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Non-Keratinizing Small Cell Squamous Cell Carcinoma

MedGen UID:
137731
•Concept ID:
C0334249
•
Neoplastic Process
Synonyms: Epidermoid carcinoma, small cell, nonkeratinizing; Non-keratinizing epidermoid carcinoma - small cell; Non-keratinizing squamous cell carcinoma - small cell; Squamous cell carcinoma, small cell, nonkeratinizing
SNOMED CT: Non-keratinizing squamous cell carcinoma - small cell (35718007); Non-keratinizing epidermoid carcinoma - small cell (35718007); Squamous cell carcinoma, small cell, nonkeratinizing (35718007); Epidermoid carcinoma, small cell, nonkeratinizing (35718007)

Definition

A squamous cell carcinoma composed of small atypical cells, without morphologic evidence of keratin production. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Keratinizing Small Cell Squamous Cell Carcinoma

Professional guidelines

PubMed

Utility of p40 in the Differential Diagnosis of Small Round Blue Cell Tumors of the Sinonasal Tract.
Tilson MP, Bishop JA
Head Neck Pathol 2014 Jun;8(2):141-5. Epub 2013 Oct 11 doi: 10.1007/s12105-013-0496-2. PMID: 24114197Free PMC Article
The relationship between expression of p53/bcl-2 and clinicopathological criteria in cervix squamous cell carcinomas.
Bitiren M, Cakmak EA, Gocmen A, Inaloz SS, Sari I, Karakok M, Aydin A
Eur J Gynaecol Oncol 2003;24(5):411-2. PMID: 14584658

Recent clinical studies

Etiology

Human papillomavirus and Epstein-Barr virus in nasopharyngeal carcinoma in a non-endemic eastern european population.
Svajdler M Jr, Kaspirkova J, Mezencev R, Laco J, Torday T, Dubinsky P, Straka L, Ondic O, Michal M, Skalova A
Neoplasma 2016;63(1):107-14. doi: 10.4149/neo_2016_013. PMID: 26639240
Among sinonasal tumors, CDX-2 immunoexpression is not restricted to intestinal-type adenocarcinomas.
Tilson MP, Gallia GL, Bishop JA
Head Neck Pathol 2014 Mar;8(1):59-65. Epub 2013 Jul 12 doi: 10.1007/s12105-013-0475-7. PMID: 23846317Free PMC Article
Human papillomavirus (HPV) related carcinomas of the upper aerodigestive tract.
El-Mofty SK
Head Neck Pathol 2007 Dec;1(2):181-5. Epub 2007 Oct 26 doi: 10.1007/s12105-007-0021-6. PMID: 20614273Free PMC Article
The association of squamous cell carcinomas of the nasopharynx with Epstein-Barr virus shows geographical variation reminiscent of Burkitt's lymphoma.
Nicholls JM, Agathanggelou A, Fung K, Zeng X, Niedobitek G
J Pathol 1997 Oct;183(2):164-8. doi: 10.1002/(SICI)1096-9896(199710)183:2<164::AID-PATH919>3.0.CO;2-J. PMID: 9390028
Invasive squamous cell carcinoma of the uterine cervix. VI. Prediction value of non-keratinizing, parakeratotic and orthokeratotic cell forms and clinical staging.
Willén H, Willén R, Stendahl U
Acta Radiol Oncol 1982;21(6):401-6. doi: 10.3109/02841868209134319. PMID: 6305117

Diagnosis

Programmed death ligand-1 expression and its association with the degree of differentiation and the presence of necrosis in non-small cell lung carcinoma.
Blichárová A, Tancoš V, Benetinová Z, Verbóová Ľ, Grendár M, Mazuráková A, Plank L, Mechírová E
Pathol Res Pract 2023 Feb;242:154296. Epub 2023 Jan 4 doi: 10.1016/j.prp.2022.154296. PMID: 36610327
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223
Non-keratinizing undifferentiated carcinoma of the nasopharynx.
Boia ER, Boia M, Balica NC, Rusu LC, Mazilu O, Solovan C, Baderca F
Rom J Morphol Embryol 2013;54(3 Suppl):839-43. PMID: 24322037

Therapy

ALK-rearranged squamous cell lung carcinoma responding to crizotinib: A missing link in the field of non-small cell lung cancer?
Vergne F, Quéré G, Andrieu-Key S, Descourt R, Quintin-Roué I, Talagas M, De Braekeleer M, Marcorelles P, Uguen A
Lung Cancer 2016 Jan;91:67-9. Epub 2015 Nov 10 doi: 10.1016/j.lungcan.2015.11.010. PMID: 26603857
Case report: primary cystic keratinizing squamous cell carcinoma of the liver in a patient with treated nasopharyngeal carcinoma.
Chou YY, Lee WJ, Su CT, Hsu HC
J Gastroenterol Hepatol 1997 Mar;12(3):229-32. doi: 10.1111/j.1440-1746.1997.tb00413.x. PMID: 9142640

Prognosis

Intracellular calprotectin (S100A8/A9) controls epithelial differentiation and caspase-mediated cleavage of EGFR in head and neck squamous cell carcinoma.
Argyris PP, Slama Z, Malz C, Koutlas IG, Pakzad B, Patel K, Kademani D, Khammanivong A, Herzberg MC
Oral Oncol 2019 Aug;95:1-10. Epub 2019 Jun 4 doi: 10.1016/j.oraloncology.2019.05.027. PMID: 31345374Free PMC Article
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223
Histological cell type and DNA value in the prognosis of squamous cell cancer of uterine cervix.
Ng AB, Atkin NB
Br J Cancer 1973 Oct;28(4):322-31. doi: 10.1038/bjc.1973.155. PMID: 4759940Free PMC Article

Clinical prediction guides

Programmed death ligand-1 expression and its association with the degree of differentiation and the presence of necrosis in non-small cell lung carcinoma.
Blichárová A, Tancoš V, Benetinová Z, Verbóová Ľ, Grendár M, Mazuráková A, Plank L, Mechírová E
Pathol Res Pract 2023 Feb;242:154296. Epub 2023 Jan 4 doi: 10.1016/j.prp.2022.154296. PMID: 36610327
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
Sinonasal small round blue cell tumors: An approach to diagnosis.
Simons SA, Bridge JA, Leon ME
Semin Diagn Pathol 2016 Mar;33(2):91-103. Epub 2015 Sep 10 doi: 10.1053/j.semdp.2015.09.010. PMID: 26585346
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223
Histological cell type and DNA value in the prognosis of squamous cell cancer of uterine cervix.
Ng AB, Atkin NB
Br J Cancer 1973 Oct;28(4):322-31. doi: 10.1038/bjc.1973.155. PMID: 4759940Free PMC Article

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