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Abnormal location of the eyebrow

MedGen UID:
1372060
•Concept ID:
C4477036
•
Anatomical Abnormality
Synonyms: Abnormal location of eyebrows; Abnormally placed eyebrows
 
HPO: HP:0040296

Definition

Anomalous anatomical placement of the eyebrow. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal location of the eyebrow

Professional guidelines

PubMed

Okur-Chung neurodevelopmental syndrome: Eight additional cases with implications on phenotype and genotype expansion.
Chiu ATG, Pei SLC, Mak CCY, Leung GKC, Yu MHC, Lee SL, Vreeburg M, Pfundt R, van der Burgt I, Kleefstra T, Frederic TM, Nambot S, Faivre L, Bruel AL, Rossi M, Isidor B, Küry S, Cogne B, Besnard T, Willems M, Reijnders MRF, Chung BHY
Clin Genet 2018 Apr;93(4):880-890. Epub 2018 Feb 13 doi: 10.1111/cge.13196. PMID: 29240241
Phenotype and genotype in 103 patients with tricho-rhino-phalangeal syndrome.
Maas SM, Shaw AC, Bikker H, Lüdecke HJ, van der Tuin K, Badura-Stronka M, Belligni E, Biamino E, Bonati MT, Carvalho DR, Cobben J, de Man SA, Den Hollander NS, Di Donato N, Garavelli L, Grønborg S, Herkert JC, Hoogeboom AJ, Jamsheer A, Latos-Bielenska A, Maat-Kievit A, Magnani C, Marcelis C, Mathijssen IB, Nielsen M, Otten E, Ousager LB, Pilch J, Plomp A, Poke G, Poluha A, Posmyk R, Rieubland C, Silengo M, Simon M, Steichen E, Stumpel C, Szakszon K, Polonkai E, van den Ende J, van der Steen A, van Essen T, van Haeringen A, van Hagen JM, Verheij JB, Mannens MM, Hennekam RC
Eur J Med Genet 2015 May;58(5):279-92. Epub 2015 Mar 16 doi: 10.1016/j.ejmg.2015.03.002. PMID: 25792522
Non-invasive quick diagnosis of cardiovascular problems from visible and invisible abnormal changes with increased cardiac troponin I appearing on cardiovascular representation areas of the eyebrows, left upper lip, etc. of the face & hands: beneficial manual stimulation of hands for acute anginal chest pain, and important factors in safe, effective treatment.
Omura Y, Jones MK, Duvvi H, Shimotsuura Y, Ohki M, Rodriques A
Acupunct Electrother Res 2014;39(2):135-67. doi: 10.3727/036012914x14054537750463. PMID: 25219029

Recent clinical studies

Etiology

The Course of Superficial Temporal Artery in Patients with Microtia and its Relationship with the Remnant.
Fu YY, Gao XL, Li CL, Zhang TY
Aesthetic Plast Surg 2022 Aug;46(4):1706-1712. Epub 2022 Apr 6 doi: 10.1007/s00266-022-02802-0. PMID: 35386006
Follicular keratosis of the face in pediatric patients of color.
Grullon K, Ashi SA, Shea CR, Ruiz de Luzuriaga AM, Stein SL, Rosenblatt AE
Pediatr Dermatol 2022 Mar;39(2):231-235. Epub 2022 Feb 17 doi: 10.1111/pde.14946. PMID: 35178760
Clinical and histological features and outcomes of upper eyelid colobomas in the Saudi population.
Al Essa D, Khandekar R, Galindo-Ferreiro A, Edward DP, Maktabi A, Al Hussein H, Al Sheikh O, Strianese D, Schellini SA
Orbit 2020 Oct;39(5):325-330. Epub 2019 Nov 13 doi: 10.1080/01676830.2019.1690006. PMID: 31722593
Left Supraorbital Eyebrow Approach for Microscopic Fenestration of a Neuroglial Cyst.
Borghei-Razavi H, Das P, Kshettry V
World Neurosurg 2018 Oct;118:161. Epub 2018 Jul 17 doi: 10.1016/j.wneu.2018.07.043. PMID: 30026159
1q21.3 deletion involving GATAD2B: An emerging recurrent microdeletion syndrome.
Tim-Aroon T, Jinawath N, Thammachote W, Sinpitak P, Limrungsikul A, Khongkhatithum C, Wattanasirichaigoon D
Am J Med Genet A 2017 Mar;173(3):766-770. doi: 10.1002/ajmg.a.38082. PMID: 28211977

