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Oligoclonal T cell expansion

MedGen UID:
1377498
•Concept ID:
C4479459
•
Cell or Molecular Dysfunction
Synonym: Oligoclonal T-cell expansions
 
HPO: HP:0031430

Definition

The presence of a population of T cells with a restricted T cell receptor (TCR) repertoire derived from a limited number of TCR clones. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOligoclonal T cell expansion

Professional guidelines

PubMed

Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment.
Turner CT, Brown J, Shaw E, Uddin I, Tsaliki E, Roe JK, Pollara G, Sun Y, Heather JM, Lipman M, Chain B, Noursadeghi M
Front Immunol 2021;12:634489. Epub 2021 Feb 25 doi: 10.3389/fimmu.2021.634489. PMID: 33732256Free PMC Article
Analysis of lymphocyte phenotype and T cell receptor genotype in Felty's syndrome.
Meliconi R, Kingsley GH, Pitzalis C, Sakkas L, Panayi GS
J Rheumatol 1992 Jul;19(7):1058-64. PMID: 1380988

Recent clinical studies

Etiology

Pegilodecakin combined with pembrolizumab or nivolumab for patients with advanced solid tumours (IVY): a multicentre, multicohort, open-label, phase 1b trial.
Naing A, Wong DJ, Infante JR, Korn WM, Aljumaily R, Papadopoulos KP, Autio KA, Pant S, Bauer TM, Drakaki A, Daver NG, Hung A, Ratti N, McCauley S, Van Vlasselaer P, Verma R, Ferry D, Oft M, Diab A, Garon EB, Tannir NM
Lancet Oncol 2019 Nov;20(11):1544-1555. Epub 2019 Sep 25 doi: 10.1016/S1470-2045(19)30514-5. PMID: 31563517Free PMC Article
Molecular analysis of T-cell clonality with concomitant specific T-cell proliferation in vitro in nickel-allergic individuals.
Summer B, Sander CA, Przybilla B, Thomas P
Allergy 2001 Aug;56(8):767-70. doi: 10.1034/j.1398-9995.2001.056008767.x. PMID: 11488671
Multiple mechanisms support oligoclonal T cell expansion in rheumatoid synovitis.
Rittner HL, Zettl A, Jendro MC, Bartz-Bazzanella P, Goronzy JJ, Weyand CM
Mol Med 1997 Jul;3(7):452-65. PMID: 9260157Free PMC Article

Diagnosis

Clinical and immunophenotypic features of atypical complete DiGeorge syndrome.
Vu QV, Wada T, Toma T, Tajima H, Maeda M, Tanaka R, Oh-Ishi T, Yachie A
Pediatr Int 2013 Feb;55(1):2-6. Epub 2012 Dec 11 doi: 10.1111/j.1442-200X.2012.03722.x. PMID: 22978387
Regressed cutaneous malignant melanoma mimicking lymphoma: a potential diagnostic pitfall.
Menasce LP, Shanks JH, Howarth VS, Banerjee SS
Int J Surg Pathol 2005 Jul;13(3):281-4. doi: 10.1177/106689690501300310. PMID: 16086086
Molecular analysis of T-cell receptor repertoire in bone marrow transplant recipients: evidence for oligoclonal T-cell expansion in graft-versus-host disease lesions.
Liu X, Chesnokova V, Forman SJ, Diamond DJ
Blood 1996 Apr 1;87(7):3032-44. PMID: 8639927
T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor beta-chain CDR3 size determination: evidence for oligoclonal expansions in tumours and inflammatory diseases.
Even J, Lim A, Puisieux I, Ferradini L, Dietrich PY, Toubert A, Hercend T, Triebel F, Pannetier C, Kourilsky P
Res Immunol 1995 Feb;146(2):65-80. doi: 10.1016/0923-2494(96)80240-9. PMID: 7481075

