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Adenocarcinoma In Situ in Adenomatous Polyp

MedGen UID:
137738
•Concept ID:
C0334290
•
Neoplastic Process
Synonyms: Adenocarcinoma in situ in adenomatous polyp; Adenocarcinoma in situ in polypoid adenoma; Carcinoma in situ in adenomatous polyp
SNOMED CT: Adenocarcinoma in situ in adenomatous polyp (60286009); Carcinoma in situ in adenomatous polyp (60286009); Adenocarcinoma in situ in polypoid adenoma (60286009)

Definition

A non-invasive adenocarcinoma arising from the neoplastic glandular cells in an adenomatous polyp. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdenocarcinoma In Situ in Adenomatous Polyp

Recent clinical studies

Etiology

Gallbladder cancers: associated conditions, histological types, prognosis, and prevention.
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695
Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence.
Alaiyan B, Ilyayev N, Stojadinovic A, Izadjoo M, Roistacher M, Pavlov V, Tzivin V, Halle D, Pan H, Trink B, Gure AO, Nissan A
BMC Cancer 2013 Apr 17;13:196. doi: 10.1186/1471-2407-13-196. PMID: 23594791Free PMC Article
ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis.
Barone M, Scavo MP, Papagni S, Piscitelli D, Guido R, Di Lena M, Comelli MC, Di Leo A
Scand J Gastroenterol 2010 Nov;45(11):1320-8. Epub 2010 May 6 doi: 10.3109/00365521.2010.487915. PMID: 20446826
Pulmonary preinvasive neoplasia.
Kerr KM
J Clin Pathol 2001 Apr;54(4):257-71. doi: 10.1136/jcp.54.4.257. PMID: 11304841Free PMC Article
Colonoscopic polypectomy.
Leaverton GH, Haun TM, Meihoff WE
Am Surg 1976 Jul;42(7):449-54. PMID: 937851

Diagnosis

Artificial Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy.
Rodriguez-Diaz E, Jepeal LI, Baffy G, Lo WK, MashimoMD H, A'amar O, Bigio IJ, Singh SK
Dig Dis Sci 2022 Feb;67(2):613-621. Epub 2021 Mar 24 doi: 10.1007/s10620-021-06901-x. PMID: 33761089
microRNA-17 Is the Most Up-Regulated Member of the miR-17-92 Cluster during Early Colon Cancer Evolution.
Knudsen KN, Nielsen BS, Lindebjerg J, Hansen TF, Holst R, Sørensen FB
PLoS One 2015;10(10):e0140503. Epub 2015 Oct 14 doi: 10.1371/journal.pone.0140503. PMID: 26465597Free PMC Article
Gallbladder cancers: associated conditions, histological types, prognosis, and prevention.
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695
Localization of tissue inhibitor of metalloproteinases 1 (TIMP-1) in human colorectal adenoma and adenocarcinoma.
Holten-Andersen MN, Hansen U, Brünner N, Nielsen HJ, Illemann M, Nielsen BS
Int J Cancer 2005 Jan 10;113(2):198-206. doi: 10.1002/ijc.20566. PMID: 15386409
Colonoscopic polypectomy.
Leaverton GH, Haun TM, Meihoff WE
Am Surg 1976 Jul;42(7):449-54. PMID: 937851