Diagnosis

The Course of Superficial Temporal Artery in Patients with Microtia and its Relationship with the Remnant.
Fu YY, Gao XL, Li CL, Zhang TY
Aesthetic Plast Surg 2022 Aug;46(4):1706-1712. Epub 2022 Apr 6 doi: 10.1007/s00266-022-02802-0. PMID: 35386006
ZMYND11-related syndromic intellectual disability: 16 patients delineating and expanding the phenotypic spectrum.
Yates TM, Drucker M, Barnicoat A, Low K, Gerkes EH, Fry AE, Parker MJ, O'Driscoll M, Charles P, Cox H, Marey I, Keren B, Rinne T, McEntagart M, Ramachandran V, Drury S, Vansenne F, Sival DA, Herkert JC, Callewaert B, Tan WH, Balasubramanian M
Hum Mutat 2020 May;41(5):1042-1050. Epub 2020 Mar 5 doi: 10.1002/humu.24001. PMID: 32097528
1q21.3 deletion involving GATAD2B: An emerging recurrent microdeletion syndrome.
Tim-Aroon T, Jinawath N, Thammachote W, Sinpitak P, Limrungsikul A, Khongkhatithum C, Wattanasirichaigoon D
Am J Med Genet A 2017 Mar;173(3):766-770. doi: 10.1002/ajmg.a.38082. PMID: 28211977
Further delineation of the phenotype of truncating KMT2A mutations: The extended Wiedemann-Steiner syndrome.
Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, Wang L, Fan Y, Gu X, Yu Y
Am J Med Genet A 2017 Feb;173(2):510-514. Epub 2016 Oct 19 doi: 10.1002/ajmg.a.38025. PMID: 27759909
Alpha-mannosidosis.
Malm D, Nilssen Ø
Orphanet J Rare Dis 2008 Jul 23;3:21. doi: 10.1186/1750-1172-3-21. PMID: 18651971Free PMC Article

Therapy

Keratosis pilaris and filaggrin loss-of-function mutations in patients with atopic dermatitis - Results of a Finnish cross-sectional study.
Salava A, Salo V, Remitz A
J Dermatol 2022 Sep;49(9):928-932. Epub 2022 May 26 doi: 10.1111/1346-8138.16477. PMID: 35616138Free PMC Article
Clinical manifestations of Waardenburg syndrome in a male adolescent in Mali, West Africa.
Imperato PJ, Imperato GH
J Community Health 2015 Feb;40(1):103-9. doi: 10.1007/s10900-014-9942-7. PMID: 25224968
Predictors of ostial side branch damage during provisional stenting of coronary bifurcation lesions not involving the side branch origin: an ultrasonographic study.
Suárez de Lezo J, Medina A, Martín P, Novoa J, Suárez de Lezo J, Pan M, Caballero E, Melián F, Mazuelos F, Quevedo V
EuroIntervention 2012 Feb;7(10):1147-54. doi: 10.4244/EIJV7I10A185. PMID: 22030298
Keratosis pilaris rubra and keratosis pilaris atrophicans faciei treated with pulsed dye laser: report of 10 cases.
Alcántara González J, Boixeda P, Truchuelo Díez MT, Fleta Asín B
J Eur Acad Dermatol Venereol 2011 Jun;25(6):710-4. Epub 2010 Jun 21 doi: 10.1111/j.1468-3083.2010.03772.x. PMID: 20569297
Organ representation areas of different internal organs localized on the eyebrows & eyelids by the Bi-Digital O-Ring Test electromagnetic resonance phenomenon between 2 identical molecules--Part I: Detection of increased markers for cancer & heart disease from white hairs on the eyebrows and marked decrease in the markers after taking one optimal dose of DHEA.
Omura Y
Acupunct Electrother Res 2008;33(3-4):193-224. doi: 10.3727/036012908803861159. PMID: 19301629

