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Cellular Blue Nevus

MedGen UID:
137764
Concept ID:
C0334448
Neoplastic Process
Synonyms: Blue Nevi, Cellular; Blue Nevus, Cellular; Cellular Blue Nevi; Nevi, Cellular Blue; Nevus, Cellular Blue
SNOMED CT: Cellular blue nevus (88006009); Cellular blue nevus of skin (254808005)

Definition

A blue nevus characterized by a multinodular cellular infiltrate with a dumb-bell architecture occupying the reticular dermis. The cellular infiltrate often extends into the subcutaneous tissue. The cellular infiltrate is composed of spindle-shaped melanocytes with pale cytoplasm alternating with bundles of pigmented spindle-shaped melanocytes. In occasional cases an increased mitotic activity, focal necrosis, and nuclear pleomorphism may be seen. Such cases with atypical features may have an uncertain malignant potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular Blue Nevus

Professional guidelines

PubMed

Mologousis MA, Moustafa D, Hawryluk EB
Pediatr Dermatol 2024 Mar-Apr;41(2):266-269. Epub 2023 Dec 21 doi: 10.1111/pde.15507. PMID: 38128580
Lasota J, Chłopek M, Kaczorowski M, Natálie K, Ryś J, Kopczyński J, Sulaieva O, Michal M, Kruczak A, Harazin-Lechowska A, Szczepaniak M, Koshyk O, Hałoń A, Czapiewski P, Abdullaev Z, Kowalik A, Aldape KD, Michal M, Miettinen M
Am J Surg Pathol 2024 Jan 1;48(1):97-105. Epub 2023 Oct 27 doi: 10.1097/PAS.0000000000002144. PMID: 37899499
Yaman B, Kandiloğlu G, Kumbaraci BS, Akalin T
Turk Patoloji Derg 2015;31(2):89-94. doi: 10.5146/tjpath.2014.01296. PMID: 25690862

Recent clinical studies

Etiology

Thangaiah JJ, Westling BE, Roden AC, Giannini C, Tetzlaff M, Cho WC, Folpe AL
Ann Diagn Pathol 2022 Aug;59:151967. Epub 2022 May 6 doi: 10.1016/j.anndiagpath.2022.151967. PMID: 35567887
Suller AL, Zhao J, Hodgson NM, Erdag G, Seethala RR, Ramasubramanian A, Fu R
Orbit 2022 Oct;41(5):527-534. Epub 2022 Apr 28 doi: 10.1080/01676830.2022.2065315. PMID: 35482915
Daltro LR, Yaegashi LB, Freitas RA, Fantini BC, Souza CD
An Bras Dermatol 2017 Jan-Feb;92(1):110-112. doi: 10.1590/abd1806-4841.20174502. PMID: 28225968Free PMC Article
Spring P, Perrier P, Erba P, Hagmann P, Mihm MC, Hohl D
Dermatology 2013;227(1):21-5. Epub 2013 Jul 11 doi: 10.1159/000351317. PMID: 23860244
Murali R, McCarthy SW, Scolyer RA
Adv Anat Pathol 2009 Nov;16(6):365-82. doi: 10.1097/PAP.0b013e3181bb6b53. PMID: 19851128

Diagnosis

Henning A, Billings S, Ko J, Weaver J
Am J Dermatopathol 2021 May 1;43(5):e61-e64. doi: 10.1097/DAD.0000000000001913. PMID: 33534207
Zembowicz A
Clin Lab Med 2017 Sep;37(3):401-415. Epub 2017 Jul 4 doi: 10.1016/j.cll.2017.05.001. PMID: 28802492
He T, Mao C, Xu D, Yan H
Ann Clin Lab Sci 2017 Aug;47(4):477-480. PMID: 28801376
Borgenvik TL, Karlsvik TM, Ray S, Fawzy M, James N
ANZ J Surg 2017 May;87(5):345-349. Epub 2017 Mar 20 doi: 10.1111/ans.13946. PMID: 28318130
Eskue K, Prieto VG, Malpica A
Int J Gynecol Pathol 2010 Nov;29(6):583-6. doi: 10.1097/PGP.0b013e3181e4b797. PMID: 20881851

Therapy

Nakamura Y, Shibata-Ito M, Nakamura Y, Ishitsuka Y, Fujisawa Y, Kawachi Y, Otsuka F
Pediatr Dermatol 2012 Sep-Oct;29(5):651-5. Epub 2012 Jan 26 doi: 10.1111/j.1525-1470.2011.01662.x. PMID: 22277073
Calista D, Schianchi S, Landi C
Int J Dermatol 1998 Feb;37(2):126-7. doi: 10.1046/j.1365-4362.1998.00370.x. PMID: 9542669

Prognosis

Sayed-Ahmed I, Murillo JC, Monsalve P, Ulloa JP, Fernandez MP, Wong J, Elgart G, Galor A, Dubovy SR, Karp CL
Ophthalmology 2018 Aug;125(8):1189-1198. Epub 2018 Mar 15 doi: 10.1016/j.ophtha.2018.02.006. PMID: 29551421Free PMC Article
Borgenvik TL, Karlsvik TM, Ray S, Fawzy M, James N
ANZ J Surg 2017 May;87(5):345-349. Epub 2017 Mar 20 doi: 10.1111/ans.13946. PMID: 28318130
Yaman B, Kandiloğlu G, Kumbaraci BS, Akalin T
Turk Patoloji Derg 2015;31(2):89-94. doi: 10.5146/tjpath.2014.01296. PMID: 25690862
Richards HW, Medrano EE
Pigment Cell Melanoma Res 2009 Feb;22(1):14-29. Epub 2008 Nov 27 doi: 10.1111/j.1755-148X.2008.00534.x. PMID: 19040501
Aloi F, Pich A, Pippione M
Dermatology 1996;192(1):36-40. doi: 10.1159/000246311. PMID: 8832950

Clinical prediction guides

Borgenvik TL, Karlsvik TM, Ray S, Fawzy M, James N
ANZ J Surg 2017 May;87(5):345-349. Epub 2017 Mar 20 doi: 10.1111/ans.13946. PMID: 28318130
Yaman B, Kandiloğlu G, Kumbaraci BS, Akalin T
Turk Patoloji Derg 2015;31(2):89-94. doi: 10.5146/tjpath.2014.01296. PMID: 25690862
Barros JA, Kafler CC, Barros JC, Proto RS, Priscila dos Santos C, Machado Filho CD
An Bras Dermatol 2012 Jul-Aug;87(4):661-2. doi: 10.1590/s0365-05962012000400031. PMID: 22892793
Dhouib RS, Sassi S, Jbeli A, Driss M, Mrad K, Abbes I, Ben Romdhane K
Pathologica 2008 Jun;100(3):181-4. PMID: 18841824
Zembowicz A, Granter SR, McKee PH, Mihm MC
Am J Surg Pathol 2002 Nov;26(11):1493-500. doi: 10.1097/00000478-200211000-00012. PMID: 12409726

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