Therapy

Clinical outcome of endoscopic resection for nonampullary duodenal tumors.
Nonaka S, Oda I, Tada K, Mori G, Sato Y, Abe S, Suzuki H, Yoshinaga S, Nakajima T, Matsuda T, Taniguchi H, Saito Y, Maetani I
Endoscopy 2015 Feb;47(2):129-35. Epub 2014 Oct 14 doi: 10.1055/s-0034-1390774. PMID: 25314330
Gallbladder cancers: associated conditions, histological types, prognosis, and prevention.
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695
Transanal endoscopic microsurgery: a Brazilian initial experience in private practice.
Araujo SE, Seid VE, de Araujo Horcel L, de Araujo Horcel G, Bertoncini AB
Hepatogastroenterology 2012 Sep;59(118):1822-7. doi: 10.5754/hge12021. PMID: 22389269
Flexible sigmoidoscopy screening for colorectal cancer in average-risk subjects: a community-based pilot project.
Olynyk JK, Aquilia S, Fletcher DR, Dickinson JA
Med J Aust 1996 Jul 15;165(2):74-6. doi: 10.5694/j.1326-5377.1996.tb124851.x. PMID: 8692065
Safer colonoscopic polypectomy with local submucosal injection of hypertonic saline-epinephrine solution.
Shirai M, Nakamura T, Matsuura A, Ito Y, Kobayashi S
Am J Gastroenterol 1994 Mar;89(3):334-8. PMID: 8122640

Prognosis

Artificial Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy.
Rodriguez-Diaz E, Jepeal LI, Baffy G, Lo WK, MashimoMD H, A'amar O, Bigio IJ, Singh SK
Dig Dis Sci 2022 Feb;67(2):613-621. Epub 2021 Mar 24 doi: 10.1007/s10620-021-06901-x. PMID: 33761089
TRAP1 protein signature predicts outcome in human metastatic colorectal carcinoma.
Maddalena F, Simeon V, Vita G, Bochicchio A, Possidente L, Sisinni L, Lettini G, Condelli V, Matassa DS, Li Bergolis V, Fersini A, Romito S, Aieta M, Ambrosi A, Esposito F, Landriscina M
Oncotarget 2017 Mar 28;8(13):21229-21240. doi: 10.18632/oncotarget.15070. PMID: 28177905Free PMC Article
Gallbladder cancers: associated conditions, histological types, prognosis, and prevention.
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695
ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis.
Barone M, Scavo MP, Papagni S, Piscitelli D, Guido R, Di Lena M, Comelli MC, Di Leo A
Scand J Gastroenterol 2010 Nov;45(11):1320-8. Epub 2010 May 6 doi: 10.3109/00365521.2010.487915. PMID: 20446826
Pathology of colorectal cancer.
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519

Clinical prediction guides

Artificial Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy.
Rodriguez-Diaz E, Jepeal LI, Baffy G, Lo WK, MashimoMD H, A'amar O, Bigio IJ, Singh SK
Dig Dis Sci 2022 Feb;67(2):613-621. Epub 2021 Mar 24 doi: 10.1007/s10620-021-06901-x. PMID: 33761089
TRAP1 protein signature predicts outcome in human metastatic colorectal carcinoma.
Maddalena F, Simeon V, Vita G, Bochicchio A, Possidente L, Sisinni L, Lettini G, Condelli V, Matassa DS, Li Bergolis V, Fersini A, Romito S, Aieta M, Ambrosi A, Esposito F, Landriscina M
Oncotarget 2017 Mar 28;8(13):21229-21240. doi: 10.18632/oncotarget.15070. PMID: 28177905Free PMC Article
Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence.
Alaiyan B, Ilyayev N, Stojadinovic A, Izadjoo M, Roistacher M, Pavlov V, Tzivin V, Halle D, Pan H, Trink B, Gure AO, Nissan A
BMC Cancer 2013 Apr 17;13:196. doi: 10.1186/1471-2407-13-196. PMID: 23594791Free PMC Article
ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis.
Barone M, Scavo MP, Papagni S, Piscitelli D, Guido R, Di Lena M, Comelli MC, Di Leo A
Scand J Gastroenterol 2010 Nov;45(11):1320-8. Epub 2010 May 6 doi: 10.3109/00365521.2010.487915. PMID: 20446826
Plasminogen activators and inhibitor type 1 in neoplastic colonic tissue from patients with familial adenomatous polyposis.
Sier CF, Vloedgraven HJ, Griffioen G, Ganesh S, Nagengast FM, Lamers CB, Verspaget HW
Br J Cancer 1995 Feb;71(2):393-6. doi: 10.1038/bjc.1995.80. PMID: 7841059Free PMC Article

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