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Cerebral Intraventricular Hemorrhage

MedGen UID:
1371930
•Concept ID:
C4505184
•
Disease or Syndrome
Synonyms: Cerebral Intraventricular Haemorrhage; Cerebral Intraventricular Haemorrhages; Cerebral Intraventricular Hemorrhages; Haemorrhage, Cerebral Intraventricular; Hemorrhage, Cerebral Intraventricular; Intraventricular Haemorrhage, Cerebral; Intraventricular Haemorrhages, Cerebral; Intraventricular Hemorrhage, Cerebral

Definition

Bleeding within the CEREBRAL VENTRICLES. It is associated with intraventricular trauma, aneurysm, vascular malformations, hypertension and in VERY LOW BIRTH WEIGHT infants. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebral Intraventricular Hemorrhage

Professional guidelines

PubMed

Fibrinolysis Treatment for Cerebral Intraventricular Hemorrhage: A Temporal and Spatial Voxel-Based Analysis.
Strinitz M, Kuramatsu J, Kaschka I, Kloska S, Dörfler A, Schwab S, Huttner HB, Seifert F
J Neuroimaging 2016 Sep;26(5):525-31. Epub 2016 Mar 14 doi: 10.1111/jon.12343. PMID: 26988440
Tailor-made circulatory management based on the stress-velocity relationship in preterm infants.
Toyoshima K, Kawataki M, Ohyama M, Shibasaki J, Yamaguchi N, Hoshino R, Itani Y, Nakazawa M
J Formos Med Assoc 2013 Sep;112(9):510-7. Epub 2013 May 17 doi: 10.1016/j.jfma.2013.02.011. PMID: 23685083
Multifocal or chaotic atrial rhythm: report of nine infants, delineation of clinical course and management, and review of the literature.
Liberthson RR, Colan SD
Pediatr Cardiol 1982;2(3):179-84. doi: 10.1007/BF02332108. PMID: 7111053

Recent clinical studies

Etiology

Severity of Bronchopulmonary Dysplasia Among Very Preterm Infants in the United States.
Jensen EA, Edwards EM, Greenberg LT, Soll RF, Ehret DEY, Horbar JD
Pediatrics 2021 Jul;148(1) Epub 2021 Jun 2 doi: 10.1542/peds.2020-030007. PMID: 34078747Free PMC Article
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
McGoldrick E, Stewart F, Parker R, Dalziel SR
Cochrane Database Syst Rev 2020 Dec 25;12(12):CD004454. doi: 10.1002/14651858.CD004454.pub4. PMID: 33368142Free PMC Article
Neonatal Intraventricular Hemorrhage and Hospitalization in Childhood.
Kaur A, Luu TM, Shah PS, Ayoub A, Auger N
Pediatr Neurol 2020 Feb;103:35-42. Epub 2019 Oct 19 doi: 10.1016/j.pediatrneurol.2019.09.007. PMID: 31753542
Association of Umbilical Cord Milking vs Delayed Umbilical Cord Clamping With Death or Severe Intraventricular Hemorrhage Among Preterm Infants.
Katheria A, Reister F, Essers J, Mendler M, Hummler H, Subramaniam A, Carlo W, Tita A, Truong G, Davis-Nelson S, Schmölzer G, Chari R, Kaempf J, Tomlinson M, Yanowitz T, Beck S, Simhan H, Dempsey E, O'Donoghue K, Bhat S, Hoffman M, Faksh A, Arnell K, Rich W, Finer N, Vaucher Y, Khanna P, Meyers M, Varner M, Allman P, Szychowski J, Cutter G
JAMA 2019 Nov 19;322(19):1877-1886. doi: 10.1001/jama.2019.16004. PMID: 31742630Free PMC Article
Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.
Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould WA, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP Jr, Rosenblum M, Thompson RE, Awad IA; CLEAR III Investigators
Lancet 2017 Feb 11;389(10069):603-611. Epub 2017 Jan 10 doi: 10.1016/S0140-6736(16)32410-2. PMID: 28081952Free PMC Article

