Anomalous insertion of papillary muscle directly into anterior mitral leaflet

MedGen UID:: 1373347
•Concept ID:: C4476782
•: Congenital Abnormality

HPO:	HP:0025446

Definition

A congenital malformation in which one or both of the papillary muscles (posteromedial or anterolateral) insert directly (that is, without interpositioned chordae tendineae) into the anterior mitral leaflet. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAnomalous insertion of papillary muscle directly into anterior mitral leaflet

Abnormality of the cardiovascular system
- Abnormal cardiovascular system morphology
  - Abnormal heart morphology
    - Abnormal cardiac ventricle morphology
      - Abnormal left ventricle morphology
        Abnormal papillary muscle morphology
        Anomalous insertion of papillary muscle directly into anterior mitral leaflet

Recent clinical studies

Etiology

Anomalous papillary muscles-Implications in the surgical treatment of hypertrophic obstructive cardiomyopathy.

Lentz Carvalho J, Schaff HV, Morris CS, Nishimura RA, Ommen SR, Maleszewski JJ, Dearani JA
J Thorac Cardiovasc Surg 2022 Jan;163(1):83-89.e1. Epub 2020 Apr 15 doi: 10.1016/j.jtcvs.2020.04.007. PMID: 32414597

Surgery for Anomalous Papillary Muscle Directly Into the Anterior Mitral Leaflet.

Mutsuga M, Tokuda Y, Fujimoto K, Terazawa S, Ito H, Narita Y, Usui A
Ann Thorac Surg 2021 May;111(5):1512-1518. Epub 2020 Sep 24 doi: 10.1016/j.athoracsur.2020.07.031. PMID: 32980328

Diversity of structural mitral valve alterations in hypertrophic cardiomyopathy.

Klues HG, Maron BJ, Dollar AL, Roberts WC
Circulation 1992 May;85(5):1651-60. doi: 10.1161/01.cir.85.5.1651. PMID: 1572023

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Diagnosis

Anomalous papillary muscles-Implications in the surgical treatment of hypertrophic obstructive cardiomyopathy.

Papillary muscle insertion directly into the anterior mitral leaflet in hypertrophic cardiomyopathy, its identification and cause of outflow obstruction by cardiac magnetic resonance imaging, and its surgical management.

Rowin EJ, Maron BJ, Lesser JR, Rastegar H, Maron MS
Am J Cardiol 2013 Jun 1;111(11):1677-9. Epub 2013 Mar 15 doi: 10.1016/j.amjcard.2013.01.340. PMID: 23499271

Pitfalls in clinical recognition and a novel operative approach for hypertrophic cardiomyopathy with severe outflow obstruction due to anomalous papillary muscle.

Maron BJ, Nishimura RA, Danielson GK
Circulation 1998 Dec 8;98(23):2505-8. doi: 10.1161/01.cir.98.23.2505. PMID: 9843454

Hypertrophic obstructive cardiomyopathy in combination with anomalous insertion of papillary muscle directly into anterior mitral leaflet and "sawfish" systolic narrowing of the left anterior descending coronary artery.

Taşdemir O, Küçükaksu DS, Kural T, Bayazit K
Tex Heart Inst J 1994;21(4):317-20. PMID: 7888810 Free PMC Article

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