Impaired annexin V binding to platelet phosphatidylserine

MedGen UID:: 1378738
•Concept ID:: C4476991
•: Cell or Molecular Dysfunction

HPO:	HP:0031132

Definition

Reduced binding of annexin V to platelet membrane, which is mediated by exposed phosphatidylserine. This can be measured by flow cytometry. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVImpaired annexin V binding to platelet phosphatidylserine

Phenotypic abnormality
- Abnormality of blood and blood-forming tissues
  - Abnormality of thrombocytes
    - Abnormal platelet function
      - Abnormal platelet phosphatidylserine exposure
        Impaired annexin V binding to platelet phosphatidylserine
        Increased annexin V binding to platelet phosphatidylserine

Recent clinical studies

Diagnosis

Detection of the procoagulant activity of microparticle-associated phosphatidylserine using XACT.

Connor DE, Exner T, Ma DD, Joseph JE
Blood Coagul Fibrinolysis 2009 Oct;20(7):558-64. doi: 10.1097/MBC.0b013e32832ee915. PMID: 19593114

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Clinical prediction guides

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment.

Poehler AM, Xiang W, Spitzer P, May VE, Meixner H, Rockenstein E, Chutna O, Outeiro TF, Winkler J, Masliah E, Klucken J
Autophagy 2014;10(12):2171-92. doi: 10.4161/auto.36436. PMID: 25484190 Free PMC Article

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Impaired annexin V binding to platelet phosphatidylserine

Definition

Term Hierarchy

Recent clinical studies

Diagnosis

Clinical prediction guides

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Clinical resources

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Reviews

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