Diagnosis

Severity of Bronchopulmonary Dysplasia Among Very Preterm Infants in the United States.
Jensen EA, Edwards EM, Greenberg LT, Soll RF, Ehret DEY, Horbar JD
Pediatrics 2021 Jul;148(1) Epub 2021 Jun 2 doi: 10.1542/peds.2020-030007. PMID: 34078747Free PMC Article
Antenatal diagnosis of fetal intraventricular hemorrhage: systematic review and meta-analysis.
Dunbar MJ, Woodward K, Leijser LM, Kirton A
Dev Med Child Neurol 2021 Feb;63(2):144-155. Epub 2020 Oct 22 doi: 10.1111/dmcn.14713. PMID: 33094492
Intracranial Hemorrhage.
Society for Maternal-Fetal Medicine (SMFM), Monteagudo A
Am J Obstet Gynecol 2020 Dec;223(6):B34-B37. Epub 2020 Nov 7 doi: 10.1016/j.ajog.2020.08.183. PMID: 33168218
Revolution in stroke.
Furie KL, Wong KS
J Neurol Neurosurg Psychiatry 2017 Jan;88(1):1. doi: 10.1136/jnnp-2016-315210. PMID: 27980045
Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.
Papile LA, Burstein J, Burstein R, Koffler H
J Pediatr 1978 Apr;92(4):529-34. doi: 10.1016/s0022-3476(78)80282-0. PMID: 305471

Therapy

Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
McGoldrick E, Stewart F, Parker R, Dalziel SR
Cochrane Database Syst Rev 2020 Dec 25;12(12):CD004454. doi: 10.1002/14651858.CD004454.pub4. PMID: 33368142Free PMC Article
Fibrinolytics and Intraventricular Hemorrhage: A Systematic Review and Meta-analysis.
van Solinge TS, Muskens IS, Kavouridis VK, Gormley WB, Mekary RA, Broekman MLD, Arnaout O
Neurocrit Care 2020 Feb;32(1):262-271. doi: 10.1007/s12028-019-00786-5. PMID: 31376141Free PMC Article
Association of Umbilical Cord Milking vs Delayed Umbilical Cord Clamping With Death or Severe Intraventricular Hemorrhage Among Preterm Infants.
Katheria A, Reister F, Essers J, Mendler M, Hummler H, Subramaniam A, Carlo W, Tita A, Truong G, Davis-Nelson S, Schmölzer G, Chari R, Kaempf J, Tomlinson M, Yanowitz T, Beck S, Simhan H, Dempsey E, O'Donoghue K, Bhat S, Hoffman M, Faksh A, Arnell K, Rich W, Finer N, Vaucher Y, Khanna P, Meyers M, Varner M, Allman P, Szychowski J, Cutter G
JAMA 2019 Nov 19;322(19):1877-1886. doi: 10.1001/jama.2019.16004. PMID: 31742630Free PMC Article
Fibrinolytic for treatment of intraventricular hemorrhage: A meta-analysis and systematic review.
Baker AD, Rivera Perla KM, Yu Z, Dlugash R, Avadhani R, Mould WA, Ziai W, Thompson RE, Staykov D, Hanley DF
Int J Stroke 2018 Jan;13(1):11-23. Epub 2017 Sep 18 doi: 10.1177/1747493017730745. PMID: 28920538
Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.
Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould WA, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP Jr, Rosenblum M, Thompson RE, Awad IA; CLEAR III Investigators
Lancet 2017 Feb 11;389(10069):603-611. Epub 2017 Jan 10 doi: 10.1016/S0140-6736(16)32410-2. PMID: 28081952Free PMC Article

Prognosis

Severity of Bronchopulmonary Dysplasia Among Very Preterm Infants in the United States.
Jensen EA, Edwards EM, Greenberg LT, Soll RF, Ehret DEY, Horbar JD
Pediatrics 2021 Jul;148(1) Epub 2021 Jun 2 doi: 10.1542/peds.2020-030007. PMID: 34078747Free PMC Article
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
McGoldrick E, Stewart F, Parker R, Dalziel SR
Cochrane Database Syst Rev 2020 Dec 25;12(12):CD004454. doi: 10.1002/14651858.CD004454.pub4. PMID: 33368142Free PMC Article
Intracranial Hemorrhage.
Society for Maternal-Fetal Medicine (SMFM), Monteagudo A
Am J Obstet Gynecol 2020 Dec;223(6):B34-B37. Epub 2020 Nov 7 doi: 10.1016/j.ajog.2020.08.183. PMID: 33168218
Neonatal Intraventricular Hemorrhage and Hospitalization in Childhood.
Kaur A, Luu TM, Shah PS, Ayoub A, Auger N
Pediatr Neurol 2020 Feb;103:35-42. Epub 2019 Oct 19 doi: 10.1016/j.pediatrneurol.2019.09.007. PMID: 31753542
Stem Cells for Extreme Prematurity.
Thébaud B
Am J Perinatol 2019 Jul;36(S 02):S68-S73. Epub 2019 Jun 25 doi: 10.1055/s-0039-1691774. PMID: 31238363