Therapy

Case report: A persistently expanded T cell response in an exceptional responder to radiation and atezolizumab for metastatic non-small cell lung cancer.
Coffey DG, Xu Y, Towlerton AMH, Kowanetz M, Hegde P, Darwish M, Yadav M, Blanchette C, Ruppert SM, Bertino S, Xu Q, Ferretti A, Weinheimer A, Hellmann M, Qin A, Thomas D, Warren EH, Ramnath N
Front Immunol 2022;13:961105. Epub 2022 Sep 9 doi: 10.3389/fimmu.2022.961105. PMID: 36159875Free PMC Article
Oligoclonal T-cell expansion in a patient with bone marrow failure after CD19 CAR-T therapy for Richter-transformed DLBCL.
Rejeski K, Wu Z, Blumenberg V, Kunz WG, Müller S, Kajigaya S, Gao S, Bücklein VL, Frölich L, Schmidt C, von Bergwelt-Baildon M, Feng X, Young NS, Subklewe M
Blood 2022 Nov 17;140(20):2175-2179. doi: 10.1182/blood.2022017015. PMID: 35776908Free PMC Article
Persistent T Cell Repertoire Perturbation and T Cell Activation in HIV After Long Term Treatment.
Turner CT, Brown J, Shaw E, Uddin I, Tsaliki E, Roe JK, Pollara G, Sun Y, Heather JM, Lipman M, Chain B, Noursadeghi M
Front Immunol 2021;12:634489. Epub 2021 Feb 25 doi: 10.3389/fimmu.2021.634489. PMID: 33732256Free PMC Article
Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer.
Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ
Nature 2015 Apr 16;520(7547):373-7. Epub 2015 Mar 9 doi: 10.1038/nature14292. PMID: 25754329Free PMC Article
Oligoclonal T cell expansion in myelodysplastic syndrome: evidence for an autoimmune process.
Epperson DE, Nakamura R, Saunthararajah Y, Melenhorst J, Barrett AJ
Leuk Res 2001 Dec;25(12):1075-83. doi: 10.1016/s0145-2126(01)00083-2. PMID: 11684279

Prognosis

Oligoclonal T Cells Transiently Expand and Express Tim-3 and PD-1 Following Anti-CD19 CAR T Cell Therapy: A Case Report.
Funk CR, Petersen CT, Jagirdar N, Ravindranathan S, Jaye DL, Flowers CR, Langston A, Waller EK
Int J Mol Sci 2018 Dec 19;19(12) doi: 10.3390/ijms19124118. PMID: 30572564Free PMC Article
Extensive clonal expansion of T lymphocytes causes contracted diversity of complementarity-determining region 3 and skewed T cell receptor repertoires after allogeneic hematopoietic cell transplantation.
Hirokawa M, Matsutani T, Horiuchi T, Kawabata Y, Kitabayashi A, Yoshioka T, Tsuruta Y, Suzuki R, Miura AB
Bone Marrow Transplant 2001 Mar;27(6):607-14. doi: 10.1038/sj.bmt.1702858. PMID: 11319590
Analysis of accumulated T cell clonotypes in patients with systemic lupus erythematosus.
Kato T, Kurokawa M, Sasakawa H, Masuko-Hongo K, Matsui T, Sekine T, Tanaka C, Yamamoto K, Nishioka K
Arthritis Rheum 2000 Dec;43(12):2712-21. doi: 10.1002/1529-0131(200012)43:12<2712::AID-ANR11>3.0.CO;2-T. PMID: 11145029
T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor beta-chain CDR3 size determination: evidence for oligoclonal expansions in tumours and inflammatory diseases.
Even J, Lim A, Puisieux I, Ferradini L, Dietrich PY, Toubert A, Hercend T, Triebel F, Pannetier C, Kourilsky P
Res Immunol 1995 Feb;146(2):65-80. doi: 10.1016/0923-2494(96)80240-9. PMID: 7481075

Clinical prediction guides

Oligoclonal T Cells Transiently Expand and Express Tim-3 and PD-1 Following Anti-CD19 CAR T Cell Therapy: A Case Report.
Funk CR, Petersen CT, Jagirdar N, Ravindranathan S, Jaye DL, Flowers CR, Langston A, Waller EK
Int J Mol Sci 2018 Dec 19;19(12) doi: 10.3390/ijms19124118. PMID: 30572564Free PMC Article
Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema.
Motz GT, Eppert BL, Sun G, Wesselkamper SC, Linke MJ, Deka R, Borchers MT
J Immunol 2008 Dec 1;181(11):8036-43. doi: 10.4049/jimmunol.181.11.8036. PMID: 19017996
Oligoclonal expansion of intraepidermal T cells in psoriasis skin lesions.
Lin WJ, Norris DA, Achziger M, Kotzin BL, Tomkinson B
J Invest Dermatol 2001 Dec;117(6):1546-53. doi: 10.1046/j.0022-202x.2001.01548.x. PMID: 11886521
Molecular analysis of T-cell clonality with concomitant specific T-cell proliferation in vitro in nickel-allergic individuals.
Summer B, Sander CA, Przybilla B, Thomas P
Allergy 2001 Aug;56(8):767-70. doi: 10.1034/j.1398-9995.2001.056008767.x. PMID: 11488671
Lymphadenopathy, oligoclonal T cell receptor rearrangement and systemic lupus erythematosus.
Khraishi M, Reis M, Berinstein N, Rubin L
J Rheumatol 1992 Dec;19(12):1966-9. PMID: 1294749

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