Prognosis

The Course of Superficial Temporal Artery in Patients with Microtia and its Relationship with the Remnant.
Fu YY, Gao XL, Li CL, Zhang TY
Aesthetic Plast Surg 2022 Aug;46(4):1706-1712. Epub 2022 Apr 6 doi: 10.1007/s00266-022-02802-0. PMID: 35386006
SRD5A3-CDG: 3D structure modeling, clinical spectrum, and computer-based dysmorphic facial recognition.
Ben Ayed I, Ouarda W, Frikha F, Kammoun F, Souissi A, Ben Said M, Bouzid A, Elloumi I, Hamdani TM, Gharbi N, Baklouti N, Guirat M, Mejdoub F, Kharrat N, Boujelbene I, Abdelhedi F, Belguith N, Keskes L, Gibriel AA, Kamoun H, Triki C, Alimi AM, Masmoudi S
Am J Med Genet A 2021 Apr;185(4):1081-1090. Epub 2021 Jan 6 doi: 10.1002/ajmg.a.62065. PMID: 33403770
ZMYND11-related syndromic intellectual disability: 16 patients delineating and expanding the phenotypic spectrum.
Yates TM, Drucker M, Barnicoat A, Low K, Gerkes EH, Fry AE, Parker MJ, O'Driscoll M, Charles P, Cox H, Marey I, Keren B, Rinne T, McEntagart M, Ramachandran V, Drury S, Vansenne F, Sival DA, Herkert JC, Callewaert B, Tan WH, Balasubramanian M
Hum Mutat 2020 May;41(5):1042-1050. Epub 2020 Mar 5 doi: 10.1002/humu.24001. PMID: 32097528
De novo missense variants in MEIS2 recapitulate the microdeletion phenotype of cardiac and palate abnormalities, developmental delay, intellectual disability and dysmorphic features.
Douglas G, Cho MT, Telegrafi A, Winter S, Carmichael J, Zackai EH, Deardorff MA, Harr M, Williams L, Psychogios A, Erwin AL, Grebe T, Retterer K, Juusola J
Am J Med Genet A 2018 Sep;176(9):1845-1851. Epub 2018 Jul 28 doi: 10.1002/ajmg.a.40368. PMID: 30055086
Alpha-mannosidosis.
Malm D, Nilssen Ø
Orphanet J Rare Dis 2008 Jul 23;3:21. doi: 10.1186/1750-1172-3-21. PMID: 18651971Free PMC Article

Clinical prediction guides

Keratosis pilaris and filaggrin loss-of-function mutations in patients with atopic dermatitis - Results of a Finnish cross-sectional study.
Salava A, Salo V, Remitz A
J Dermatol 2022 Sep;49(9):928-932. Epub 2022 May 26 doi: 10.1111/1346-8138.16477. PMID: 35616138Free PMC Article
SRD5A3-CDG: 3D structure modeling, clinical spectrum, and computer-based dysmorphic facial recognition.
Ben Ayed I, Ouarda W, Frikha F, Kammoun F, Souissi A, Ben Said M, Bouzid A, Elloumi I, Hamdani TM, Gharbi N, Baklouti N, Guirat M, Mejdoub F, Kharrat N, Boujelbene I, Abdelhedi F, Belguith N, Keskes L, Gibriel AA, Kamoun H, Triki C, Alimi AM, Masmoudi S
Am J Med Genet A 2021 Apr;185(4):1081-1090. Epub 2021 Jan 6 doi: 10.1002/ajmg.a.62065. PMID: 33403770
ZMYND11-related syndromic intellectual disability: 16 patients delineating and expanding the phenotypic spectrum.
Yates TM, Drucker M, Barnicoat A, Low K, Gerkes EH, Fry AE, Parker MJ, O'Driscoll M, Charles P, Cox H, Marey I, Keren B, Rinne T, McEntagart M, Ramachandran V, Drury S, Vansenne F, Sival DA, Herkert JC, Callewaert B, Tan WH, Balasubramanian M
Hum Mutat 2020 May;41(5):1042-1050. Epub 2020 Mar 5 doi: 10.1002/humu.24001. PMID: 32097528
Left Supraorbital Eyebrow Approach for Microscopic Fenestration of a Neuroglial Cyst.
Borghei-Razavi H, Das P, Kshettry V
World Neurosurg 2018 Oct;118:161. Epub 2018 Jul 17 doi: 10.1016/j.wneu.2018.07.043. PMID: 30026159
Further delineation of the phenotype of truncating KMT2A mutations: The extended Wiedemann-Steiner syndrome.
Sun Y, Hu G, Liu H, Zhang X, Huang Z, Yan H, Wang L, Fan Y, Gu X, Yu Y
Am J Med Genet A 2017 Feb;173(2):510-514. Epub 2016 Oct 19 doi: 10.1002/ajmg.a.38025. PMID: 27759909

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