Clinical prediction guides

Severity of Bronchopulmonary Dysplasia Among Very Preterm Infants in the United States.
Jensen EA, Edwards EM, Greenberg LT, Soll RF, Ehret DEY, Horbar JD
Pediatrics 2021 Jul;148(1) Epub 2021 Jun 2 doi: 10.1542/peds.2020-030007. PMID: 34078747Free PMC Article
Neonatal Intraventricular Hemorrhage and Hospitalization in Childhood.
Kaur A, Luu TM, Shah PS, Ayoub A, Auger N
Pediatr Neurol 2020 Feb;103:35-42. Epub 2019 Oct 19 doi: 10.1016/j.pediatrneurol.2019.09.007. PMID: 31753542
Association of Umbilical Cord Milking vs Delayed Umbilical Cord Clamping With Death or Severe Intraventricular Hemorrhage Among Preterm Infants.
Katheria A, Reister F, Essers J, Mendler M, Hummler H, Subramaniam A, Carlo W, Tita A, Truong G, Davis-Nelson S, Schmölzer G, Chari R, Kaempf J, Tomlinson M, Yanowitz T, Beck S, Simhan H, Dempsey E, O'Donoghue K, Bhat S, Hoffman M, Faksh A, Arnell K, Rich W, Finer N, Vaucher Y, Khanna P, Meyers M, Varner M, Allman P, Szychowski J, Cutter G
JAMA 2019 Nov 19;322(19):1877-1886. doi: 10.1001/jama.2019.16004. PMID: 31742630Free PMC Article
Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.
Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould WA, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP Jr, Rosenblum M, Thompson RE, Awad IA; CLEAR III Investigators
Lancet 2017 Feb 11;389(10069):603-611. Epub 2017 Jan 10 doi: 10.1016/S0140-6736(16)32410-2. PMID: 28081952Free PMC Article
Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm.
Papile LA, Burstein J, Burstein R, Koffler H
J Pediatr 1978 Apr;92(4):529-34. doi: 10.1016/s0022-3476(78)80282-0. PMID: 305471

Recent systematic reviews

The histologic fetal inflammatory response and neonatal outcomes: systematic review and meta-analysis.
Kovács K, Kovács ŐZ, Bajzát D, Imrei M, Nagy R, Németh D, Kói T, Szabó M, Fintha A, Hegyi P, Garami M, Gasparics Á
Am J Obstet Gynecol 2024 May;230(5):493-511.e3. Epub 2023 Nov 13 doi: 10.1016/j.ajog.2023.11.1223. PMID: 37967697
Antenatal diagnosis of fetal intraventricular hemorrhage: systematic review and meta-analysis.
Dunbar MJ, Woodward K, Leijser LM, Kirton A
Dev Med Child Neurol 2021 Feb;63(2):144-155. Epub 2020 Oct 22 doi: 10.1111/dmcn.14713. PMID: 33094492
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
McGoldrick E, Stewart F, Parker R, Dalziel SR
Cochrane Database Syst Rev 2020 Dec 25;12(12):CD004454. doi: 10.1002/14651858.CD004454.pub4. PMID: 33368142Free PMC Article
Fibrinolytics and Intraventricular Hemorrhage: A Systematic Review and Meta-analysis.
van Solinge TS, Muskens IS, Kavouridis VK, Gormley WB, Mekary RA, Broekman MLD, Arnaout O
Neurocrit Care 2020 Feb;32(1):262-271. doi: 10.1007/s12028-019-00786-5. PMID: 31376141Free PMC Article
Fibrinolytic for treatment of intraventricular hemorrhage: A meta-analysis and systematic review.
Baker AD, Rivera Perla KM, Yu Z, Dlugash R, Avadhani R, Mould WA, Ziai W, Thompson RE, Staykov D, Hanley DF
Int J Stroke 2018 Jan;13(1):11-23. Epub 2017 Sep 18 doi: 10.1177/1747493017730745. PMID: 28920538

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