;54(5):1257-1264. Epub 2022 Dec 22 doi: 10.1016/j.injury.2022.12.021. PMID: 36577625
An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment.
Miller CB, Rae CD, Green MA, Yee BJ, Gordon CJ, D'Rozario AL, Kyle SD, Espie CA, Grunstein RR, Bartlett DJ
Sleep 2017 Nov 1;40(11) doi: 10.1093/sleep/zsx148. PMID: 28958033
MRS of brain metabolite levels demonstrates the ability of scavenging of excess brain glutamate to protect against nerve agent induced seizures.
Ruban A, Biton IE, Markovich A, Mirelman D
Int J Mol Sci 2015 Feb 2;16(2):3226-36. doi: 10.3390/ijms16023226. PMID: 25648322Free PMC Article
Prognostic factors for acute encephalopathy with bright tree appearance.
Azuma J, Nabatame S, Nakano S, Iwatani Y, Kitai Y, Tominaga K, Kagitani-Shimono K, Okinaga T, Yamamoto T, Nagai T, Ozono K
Brain Dev 2015 Feb;37(2):191-9. Epub 2014 Apr 28 doi: 10.1016/j.braindev.2014.04.001. PMID: 24787271
Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors.
Pazos MR, Mohammed N, Lafuente H, Santos M, Martínez-Pinilla E, Moreno E, Valdizan E, Romero J, Pazos A, Franco R, Hillard CJ, Alvarez FJ, Martínez-Orgado J
Neuropharmacology 2013 Aug;71:282-91. Epub 2013 Apr 12 doi: 10.1016/j.neuropharm.2013.03.027. PMID: 23587650

Prognosis

Acquired Factor XIII Deficiency in Patients with Multiple Trauma.
Hetz M, Juratli T, Tiebel O, Giesecke MT, Tsitsilonis S, Held HC, Beyer F, Kleber C
Injury 2023 May;54(5):1257-1264. Epub 2022 Dec 22 doi: 10.1016/j.injury.2022.12.021. PMID: 36577625
Association between Subcortical Morphology and Cerebral White Matter Energy Metabolism in Neonates with Congenital Heart Disease.
Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Bluml S, Paquette L, Panigrahy A
Sci Rep 2018 Sep 19;8(1):14057. doi: 10.1038/s41598-018-32288-3. PMID: 30232359Free PMC Article
Prognostic factors for acute encephalopathy with bright tree appearance.
Azuma J, Nabatame S, Nakano S, Iwatani Y, Kitai Y, Tominaga K, Kagitani-Shimono K, Okinaga T, Yamamoto T, Nagai T, Ozono K
Brain Dev 2015 Feb;37(2):191-9. Epub 2014 Apr 28 doi: 10.1016/j.braindev.2014.04.001. PMID: 24787271
Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors.
Pazos MR, Mohammed N, Lafuente H, Santos M, Martínez-Pinilla E, Moreno E, Valdizan E, Romero J, Pazos A, Franco R, Hillard CJ, Alvarez FJ, Martínez-Orgado J
Neuropharmacology 2013 Aug;71:282-91. Epub 2013 Apr 12 doi: 10.1016/j.neuropharm.2013.03.027. PMID: 23587650
1H MRS in acute traumatic brain injury.
Ross BD, Ernst T, Kreis R, Haseler LJ, Bayer S, Danielsen E, Blüml S, Shonk T, Mandigo JC, Caton W, Clark C, Jensen SW, Lehman NL, Arcinue E, Pudenz R, Shelden CH
J Magn Reson Imaging 1998 Jul-Aug;8(4):829-40. doi: 10.1002/jmri.1880080412. PMID: 9702884

Clinical prediction guides

Acquired Factor XIII Deficiency in Patients with Multiple Trauma.
Hetz M, Juratli T, Tiebel O, Giesecke MT, Tsitsilonis S, Held HC, Beyer F, Kleber C
Injury 2023 May;54(5):1257-1264. Epub 2022 Dec 22 doi: 10.1016/j.injury.2022.12.021. PMID: 36577625
Association between Subcortical Morphology and Cerebral White Matter Energy Metabolism in Neonates with Congenital Heart Disease.
Gertsvolf N, Votava-Smith JK, Ceschin R, Del Castillo S, Lee V, Lai HA, Bluml S, Paquette L, Panigrahy A
Sci Rep 2018 Sep 19;8(1):14057. doi: 10.1038/s41598-018-32288-3. PMID: 30232359Free PMC Article
Magnetic Resonance Spectroscopy for Traumatic Brain Injury.
Croall I, Smith FE, Blamire AM
Top Magn Reson Imaging 2015 Oct;24(5):267-74. doi: 10.1097/RMR.0000000000000063. PMID: 26502308
Prognostic factors for acute encephalopathy with bright tree appearance.
Azuma J, Nabatame S, Nakano S, Iwatani Y, Kitai Y, Tominaga K, Kagitani-Shimono K, Okinaga T, Yamamoto T, Nagai T, Ozono K
Brain Dev 2015 Feb;37(2):191-9. Epub 2014 Apr 28 doi: 10.1016/j.braindev.2014.04.001. PMID: 24787271
MRI, (1)H-MRS, and functional MRI during and after prolonged nonconvulsive seizure activity.
Lazeyras F, Blanke O, Zimine I, Delavelle J, Perrig SH, Seeck M
Neurology 2000 Dec 12;55(11):1677-82. doi: 10.1212/wnl.55.11.1677. PMID: 11113222

Recent systematic reviews

Brain lactate and pH in schizophrenia and bipolar disorder: a systematic review of findings from magnetic resonance studies.
Dogan AE, Yuksel C, Du F, Chouinard VA, Öngür D
Neuropsychopharmacology 2018 Jul;43(8):1681-1690. Epub 2018 Mar 14 doi: 10.1038/s41386-018-0041-9. PMID: 29581538Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...